نتائج البحث - "Jordan Tang"

المساهمون: Ghosh, A. K., Brindisi, M., Yen, Y. -C., Lendy, E. K., Kovela, S., Cardenas, E. L., Reddy, B. S., Rao, K. V., Downs, D., Huang, X., Tang, J., Mesecar, A. D.

المصدر: ChemMedChem. 14(5)

مصطلحات موضوعية: Isostere, Stereochemistry, BACE2 inhibitor, Drug Evaluation, Preclinical, Crystallography, X-Ray, Biochemistry, Article, chemistry.chemical_compound, Structure-Activity Relationship, Tmem27, Drug Discovery, Amyloid precursor protein, Ethylamines, Structure–activity relationship, Aspartic Acid Endopeptidases, Humans, Hypoglycemic Agents, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, type 2 diabete, Trifluoromethyl, Binding Sites, biology, Molecular Structure, Organic Chemistry, BACE2 inhibitors, structure-based design, type 2 diabetes, β-secretase 2, Molecular Docking Simulation, Memapsin 1, Enzyme, chemistry, Diabetes Mellitus, Type 2, Docking (molecular), biology.protein, Molecular Medicine, Thermodynamics, Amyloid Precursor Protein Secretases, Selectivity, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fba27ca172570d648b5c71e66b4c56d
https://pubmed.ncbi.nlm.nih.gov/30637955

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4

Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes

المؤلفون: Andrew D. Mesecar, Emilio L. Cárdenas, Deborah Downs, Kanury V. S. Rao, Yu-Chen Yen, Xiangping Huang, Jordan Tang, Arun K. Ghosh, Bhavanam Sekhara Reddy

المصدر: Chemical Science. 7:3117-3122

مصطلحات موضوعية: 0301 basic medicine, Cathepsin, Chemistry, General Chemistry, Type 2 diabetes, Pharmacology, Highly selective, medicine.disease, Combinatorial chemistry, 3. Good health, 03 medical and health sciences, Memapsin 1, 030104 developmental biology, β secretase, medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573b8d66f02273c2c3c567ed0e16a2b0
https://doi.org/10.1039/c5sc03718b

5

Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand

المؤلفون: Nagaswamy Kumaragurubaran, Koena Ghosh, Andrew D. Mesecar, Arun K. Ghosh, Emma K. Lendy, Jordan Tang, Margherita Brindisi, Yu-Chen Yen, Xiangping Huang

المساهمون: Ghosh, A. K., Ghosh, K., Brindisi, M., Lendy, E. K., Yen, Y. -C., Kumaragurubaran, N., Huang, X., Tang, J., Mesecar, A. D.

مصطلحات موضوعية: 0301 basic medicine, Amide, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Isoxazole, Catalytic Domain, Drug Discovery, Aspartic Acid Endopeptidases, β-secretase, Aspartic Acid Endopeptidase, Amyloid Precursor Protein Secretase, Memapsin 2, Alanine, Crystallography, biology, Bicyclic molecule, Molecular Structure, Chemistry, BACE-1, Alzheimer's disease, symbols, Molecular Medicine, van der Waals force, Carboxylic Acid, Human, Stereochemistry, Isoxazoline, Amides, Amyloid Precursor Protein Secretases, Bridged Bicyclo Compounds, Cysteine, Humans, Isoxazoles, Protease Inhibitors, 010402 general chemistry, Article, 03 medical and health sciences, symbols.namesake, mental disorders, Hydrolase, Molecule, Molecular Biology, Ligand, Organic Chemistry, Active site, 0104 chemical sciences, 030104 developmental biology, biology.protein, X-Ray, Bridged Bicyclo Compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ab8582625d739744a324e7c35a80f3
http://hdl.handle.net/11588/771102

6

Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand

المؤلفون: Andrew D. Mesecar, Thippeswamy Devasamudram, Xiao Ming Xu, Jordan Tang, Yu-Chen Yen, Xiangping Huang, Gerald Koelsch, Arun K. Ghosh, Geoffrey Bilcer, Margherita Brindisi, Hui Lei

المساهمون: Ghosh, Arun K., Brindisi, Margherita, Yen, Yu Chen, Xu, Xiaoming, Huang, Xiangping, Devasamudram, Thippeswamy, Bilcer, Geoffrey, Lei, Hui, Koelsch, Gerald, Mesecar, Andrew D., Tang, Jordan

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:668-672

مصطلحات موضوعية: Protease Inhibitor, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Crystallography, X-Ray, Ligands, Biochemistry, chemistry.chemical_compound, Catalytic Domain, Drug Discovery, β-secretase, Moiety, Amyloid Precursor Protein Secretase, Alzheimer's disease, BACE-1, Memapsin 2, Protease inhibitors, Amyloid Precursor Protein Secretases, Binding Sites, Kinetics, Molecular Dynamics Simulation, Protease Inhibitors, Protein Binding, Pyrazoles, Structure-Activity Relationship, Thiazoles, Drug Design, Molecular Medicine, Molecular Biology, 3003, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Crystallography, biology, Stereochemistry, Ligand, Article, Structure–activity relationship, Binding site, Thiazole, Kinetic, Binding Site, Active site, Combinatorial chemistry, chemistry, X-Ray, biology.protein, Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ca53b6dd2a23f1f20f45eecab6420d
https://doi.org/10.1016/j.bmcl.2014.11.087

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7

Beneficial Effects of the β-Secretase Inhibitor GRL-8234 in 5XFAD Alzheimer’s Transgenic Mice Lessen During Disease Progression

المؤلفون: Latha Devi, Masuo Ohno, Jordan Tang

المصدر: Current Alzheimer Research. 12:13-21

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b8435b27bebe51a74b287bd8855af5ba
https://doi.org/10.2174/1567205012666141218125042

8

Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands

المؤلفون: Andrew D. Mesecar, Emilio L. Cárdenas, Jordan Tang, Yu-Chen Yen, Margherita Brindisi, Xiangping Huang, Nagaswamy Kumaragurubaran, Jean Rene Ella-Menye, Arun K. Ghosh

المساهمون: Ghosh, Arun K., Brindisi, Margherita, Yen, Yu-Chen, Cã¡rdenas, Emilio L., Ella-Menye, Jean-Rene, Kumaragurubaran, Nagaswamy, Huang, Xiangping, Tang, Jordan, Mesecar, Andrew D.

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Phthalic Acids, Pharmaceutical Science, Crystal structure, 01 natural sciences, Biochemistry, Piperazines, Article, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Î²-Secretase, mental disorders, Drug Discovery, Aspartic Acid Endopeptidases, Structure–activity relationship, Aspartic Acid Endopeptidase, Amyloid Precursor Protein Secretase, Memapsin 2, Phthalic Acid, Piperazine, Molecular Biology, Bicyclic molecule, 010405 organic chemistry, BACE-1, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, X-ray, Protease inhibitors, Alzheimer's disease, 0104 chemical sciences, Phthalic acid, 030104 developmental biology, Design synthesis, chemistry, Protease inhibitor, β secretase, Amyloid Precursor Protein Secretases, Molecular Medicine, 3003

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae81974b3994c5ead563c93b995ec91
http://hdl.handle.net/11588/771128

9

Cover Feature: Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies (ChemMedChem 5/2019)

المؤلفون: Margherita Brindisi, Arun K. Ghosh, Bhavanam Sekhara Reddy, Andrew D. Mesecar, Kalapala Venketeswara Rao, Deborah Downs, Jordan Tang, Satish Kovela, Emma K. Lendy, Emilio L. Cárdenas, Yu-Chen Yen, Xiangping Huang

المصدر: ChemMedChem. 14:513-513

مصطلحات موضوعية: Pharmacology, Stereochemistry, Chemistry, Organic Chemistry, Highly selective, Biochemistry, Design synthesis, Feature (computer vision), Drug Discovery, β secretase, Molecular Medicine, Structure–activity relationship, Cover (algebra), General Pharmacology, Toxicology and Pharmaceutics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dbd9b7e06126cf58b3b66af6067e505a
https://doi.org/10.1002/cmdc.201900100

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10

Structure–activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease

المؤلفون: Liu Cao, Jordan Tang, Lin Hong, Kathleen A. Coughlan, Liang Wang, Xiaoman Li

المصدر: Acta Biochimica et Biophysica Sinica. 45:613-621

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afadb60549e301417a953bcc794018d
https://doi.org/10.1093/abbs/gmt050

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