المؤلفون: Ana Maranha, Mafalda Costa, Jorge Ripoll-Rozada, José A. Manso, Vanessa Miranda, Vera M. Mendes, Bruno Manadas, Sandra Macedo-Ribeiro, M. Rita Ventura, Pedro José Barbosa Pereira, Nuno Empadinhas

المصدر: Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2399-3642

URL الوصول: https://doaj.org/article/160414c28e904d199761ec1e0d62082e

المؤلفون: Emma E. Watson, Xuyu Liu, Robert E. Thompson, Jorge Ripoll-Rozada, Mike Wu, Imala Alwis, Alessandro Gori, Choy-Theng Loh, Benjamin L. Parker, Gottfried Otting, Shaun Jackson, Pedro José Barbosa Pereira, Richard J. Payne

المصدر: ACS Central Science, Vol 4, Iss 4, Pp 468-476 (2018)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2374-7951

URL الوصول: https://doaj.org/article/39f6c6008a294a2faf94d657f88622d6

المؤلفون: Jorge Ripoll-Rozada, Joshua W. C. Maxwell, Richard J. Payne, Pedro José Barbosa Pereira

المصدر: Biochemical Society Transactions. 50:387-401

مصطلحات موضوعية: Thrombin, Animals, Anticoagulants, Tyrosine, Amino Acid Sequence, Hirudins, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e373b6e06444dcb86976b109c5b0ceaf
https://doi.org/10.1042/bst20210600

المؤلفون: Daniel J Ford, Henri M. H. Spronk, Wenyu Liu, Vishnu M. Sasi, Colin J. Jackson, Tilman M. Hackeng, Nisharnthi M Duggan, Pedro Pereira, Hiroaki Suga, Stijn M. Agten, Anneliese S. Ashhurst, Rene van Oerle, Jorge Ripoll-Rozada, Richard J. Payne, Joe A. Kaczmarski, Leo Corcilius, Toby Passioura, Sarah E. Fry

المساهمون: Biochemie, RS: Carim - B01 Blood proteins & engineering, RS: Carim - B04 Clinical thrombosis and Haemostasis

المصدر: Journal of Medicinal Chemistry, 64(11), 7853-7876. American Chemical Society

مصطلحات موضوعية: Factor XIIa, Peptide, COAGULATION-FACTOR XII, 01 natural sciences, IN-VITRO SELECTION, Serine, Drug Discovery, Messenger/chemistry, Puromycin/chemistry, chemistry.chemical_classification, 0303 health sciences, Chemistry, Protein Stability, Peptides, Cyclic/chemistry, Alanine scanning, Cyclic peptide, Biochemistry, Genetic Code, Molecular Medicine, RNA, Messenger/chemistry, Kallikreins, Puromycin, Partial Thromboplastin Time, Proteases, Serine Proteinase Inhibitors, Molecular Dynamics Simulation, Peptides, Cyclic, VALIDATION, 03 medical and health sciences, Inhibitory Concentration 50, Structure-Activity Relationship, MACROCYCLE INHIBITOR, mRNA display, Humans, RNA, Messenger, Binding site, 030304 developmental biology, Gene Library, Binding Sites, Factor XIIa/antagonists & inhibitors, Cyclic/chemistry, 0104 chemical sciences, Serine Proteinase Inhibitors/chemistry, THROMBUS FORMATION, 010404 medicinal & biomolecular chemistry, Kallikreins/chemistry, Prothrombin Time, RNA, Peptides, GENERATION

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0a2fcd6f50b94b3bfc83aa64363fc4
https://doi.org/10.1021/acs.jmedchem.1c00651

المؤلفون: Ana Maranha, Mafalda Costa, Jorge Ripoll-Rozada, José A. Manso, Vanessa Miranda, Vera M. Mendes, Bruno Manadas, Sandra Macedo-Ribeiro, M. Rita Ventura, Pedro José Barbosa Pereira, Nuno Empadinhas

المساهمون: Universidad de Cantabria

المصدر: Communications biology, 2023, 6(1), 108

مصطلحات موضوعية: Medicine (miscellaneous), General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01017da7a80725bb99e047c42290260
https://doi.org/10.21203/rs.3.rs-1362692/v1

المؤلفون: Mike C. L. Wu, Imala Alwis, Richard J. Payne, Pedro Pereira, Shaun P. Jackson, Emma E. Watson, Jorge Ripoll-Rozada, Stijn M. Agten, Luke J. Dowman

المساهمون: Biochemie, RS: Carim - B01 Blood proteins & engineering

المصدر: Angewandte Chemie-International Edition, 60(10), 5348-5356. Wiley-VCH Verlag

مصطلحات موضوعية: Male, Proteases, Tsetse Flies, protein synthesis, medicine.medical_treatment, Protein Engineering, 010402 general chemistry, 01 natural sciences, Catalysis, Thrombin, Amblyomma, Catalytic Domain, Anopheles, medicine, Animals, Humans, Salivary Proteins and Peptides, Protease, biology, 010405 organic chemistry, Chemistry, anticoagulant, Rational design, Anticoagulants, Active site, Thrombosis, General Chemistry, Native chemical ligation, 0104 chemical sciences, Mice, Inbred C57BL, Coagulation, Biochemistry, peptide ligation, biology.protein, peptide engineering, Platelet Aggregation Inhibitors, Protein Binding, medicine.drug, Discovery and development of direct thrombin inhibitors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b8ae05a719d1ad3bf8caa24794e3ba
https://doi.org/10.1002/anie.202015127

المؤلفون: Stijn M. Agten, Emma E. Watson, Jorge Ripoll‐Rozada, Luke J. Dowman, Mike C. L. Wu, Imala Alwis, Shaun P. Jackson, Pedro José Barbosa Pereira, Richard J. Payne

المصدر: Angewandte Chemie. 133:5408-5416

مصطلحات موضوعية: General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::22079735b5dec7102353a97fb283be13
https://doi.org/10.1002/ange.202015127

المؤلفون: Jorge Ripoll-Rozada, Bárbara M. Calisto, Pedro Pereira, Richard J. Payne, Stijn M. Agten, Luke J. Dowman

المصدر: Chemical Communications, 57(83), 10923-10926. Royal Society of Chemistry

مصطلحات موضوعية: ANTICOAGULANT, Tyrosine sulfation, Stereochemistry, Context (language use), Crystallography, X-Ray, Sulfotyrosine, Antithrombins, SALIVA, Catalysis, chemistry.chemical_compound, Thrombin, REVEALS, BINDING, Materials Chemistry, medicine, Humans, Acid stable, Enzyme Assays, SULFOPROTEINS, Chemistry, RECOGNITION, Metals and Alloys, General Chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Sulfonate, SULFOPEPTIDES, Ceramics and Composites, Tyrosine, TYROSINE SULFATION, Peptides, Protein Binding, Discovery and development of direct thrombin inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2832f1a00825e0326796a93da730a64
https://doi.org/10.1039/d1cc04742f

المؤلفون: Richard J. Payne, Daniel Clayton, Sameer S. Kulkarni, Jorge Ripoll-Rozada, Jessica Sayers, Pedro Pereira, Luke J. Dowman

المصدر: RSC Chemical Biology. 1:379-384

مصطلحات موضوعية: Tyrosine sulfation, 010405 organic chemistry, Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, Chemical synthesis, 0104 chemical sciences, Thrombin, Sulfation, Chemistry (miscellaneous), medicine, Potency, Ligation, Molecular Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b2e14be1be4adaff04bd10a578492867
https://doi.org/10.1039/d0cb00146e

المؤلفون: Ashley Lee, Tim Pasch, Charlotte Franck, Shaun P. Jackson, Emma E. Watson, Jessica Sayers, Bhavesh Premdjee, Pedro M. Martins, Pedro Pereira, Jorge Ripoll-Rozada, Richard J. Payne, Mike C. L. Wu, Maria Filipa Pinto

المصدر: Proceedings of the National Academy of Sciences. 116:13873-13878

مصطلحات موضوعية: medicine.drug_class, Peptide, Serine, Structure-Activity Relationship, Sulfation, Thrombin, medicine, Humans, Amino Acid Sequence, Salivary Proteins and Peptides, Tyrosine, Blood Coagulation, Peptide sequence, Gene Library, chemistry.chemical_classification, Multidisciplinary, Chemistry, Biomolecule, Anticoagulant, Anticoagulants, Computational Biology, Biochemistry, Physical Sciences, Insect Proteins, Protein Processing, Post-Translational, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62b200a1628977e0588688668e3c323
https://doi.org/10.1073/pnas.1905177116