نتائج البحث - "Joris Vandenbossche"

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دورية أكاديمية

A quantitative systems pharmacology model for acute viral hepatitis B

المؤلفون: Eduardo Asín-Prieto, Zinnia P. Parra-Guillen, José David Gómez Mantilla, Joris Vandenbossche, Kim Stuyckens, Xavier Woot de Trixhe, Juan José Perez-Ruixo, Iñaki F. Troconiz

المصدر: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4997-5007 (2021)

مصطلحات موضوعية: Hepatitis B, Quantitative systems pharmacology, Mechanistic modeling, Immune system dynamics, Viral dynamics, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037021003834; https://doaj.org/toc/2001-0370

URL الوصول: https://doaj.org/article/fee79ea1370e4a26ac189229868cebc8

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Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection

المؤلفون: Harry L A Janssen, Jinlin Hou, Tarik Asselah, Henry L Y Chan, Fabien Zoulim, Yasuhito Tanaka, Ewa Janczewska, Ronald G Nahass, Stefan Bourgeois, Maria Buti, Pietro Lampertico, Oliver Lenz, Thierry Verbinnen, Joris Vandenbossche, Willem Talloen, Ronald Kalmeijer, Maria Beumont, Michael Biermer, Umesh Shukla

المساهمون: Gastroenterology & Hepatology, Institut Català de la Salut, [Janssen HLA] Toronto General Hospital, Toronto, Ontario, Canada. Erasmus Medical Center, Rotterdam, Zuid-Holland, The Netherlands. [Hou J] Nanfang Hospital, Southern Medical University, Guangzhou, China. [Asselah T] Université de Paris Cité, INSERM UMR1149, Hôpital Beaujon AP-HP, Clichy, France. [Chan HLY] The Chinese University of Hong Kong, Hong Kong SAR, China. [Zoulim F] Hospices Civils de Lyon and Lyon University & INSERM U1052-Cancer Research Institute of Lyon, Lyon, France. [Tanaka Y] Department of Gastroenterology and Hepatology, Kumamoto University, Kumamoto, Japan. [Buti M] Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBERHED del Instituto Carlos III, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus

المصدر: Gut. BMJ Publishing Group
Scientia

مصطلحات موضوعية: SDG 3 - Good Health and Well-being, Otros calificadores::/uso terapéutico [Otros calificadores], acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antivíricos [COMPUESTOS QUÍMICOS Y DROGAS], Gastroenterology, Medicaments antivírics - Ús terapèutic, Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Other subheadings::/therapeutic use [Other subheadings], Other subheadings::Other subheadings::/drug therapy [Other subheadings], Hepatitis B - Tractament, virosis::infecciones por virus ADN::infecciones por Hepadnaviridae::hepatitis B::hepatitis B crónica [ENFERMEDADES], Virus Diseases::DNA Virus Infections::Hepadnaviridae Infections::Hepatitis B::Hepatitis B, Chronic [DISEASES], Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents [CHEMICALS AND DRUGS]

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f702b8cc4a17edfe62562c85466ffa3f
https://doi.org/10.1136/gutjnl-2022-328041

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Drug‐Drug Interactions With the Hepatitis B Virus Capsid Assembly Modulator JNJ‐56136379 (Bersacapavir)

المؤلفون: Joris, Vandenbossche, Jeysen, Yogaratnam, Vera, Hillewaert, Freya, Rasschaert, Willem, Talloen, Jeike, Biewenga, Jan, Snoeys, Thomas N, Kakuda, Martyn, Palmer, Julius, Nangosyah, Michael, Biermer

المصدر: Clinical Pharmacology in Drug Development. 11:1419-1429

مصطلحات موضوعية: Adult, Hepatitis B virus, Midazolam, Pharmaceutical Science, Ethinyl Estradiol, Antiviral Agents, Capsid, Humans, Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A, Female, Drug Interactions, Pharmacology (medical), Itraconazole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46aeb60d5492b55a4cdaa1a03186527
https://doi.org/10.1002/cpdd.1164

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A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults

المؤلفون: Wim Pierson, Marianne Tuefferd, Florence Herschke, Leen Slaets, Marjolein Crabbe, Dorien Verstappen, Steffi De Pelsmaeker, Ian Strickland, Edward J Gane, Christian Schwabe, Yingjie Zhang, Peter Meerts, Joris Vandenbossche, Pieter Van Remoortere, Inge Verbrugge, An De Creus

المصدر: Antiviral Therapy. 28:135965352311728

مصطلحات موضوعية: Pharmacology, Infectious Diseases, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::907c3e6cb9893ef4af40ac097e45b8da
https://doi.org/10.1177/13596535231172878

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A quantitative systems pharmacology model for acute viral hepatitis B

المؤلفون: Iñaki F. Trocóniz, Juan Jose Perez-Ruixo, Xavier Woot de Trixhe, Eduardo Asín-Prieto, Kim Stuyckens, Zinnia P. Parra-Guillen, José David Gómez Mantilla, Joris Vandenbossche

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4997-5007 (2021)

مصطلحات موضوعية: Mechanistic modeling, Disease, dHep, debris hepatocytes, medicine.disease_cause, Biochemistry, LPC, long-lived plasma cells, Immune system dynamics, Structural Biology, DC, dendritic cells, PB, plasmablasts, Medicine, QSP, quantitative systems pharmacology, Liver infection, TRAIL, tumor necrosis factor–related apoptosis-inducing ligand, Th0, naïve T cells, Hepatitis B, Computer Science Applications, CTL, antigen-specific cytotoxic T lymphocytes, HBsAg, hepatitis B surface antigen, anti-HBc, specific antibodies against core hepatitis B antigen, anti-HBs, specific antibodies against surface hepatitis B antigen, CTL*, activated CTL, HB, Hepatitis B, iHep, infected hepatocytes, Viral dynamics, ODE, ordinary differential equations, CHB, chronic hepatitis B, Biotechnology, Systems pharmacology, Research Article, NK*, activated NK, pDC, plasmacytoid DC, PL, plasma, SPC, short-lived plasma cells, Biophysics, Heptot, total hepatocytes, Virus, NK, natural killer cells, Quantitative systems pharmacology, Immune system, PC, plasma cells, ALT, alanine aminotransferase, Genetics, CTLm, memory CTL, Hep, hepatocytes, IFN, interferon, DC*, activated dendritic cells, HBV, hepatitis B virus, HBV DNA, circulating DNA levels of HBV, MDSC, myeloid-derived suppressor cells, ComputingMethodologies_COMPUTERGRAPHICS, Hepatitis B virus, AHB, acute hepatitis B, business.industry, LV, liver, medicine.disease, Treg, regulatory T cells, Immunology, LN, lymph node, business, TP248.13-248.65, CD8

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722cc9968b8cd803c557713cd9269da2
http://europepmc.org/articles/PMC8449028

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JNJ-64794964, a TLR-7 agonist, in healthy adults

المؤلفون: Bart Fevery, Liviawati S Wu, Rui Li, Leen Slaets, An De Creus, Abbie Oey, Ilham Smyej, Ullrich Schwertschlag, Samia Siddiqui, Pieter Van Remoortere, Christian Schwabe, E.J. Gane, Mina Pastagia, Joris Vandenbossche, Clark Musto

المصدر: Antiviral Therapy. 26:58-68

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fef35dafbdcd92b566916dc647020f2
https://doi.org/10.1177/13596535211056581

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Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants

المؤلفون: Liviawati S Wu, Yue Hu, Edward J Gane, Leen Slaets, An De Creus, Yanhua Ding, Junqi Niu, Christian Schwabe, Nele Goeyvaerts, Zhongnan Xu, Dandan Huo, Marianne Tuefferd, Inge Verbrugge, Pieter Van Remoortere, Ullrich Schwertschlag, Joris Vandenbossche

المصدر: Antiviral Therapy. 28:135965352311516

مصطلحات موضوعية: Pharmacology, Infectious Diseases, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8a0e7a238c633fd96ae9cd28c86764a1
https://doi.org/10.1177/13596535231151626

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Pharmacokinetics, Safety and Tolerability of JNJ-56136379, a Novel Hepatitis B Virus Capsid Assembly Modulator, in Healthy Subjects

المؤلفون: Jan Martin Berke, Loeckie de Zwart, Willem Talloen, Maarten van den Boer, Jan Snoeys, Joris Vandenbossche, Jeysen Yogaratnam, W. Jessner, Jeike Biewenga

المصدر: Advances in Therapy. 36:2450-2462

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee338a6355add8de582946c10623603d
https://doi.org/10.1007/s12325-019-01017-1

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JNJ-56136379, an HBV Capsid Assembly Modulator, Is Well-Tolerated and Has Antiviral Activity in a Phase 1 Study of Patients With Chronic Infection

المؤلفون: Javier Crespo, Maria Buti, Christoph Sarrazin, Fabien Zoulim, Iurie Moscalu, Willem Talloen, Jeysen Yogaratnam, John Fry, Joris Vandenbossche, Juan Manuel Pascasio, Thomas Vanwolleghem, Oliver Lenz, Adrian Streinu-Cercel, Suzanne Bourgeois, Thierry Verbinnen, Umesh Shukla

المساهمون: Gastroenterology & Hepatology, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Gastroenterology, 159(2), 521-+. W.B. Saunders
Gastroenterology
Gastroenterology, WB Saunders, 2020, 159, pp.521-533.e9. ⟨10.1053/j.gastro.2020.04.036⟩

مصطلحات موضوعية: 0301 basic medicine, Male, HBsAg, medicine.medical_specialty, Hepatitis B virus, [SDV]Life Sciences [q-bio], Cmax, Administration, Oral, medicine.disease_cause, Placebo, HBeAg, Gastroenterology, Loading dose, Antiviral Agents, 03 medical and health sciences, Cmin, Young Adult, 0302 clinical medicine, Capsid, Hepatitis B, Chronic, Pharmacokinetics, Double-Blind Method, Internal medicine, medicine, Humans, Organic Chemicals, Hepatology, Dose-Response Relationship, Drug, business.industry, Virus Assembly, Area under the curve, Middle Aged, 3. Good health, 030104 developmental biology, Treatment Outcome, Liver, DNA, Viral, 030211 gastroenterology & hepatology, Female, Human medicine, Drug, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8e15501fdbb16f4db4269cc116b319
http://www.gastrojournal.org/article/S0016508520305199/pdf

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Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy

المؤلفون: Moana Hodari, David Blue, Jan Martin Berke, Joris Vandenbossche, Sandra De Meyer, Jeysen Yogaratnam, Thierry Verbinnen, Oliver Lenz, Umesh Shukla, Willem Talloen

المصدر: Journal of viral hepatitisREFERENCES. 27(11)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb72a2882652d59381a57ed917dd0c7
https://pubmed.ncbi.nlm.nih.gov/32579776

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