-
1
المؤلفون: Landon R. Whitby, Kevin Kelnar, Jin Ren, Peter A. Beal, Sujiet Puthenveetil, Joseph F. Krebs
المصدر: Nucleic Acids Research
مصطلحات موضوعية: Models, Molecular, Small interfering RNA, viruses, Cell Line, eIF-2 Kinase, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Genetics, Humans, RNA, Small Interfering, Binding site, Kinase activity, 030304 developmental biology, 0303 health sciences, EIF-2 kinase, Binding Sites, biology, Hydroxyl Radical, RNA, biochemical phenomena, metabolism, and nutrition, Molecular biology, Protein kinase R, Protein Structure, Tertiary, Cell biology, Enzyme Activation, enzymes and coenzymes (carbohydrates), RNA silencing, 030220 oncology & carcinogenesis, biology.protein, RNA Interference
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3109cb543b8b552b8ada4bfb523c589c
https://doi.org/10.1093/nar/gkl464 -
2
المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
-
3
المؤلفون: Anu Srinivasan, Lawrence C. Fritz, Joseph F. Krebs, Kevin J. Tomaselli, Joe C. Wu, Angela M. Wong
المصدر: Biochemistry. 39:16056-16063
مصطلحات موضوعية: Octoxynol, Detergents, Molecular Sequence Data, Caspase 3, Biochemistry, Chromatography, Affinity, Substrate Specificity, law.invention, Mice, Glucosides, Affinity chromatography, Coumarins, law, Zymogen, Animals, Humans, Amino Acid Sequence, Lymphocytes, Binding selectivity, Caspase, Cell Line, Transformed, chemistry.chemical_classification, Enzyme Precursors, biology, Hydrolysis, Caspase 1, Cell Membrane, Membrane Proteins, Caspase Inhibitors, Molecular biology, Amino acid, Enzyme Activation, Kinetics, Membrane, chemistry, Caspases, biology.protein, Recombinant DNA, Oligopeptides
-
4
المؤلفون: Christian Leist, Kim Hoang, Anu Srinivasan, Donald S. Karanewsky, Tam Vu, Lawrence C. Fritz, Robert C. Armstrong, Joe C. Wu, Bryan Pham, Teresa Aja, Rob Sayers, Albert Schmitz, Angela M. Wong, Joseph F. Krebs, Aileen Aboy, Kevin J. Tomaselli
المصدر: The Journal of Cell Biology
مصطلحات موضوعية: caspase, Cytochrome c Group, Caspase 3, Cell Line, Coumarins, Zymogen, Humans, Bcl-2, programmed cell death, Caspase, Enzyme Precursors, biology, Hydrolysis, Cytochrome c, apoptosis, Membrane Proteins, Cell Biology, Caspase Inhibitors, Cell biology, Enzyme Activation, Cytosol, cytochrome c, Membrane, Proto-Oncogene Proteins c-bcl-2, Cytoplasm, Caspases, biology.protein, Oligopeptides, Intracellular, Subcellular Fractions, Regular Articles
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789f6e636e676d741d6d8f50362f45a9
https://doi.org/10.1083/jcb.144.5.915 -
5
المؤلفون: Joseph A. Trapani, Kevin J. Tomaselli, Teresa Fernandes-Alnemri, Lawrence C. Fritz, Emad S. Alnemri, Lijuan Wang, Florencia Bullrich, Joseph F. Krebs, Robert C. Armstrong, Gerald Litwack, Srinivasa M. Srinivasula
المصدر: Proceedings of the National Academy of Sciences. 93:7464-7469
مصطلحات موضوعية: Proteases, T-Lymphocytes, medicine.medical_treatment, Molecular Sequence Data, Apoptosis, Rodentia, Hybrid Cells, Caspase 8, Polymerase Chain Reaction, Cell Line, Tumor Cells, Cultured, medicine, Animals, Humans, Amino Acid Sequence, FADD, Cloning, Molecular, Caspase 10, Chromosomes, Artificial, Yeast, Caspase, DNA Primers, Serine protease, Multidisciplinary, Protease, Base Sequence, Sequence Homology, Amino Acid, biology, Caspase 3, Chromosome Mapping, Caspase 9, Recombinant Proteins, Enzyme Activation, Granzyme B, Cysteine Endopeptidases, Kinetics, Biochemistry, Caspases, Chromosomes, Human, Pair 2, biology.protein, Death effector domain, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdb127d17a49ff370857712a3bb6bce
https://doi.org/10.1073/pnas.93.15.7464 -
6
المؤلفون: Joseph F. Krebs, Jialing Xiang, Smita Gaur, Lawrence C. Fritz, Xu Bai, Kevin J. Tomaselli, Stanley J. Korsmeyer, Teresa Aja, Donald S. Karanewsky, Robert C. Armstrong, Kim Hoang
المصدر: Journal of Biological Chemistry. 271:16850-16855
مصطلحات موضوعية: Proteases, Programmed cell death, medicine.medical_treatment, Molecular Sequence Data, Caspase 1, Apoptosis, Cysteine Proteinase Inhibitors, Proto-Oncogene Mas, Biochemistry, Jurkat cells, Cell Line, Enzyme activator, Proto-Oncogene Proteins, medicine, Humans, Amino Acid Sequence, fas Receptor, Molecular Biology, Caspase, Protease, biology, Caspase 3, Hydrolysis, fungi, Cell Biology, Molecular biology, Cell biology, Enzyme Activation, Cysteine Endopeptidases, Proto-Oncogene Proteins c-bcl-2, Caspases, biology.protein, Protein Processing, Post-Translational
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc541b7846591585e609d45b148ec91
https://doi.org/10.1074/jbc.271.28.16850 -
7
المصدر: Biochemistry. 34:3981-3989
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Carbonic anhydrase II, Biochemistry, Protein structure, Leucine, Transition state analog, Carbonic anhydrase, medicine, Side chain, Humans, Binding site, Carbonic Anhydrase Inhibitors, Carbonic Anhydrases, Dansyl Compounds, chemistry.chemical_classification, Binding Sites, Fourier Analysis, biology, Chemistry, Recombinant Proteins, Amino acid, Acetazolamide, Kinetics, Mutagenesis, Site-Directed, biology.protein, medicine.drug
-
8
المؤلفون: Jon D. Stewart, Joseph F. Krebs, Stephen J. Benkovic, Gary Siuzdak, H.J. Dyson
المصدر: Biochemistry. 34:720-723
مصطلحات موضوعية: Electrospray, Binding Sites, Protein mass spectrometry, biology, Stereochemistry, Chemistry, Acylation, Substrate (chemistry), Active site, Antibodies, Catalytic, Mass spectrometry, Biochemistry, Mass Spectrometry, Recombinant Proteins, Sample preparation in mass spectrometry, chemistry.chemical_compound, biology.protein, Anilides, Immunoglobulin Fragments, Hapten, Acyl group
-
9
المؤلفون: Gary Siuzdak, Anthony J. Berdis, David B. Smithrud, Stephen J. Benkovic, John D. Stewart, Joseph F. Krebs
المصدر: Proceedings of the National Academy of Sciences. 91:7404-7409
مصطلحات موضوعية: Aniline Compounds, Binding Sites, Multidisciplinary, Immunogen, Chemistry, Stereochemistry, Antibodies, Catalytic, Catalysis, chemistry.chemical_compound, Nucleophile, Covalent bond, Tetrahedral carbonyl addition compound, Amide, Reactivity (chemistry), Binding site, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a33aa24e90a4c7851154ec907a3dce0
https://doi.org/10.1073/pnas.91.16.7404 -
10
المصدر: Journal of Biological Chemistry. 268:27458-27466
مصطلحات موضوعية: chemistry.chemical_classification, Hydrogen bond, Stereochemistry, Carbonic anhydrase II, Bicarbonate, Cell Biology, Biochemistry, Amino acid, chemistry.chemical_compound, symbols.namesake, Enzyme, chemistry, Mole, symbols, Side chain, van der Waals force, Molecular Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9a1786d6e19a97dd57589275e84eae98
https://doi.org/10.1016/s0021-9258(19)74269-0