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1
المؤلفون: Manish K. Jha, Abu Minhajuddin, Holli Slater, Taryn L. Mayes, Joseph Blader, Ryan Brown, Cynthia Garza, Beth D. Kennard, David Riddle, Eric A. Storch, Joseph Shotwell, Cesar A. Soutullo, Sarah M. Wakefield, Madhukar H. Trivedi
المصدر: Journal of Psychiatric Research. 161:179-187
مصطلحات موضوعية: Psychiatry and Mental health, Biological Psychiatry
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2
المؤلفون: Kien T. Nguyen, Chester A. Metcalf, Douglas Bevan, Jan Antoinette C. Romero, Bin Wang, Dominic Ryan, Jing Zhang, Jared Silverman, Felix Epie, Anu Daniel, Nicole M. Carter, Terence Moy, Yanzhi Zhang, Jason B. Cross, Ajit Chavan, Lippa Blaise S, Qingyi Yang, Katherine M. Poutsiaka, Joseph Shotwell, Roland E. Dolle, Brian Chamberlain, Xin Zhang
المصدر: Journal of Medicinal Chemistry. 58:8503-8512
مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, Models, Molecular, Drug, Indoles, media_common.quotation_subject, Gram-positive bacteria, Crystallography, X-Ray, Gram-Positive Bacteria, DNA gyrase, Microbiology, Bacterial protein, Human health, Bacterial Proteins, Drug Discovery, Humans, Topoisomerase II Inhibitors, Urea, Gram-Positive Bacterial Infections, Gram-positive bacterial infections, media_common, biology, Chemistry, Staphylococcal Infections, biology.organism_classification, Multidrug resistant bacteria, DNA Gyrase, Molecular Medicine, Bacteria
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3Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
المؤلفون: Jan Antoinette C. Romero, Michael F. Mesleh, Douglas Bevan, Joseph Shotwell, Ole A. Andersen, Kien T. Nguyen, Bin Wang, Jing Zhang, Katherine M. Poutsiaka, Qingyi Yang, Anu Daniel, Brian Chamberlain, Lippa Blaise S, Nicole M. Carter, Roland E. Dolle, Terence Moy, Chester A. Metcalf, Jason B. Cross, John J. Barker, M. Dominic Ryan, Jared Silverman, Felix Epie
مصطلحات موضوعية: 010405 organic chemistry, Protein subunit, ATPase, Organic Chemistry, DNA replication, Computational biology, Biology, biology.organism_classification, Bioinformatics, 01 natural sciences, Biochemistry, DNA gyrase, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Discovery, biology.protein, Antibacterial activity, Low resistance, Bacteria
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461bdfd2f15b29c8a0f1afd5fa1ba2d4
https://europepmc.org/articles/PMC4834655/ -
4
المؤلفون: Michael F. Mesleh, Joseph Shotwell, Terence Moy, Jan Kahmann, Michael W. Wood, Andrea T. Hadfield, Ole A. Andersen, Roland E. Dolle, M. Dominic Ryan, John M. Barker, Brunella Felicetti, Kien T. Nguyen, Christoph Scheich, Jason B. Cross, Qingyi Yang, Jing Zhang, Lippa Blaise S, Robert K. Y. Cheng
المصدر: Bioorganicmedicinal chemistry letters. 26(4)
مصطلحات موضوعية: DNA Topoisomerase IV, Staphylococcus aureus, Magnetic Resonance Spectroscopy, Topoisomerase IV, Protein subunit, Clinical Biochemistry, Pharmaceutical Science, Plasma protein binding, Molecular Dynamics Simulation, medicine.disease_cause, Crystallography, X-Ray, Ligands, 01 natural sciences, Biochemistry, DNA gyrase, Bacterial Proteins, Drug Discovery, medicine, Escherichia coli, Topoisomerase II Inhibitors, Binding site, Molecular Biology, Adenosine Triphosphatases, Ligand efficiency, Binding Sites, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, biochemical phenomena, metabolism, and nutrition, 0104 chemical sciences, Anti-Bacterial Agents, Protein Structure, Tertiary, 010404 medicinal & biomolecular chemistry, DNA Gyrase, Drug Design, biology.protein, Molecular Medicine, Topoisomerase-II Inhibitor, Protein Binding
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5
المؤلفون: Anu Daniel, Chester A. Metcalf, Qingyi Yang, Roland E. Dolle, Jared Silverman, Felix Epie, Anu Arya, Jan Antoinette C. Romero, Kien T. Nguyen, Lippa Blaise S, Terence Moy, Yuchuan Wu, Jason B. Cross, Dominic Ryan, Joseph Shotwell, Douglas Bevan, Brian Chamberlain, Jing Zhang, Nicole M. Carter, Vipul Kumar, Bin Wang, Katherine M. Poutsiaka
المصدر: ACS medicinal chemistry letters. 6(10)
مصطلحات موضوعية: Drug, Indazole, medicine.drug_class, media_common.quotation_subject, Topoisomerase, Organic Chemistry, Antibiotics, Biology, Biochemistry, DNA gyrase, chemistry.chemical_compound, Antibiotic resistance, Mechanism of action, chemistry, Drug Discovery, medicine, biology.protein, medicine.symptom, Antibacterial activity, media_common
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6
المؤلفون: Joseph Shotwell, Craig M. Crews, Stefan Somlo, Dayne Okuhara, Stephanie J. Leuenroth, Zhiheng Yu, Glen S. Markowitz
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 104(11)
مصطلحات موضوعية: medicine.medical_specialty, endocrine system, TRPP Cation Channels, Autosomal dominant polycystic kidney disease, chemistry.chemical_element, Mice, Transgenic, Biology, Calcium, Protein Serine-Threonine Kinases, urologic and male genital diseases, Kidney, chemistry.chemical_compound, Mice, Internal medicine, medicine, Polycystic kidney disease, Animals, Transgenes, Medicine, Chinese Traditional, Polycystic Kidney Diseases, Multidisciplinary, Voltage-dependent calcium channel, urogenital system, Cilium, Epithelial Cells, Triptolide, Phenanthrenes, Biological Sciences, medicine.disease, Endocrinology, medicine.anatomical_structure, chemistry, p21-Activated Kinases, Cancer research, Epoxy Compounds, Calcium Channels, Signal transduction, Diterpenes, Immunosuppressive Agents, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0ab6d2ee7a7c603d0930290d36d5e1
https://pubmed.ncbi.nlm.nih.gov/17360534 -
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المؤلفون: Cathleen M. Brdlik, Joseph Shotwell, Mary E. Matyskiela, Jing-Ruey J. Yeh, Rong Ju, Wenjun Zhang, Craig M. Crews, Yi Zhang
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 103(27)
مصطلحات موضوعية: Time Factors, Angiogenesis, Biology, Aminopeptidases, Gene Expression Regulation, Enzymologic, Mice, Animals, Humans, Cells, Cultured, Cell Proliferation, Mice, Knockout, Gene knockdown, Multidisciplinary, Cell growth, Endothelial Cells, Gene Expression Regulation, Developmental, Metalloendopeptidases, Gastrula, Biological Sciences, Molecular biology, Embryonic stem cell, METAP2, Cell biology, Endothelial stem cell, Mice, Inbred C57BL, Phenotype, Knockout mouse, Hemangioblast, RNA Interference, Tumor Suppressor Protein p53
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36b7708a3d74dfd89b922907f69ee24
https://pubmed.ncbi.nlm.nih.gov/16790550 -
8دورية أكاديمية
المؤلفون: Jing Zhang, Qingyi Yang, Jason B. Cross, Jan AntoinetteC. Romero, Katherine M. Poutsiaka, Felix Epie, Douglas Bevan, Bin Wang, Yanzhi Zhang, Ajit Chavan, Xin Zhang, Terence Moy, Anu Daniel, Kien Nguyen, Brian Chamberlain, Nicole Carter, Joseph Shotwell, Jared Silverman, Chester A. Metcalf, Dominic Ryan
المصدر: Journal of Medicinal Chemistry; Nov2015, Vol. 58 Issue 21, p8503-8512, 10p