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المؤلفون: David Serra, Vijay R. More, Steven K. Engle, Matthew Gallacher, Prajakta Shimpi, Michael E. Dunn, Nicholas M.P. King, Thomas G. Manfredi, Kathryn E. Gropp, Heidi M. Colton, Josh Powe, Frederick J. Vetter, Luis A Rodriguez, Kevin Agostinucci
المصدر: Toxicologic Pathology. 45:344-352
مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, medicine.medical_specialty, medicine.drug_class, Toxicology, Left ventricular hypertrophy, Ventricular Function, Left, Pathology and Forensic Medicine, Diagnosis, Differential, Rats, Sprague-Dawley, 03 medical and health sciences, Atrial natriuretic peptide, Internal medicine, medicine, Natriuretic peptide, Animals, Natriuretic Peptides, Ventricular remodeling, Oxazoles, Molecular Biology, Swimming, Cardiotoxicity, Ventricular Remodeling, business.industry, Cell Biology, Brain natriuretic peptide, medicine.disease, NPR2, PPAR gamma, 030104 developmental biology, Endocrinology, Tyrosine, Hypertrophy, Left Ventricular, business, Biomarkers
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0d2691f50122c454d6677b129f75f2
https://doi.org/10.1177/0192623316634231 -
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المؤلفون: Gajja S. Salomons, Yong Cang, Scott A. Biller, Hua Yang, Josh Powe, Dongwei Zhu, Stefan Gross, Stuart Murray, Kimberly Straley, Samuel V. Agresta, Karen S. Regan, Katharine E. Yen, Yaguang Si, Mya Steadman, Wei Liu, Lenny Dang, Ana Pop, Yue Chen, Erin Artin, Marion Dorsch, Jeremy Travins, Stephanie Santiago, Shengfang Jin, Muriel D. David, Cyril Quivoron, Andrew Kernytsky, Virginie Penard-Lacronique, Lee Silverman, Chenming Lu, Shin San Michael Su, Zhizhong Lin, Erwin E.W. Jansen, Fang Wang, Eduard A. Struys
المساهمون: Laboratory Medicine, Amsterdam Neuroscience - Cellular & Molecular Mechanisms
المصدر: Journal of Inherited Metabolic Disease
Journal of Inherited Metabolic Disease, 39(6), 807-820. Springer Netherlands
Wang, F, Travins, J, Lin, Z, Si, Y, Chen, Y, Powe, J, Murray, S, Zhu, D, Artin, E, Gross, S, Santiago, S, Steadman, M, Kernytsky, A, Straley, K, Lu, C, Pop, A, Struys, E A, Jansen, E E W, Salomons, G S, David, M D, Quivoron, C, Penard-Lacronique, V, Regan, K S, Liu, W, Dang, L, Yang, H, Silverman, L, Agresta, S, Dorsch, M, Biller, S, Yen, K, Cang, Y, Su, S S M & Jin, S 2016, ' A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model ', Journal of Inherited Metabolic Disease, vol. 39, no. 6, pp. 807-820 . https://doi.org/10.1007/s10545-016-9960-yمصطلحات موضوعية: 0301 basic medicine, Mutant, Cardiomyopathy, Locus (genetics), Biology, IDH2, Germline, Small Molecule Libraries, 03 medical and health sciences, Epilepsy, Mice, Genetics, medicine, Animals, Genetics(clinical), Gene, Genetics (clinical), chemistry.chemical_classification, Brain Diseases, Metabolic, Inborn, medicine.disease, Isocitrate Dehydrogenase, Disease Models, Animal, 030104 developmental biology, Enzyme, chemistry, Mutation, Cancer research, Original Article, Cardiomyopathies
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المؤلفون: John Newcomb, James M. Gavin, Nancy J. Bump, Stephen Tirrell, Lawrence R. Dick, Saurabh Menon, Jessica Huck, Petter Veiby, Benjamin S. Amidon, Yu Yang, Marc L. Hyer, Paul D. Greenspan, Fleming Paul E, Teresa A. Soucy, Jim Brownell, Michael Sintchak, Josh Powe, Steve Langston, Mark Manfredi, Judy Shi, Jeff Ciavarri, Darshan S. Sappal, Frank Bruzzese, Mike Kuranda, Katherine Galvin, Michael Milhollen, Ping Li, Neil F. Bence, Jing Tao Wu, Claudia Rabino, Chris Claiborne, Tary Traore, Jennifer Duffy, Jessica Riceberg, Robert J. Griffin, Kara Hoar, Anya Lublinsky, Bradley Stringer, Sai M Pulukuri
المصدر: Nature medicine. 24(2)
مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, DNA Repair, Ubiquitin-activating enzyme, Plasma protein binding, Ubiquitin-Activating Enzymes, Sulfides, Imides, General Biochemistry, Genetics and Molecular Biology, Small Molecule Libraries, 03 medical and health sciences, Mice, Ubiquitin, Cell Line, Tumor, Neoplasms, Animals, Humans, chemistry.chemical_classification, Sulfonamides, biology, Chemistry, Nucleosides, General Medicine, Small molecule, Xenograft Model Antitumor Assays, 030104 developmental biology, Enzyme, Pyrimidines, Proteasome, Cell culture, Cancer cell, Cancer research, biology.protein, Pyrazoles, DNA Damage, Protein Binding
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