المؤلفون: Craig C. Correll, Robert G. Aslanian, Li Xiao, Rema Bitar, Wei Zhou, John W. Butcher, Charles G. Garlisi, Joshua Close, Rachel N. Maccoss, Joon Jung, Scott Crawford, Kevin M. Maloney, Purakkattle Biju, Anandan Palani, Xianhai Huang, Xiaoxin Yang, Kevin D. McCormick, Scott Peterson, Hongjun Zhang, Diane Rindgen, Ying Huang, Alexei V. Buevich, Ning Shao, Li Dong, Phieng Siliphaivanh, Jason D. Brubaker, Michelle Martinez, Hongchen Qiu, François G. Gervais, Ravi P. Nargund, Zhidan Liu

المصدر: ACS Medicinal Chemistry Letters. 9:679-684

مصطلحات موضوعية: 0301 basic medicine, Drug, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, medicine.drug_class, media_common.quotation_subject, Organic Chemistry, Pharmacology, medicine.disease, Receptor antagonist, 01 natural sciences, Biochemistry, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, Pharmacokinetics, Drug Discovery, medicine, Antagonism, Crth2 antagonist, Receptor, media_common, Asthma, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efda955acd4eb892808b6d65e2545f5
https://doi.org/10.1021/acsmedchemlett.8b00145

المؤلفون: Kevin W. Johnson, Peter Fuller, Sujal V. Deshmukh, Fang He, Peter Goldenblatt, Lauren Dorosh, Hongbo Zeng, Jason D. Brubaker, Luis E. Torres, Tony Siu, Fiona Elwood, Charles A. Lesburg, Sangita B. Patel, Duan Liu, Elma Kadic, Christopher J. Dinsmore, Xavier Fradera, Lynsey Shaffer, Jonathan R. Young, Lily Y. Moy, Feng Shi, Carla Alpert, Joel A. Klappenbach, Joshua Close, Rafael Fernandez, Hongshi Yu, Nathan Bays, Dawn M. Mampreian

المصدر: Journal of Medicinal Chemistry. 60:9676-9690

مصطلحات موضوعية: 0301 basic medicine, Halogenation, Stereochemistry, medicine.drug_class, Carboxamide, Pyrazole, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Ligand efficiency, Chemistry, Drug discovery, Janus Kinase 1, Ligand (biochemistry), Rats, Bioavailability, Molecular Docking Simulation, 030104 developmental biology, Pyran, Pyrazoles, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6959a9f84f358dff1679660f1f0b87e
https://doi.org/10.1021/acs.jmedchem.7b01135

المؤلفون: Tina Zimmermann, Steven Bench, Andrea Romagnani, Klaus P. Hoeflich, Carsten Wolter, Michael Sheets, Kerrie Faia, Kerry-Ann Bright, Timothy LaBranche, Marion Dorsch, Alberto Toso, Gordon Heidkamp, James R. Bischoff, Alison Ribeiro, Joshua Close, Marina Bacac, Felix Scheuplein, Nisha Perez, Caitlin Utt, Emanuele Perola, Jan Eckmann, Kristina Fetalvero, Stefan Gross, Qiongfang Cao, Debora Paduraru, Grace O. Silva, Chaoyang Ye, Marly I. Roche, Luke Green, Erin O’Hearn, Tary Traore, Weifan Weng, Jason D. Brubaker, Joseph Kim, Michael Burke, Sylvia Herter, Chandra Miduturu, Erik Gerson, Tim Guzi, Rich Woessner

المصدر: Cancer Research. 81:1717-1717

مصطلحات موضوعية: Cancer Research, Melanoma, CD3, medicine.medical_treatment, T-cell receptor, Biology, medicine.disease, Immune system, Oncology, Cancer immunotherapy, Cancer research, medicine, biology.protein, Cytokine secretion, Kinase activity, CD8

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0eb54e4cfffcf5824710a2a61ff8ed1c
https://doi.org/10.1158/1538-7445.am2021-1717

المؤلفون: Brian B. Haines, Judith C. Fleming, Joon Jung, Paul Secrist, Hongmei Wang, Thomas A. Miller, Richard W. Heidebrecht, Paul Harrington, Joshua Close, Nicole Ozerova, John Maclean, Melissa Chenard, Astrid M. Kral

المصدر: Biochemistry. 53(4)

مصطلحات موضوعية: Gene isoform, Models, Molecular, Conformational change, Protein Conformation, Cell, Histone Deacetylase 2, Mice, Nude, Antineoplastic Agents, Histone Deacetylase 1, Biology, Hydroxamic Acids, Biochemistry, Benzoates, Substrate Specificity, Mice, Cell Line, Tumor, medicine, Animals, Humans, Fluorescent Dyes, Vorinostat, Mechanism (biology), Ligand binding assay, HDAC1, Histone Deacetylase Inhibitors, Kinetics, Histone, medicine.anatomical_structure, Mechanism of action, Xanthenes, biology.protein, Heterografts, Female, medicine.symptom, Fluorescein-5-isothiocyanate, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f01bb6ef22781c47856b23fb31baf7
https://pubmed.ncbi.nlm.nih.gov/24450491

المؤلفون: George N. Nikov, Flobert Tanga, Chris Moxham, Ziping Yang, Chaomin Li, Richard G. Ball, Joshua Close, Richard W. Heidebrecht, Gloria Y. Kwei, Lin Xu, Laura Surdi, Xiaoliu Geng, Candia Kenefic, Sanjiv J. Shah, Dan F. Savage, Valentina V. Jeliazkova-Mecheva, Jennifer Chapnick, Julie Elizabeth Burke, Solomon Kattar, Bethany Hughes, Lily Y. Moy, Sujal V. Deshmukh, Paul Moses, Damaris Diaz, John Kevin Leach, Paul Tempest, John Hendrix, Amanda Markarewicz, Nadya Smotrov, Ilona Kariv, Michael J. McNevin, Ben Munoz, Mark S. Shearman, Thomas A. Miller

المصدر: Bioorganicmedicinal chemistry letters. 22(9)

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, chemistry.chemical_compound, Mice, Pharmacokinetics, Piperidines, In vivo, Alzheimer Disease, Drug Discovery, Extracellular, Animals, γ secretase, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Amyloid beta-Peptides, Organic Chemistry, Brain, Amides, In vitro, Peptide Fragments, Enzyme, chemistry, Molecular Medicine, Piperidine, Amyloid Precursor Protein Secretases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d76db0c66a4f7b201b3015ad1e1e6a7
https://pubmed.ncbi.nlm.nih.gov/22483609

المؤلفون: Julie E. Hamill, Nicole Ozerova, Hongmei Wang, David J. Witter, Alexander A. Szewczak, Richard W. Heidebrecht, Brian B. Haines, Andreas Harsch, Richard E. Middleton, Judith C. Fleming, Chandrasekhar Mushti, Joshua Close, Jonathan B. Grimm, Melissa Chenard, Astrid M. Kral, Kevin J. Wilson, J. Paul Secrist, Thomas A. Miller, William K. Dahlberg, Bethany Hughes

المصدر: Bioorganicmedicinal chemistry letters. 19(7)

مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Transplantation, Heterologous, Organophosphonates, Pharmaceutical Science, Administration, Oral, Histone Deacetylase 2, Mice, Nude, Carboxamide, Antineoplastic Agents, Histone Deacetylase 1, Biochemistry, Histone Deacetylases, Mice, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Molecular Biology, Vorinostat, biology, Chemistry, Organic Chemistry, Histone deacetylase inhibitor, In vitro, Histone Deacetylase Inhibitors, Repressor Proteins, Enzyme inhibitor, biology.protein, Molecular Medicine, Histone deacetylase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa642b59d8b61f88f3049ae790ef4f45
https://pubmed.ncbi.nlm.nih.gov/19268585

المؤلفون: David J. Witter, Richard E. Middleton, David L. Sloman, Candia M. Kenific, Bethany Hughes, Joon Jung, Peter T. Meinke, Melissa Chenard, Astrid M. Kral, William K. Dahlberg, Joshua Close, J. Paul Secrist, Jonathan C. Cruz, Alexander A. Szewczak, Christopher Hamblett, Prasun K. Chakravarty, Andreas Harsch, Nicole Ozerova, Matthew G. Stanton, Richard W. Heidebrecht, Joey L. Methot, Paul Harrington, Thomas A. Miller, Sriram Tyagarajan, Judith C. Fleming, Julie E. Hamill

المصدر: Bioorganicmedicinal chemistry letters. 18(3)

مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Histone Deacetylase 2, Histone Deacetylase 1, Biochemistry, Histone Deacetylases, Structure-Activity Relationship, Drug Discovery, medicine, Benzene Derivatives, Humans, Protein Isoforms, Molecular Biology, Binding Sites, biology, Molecular Structure, Histone deacetylase 2, Chemistry, fungi, Organic Chemistry, Histone deacetylase inhibitor, HDAC3, HDAC1, Cell biology, Histone Deacetylase Inhibitors, Repressor Proteins, Enzyme inhibitor, biology.protein, Molecular Medicine, Histone deacetylase, Pharmacophore, Binding domain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdaa486e283fee48981ca5ca5efb9fd8
https://pubmed.ncbi.nlm.nih.gov/18182289

المؤلفون: Kral, Astrid M., Ozerova, Nicole, Joshua Close, Joon Jung, Chenard, Melissa, Fleming, Judith, Haines, Brian B., Harrington, Paul, Maclean, John, Miller, Thomas A., Secrist, Paul, Hongmei Wang, Heidebrecht Jr., Richard W.

المصدر: Biochemistry; 2/4/2014, Vol. 53 Issue 4, p735-734, 10p

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