المؤلفون: Dina Dikovskaya, John J. Cole, Susan M. Mason, Colin Nixon, Saadia A. Karim, Lynn McGarry, William Clark, Rachael N. Hewitt, Morgan A. Sammons, Jiajun Zhu, Dimitris Athineos, Joshua D.G. Leach, Francesco Marchesi, John van Tuyn, Stephen W. Tait, Claire Brock, Jennifer P. Morton, Hong Wu, Shelley L. Berger, Karen Blyth, Peter D. Adams

المصدر: Cell Reports, Vol 12, Iss 9, Pp 1483-1496 (2015)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124715008451; https://doaj.org/toc/2211-1247

URL الوصول: https://doaj.org/article/8190b7e118b64afbb59c9882cf92b89b

المؤلفون: Karen Blyth, Ewan R. Cameron, Joanne Edwards, Owen J. Sansom, Joshua D.G. Leach, William Clark, Colin Nixon, Dimitris Athineos, Steven Howard, Ann Hedley, Kirsteen J. Campbell, J. Henry M. Däbritz, Laura McDonald, Susan M. Mason, Nicholas Rooney

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1cd5d76d642f2d71107273237d8e57
https://doi.org/10.1158/0008-5472.22423628

المؤلفون: Karen Blyth, Ewan R. Cameron, Joanne Edwards, Owen J. Sansom, Joshua D.G. Leach, William Clark, Colin Nixon, Dimitris Athineos, Steven Howard, Ann Hedley, Kirsteen J. Campbell, J. Henry M. Däbritz, Laura McDonald, Susan M. Mason, Nicholas Rooney

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af3afad67572d436fb44e2aeb5dd5d2
https://doi.org/10.1158/0008-5472.22423634.v1

المؤلفون: Karen Blyth, Ewan R. Cameron, Joanne Edwards, Owen J. Sansom, Joshua D.G. Leach, William Clark, Colin Nixon, Dimitris Athineos, Steven Howard, Ann Hedley, Kirsteen J. Campbell, J. Henry M. Däbritz, Laura McDonald, Susan M. Mason, Nicholas Rooney

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9b2c8fc44285f92b9bb2df21b6d2ad
https://doi.org/10.1158/0008-5472.c.6511538.v1

المؤلفون: Karen Blyth, Ewan R. Cameron, Joanne Edwards, Owen J. Sansom, Joshua D.G. Leach, William Clark, Colin Nixon, Dimitris Athineos, Steven Howard, Ann Hedley, Kirsteen J. Campbell, J. Henry M. Däbritz, Laura McDonald, Susan M. Mason, Nicholas Rooney

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccc08d2bbed38aad46b42df51d9ec63
https://doi.org/10.1158/0008-5472.22423625

المؤلفون: Owen J. Sansom, John R. P. Knight, Simon T. Barry, Rachel A. Ridgway, David Sumpton, Rory T. Steven, Giovanny Rodriguez-Blanco, Eyal Gottlieb, Gaurav Malviya, William C. Clark, Douglas Strathdee, Emma R. Johnson, Holly Hall, Alex Dexter, Teresa Murta, David Y. Lewis, Saverio Tardito, Gregory Hamm, Gavin Brown, Colin Nixon, Kathryn Gilroy, Zoltan Takats, Sudhir B Malla, Dmitry Solovyev, Sigrid K. Fey, Fatih Ceteci, Gillian M. Mackay, Susan E. Critchlow, Ann Hedley, Nikola Vlahov, Alan M. Race, Martin Bushell, Andrew D. Campbell, Arafath Kaja Najumudeen, Richard J. A. Goodwin, Josephine Bunch, Chelsea J. Nikula, Agata Mrowinska, Philip D Dunne, Rene Jackstadt, Joshua D.G. Leach

المصدر: Nature Genetics. 53:16-26

مصطلحات موضوعية: 0303 health sciences, Mutation, Mutant, mTORC1, Biology, medicine.disease_cause, digestive system diseases, Glutamine, 03 medical and health sciences, 0302 clinical medicine, Cancer cell, Genetics, medicine, Cancer research, Amino acid transporter, KRAS, Signal transduction, neoplasms, 030217 neurology & neurosurgery, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::75b377e356fc13ecf01a28f7768fd651
https://doi.org/10.1038/s41588-020-00753-3

المؤلفون: Anne E. Willis, Laura McDonald, George Skalka, Andrew D. Campbell, Heather McKinnon, Kevin M. Haigis, John R. P. Knight, Sebastian May-Wilson, Kathryn Gilroy, William J. Faller, Emma Stanway, Leah Officer, Rachael C. L. Smith, Joshua D.G. Leach, Joseph A. Waldron, Rachel A. Ridgway, Nicola Valeri, Ewan M. Smith, Arafath Kaja Najumudeen, Nahum Sonenberg, Joanne Edwards, Rene Jackstadt, Ana Teodósio, John Le Quesne, Dustin J. Flanagan, Anne Cheasty, Georgios Kanellos, Kerri McArthur, Christopher G. Proud, Constantinos Alexandrou, Georgios Vlachogiannis, Neil P. Jones, Nikola Vlahov, Owen J. Sansom, Kathryn Af Pennel, Craig MacKay, Martin E. Swarbrick, Martin Bushell

المصدر: Knight, J R P, Alexandrou, C, Skalka, G L, Vlahov, N, Pennel, K, Officer, L, Teodosio, A, Kanellos, G, Gay, D M, May-Wilson, S, Smith, E M, Najumudeen, A K, Gilroy, K, Ridgway, R A, Flanagan, D J, Smith, R C L, McDonald, L, MacKay, C, Cheasty, A, McArthur, K, Stanway, E, Leach, J D, Jackstadt, R, Waldron, J A, Campbell, A D, Vlachogiannis, G, Valeri, N, Haigis, K M, Sonenberg, N, Proud, C G, Jones, N P, Swarbrick, M E, McKinnon, H J, Faller, W J, Quesne, J L, Edwards, J, Willis, A E, Bushell, M & Sansom, O J 2021, ' MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression ', Cancer discovery, vol. 11, no. 5, pp. 1228-1247 . https://doi.org/10.1158/2159-8290.CD-20-0652

مصطلحات موضوعية: 0301 basic medicine, Eukaryotic Initiation Factor-4E/drug effects, Colorectal cancer, Mutant, mTORC1, Biology, medicine.disease_cause, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Animals, Humans, Protein Serine-Threonine Kinases/drug effects, Phosphorylation, neoplasms, Intracellular Signaling Peptides and Proteins/drug effects, MTOR Inhibitors/pharmacology, Mutation, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, EIF4E, Translation (biology), medicine.disease, Colorectal Neoplasms/genetics, digestive system diseases, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, KRAS

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b093ca20383c7ab94bac414895dbf3
https://doi.org/10.1158/2159-8290.CD-20-0652

المؤلفون: Owen J. Sansom, T. Martins Garcia, Rana Ramadan, Vanesa Muncan, Jan Paul Medema, S. van Neerven, David J. Huels, Joshua D.G. Leach, Michele A. Battle, K. S. Carlson, Olivia D. Franklin, Louis Vermeulen, V. M. Wouters

مصطلحات موضوعية: Extracellular matrix, medicine.anatomical_structure, biology, Laminin, Paneth cell, Mesenchymal stem cell, medicine, LGR5, biology.protein, Signal transduction, Stem cell, Intestinal epithelium, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a0ff12d907fe6e719185158ab35f844a
https://doi.org/10.1101/2021.04.14.439776

المؤلفون: Joshua D.G. Leach, Jennifer P. Morton, Owen J. Sansom

المصدر: Molecular Immunology

مصطلحات موضوعية: 0301 basic medicine, Myeloid, Neutrophils, STAT3, signal transducer and activator of transcription 3, TAM, tumour-associated macrophages, EMT, epithelial to mesenchymal transition, CCR, C-C motif chemokine receptor, ICAM, intercellular adhesion molecule, APC, antigen presenting cell, TNF, tumour necrosis factor, Metastasis, 0302 clinical medicine, NET, neutrophil extracellular trap, Neoplasms, FACS, fluorescence-activated cell sorting, CXCL, C-X-C motif chemokine ligand, Tumor Microenvironment, Myeloid Cells, TGFβ, transforming growth factor beta, Neoplasm Metastasis, Epithelial cancer, PD1, programmed cell death protein 1, VEGF, vascular endothelial growth factor, Extravasation, ECM, extracellular matrix, MET, mesenchymal-to-epithelial transition, MMP, matrix metalloproteinase, Chemotaxis, Leukocyte, medicine.anatomical_structure, GM-CSF, granulocyte-macrophage colony stimulating factor, Disease Progression, G-CSF, granulocyte-colony stimulating factor, NF-κB, nuclear factor kappa B subunit 1, PI3K, phosphoinositide 3-kinase, Cell type, Stromal cell, CCL, C-C motif chemokine ligand, Immunology, CXCR, C-X-C motif chemokine receptor, TAN, tumour-associated neutrophils, Biology, Article, NK, Natural Killer, 03 medical and health sciences, ROS, reactive oxygen species, Immune system, medicine, Animals, Humans, IFN, interferon, TLR, toll-like receptor, Molecular Biology, gMDSCs, granulocytic myeloid-derived suppressor cells, Tumour microenvironment, HOCL, hypochlorous acid, Intravasation, SDF1, stromal cell-derived factor 1, medicine.disease, iNOS, Inducible nitric oxide synthase, FGF, fibroblast growth factor, IL, interleukin, 030104 developmental biology, Cancer research, TIMP-1, tissue inhibitor of metalloprotease 1, MAPK, mitogen-activated protein kinase, NLR, neutrophil to lymphocyte ratio, 030215 immunology, Homing (hematopoietic)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d05ffecb2e3e5baeafd2f36b05b85ae
https://doi.org/10.1016/j.molimm.2017.12.013

المؤلفون: William C. Clark, J. Henry M. Däbritz, Joshua D.G. Leach, Joanne Edwards, Laura McDonald, Colin Nixon, Owen J. Sansom, Steven P. Howard, Karen Blyth, Susan M. Mason, Dimitris Athineos, Ewan R. Cameron, Kirsteen J. Campbell, Nicholas Rooney, Ann Hedley

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Mice, Nude, Core Binding Factor Alpha 1 Subunit, Cell Growth Processes, Disease, Biology, Extracellular matrix, Gene Knockout Techniques, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Movement, Renal cell carcinoma, Cell Line, Tumor, medicine, Animals, Humans, Carcinoma, Renal Cell, Gene, Prognosis, medicine.disease, Kidney Neoplasms, Clear cell renal cell carcinoma, HEK293 Cells, 030104 developmental biology, Oncology, RUNX1, chemistry, Cell culture, 030220 oncology & carcinogenesis, Core Binding Factor Alpha 2 Subunit, embryonic structures, Cancer research, Heterografts, Female, Transcriptome, Kidney cancer

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169d296a122917def6d98522847289d1
https://eprints.gla.ac.uk/212726/1/212726.pdf