المؤلفون: Jonathan B. Houze, Andrea Boden, Ning Li, Dongming M. Liu, Xun Li, Jing Man Wong, Paul John Dransfield, Khanh Nguyen, Sridharan Rajamani, Gayathri Swaminath, Weston Sutherland, Yaping Sun, Ying Zhang, Vatee Pattaropong, Rhonda Chen, Vishnu Chintalgattu, Xiaochuan Ma, Murielle M. Véniant, Jim R. Turk, Ray W. Chui, Jinghong Wang, BaoXi Gao, Mark R. Fielden, Joyce Chi Yee Chan, Hugo M. Vargas, Kimberly M. Hoagland, Yinhong Chen, Yusheng Qu, Aarif Y. Khakoo, Shirley Mihardja, Qi Guo, Brandon Ason, Liaoyuan A. Hu, Ji Ma

المصدر: JCI Insight

مصطلحات موضوعية: 0301 basic medicine, Agonist, Cardiac function curve, medicine.drug_class, Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Dogs, Drug Discovery, medicine, Animals, Apelin receptor, Heart Failure, Apelin Receptors, business.industry, Heart, General Medicine, medicine.disease, Angiotensin II, Apelin, Rats, 030104 developmental biology, Losartan, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Heart failure, Vascular resistance, Intercellular Signaling Peptides and Proteins, business, medicine.drug, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3042c04a79fb6373e3d1699adde8eb0a
https://pubmed.ncbi.nlm.nih.gov/32208384

المؤلفون: John G. Allen, Brian A. Lanman, Jerry Ryan Holder, Bryant Yang, Anthony B. Reed, Les P. Miranda, Sara C. Humphreys, Joyce Chi Yee Chan, Ji Ma, Zhican Wang, Gayathri Swaminath

المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127499

مصطلحات موضوعية: Inotrope, Agonist, medicine.drug_class, Clinical Biochemistry, Myocardial Infarction, Pharmaceutical Science, Peptide, Plasma protein binding, Pharmacology, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Receptor, Molecular Biology, chemistry.chemical_classification, Apelin Receptors, Angiotensin II receptor type 1, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Lipids, Rats, 0104 chemical sciences, Apelin, 010404 medicinal & biomolecular chemistry, Injections, Intravenous, Molecular Medicine, Peptides, Endogenous agonist

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6348329f5a66f364c1e9afc3ee5606
https://doi.org/10.1016/j.bmcl.2020.127499

المؤلفون: Ruwanthi N. Gunawardane, Stephanie Masterman, Dongming Liu, Derek E. Piper, Sophia Siu, Mingyue Zhou, David Park Meininger, Joyce Chi Yee Chan, Mei Lu, Michael A. Brown, Jie Tang, John M. Delaney, Margrit Schwarz, Tim Carlson, Andrew Gates, Preston Fordstrom, Cheng Janet D, Nigel Walker, Richard Zhang

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Immunogen, medicine.drug_class, High-throughput screening, high density lipoprotein (HDL), Antigen-Antibody Complex, CHO Cells, Monoclonal antibody, Biochemistry, drug discovery, Phosphatidylcholine-Sterol O-Acyltransferase, Mice, 03 medical and health sciences, chemistry.chemical_compound, Cricetulus, Cricetinae, medicine, Animals, Humans, Protein Structure, Quaternary, Molecular Biology, Dyslipidemias, chemistry.chemical_classification, antibody engineering, biology, Drug discovery, Cholesterol, Chinese hamster ovary cell, Cholesterol, HDL, Antibodies, Monoclonal, Cell Biology, Macaca fascicularis, enzyme, 030104 developmental biology, Enzyme, chemistry, Cardiovascular Diseases, Enzymology, cholesterol metabolism, biology.protein, Binding Sites, Antibody, Antibody

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34c676d3cb2634845db3c7487845676
https://doi.org/10.1074/jbc.m115.672790

المؤلفون: Marc W. Retter, Mark Leo Michaels, Derek E. Piper, Katherine C Matsuda, Lei Zhou, Chadwick T. King, Wei Wang, Higbee Jared Martin, Jeonghoon Sun, Howard Monique L, Simon Jackson, Ren Xu, Randal R. Ketchem, Brandon Ason, Jie Tang, Kirk Henne, Joyce Chi Yee Chan

المصدر: The Journal of pharmacology and experimental therapeutics. 353(1)

مصطلحات موضوعية: Male, Receptor complex, medicine.drug_class, Plasma protein binding, Receptors, Fc, Pharmacology, Monoclonal antibody, Neonatal Fc receptor, Antigen, medicine, Animals, Humans, Receptor, Mice, Knockout, biology, Chemistry, PCSK9, Serine Endopeptidases, Antibodies, Monoclonal, Cholesterol, LDL, Hydrogen-Ion Concentration, Macaca mulatta, Immunoglobulin Fc Fragments, Mice, Inbred C57BL, biology.protein, Molecular Medicine, Proprotein Convertases, Antibody, Proprotein Convertase 9, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f51d0f83b17b3574d22d7dc84b3f51
https://pubmed.ncbi.nlm.nih.gov/25653417

المؤلفون: Joyce Chi Yee Chan, Simon Jackson, Hans M.G. Princen, José W.A. van der Hoorn, Scott M. Wasserman, Elsbet J. Pieterman, Brandon Ason, Kathy Nguyen, Susan Shetterly, Mei Di, Margrit Schwarz, J. Wouter Jukema, Jie Tang, Edward Lee, Rob Scott, Wen-Chen Yeh

المصدر: Journal of Lipid Research, 55(11), 2370-2379
Journal of Lipid Research, Vol 55, Iss 11, Pp 2370-2379 (2014)
Journal of Lipid Research, 11, 55, 2370-2379

مصطلحات موضوعية: Apolipoprotein E, Biomedical Innovation, Biochemistry, chemistry.chemical_compound, Gene Knockout Techniques, Mice, Endocrinology, Life, Anti-proprotein convertase subtilisin/kexin type 9 antibody, Research Articles, apolipoprotein E, biology, Serine Endopeptidases, low density lipoprotein receptor, anti-proprotein convertase subtilisin/kexin type 9 antibody, Cholesterol, Liver, Kexin, Female, lipids (amino acids, peptides, and proteins), Proprotein Convertases, Antibody, medicine.symptom, Proprotein Convertase 9, MHR - Metabolic Health Research, Healthy Living, medicine.medical_specialty, Low density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9, QD415-436, Antibodies, Lesion, Apolipoproteins E, proprotein convertase subtilisin/kexin type 9, Internal medicine, medicine, Animals, Humans, Biology, PCSK9, Cell Biology, Proprotein convertase, Atherosclerosis, Cholesterol Ester Transfer Proteins, chemistry, Receptors, LDL, LDL receptor, biology.protein, ELSS - Earth, Life and Social Sciences

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39084ecc72a660fcf4dd482ee87539a
https://hdl.handle.net/1887/103264

المؤلفون: William P. Dole, Ole Knudson, Faye Wu, Joyce Chi Yee Chan, John Morser, Qingyu Wu

المصدر: Proceedings of the National Academy of Sciences. 102:785-790

مصطلحات موضوعية: Male, Cardiac function curve, medicine.medical_specialty, medicine.drug_class, Embryonic Development, Cardiomegaly, Sodium Chloride, Preeclampsia, Mice, Atrial natriuretic peptide, Pregnancy, Internal medicine, medicine, Natriuretic peptide, Animals, Protein Precursors, Serine protease, Multidisciplinary, biology, Chemistry, Serine Endopeptidases, Biological Sciences, medicine.disease, Hypertensive heart disease, Pregnancy Complications, Proteinuria, Blood pressure, Endocrinology, Hypertension, cardiovascular system, biology.protein, Female, hormones, hormone substitutes, and hormone antagonists, Atrial Natriuretic Factor, circulatory and respiratory physiology, Hormone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2489f6ac4cc53e1339959e00f4d87605
https://doi.org/10.1073/pnas.0407234102

المؤلفون: Jorge G. Ganopolsky, Elliot D. Rosen, Mark A. Suckow, Francisco Noria, Erica C. Brown, Francis J. Castellino, Mayra J. Sandoval-Cooper, David Gailani, Victoria A. Ploplis, Ivo Cornelissen, Joyce Chi Yee Chan

المصدر: The American Journal of Pathology. 158:469-479

مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Genotype, Factor XI Deficiency, Ratón, Fibrin, Pathology and Forensic Medicine, Embryonic and Fetal Development, Mice, chemistry.chemical_compound, Pregnancy, Protein C deficiency, Plasminogen Activator Inhibitor 1, medicine, Coagulopathy, Animals, Lung, Factor XI, Crosses, Genetic, biology, Interleukin-6, Tumor Necrosis Factor-alpha, Myocardium, Protein C Deficiency, Regular Article, Embryo, Mammalian, medicine.disease, Molecular biology, Mice, Mutant Strains, Mice, Inbred C57BL, Microscopy, Electron, Animals, Newborn, Liver, Solubility, chemistry, Plasminogen activator inhibitor-1, Mutation, biology.protein, Female, Lymph Nodes, Lymph, Protein C, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fdf308db5e20c95ac8ff8c857dba01
https://doi.org/10.1016/s0002-9440(10)63989-2

المؤلفون: Joyce Chi Yee Chan

المصدر: Frontiers in Bioscience. 6:d98-104

مصطلحات موضوعية: Factor VII Deficiency, Andrology, Mice, Tissue factor, chemistry.chemical_compound, Exon, hemic and lymphatic diseases, Animals, Humans, Medicine, cardiovascular diseases, Receptor, Hemostasis, Factor VII, business.industry, Gene targeting, Embryo, Phenotype, Animals, Newborn, Coagulation, chemistry, Gene Targeting, Mutation, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0daf64a6426a138d3b29f7160999e0
https://doi.org/10.2741/a597

المؤلفون: Higbee Jared Martin, Bei Shan, Margrit Schwarz, Wen-Chen Yeh, William G. Romanow, Qiong Cao, Mei Lu, Joyce Chi Yee Chan, Richard Zhang, Yongmei Di, Ping Cao, Maurice Emery, Evelyn Yang, Stephen T. Thibault, Lei Zhou, Susan Shetterly, Gayle Kwon, Timothy W. Yu, Dongming Liu, Wenyan D. Shen, Kirk Henne, Oscar Pan, Mei-Mei Tsai, Heather Salomonis, Bryna Fuchslocher, Ziva Arimura, Nigel Walker, Qiang Liu, Mark Daris, Derek E. Piper, Kijeong Lee, Simon Mark Jackson, Wei Wang, Chadwick T. King, Jie Tang, Xiao-Ping Yang, Jackie Sheng, Yan Wang, Marc W. Retter, Zhen Xia

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 106(24)

مصطلحات موضوعية: medicine.medical_specialty, Statin, medicine.drug_class, Bococizumab, Biology, Crystallography, X-Ray, chemistry.chemical_compound, Mice, Neutralization Tests, Internal medicine, medicine, Animals, Neutralizing antibody, Mice, Knockout, Multidisciplinary, Cholesterol, PCSK9, Serine Endopeptidases, nutritional and metabolic diseases, Antibodies, Monoclonal, Proprotein convertase, Molecular biology, Mice, Inbred C57BL, Macaca fascicularis, Endocrinology, chemistry, Receptors, LDL, LDL receptor, biology.protein, Kexin, lipids (amino acids, peptides, and proteins), Proprotein Convertases, Proprotein Convertase 9

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6547ec9849672f16af5dab324c2e1c67
https://pubmed.ncbi.nlm.nih.gov/20425252

المؤلفون: Peter Carmeliet, Lieve Moons, Francis J. Castellino, Louise R. Jalbert, Elliot D. Rosen, Joyce Chi Yee Chan, Desire Collen

المصدر: Scopus-Elsevier

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Inflammation, Biology, Fibrinogen, Mice, Protein C deficiency, Consumptive Coagulopathy, Internal medicine, medicine, Animals, Disseminated intravascular coagulation, Recombination, Genetic, Brain, Protein C Deficiency, Embryo, General Medicine, Disseminated Intravascular Coagulation, medicine.disease, Thrombosis, Mice, Mutant Strains, Endocrinology, Coagulation, Animals, Newborn, Liver, Mutagenesis, Site-Directed, Genes, Lethal, medicine.symptom, medicine.drug, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1136f9d49feaafc56c2f53fc273ffa
https://europepmc.org/articles/PMC508997/