يعرض 1 - 2 نتائج من 2 نتيجة بحث عن '"Julia H Shin"', وقت الاستعلام: 1.01s تنقيح النتائج
  1. 1
    The Interleukin‐1 Receptor–Associated Kinase 4 Inhibitor PF‐06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial

    المؤلفون: Julia H Shin, Steven A. Gilbert, Vikram R. Rao, Betsy J. Barnes, Lih-Ling Lin, Ken Dower, Virginia Pascual, Bruce A. Jacobson, Iain Kilty, Jean J Beebe, Tatyana Andreyeva, Bruce L. Homer, Joanne Brodfuehrer, Weiyong Sun, Martin Hegen, Simeon Ramsey, M Nusrat Sharif, Margaret Fleming, Mera Tilley, Heng Liu, Aaron Winkler, Aiping Jiao, Saurav De, Shruti Athale, Peter T. Symanowicz, Ju Wang, Spencer I. Danto

    المصدر: Arthritis & Rheumatology. 73:2206-2218

    مصطلحات موضوعية: Lactams, Immunology, Arthritis, Inflammation, Peripheral blood mononuclear cell, Mice, Rheumatology, In vivo, Rheumatic Diseases, medicine, Animals, Humans, Immunology and Allergy, Kinase activity, skin and connective tissue diseases, Systemic lupus erythematosus, business.industry, Macrophages, Autoantibody, Dendritic Cells, Isoquinolines, medicine.disease, IRAK4, Arthritis, Experimental, Synoviocytes, Rats, Disease Models, Animal, Interleukin-1 Receptor-Associated Kinases, Leukocytes, Mononuclear, medicine.symptom, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea4d3ef98a73e9f525a4ce2b040208a
    https://doi.org/10.1002/art.41953

    View record at Wiley
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  2. 2
    Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

    المؤلفون: Lori Krim Gavrin, David Hepworth, Jennifer R. Thomason, Iain Kilty, Joel Adam Goldberg, Christoph W. Zapf, Vikram R. Rao, Brian P. Boscoe, Akshay Patny, Peter T. Symanowicz, Marina W.H. Shen, Kevin J. Curran, Elizabeth Murphy, Martin Hegen, Fabien Vincent, Richard Vargas, Satwik Kamtekar, Heidi M. Morgan, Heidi R. Hope, Richard K. Frisbie, Jeanne S. Chang, Ken Dower, Susan E. Drozda, Strohbach Joseph Walter, Mathias John Paul, David R. Anderson, Jacqueline E. Day, Stephen W. Wright, Ivan J. Samardjiev, Seungil Han, Julia H Shin, Frank Lovering, Andrea G Bree, Arthur Lee, Holly H. Soutter, Joanne Brodfuehrer, John David Trzupek, Brian Samas, Christoph Martin Dehnhardt, Michael Dennis Lowe, Catherine M. Ambler, Seung Won Chung, Eddine Saiah, Nikolaos Papaioannou, Pierce Betsy S, Jiangli Yan, Katherine L. Lee, Lih-Ling Lin, Chulho Choi

    المصدر: Journal of Medicinal Chemistry. 60:5521-5542

    مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Lactams, Stereochemistry, medicine.drug_class, Administration, Oral, Carboxamide, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, Humans, Structure–activity relationship, Protein Kinase Inhibitors, ADME, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Chemistry, Active site, Isoquinolines, IRAK4, Combinatorial chemistry, Interleukin-1 Receptor-Associated Kinases, 030104 developmental biology, Lipophilic efficiency, Lipophilicity, biology.protein, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d71e108dde9e50f577dacbc8e3364e
    https://doi.org/10.1021/acs.jmedchem.7b00231

    Find this issue from the American Chemical Society
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