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1دورية أكاديمية
المؤلفون: Irene Hallyburton, Raffaella Grimaldi, Andrew Woodland, Beatriz Baragaña, Torsten Luksch, Daniel Spinks, Daniel James, Didier Leroy, David Waterson, Alan H. Fairlamb, Paul G. Wyatt, Ian H. Gilbert, Julie A. Frearson
المصدر: Malaria Journal, Vol 16, Iss 1, Pp 1-11 (2017)
مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
وصف الملف: electronic resource
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المؤلفون: Stephan Meister, Vicky M. Avery, Yevgeniya Antonova-Koch, Elizabeth A. Winzeler, Benigno Crespo, David Waterson, Alan H. Fairlamb, Jennifer Riley, Neil R. Norcross, Laura M. Sanz, Irene Hallyburton, Julie A. Frearson, Ian H. Gilbert, Paul Willis, Francisco-Javier Gamo, Simon F. Campbell, Suzanne Norval, Maria Osuna-Cabello, Cristina de Cozar, Robert E. Sinden, David W. Gray, Sandra Duffy, Andrea Ruecker, Caroline Wilson, Michael J. Delves, Beatriz Baragaña, Daniel A. Fletcher, Kevin D. Read
المصدر: Chemmedchem
مصطلحات موضوعية: Plasmodium berghei, Plasmodium falciparum, malaria, hit optimization, 01 natural sciences, Biochemistry, Antimalarials, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Parasitic Sensitivity Tests, Pharmacokinetics, Acetamides, Drug Discovery, medicine, Animals, Humans, Potency, Antimalarial Agent, antimalarial agents, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Full Paper, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, Full Papers, biology.organism_classification, Propanamide, 3. Good health, 0104 chemical sciences, aminoacetamides, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, chemistry, Microsomes, Liver, Microsome, Molecular Medicine, Gamete, Selectivity, Plasmodium cynomolgi
وصف الملف: application/pdf
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3دورية أكاديمية
المؤلفون: Naomi Tidten-Luksch, Raffaella Grimaldi, Leah S Torrie, Julie A Frearson, William N Hunter, Ruth Brenk
المصدر: PLoS ONE, Vol 7, Iss 4, p e35792 (2012)
وصف الملف: electronic resource
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المؤلفون: Justin R, Harrison, Stephen, Brand, Victoria, Smith, David A, Robinson, Stephen, Thompson, Alasdair, Smith, Kenneth, Davies, Ngai, Mok, Leah S, Torrie, Iain, Collie, Irene, Hallyburton, Suzanne, Norval, Frederick R C, Simeons, Laste, Stojanovski, Julie A, Frearson, Ruth, Brenk, Paul G, Wyatt, Ian H, Gilbert, Kevin D, Read
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Models, Molecular, Molecular Structure, Cell Survival, Protein Conformation, Trypanosoma brucei brucei, Mice, Inbred Strains, Trypanocidal Agents, Article, Mice, Structure-Activity Relationship, Trypanosomiasis, African, Blood-Brain Barrier, Drug Design, Animals, Humans, Female, Acyltransferases
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5
المؤلفون: Tracy, Bayliss, David A, Robinson, Victoria C, Smith, Stephen, Brand, Stuart P, McElroy, Leah S, Torrie, Chido, Mpamhanga, Suzanne, Norval, Laste, Stojanovski, Ruth, Brenk, Julie A, Frearson, Kevin D, Read, Ian H, Gilbert, Paul G, Wyatt
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Sulfonamides, Trypanosoma brucei brucei, Aminopyridines, Brain, Crystallography, X-Ray, Trypanocidal Agents, Article, Mice, Trypanosomiasis, African, Drug Design, parasitic diseases, Animals, Humans, Enzyme Inhibitors, Acyltransferases
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المؤلفون: Daan M. F. van Aalten, Iva Navratilova, Susanne Eskilsson, Wenxia Fang, Olawale G. Raimi, Iain T. Collie, Julie A. Frearson, Tonia Aristotelous, Justin R. Harrison, Michael D. Urbaniak, Michael A. J. Ferguson
المصدر: ACS Chemical Biology
مصطلحات موضوعية: Protein Conformation, Trypanosoma brucei brucei, Allosteric regulation, Trypanosoma brucei, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Catalytic Domain, Humans, Transferase, Enzyme kinetics, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Uridine Diphosphate N-Acetylglucosamine, biology, 010405 organic chemistry, Active site, Articles, General Medicine, biology.organism_classification, Nucleotidyltransferases, Trypanocidal Agents, Molecular biology, 0104 chemical sciences, Uridine diphosphate, Trypanosomiasis, African, Uridine diphosphate N-acetylglucosamine, Enzyme, chemistry, biology.protein, Molecular Medicine
وصف الملف: application/pdf
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7
المؤلفون: Julie A. Frearson, Susan Wyllie, Irene Hallyburton, David W. Gray, Manu De Rycker, John Thomas, Alan H. Fairlamb, Paul G. Wyatt, Lorna Campbell, Ian H. Gilbert, Dhananjay Joshi, Scott Cameron
المصدر: Antimicrobial Agents and Chemotherapy. 57:2913-2922
مصطلحات موضوعية: Antiprotozoal Agents, Leishmania donovani, Cell Line, Microbiology, Parasitic Sensitivity Tests, Drug Discovery, High-Throughput Screening Assays, medicine, Humans, Pharmacology (medical), Amastigote, Axenic, Pharmacology, biology, Axenic Culture, Drug discovery, Macrophages, Intracellular parasite, biology.organism_classification, Leishmania, medicine.disease, Infectious Diseases, Visceral leishmaniasis, Susceptibility, Leishmaniasis, Visceral
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424c2b67c1b09871f9f66fc016bb3806
https://doi.org/10.1128/aac.02398-12 -
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المؤلفون: Andrew Woodland, Torsten Luksch, Julie A. Frearson, Kayode K. Ojo, Paul G. Wyatt, Ian H. Gilbert, Ruth Brenk, Laura A. T. Cleghorn, Wesley C. Van Voorhis, Raffaella Grimaldi
المصدر: Chemmedchem
مصطلحات موضوعية: Models, Molecular, Trypanosoma brucei brucei, Biology, Trypanosoma brucei, Biochemistry, GSK3, Cell Line, Glycogen Synthase Kinase 3, Structure-Activity Relationship, 03 medical and health sciences, Parasitic Sensitivity Tests, medicinal chemistry, parasitic diseases, Drug Discovery, medicine, Humans, Structure–activity relationship, African trypanosomiasis, General Pharmacology, Toxicology and Pharmaceutics, Protein kinase A, Protein Kinase Inhibitors, Cell Proliferation, 030304 developmental biology, Pharmacology, protein kinases, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, 030306 microbiology, Drug discovery, Kinase, Organic Chemistry, Full Papers, medicine.disease, biology.organism_classification, Trypanocidal Agents, In vitro, 3. Good health, Molecular Medicine, Pharmacophore, antiprotozoal agents
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المؤلفون: Iain T. Collie, Julie A. Frearson, Paul G. Wyatt, Laura A. T. Cleghorn, Ruth Brenk, Chidochangu P. Mpamhanga, Roderick G. Walker, Torsten Luksch, Jeremy C. Mottram, Andrew Woodland, Neil R. Norcross, Ian H. Gilbert, Leah S. Torrie
المصدر: Chemmedchem
مصطلحات موضوعية: Drug Evaluation, Preclinical, Protozoan Proteins, cyclin-dependent cdc2-related kinases, Trypanosoma brucei, Biochemistry, Structure-Activity Relationship, Cyclin-dependent kinase, CDC2 Protein Kinase, Drug Discovery, Humans, Urea, Computer Simulation, General Pharmacology, Toxicology and Pharmaceutics, Protein kinase A, Protein Kinase Inhibitors, leishmaniasis, Leishmania, Pharmacology, Cyclin-dependent kinase 1, Binding Sites, biology, Kinase, ureas, Organic Chemistry, Cyclin-dependent kinase 2, Full Papers, biology.organism_classification, Protein Structure, Tertiary, CRK3, Pyrimidines, triazolopyridines, biology.protein, Pyrazoles, Molecular Medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2202f6601d8578d3a2bae1b2198e8018
https://doi.org/10.1002/cmdc.201100344 -
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المؤلفون: Nicola J, Gardner, Peter J, Gillespie, Jamie T, Carrington, Emma J, Shanks, Stuart P, McElroy, Emma J, Haagensen, Julie A, Frearson, Andrew, Woodland, J Julian, Blow
المصدر: Cell Chemical Biology
مصطلحات موضوعية: DNA Replication, Minichromosome Maintenance Proteins, replication licensing, Xenopus, Origin Recognition Complex, Nuclear Proteins, Cell Cycle Proteins, Replication Origin, DNA, Xenopus Proteins, Chromatin, Article, Thiazoles, cancer therapeutics, Adenosine Triphosphate, Allosteric Regulation, ORC, Cell Line, Tumor, Quinolines, Animals, Humans, Amines, MCM2–7