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1دورية أكاديمية
المؤلفون: Delphine Bachelet, Thilo Albert, Cyprien Mbogning, Signe Hässler, Yuan Zhang, Stephan Schultze-Strasser, Yohann Repessé, Julie Rayes, Anna Pavlova, Behnaz Pezeshkpoor, Kerstin Liphardt, Julie E Davidson, Agnès Hincelin-Méry, Pierre Dönnes, Sébastien Lacroix-Desmazes, Christoph Königs, Johannes Oldenburg, Philippe Broët, ABIRISK consortium
المصدر: PLoS ONE, Vol 14, Iss 6, p e0218258 (2019)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1932-6203
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المؤلفون: Sapna Rao, Beulah Ji, Laurence S. Magder, Michelle Petri, David L. Roth, Qinggong Fu, Julie E. Davidson
المصدر: The Journal of Rheumatology. 45:671-677
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Biopsy, Immunology, 030232 urology & nephrology, Lupus nephritis, Kaplan-Meier Estimate, Kidney, Disease-Free Survival, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, medicine, Clinical endpoint, Humans, Immunology and Allergy, Renal Insufficiency, Chronic, Aged, Proportional Hazards Models, Retrospective Studies, 030203 arthritis & rheumatology, Systemic lupus erythematosus, Proportional hazards model, business.industry, Remission Induction, Retrospective cohort study, Middle Aged, medicine.disease, Lupus Nephritis, Belimumab, Creatinine, Multivariate Analysis, Cohort, Disease Progression, Kidney Failure, Chronic, Female, business, Follow-Up Studies, Cohort study, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25956d2e7234ca14f8d45ef31eb4104f
https://doi.org/10.3899/jrheum.161554 -
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المؤلفون: Tom W J Huizinga, M M J Herenius, Pierre Dönnes, Philippe Broët, Bernard Combe, Marc Pallardy, Sylvie Chollet-Martin, Delphine Bachelet, Anne Musters, Signe Hässler, Paul P. Tak, Florian Deisenhammer, Salima Hacein-Bey-Abina, G. Akdemir, Bruno Fautrel, Jocelyn Quistrebert, Saedis Saevarsdottir, Cyprien Mbogning, Xavier Mariette, Aude Gleizes, Naoimh Donnellan, Agnes Hincelin-Mery, Julie E. Davidson, Martina Johannesson, Carla A. Wijbrandts, Sytske Anne Bergstra, Anna Fogdell-Hahn, Imad Abugessaisa, Niek de Vries
المساهمون: Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris-Saclay, GlaxoSmithKline, Glaxo Smith Kline, University of Cambridge [UK] (CAM), Universiteit Gent = Ghent University [Belgium] (UGENT), Leiden University Medical Center (LUMC), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Hôpital Lapeyronie [Montpellier] (CHU), Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de recherche Phytopharmacie et Médiateurs Chimiques (UPMC), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Innsbruck Medical University [Austria] (IMU), Sanofi Aventis R&D [Chilly-Mazarin], Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS - UM 4 (UMR 8258 / U1022)), Institut de Chimie du CNRS (INC)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Sorbonne Paris Cité (USPC), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Paul Brousse, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse, CHU Sainte Justine [Montréal], Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Rhumatologie [CHU Pitié Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC), Universiteit Gent = Ghent University (UGENT), Universiteit Leiden, Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Graduate School, 01 Internal and external specialisms, AII - Inflammatory diseases, Clinical Immunology and Rheumatology, Experimental Immunology, Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] (I3), CHU Charles Foix [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)
المصدر: Seminars in Arthritis and Rheumatism
Seminars in Arthritis and Rheumatism, WB Saunders, 2019, 48 (6), pp.967-975. ⟨10.1016/j.semarthrit.2018.10.006⟩
Seminars in Arthritis and Rheumatism, 2019, 48 (6), pp.967-975. ⟨10.1016/j.semarthrit.2018.10.006⟩
Seminars in arthritis and rheumatism, 48(6), 967-975. W.B. Saunders Ltd
Seminars in Arthritis and Rheumatism, 48(6), 967-975مصطلحات موضوعية: Male, Anti-TNF treatment, Arthritis, Rheumatoid, 0302 clinical medicine, immune system diseases, Anti-drug antibodies, Medicine, Cumulative incidence, 030212 general & internal medicine, skin and connective tissue diseases, biology, Incidence (epidemiology), Incidence, Middle Aged, 3. Good health, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Antirheumatic Agents, Rheumatoid arthritis, [SDV.IMM]Life Sciences [q-bio]/Immunology, Drug Therapy, Combination, Female, Antibody, medicine.drug, Adult, musculoskeletal diseases, medicine.medical_specialty, Antibodies, 03 medical and health sciences, Rheumatology, Internal medicine, Adalimumab, Humans, Aged, Retrospective Studies, 030203 arthritis & rheumatology, business.industry, Proportional hazards model, medicine.disease, Infliximab, Methotrexate, Anesthesiology and Pain Medicine, Risk factors, biology.protein, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
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المؤلفون: Alison Nightingale, C. Molta, Julie E. Davidson, H. Kan, Neil McHugh
المصدر: Nightingale, A, Davidson, J, Molta, C, Kan, H & McHugh, N 2017, ' Presentation of SLE in UK primary care using the Clinical Practice Research Datalink ', Lupus Science & Medicine . https://doi.org/10.1136/lupus-2016-000172
Lupus Science & Medicineمصطلحات موضوعية: medicine.medical_specialty, Pediatrics, Epidemiology, Immunology, Mucocutaneous zone, Primary care, Systemic Lupus Erythematosus, 03 medical and health sciences, 0302 clinical medicine, Disease Presentation, Diagnostic Delay, immune system diseases, medicine, 030212 general & internal medicine, skin and connective tissue diseases, Primary Care, 030203 arthritis & rheumatology, Systemic lupus erythematosus, business.industry, Medical record, General Medicine, medicine.disease, Epidemiology and Outcomes, Log-rank test, Clinical Practice Research Datalink, Presentation (obstetrics), business
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed19f73632f32f623cf6cb1ead84928
https://purehost.bath.ac.uk/ws/files/153619506/e000172.full.pdf -
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المؤلفون: Michael Gilbert, Nabarun Dasgupta, Jeffery L. Painter, Beta Win, Jonathan Sayegh, Christopher M. Menone, Julie E Davidson, H.G. Bell, Monica J. Barratt, Christina Winter, Laurie S Anderson
المصدر: JMIR Public Health and Surveillance
مصطلحات موضوعية: medicine.medical_specialty, 020205 medical informatics, Prescription Drug Misuse, prescription drug misuse, social media, Health Informatics, Venlafaxine, Context (language use), 02 engineering and technology, amitriptyline, bupropion, Infodemiology, 03 medical and health sciences, 0302 clinical medicine, Health care, 0202 electrical engineering, electronic engineering, information engineering, medicine, Active listening, 030212 general & internal medicine, harm reduction, Psychiatry, community-based participatory research, Original Paper, Internet, business.industry, Public Health, Environmental and Occupational Health, 3. Good health, substance-related disorders, Inter-rater reliability, Infoveillance, pharmacovigilance, venlafaxine hydrochloride, business, medicine.drug
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المؤلفون: Manuela Comabella, Naoimnh Donnellan, Per Soelberg Sørensen, Signe Hässler, Pierre Dönnes, Ryan Ramanujam, Bernd C. Kieseier, Marc Pallardy, Michael Auer, Anna Fogdell-Hahn, Cyprien Mbogning, Florian Deisenhammer, Bernhard Hemmer, Delphine Bachelet, Nicolás Fissolo, Phillippe Broet, Raija L.P. Lindberg, Claudia Sievers, Clemens Warnke, Kathleen Ingenhoven, Verena Grummel, Andy Lawton, Dorothea Buck, Tobias Derfuss, Jenny Link, Hans-Peter Hartung, Poul Erik Jensen, Xavier Montalban, Julie E. Davidson, Dan Sikkema, Malin Ryner
المساهمون: Institut Català de la Salut, [Link J] Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. [Ramanujam R] Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. KTH - Royal Institute of Technology, Stockholm, Sweden. [Auer M] Innsbruck Medical University, Innsbruck, Austria. [Ryner M] Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. [Hässler S, Bachelet D] CESP, Université Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France. [Fissolo N, Comabella M, Montalban X] Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain., Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus
المصدر: PLoS ONE, Vol 12, Iss 2, p e0170395 (2017)
Scientia
Recercat. Dipósit de la Recerca de Catalunya
instname
Link, J, Ramanujam, R, Auer, M, Ryner, M, Hässler, S, Bachelet, D, Mbogning, C, Warnke, C, Buck, D, Hyldgaard Jensen, P E, Sievers, C, Ingenhoven, K, Fissolo, N, Lindberg, R, Grummel, V, Donnellan, N, Comabella, M, Montalban, X, Kieseier, B, Soelberg Sørensen, P, Hartung, H-P, Derfuss, T, Lawton, A, Sikkema, D, Pallardy, M, Hemmer, B, Deisenhammer, F, Broët, P, Dönnes, P, Davidson, J, Fogdell-Hahn, A & ABIRISK Consortium 2017, ' Clinical practice of analysis of anti-drug antibodies against interferon beta and natalizumab in multiple sclerosis patients in Europe : A descriptive study of test results ', PLOS ONE, vol. 12, no. 2, e0170395 . https://doi.org/10.1371/journal.pone.0170395
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
PLoS ONEمصطلحات موضوعية: Male, 0301 basic medicine, Time Factors, Physiology, Denmark, lcsh:Medicine, Esclerosi múltiple, Biochemistry, Geographical Locations, 0302 clinical medicine, Natalizumab, Immune Physiology, Medicine and Health Sciences, Otros calificadores::Otros calificadores::/inmunología [Otros calificadores], Young adult, Child, lcsh:Science, aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales::anticuerpos monoclonales humanizados::natalizumab [COMPUESTOS QUÍMICOS Y DROGAS], media_common, Aged, 80 and over, Immune System Proteins, Multidisciplinary, Pharmaceutics, Age Factors, Natalizumab/adverse effects, Antígens - Immunologia, Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis [DISEASES], Neurodegenerative Diseases, Middle Aged, Interferó - Immunologia, 3. Good health, Test (assessment), Europe, Neurology, Austria, Child, Preschool, enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple [ENFERMEDADES], Female, localizaciones geográficas::Europa (continente) [DENOMINACIONES GEOGRÁFICAS], Research Article, medicine.drug, Adult, Drug, medicine.medical_specialty, Multiple Sclerosis, Adolescent, Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal::Antibodies, Monoclonal, Humanized::Natalizumab [CHEMICALS AND DRUGS], media_common.quotation_subject, Immunology, MEDLINE, Geographic Locations::Europe [GEOGRAPHICALS], Antibodies, Autoimmune Diseases, Interferon-beta/adverse effects, Young Adult, 03 medical and health sciences, Sex Factors, Pharmacotherapy, Drug Therapy, Immunologic Factors/adverse effects, Other subheadings::Other subheadings::/immunology [Other subheadings], Internal medicine, medicine, Immunologic Factors, Humans, Antibodies/immunology, Antigens, Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interferons::Interferon Type I::Interferon-beta [CHEMICALS AND DRUGS], Aged, Retrospective Studies, Pharmacology, Sweden, Drug Screening, Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies [CHEMICALS AND DRUGS], aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos [COMPUESTOS QUÍMICOS Y DROGAS], Multiple sclerosis, lcsh:R, Infant, Newborn, Biology and Life Sciences, Proteins, Infant, nutritional and metabolic diseases, Retrospective cohort study, Interferon-beta, medicine.disease, Demyelinating Disorders, 030104 developmental biology, People and Places, Multiple Sclerosis/drug therapy, Clinical Immunology, lcsh:Q, Interferons, Clinical Medicine, aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::interferones::interferón de tipo I::interferón beta [COMPUESTOS QUÍMICOS Y DROGAS], 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المؤلفون: Julie E. Davidson, Dan Sikkema, Malin Ryner, Poul Erik Hyldgaard Jensen, Marc Pallardy, Ryan Ramanujam, Agnes Hincelin-Mery, Michael Auer, Kathleen Ingenhoven, Bernd C. Kieseier, Philippe Broët, Clemens Warnke, Per Soelberg Sørensen, Hans-Peter Hartung, Naoimh Donnellan, Delphine Bachelet, B. Hemmer, Anna Fogdell-Hahn, Dorothea Buck, Florian Deisenhammer, Nils Koch-Henriksen, Signe Hässler, Cyprien Mbogning, Pierre Dönnes, Andy Lawton, Verena Grummel, Jenny Link
المصدر: Bachelet, D, Hässler, S, Mbogning, C, Link, J, Ryner, M, Ramanujam, R, Auer, M, Jensen, P E H, Koch-Henriksen, N, Warnke, C, Ingenhoven, K, Buck, D, Grummel, V, Lawton, A, Donnellan, N, Hincelin-Mery, A, Sikkema, D, Pallardy, M, Kieseier, B, Hemmer, B, Hartung, H P, Soelberg Sorensen, P, Deisenhammer, F, Dönnes, P, Davidson, J, Fogdell-Hahn, A, Broët, P & ABIRISK Consortium 2016, ' Occurrence of Anti-Drug Antibodies against Interferon-Beta and Natalizumab in Multiple Sclerosis : A Collaborative Cohort Analysis ', P L o S One, vol. 11, no. 11, e0162752, pp. 1-19 . https://doi.org/10.1371/journal.pone.0162752
PLoS ONE, Vol 11, Iss 11, p e0162752 (2016)
PLoS ONEمصطلحات موضوعية: 0301 basic medicine, Male, Pediatrics, Research Facilities, Databases, Factual, Physiology, Denmark, lcsh:Medicine, Biochemistry, Cohort Studies, Geographical Locations, White Blood Cells, 0302 clinical medicine, Natalizumab, Risk Factors, Animal Cells, Immune Physiology, Medicine and Health Sciences, lcsh:Science, Immune Response, media_common, Multidisciplinary, Immune System Proteins, biology, T Cells, Neurodegenerative Diseases, Middle Aged, Antibodies, Anti-Idiotypic, Europe, Neurology, Population Surveillance, Austria, Female, Antibody, Cellular Types, Research Laboratories, medicine.drug, Cohort study, Research Article, Drug, Adult, medicine.medical_specialty, Multiple Sclerosis, Side effect, media_common.quotation_subject, Immune Cells, Immunology, Research and Analysis Methods, Antibodies, Autoimmune Diseases, 03 medical and health sciences, Internal medicine, medicine, Humans, Antigens, Aged, Proportional Hazards Models, Sweden, Blood Cells, Proportional hazards model, business.industry, Multiple sclerosis, lcsh:R, Biology and Life Sciences, Proteins, Interferon-beta, Cell Biology, medicine.disease, Demyelinating Disorders, Patient Outcome Assessment, 030104 developmental biology, People and Places, Etiology, biology.protein, Clinical Immunology, lcsh:Q, Clinical Medicine, business, 030217 neurology & neurosurgery
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553907749835ab6d3903ce55b5195719
https://curis.ku.dk/portal/da/publications/occurrence-of-antidrug-antibodies-against-interferonbeta-and-natalizumab-in-multiple-sclerosis(3737fcb4-b1ab-41e0-94f2-1fed2298784e).html -
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المؤلفون: George M. Savva, Ian G. McKeith, Carol Brayne, Fiona E. Matthews, Julie E. Davidson, Julia Zaccai
المصدر: British Journal of Psychiatry. 194:212-219
مصطلحات موضوعية: Male, medicine.medical_specialty, Longitudinal study, Population, Neuropsychological Tests, Irritability, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Dementia, Apathy, Psychiatry, education, Depression (differential diagnoses), Aged, Aged, 80 and over, Psychiatric Status Rating Scales, education.field_of_study, Wales, medicine.disease, Mental health, 030227 psychiatry, Psychiatry and Mental health, England, Psychotic Disorders, Anxiety, Female, medicine.symptom, Epidemiologic Methods, Psychology, 030217 neurology & neurosurgery
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المؤلفون: Sergii Shevchuk, Evgeny Nasonov, M H S Pereira, S Soloviev, Julie E. Davidson, O Iaremenko, Ch Baimukhamedov, Alexander Lila, R Ivanova, A Gnylorybov, Zh Omarbekova, Averyan Vasylyev, G Togizbayev
المصدر: Lupus Science & Medicine
مصطلحات موضوعية: medicine.medical_specialty, Pediatrics, Cyclophosphamide, Epidemiology, Immunology, Azathioprine, Disease, Systemic Lupus Erythematosus, Autoimmune Diseases, Internal medicine, Health care, medicine, Clinical Trials and Drug Discovery, skin and connective tissue diseases, Disease Activity, Lupus erythematosus, business.industry, Correction, General Medicine, medicine.disease, Rheumatology, Treatment, Observational study, business, medicine.drug
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المؤلفون: Julie E. Davidson, Clete A. Kushida, Charles P. Quesenberry, Rita A. Popat, Caroline M. Tanner, Amethyst Leimpeter, Stephen K. Van Den Eeden, Lorene M. Nelson, Kristen Bibeau, Kathleen B. Albers
المصدر: Sleep, vol 38, iss 7
مصطلحات موضوعية: Male, Time Factors, Myocardial Infarction, Comorbidity, Coronary Artery Disease, Cardiovascular, Medical and Health Sciences, California, Coronary artery disease, cardiovascular disease, Risk Factors, Epidemiology, 80 and over, Prevalence, Aetiology, Aged, 80 and over, screening and diagnosis, Hazard ratio, Biological Sciences, Middle Aged, Stroke, Detection, Heart Disease, Editorial, Cardiovascular Diseases, Cohort, Hypertension, Cardiology, epidemiology, Female, Cohort study, Adult, medicine.medical_specialty, Angina Pectoris, Young Adult, Clinical Research, Physiology (medical), Internal medicine, Restless Legs Syndrome, mental disorders, medicine, cohort study, Humans, cardiovascular diseases, Heart Disease - Coronary Heart Disease, Aged, Proportional Hazards Models, Retrospective Studies, Neurology & Neurosurgery, Proportional hazards model, business.industry, Psychology and Cognitive Sciences, Retrospective cohort study, medicine.disease, Atherosclerosis, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Cross-Sectional Studies, Neurology (clinical), business, 2.4 Surveillance and distribution, Follow-Up Studies
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d06b7bc06551eb75e843f20287ea91
https://pubmed.ncbi.nlm.nih.gov/26085294
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