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المؤلفون: Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106516d185208367e68bb96ffc0bed07
https://doi.org/10.1158/1535-7163.22500843.v1 -
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المؤلفون: Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4ce3c68a5bf01dbc4b5578e36679e558
https://doi.org/10.1158/1535-7163.c.6536589.v1 -
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المؤلفون: Mark A. Nagy, Robert Hilgraf, Deborah S. Mortensen, Jan Elsner, Stephen Norris, Jayashree Tikhe, Won Yoon, David Paisner, Mercedes Delgado, Paul Erdman, Jason Haelewyn, Godrej Khambatta, Li Xu, William J. Romanow, Kevin Condroski, Sogole Bahmanyar, Meg McCarrick, Brent Benish, Kate Blease, Laurie LeBrun, Mehran F. Moghaddam, Julius Apuy, Stacie S. Canan, Brydon L. Bennett, Yoshitaka Satoh
المصدر: Journal of Medicinal Chemistry. 64:18193-18208
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Dan Zhu, Xiaohui Peng, Dale Robinson, Riggs Jennifer, Kimberly E. Fultz, Julius Apuy, Tam Minh Tran, Jan Elsner, Rama K. Narla, Katerina Leftheris, Sogole Bahmanyar, Dan Cashion, Lida Tehrani, Laurie LeBrun, John F. Boylan
المصدر: Journal of Medicinal Chemistry. 64:12670-12679
مصطلحات موضوعية: Models, Molecular, Antineoplastic Agents, Breast Neoplasms, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Gene Expression Regulation, Enzymologic, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, Humans, Potency, IC50, Triple-negative breast cancer, Antitumor activity, chemistry.chemical_classification, Molecular Structure, Chemistry, Protein-Tyrosine Kinases, Gene Expression Regulation, Neoplastic, Molecular Docking Simulation, Spindle checkpoint, Enzyme, Cell culture, Cancer research, Molecular Medicine, Female
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المؤلفون: Sarah Franc, Mehran F. Moghaddam, Julius Apuy, Sayee G. Hegde, Jingjing Zhao, Cathie Xiang, Robert D. Hubbard
المصدر: Drug Metabolism Letters
مصطلحات موضوعية: Purine, Magnetic Resonance Spectroscopy, Stereochemistry, Metabolite, Clinical Biochemistry, Pharmaceutical Science, structural elucidation, Article, drug discovery, chemistry.chemical_compound, Mice, Dogs, Biotransformation, metabolite identification, Tandem Mass Spectrometry, CYP, Moiety, Animals, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), Purine metabolism, mass spectrometry, purine, novel, Biochemistry (medical), Glutathione, Metabolism, Haplorhini, NMR, Rats, chemistry, Biochemistry, Purines, metabolism, Conjugate, Chromatography, Liquid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd06c50a911f3de66dba1fe281df011
http://europepmc.org/articles/PMC5405620 -
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المؤلفون: Sogole Bahmanyar, Brian E. Cathers, Mehran F. Moghaddam, Peter Worland, Lida Tehrani, Brandon Wade Whitefield, Heather Raymon, James C. Gamez, Godrej Khambatta, Julius Apuy, Samantha J. Richardson, Rene R. Bisonette, Jingjing Zhao, Graziella I. Shevlin, Deborah Mortensen, Matt Hickman, Jan Elsner, Correa Matthew D, Roy L. Harris, Sophie Perrin-Ninkovic, Rama K. Narla, Jennifer Riggs, Kimberly Elizabeth Fultz, Sabita Sankar, Patrick Papa, John Sapienza, Stacie S. Canan, Sophie X. Peng, Jason Simon Parnes, Garrick Packard, Jim Leisten, Branden Lee
المصدر: Journal of Medicinal Chemistry. 58:5599-5608
مصطلحات موضوعية: Protein Conformation, Triazole, mTORC1, Pharmacology, mTORC2, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Dose-Response Relationship, Drug, Chemistry, Kinase, TOR Serine-Threonine Kinases, Triazoles, Xenograft Model Antitumor Assays, Rats, Molecular Docking Simulation, Biochemistry, Drug Design, Pyrazines, Molecular Medicine, Signal Transduction
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المؤلفون: Jason Simon Parnes, Rene R. Bisonette, Sophie Perrin-Ninkovic, Deborah Mortensen, Branden Lee, Peter Worland, James C. Gamez, Graziella I. Shevlin, Matt Hickman, Stacie S. Canan, Julius Apuy, Samantha J. Richardson, Jingjing Zhao, Godrej Khambatta, Sophie X. Peng, Jim Leisten, Garrick Packard, Correa Matthew D, Rama K. Narla, Lida Tehrani, Jennifer Riggs, Heather Raymon, Jan Elsner, Roy L. Harris, Kimberly Elizabeth Fultz, Patrick Papa, Sogole Bahmanyar, Brandon Wade Whitefield, Sabita Sankar, John Sapienza, Mehran F. Moghaddam, Brian E. Cathers
المصدر: Journal of Medicinal Chemistry. 58:5323-5333
مصطلحات موضوعية: Male, Models, Molecular, Antineoplastic Agents, Pharmacology, MTOR Kinase Inhibitor CC-223, Structure-Activity Relationship, In vivo, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Molecular Structure, Drug discovery, Chemistry, Kinase, TOR Serine-Threonine Kinases, RPTOR, Prostatic Neoplasms, Rats, Inhibitory potency, Pyrazines, Molecular Medicine, Signal Transduction
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المؤلفون: Jingjing Zhao, Sophie X. Peng, Brian E. Cathers, Sabita Sankar, Garrick Packard, Stacie S. Canan, Shuichan Xu, Heather Raymon, Godrej Khambatta, Rama K. Narla, Kimberly Elizabeth Fultz, Sophie Perrin-Ninkovic, Matt Hickman, Tam Tran, Samantha J. Richardson, Jim Leisten, Kamran Ghoreishi, Rene Bissonette, Mehran F. Moghaddam, Julius Apuy, Tao Shi, Deborah Mortensen, Wen Qing Yang, Weiming Xu, James C. Gamez, Peter Worland, Zeen Tong
المصدر: Molecular Cancer Therapeutics. 14:1295-1305
مصطلحات موضوعية: Cancer Research, Blotting, Western, Apoptosis, P70-S6 Kinase 1, Mechanistic Target of Rapamycin Complex 2, Mice, SCID, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biology, mTORC2, In vivo, Cell Line, Tumor, Neoplasms, Animals, Humans, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Neovascularization, Pathologic, Cell growth, Kinase, TOR Serine-Threonine Kinases, RPTOR, HCT116 Cells, Xenograft Model Antitumor Assays, Tumor Burden, HEK293 Cells, Oncology, Multiprotein Complexes, Pyrazines, Cancer research, Female
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50876b20cd6236c0e871976f53e0b444
https://doi.org/10.1158/1535-7163.mct-14-1052 -
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المؤلفون: Ashutosh A. Kulkarni, Maria Bacolod, Mehran F. Moghaddam, Zhihong O’Brien, Samantha J. Richardson, Julius Apuy, Yang Tang, Prasoon Chaturedi
المصدر: Drug metabolism letters. 8(1)
مصطلحات موضوعية: Male, Bioanalysis, Metabolite, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Models, Biological, Intestinal absorption, Permeability, Substrate Specificity, Workflow, chemistry.chemical_compound, Pharmacokinetics, Cytochrome P-450 Enzyme System, Drug Stability, In vivo, Drug Discovery, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Pharmacology (medical), Intestinal Mucosa, ADME, Chemistry, Biochemistry (medical), In vitro, High-Throughput Screening Assays, Rats, Isoenzymes, Kinetics, Intestinal Absorption, Microsomes, Liver, Administration, Intravenous, Efflux, Caco-2 Cells, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340b3b60bf9552d49d4dc20cbd860dba
https://pubmed.ncbi.nlm.nih.gov/24628405 -
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المؤلفون: April Bai, Mehran F. Moghaddam, Sayee G. Hegde, Paisner David A, Julius Apuy
المصدر: Drug metabolism letters. 6(4)
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Metabolite, Biochemistry (medical), Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Mass spectrometry, Combinatorial chemistry, Rats, chemistry.chemical_compound, Glucuronides, chemistry, Fragmentation (mass spectrometry), Microsome, Proton NMR, Microsomes, Liver, Molecule, Moiety, Organic chemistry, Animals, Pharmacology (medical), Oxidation-Reduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f8cd1607d9fed6a950e4a3d15df3c9
https://pubmed.ncbi.nlm.nih.gov/23607719