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1
المؤلفون: William P. Taylor, Mark Edward Bunnage, Hardwin O'dowd, Michael P. Clark, Dan Crawford, Sanjay Shivayogi Magavi, Bin Song, Jianglin Liang, Timothy J. Senter, Tal Kramer, Juntyma J. Engtrakul, Arun K. Mohanty, Fan Lu, Hong Gao, Yulin Huang, Swett Rebecca Jane, Bryan W. Vought, Ray Winquist, Tony Considine, Ganesh Iyer, Kenneth C. Bonanno, Elisabeth Doyle, Suganthini Nanthakumar, Raymond Kemper, Elaine Krueger, Cameron Stuver Moody, Joyce T. Coll, Paul S. Charifson, John J. Court, Wenxin Gu, Francois Maltais, Gale-Day Zachary, Ananthisrinivas Chakilam, Jon H. Come, John L. Andreassi, Morris Mark A, Brinley Furey, Christina Boucher, Martin Sanders, Harmon J. Zuccola, Gagnon Kevin James, Katrina L. Jackson, Lu Gan, Jonathan A. Phillips
المصدر: Journal of Medicinal Chemistry. 64:17753-17776
مصطلحات موضوعية: endocrine system, endocrine system diseases, Fatty Acid Elongases, Very long chain fatty acid, Central nervous system, Pyrazole, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Adrenoleukodystrophy, Thiazole, chemistry.chemical_classification, Microglia, Substrate (chemistry), medicine.disease, Amides, medicine.anatomical_structure, Enzyme, chemistry, Biochemistry, Pyrazoles, Molecular Medicine
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2
المصدر: Drug Metabolism and Disposition. 33:1621-1627
مصطلحات موضوعية: Tris, Glucuronidation, Pharmaceutical Science, Ibuprofen, Buffers, In Vitro Techniques, Biology, chemistry.chemical_compound, In vivo, medicine, Humans, Enzyme Inhibitors, Glucuronosyltransferase, Glucuronidase, Pharmacology, Dose-Response Relationship, Drug, Reproducibility of Results, Metabolism, Recombinant Proteins, UGT2B7, Kinetics, medicine.anatomical_structure, Biochemistry, chemistry, Hepatocyte, Hepatocytes, Microsomes, Liver, Microsome, Zidovudine, Drug metabolism
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b4c79b0172e2e90876c5ca10432feb
https://doi.org/10.1124/dmd.105.005058 -
3
المؤلفون: Matthew David Doroski, Joel T. Arcari, Mark S. Plummer, Andrea Marra, Thomas M. Harris, Justin I. Montgomery, Usa Reilly, Carol A. Menard, Michael D. Huband, Anthony Marfat, Jinshan Michael Chen, Christy Thoma, Karen L. Leach, John P. O'Donnell, Seung Won Chung, Loren M. Price, Joseph A. Abramite, Charlene R. Desbonnet, Eric B. McElroy, Veerabahu Shanmugasundaram, Michael Melnick, Shenping Liu, Matthew Frank Brown, Mark C. Noe, Joseph S. Warmus, Juntyma J. Engtrakul, Daniel P. Uccello, Donn G. Wishka, Robert M. Oliver, Rose Barham, Joseph Penzien, Jonathan L. Doty, John D. Knafels, Ye Che, Lisa Mullins, Elizabeth M. Collantes
المصدر: Journal of medicinal chemistry. 55(2)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Molecular Conformation, Sulfides, Crystallography, X-Ray, Hydroxamic Acids, Amidohydrolases, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, Catalytic Domain, Drug Discovery, Drug Resistance, Bacterial, Animals, Pseudomonas Infections, Sulfones, Gram, Hydroxamic acid, Phenyl Ethers, Biphenyl Compounds, Hydrogen Bonding, Stereoisomerism, Anti-Bacterial Agents, Rats, chemistry, Pseudomonas aeruginosa, Molecular Medicine, Selectivity
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4
المؤلفون: Bernard Fermini, John P. O'Donnell, Todd Wisialowski, Juntyma J. Engtrakul, Kimberly Crimin, Anthony A. Fossa
المصدر: The Journal of pharmacology and experimental therapeutics. 318(1)
مصطلحات موضوعية: Drug, Ketolides, medicine.drug_class, media_common.quotation_subject, hERG, Antibiotics, Guinea Pigs, Moxifloxacin, Telithromycin, Erythromycin, Action Potentials, Pharmacology, QT interval, Cell Line, Heart Rate, Risk Factors, Torsades de Pointes, medicine, Animals, Humans, media_common, Aza Compounds, biology, Dose-Response Relationship, Drug, business.industry, Arrhythmias, Cardiac, biochemical phenomena, metabolism, and nutrition, Ether-A-Go-Go Potassium Channels, biology.protein, Quinolines, Molecular Medicine, Action potential duration, business, medicine.drug, Fluoroquinolones
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d517a1d94baaa66a7006d864fc2ca270
https://pubmed.ncbi.nlm.nih.gov/16614168 -
5دورية أكاديمية
المؤلفون: Come JH; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Senter TJ; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Clark MP; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Court JJ; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Gale-Day Z; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Gu W; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Krueger E; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Liang J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Morris M; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Nanthakumar S; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., O'Dowd H; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Maltais F; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Iyer G; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Andreassi J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Boucher C; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Considine T; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Moody CS; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Taylor W; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Mohanty AK; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Huang Y; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Zuccola H; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Coll J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Bonanno KC; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Gagnon KJ; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Gan L; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Lu F; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Gao H; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Chakilam A; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Engtrakul J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Song B; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Crawford D; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Doyle E; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Kramer T; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Vought B; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Phillips J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Kemper R; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Sanders M; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Swett R; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Furey B; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Winquist R; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Bunnage ME; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Jackson KL; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Charifson PS; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Magavi SS; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Dec 23; Vol. 64 (24), pp. 17753-17776. Date of Electronic Publication: 2021 Nov 08.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Drug Discovery*, Enzyme Inhibitors/*pharmacology , Fatty Acid Elongases/*administration & dosage , Pyrazoles/*pharmacology, Adrenoleukodystrophy/drug therapy ; Adrenoleukodystrophy/pathology ; Amides/chemistry ; Animals ; Enzyme Inhibitors/pharmacokinetics ; Enzyme Inhibitors/therapeutic use ; Humans ; Pyrazoles/chemistry ; Pyrazoles/pharmacokinetics ; Pyrazoles/therapeutic use ; Structure-Activity Relationship
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6دورية أكاديمية
المؤلفون: Boyd MJ; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Collier PN; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Clark MP; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Deng H; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Kesavan S; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Ronkin SM; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Waal N; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Wang J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Cao J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Li P; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Come J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Davies I; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Duffy JP; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Cochran JE; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Court JJ; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Chandupatla K; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Jackson KL; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Maltais F; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., O'Dowd H; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Boucher C; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Considine T; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Taylor WP; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Gao H; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Chakilam A; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Engtrakul J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Crawford D; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Doyle E; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Phillips J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Kemper R; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Swett R; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Empfield J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Bunnage ME; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Charifson PS; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States., Magavi SS; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Dec 23; Vol. 64 (24), pp. 17777-17794. Date of Electronic Publication: 2021 Dec 06.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Drug Discovery*, Enzyme Inhibitors/*pharmacology , Fatty Acid Elongases/*antagonists & inhibitors , Pyrimidines/*pharmacology, Administration, Oral ; Adrenoleukodystrophy/drug therapy ; Animals ; Biological Availability ; Dogs ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/pharmacokinetics ; Ethers/chemistry ; HEK293 Cells ; Humans ; Macaca fascicularis ; Mice ; Pyrimidines/administration & dosage ; Pyrimidines/pharmacokinetics ; Rats
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7دورية أكاديمية
المؤلفون: Wisialowski T; Pfizer Global Research and Development, Eastern Point Rd., Building 274, Groton, CT 06340, USA., Crimin K, Engtrakul J, O'Donnell J, Fermini B, Fossa AA
المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2006 Jul; Vol. 318 (1), pp. 352-9. Date of Electronic Publication: 2006 Apr 13.
نوع المنشور: Comparative Study; Journal Article
بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
مواضيع طبية MeSH: Action Potentials/*drug effects , Arrhythmias, Cardiac/*chemically induced , Aza Compounds/*toxicity , Erythromycin/*toxicity , Ketolides/*toxicity , Quinolines/*toxicity, Action Potentials/physiology ; Animals ; Arrhythmias, Cardiac/physiopathology ; Cell Line ; Dose-Response Relationship, Drug ; Ether-A-Go-Go Potassium Channels/physiology ; Fluoroquinolones ; Guinea Pigs ; Heart Rate/drug effects ; Heart Rate/physiology ; Humans ; Moxifloxacin ; Risk Factors ; Torsades de Pointes/chemically induced ; Torsades de Pointes/physiopathology
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