نتائج البحث - "Justin, Ly"

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دورية أكاديمية

First‐in‐human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC‐2394, in healthy volunteers

المؤلفون: Fei Tang, Rebecca Kunder, Tom Chu, Avis Hains, Allen Nguyen, Jacqueline M. McBride, Yu Zhong, Sara Santagostino, Maria Wilson, Abigail Trenchak, Liuxi Chen, Justin Ly, Anita Moein, Nicholas Lewin‐Koh, Vibha Raghavan, Uyi Osaghae, Chris Wynne, Ryan Owen, David Place

المصدر: Clinical and Translational Science, Vol 16, Iss 9, Pp 1653-1666 (2023)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

URL الوصول: https://doaj.org/article/7a96997b4ebb4093a90b5db4a16716a5

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Development of an Amorphous Solid Dispersion Formulation for Mitigating Mechanical Instability of Crystalline Form and Improving Bioavailability for Early Phase Clinical Studies

المؤلفون: Cheng W. Chiang, Joseph W. Lubach, Tao Chen, Steven Chin, Justin Ly, Wei Zhang, Hao Helen Hou, Karthik Nagapudi

المصدر: Molecular Pharmaceutics. 20:2452-2464

مصطلحات موضوعية: Drug Discovery, Pharmaceutical Science, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::67185b1e458484275cb8a25b9fe7995f
https://doi.org/10.1021/acs.molpharmaceut.2c01056

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Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

المصدر: Journal of Medicinal Chemistry. 65:14721-14739

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::44ab527cf94dae143f3c4497446ed964
https://doi.org/10.1021/acs.jmedchem.2c01250

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4

Supplementary Figure legends from Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer

المؤلفون: Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7e6d4475a0ae89a8c2dfdd5ab0fdb742
https://doi.org/10.1158/0008-5472.22415367.v1

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Table S1 from Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer

المؤلفون: Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b2ed65b009a3d6a8d0c6d6fdb82b76
https://doi.org/10.1158/0008-5472.22415364

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Figure S2 from Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer

المؤلفون: Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348bd12eb407d5287c888e7de21bcfb1
https://doi.org/10.1158/0008-5472.22415379

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Note S1 from Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer

المؤلفون: Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272c8ba9d74f81c9f661d51828b510a5
https://doi.org/10.1158/0008-5472.22415370.v1

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Data from Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer

المؤلفون: Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e2a174442441346b475aa53f3b8dc698
https://doi.org/10.1158/0008-5472.c.6509253.v1

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Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

المصدر: Journal of Medicinal Chemistry. 64:3843-3869

مصطلحات موضوعية: Male, Ovalbumin, Guinea Pigs, CHO Cells, Ligands, 01 natural sciences, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, Transient receptor potential channel, Cricetulus, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Ankyrin, Binding site, Furans, TRPA1 Cation Channel, Ion channel, 030304 developmental biology, Inflammation, chemistry.chemical_classification, Oxadiazoles, 0303 health sciences, Molecular Structure, biology, Chemistry, biology.organism_classification, Small molecule, Asthma, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Mechanism of action, Purines, Biophysics, Molecular Medicine, medicine.symptom, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17e5be6b310c8cbde93a6ecff3b6232
https://doi.org/10.1021/acs.jmedchem.0c02023

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Multiple Opioid Prescribers During the Perioperative Period Increases Opioid Consumption Following Upper Extremity Surgery: A Multicenter Analysis

المؤلفون: Joseph, Paladino, Clay B, Townsend, Justin, Ly, Ryan, Judy, Christine, Conroy, Shivangi, Bhatt, Hesham, Abdelfattah, Mark, Solarz, Katharine, Woozley, Asif M, Ilyas

المصدر: Cureus.

مصطلحات موضوعية: General Engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906b2153401ec4d1b051e09356abfc5b
https://doi.org/10.7759/cureus.24541

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