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المؤلفون: Chen I-Jen, Simon Bedford, Kenneth Vielsted Christensen, Victoria Chell, Allan E. Surgenor, Lindsey Terry, Justus Claus Alfred Daechsel, Kenneth Thirstrup, Samantha Newland, Jonathan D. Moore, Garrick Paul Smith, Pamela Acheson-Dossang, Martin C. Herzig, Stuart C. Ray, Zoe Daniels, Roderick E. Hubbard, James Brooke Murray, Douglas S. Williamson, Pawel Dokurno, Morten Hentzer, Yikang Wang, Terry Shaw, Laurent David
المصدر: Journal of Medicinal Chemistry. 60:8945-8962
مصطلحات موضوعية: 0301 basic medicine, Protein domain, Mutant, Leucine-rich repeat, Kidney, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 01 natural sciences, Mice, 03 medical and health sciences, Protein Domains, Drug Discovery, Animals, Humans, CHEK1, Protein Kinase Inhibitors, Crystallography, 010405 organic chemistry, Chemistry, Kinase, Brain, Kidney metabolism, Parkinson Disease, LRRK2, Molecular biology, nervous system diseases, 0104 chemical sciences, HEK293 Cells, 030104 developmental biology, Protein kinase domain, Biochemistry, Checkpoint Kinase 1, Mutation, Molecular Medicine, Protein Binding
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المؤلفون: Karsten Skjødt, Jan Egebjerg, Jan Torleif Pedersen, Fredrik Kartberg, Christiane Volbracht, Florence Sotty, Nina Helen Rosenqvist, Lars Østergaard Pedersen, Einar M. Sigurdsson, Ayodeji A. Asuni, Pia Jul, Christian Rungsted Andersson, Jeppe Falsig, Lone Helboe, Jeffrey B. Stavenhagen, Justus Claus Alfred Daechsel, Søren Christensen
المصدر: Alzheimer's & Dementia : Translational Research & Clinical Interventions
Rosenqvist, N, Asuni, A A, Andersson, C R, Christensen, S, Daechsel, J A, Egebjerg, J, Falsig, J, Helboe, L, Jul, P, Kartberg, F, Pedersen, L Ø, Sigurdsson, E M, Sotty, F, Skjødt, K, Stavenhagen, J B, Volbracht, C & Pedersen, J T 2018, ' Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau ', Alzheimer's & Dementia: Translational Research & Clinical Interventions, vol. 4, pp. 521-534 . https://doi.org/10.1016/j.trci.2018.09.005مصطلحات موضوعية: 0301 basic medicine, Monoclonal antibody, medicine.drug_class, Tau protein, Hyperphosphorylation, Anti-tau antibodies, C10.2, Peptide, D1.2, 03 medical and health sciences, 0302 clinical medicine, C8.3, Tau seeding, mental disorders, medicine, IC50, chemistry.chemical_classification, biology, HEK 293 cells, Neurodegeneration, Featured Article, medicine.disease, Phospho-serine 396, C5.2, Cell biology, Psychiatry and Mental health, 030104 developmental biology, chemistry, biology.protein, Neurology (clinical), Antibody, 030217 neurology & neurosurgery
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المؤلفون: Laurent David, Garrick Paul Smith, Victoria Chell, Lassina Badolo, Stephen P. Watson, Douglas S. Williamson, Morten Hentzer, Chen I-Jen, Gitte Mikkelsen, Martin C. Herzig, Kenneth Vielsted Christensen, Justus Claus Alfred Daechsel
المصدر: Bioorganicmedicinal chemistry letters. 27(18)
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Aminopyridines, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 01 natural sciences, Biochemistry, Mixed Lineage Kinase, Madin Darby Canine Kidney Cells, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, In vivo, Drug Discovery, Animals, Humans, Homology modeling, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Kinase, Organic Chemistry, LRRK2, nervous system diseases, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, chemistry, Drug Design, Microsomes, Liver, Molecular Medicine, 2-Aminopyridine
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المؤلفون: Mikkel A. Rasmussen, Helena Borland, Susanne Kofoed Hansen, Karina Fog, Zeynep Tümer, Lis Hasholt, Poul Hyttel, Jørgen E. Nielsen, Tina C. Stummann, Justus Claus Alfred Daechsel, Troels Tolstrup Nielsen
المصدر: Hansen, S K, Stummann, T C, Madsen, H B, Hasholt, L F, Tümer, Z, Nielsen, J E, Rasmussen, M A, Nielsen, T T, Daechsel, J C A, Fog, K & Hyttel, P 2016, ' Induced pluripotent stem cell-derived neurons for the study of spinocerebellar ataxia type 3 ', Stem Cell Research, vol. 17, no. 2, pp. 306-317 . https://doi.org/10.1016/j.scr.2016.07.004
Stem Cell Research, Vol 17, Iss 2, Pp 306-317 (2016)مصطلحات موضوعية: 0301 basic medicine, Synapsin I, congenital, hereditary, and neonatal diseases and abnormalities, Cellular differentiation, Induced Pluripotent Stem Cells, Karyotype, Nerve Tissue Proteins, Biology, Cell Line, 03 medical and health sciences, Protein Aggregates, 0302 clinical medicine, Neural Stem Cells, medicine, Humans, Induced pluripotent stem cell, Ataxin-3, lcsh:QH301-705.5, Medicine(all), Genetics, Ionomycin, Glutamate receptor, Brain, Antigens, Nuclear, Cell Differentiation, Cell Biology, General Medicine, Human brain, Machado-Joseph Disease, Fibroblasts, medicine.disease, Cellular Reprogramming, Synapsins, Cell biology, Repressor Proteins, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), nervous system, Microscopy, Fluorescence, Spinocerebellar ataxia, biology.protein, Calcium, NeuN, 030217 neurology & neurosurgery, Acetylcholine, Developmental Biology, medicine.drug, Transcription Factors
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