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1
المؤلفون: William J. Chiou, Jiahong Wang, Jyoti R. Patel, Peer B. Jacobson, Michael E. Brune, J.T. Link, Ravi Kurukulasuriya, Hong Yong, Hing L. Sham, Steven Fung, Katina Monzon, DeAnne Stolarik, Hovis M. Imade, David W A Beno, Vince Yeh
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5414-5419
مصطلحات موضوعية: medicine.drug_class, Adamantane, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Carboxamide, In Vitro Techniques, Biochemistry, Chemical synthesis, Cell Line, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Heterocyclic Compounds, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Amide, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Animals, Humans, Organic chemistry, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Stereoisomerism, Biological activity, Enzyme Activation, Heterocyclic compound, Enzyme inhibitor, Microsomes, Liver, biology.protein, Molecular Medicine, Selectivity, hormones, hormone substitutes, and hormone antagonists
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2
المؤلفون: Phong Nguyen, Sue J. Swanson, Jyoti R. Patel, Jiahong Wang, Annika Goos-Nilsson, J.T. Link, Peer B. Jacobson, Zhenping Tian, Marlena Grynfarb, Jia Du, James M. Schmidt, Brad Zinker, Thomas W von Geldern, Steven Fung, Thomas J Reisch, Denise Wilcox, Gary Rotert, Benjamin C. Lane, Bach Hickman, Bryan Sorensen
المصدر: Journal of Medicinal Chemistry. 48:5295-5304
مصطلحات موضوعية: Male, Transcriptional Activation, Benzylamines, Hypothalamo-Hypophyseal System, medicine.medical_specialty, Side effect, Pituitary-Adrenal System, Dexamethasone, Rats, Sprague-Dawley, Mice, Radioligand Assay, chemistry.chemical_compound, Cricetulus, Receptors, Glucocorticoid, Glucocorticoid receptor, Genes, Reporter, Pregnancy, Cricetinae, Internal medicine, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Receptor, Glucocorticoids, Cells, Cultured, Tyrosine Transaminase, chemistry.chemical_classification, Sulfonamides, Triglyceride, Cholesterol, Uterus, Fatty acid, Alkaline Phosphatase, Rats, medicine.anatomical_structure, Endocrinology, chemistry, Hepatocytes, Molecular Medicine, Female, Antagonism, Hypothalamic–pituitary–adrenal axis
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3
المؤلفون: Marlena Grynfarb, Maurice Emery, Jyoti R. Patel, Annika Goos-Nilsson, Bryan K. Sorensen, Susan Swanson, David Arendsen, Gaoquan Li, James T. Link, Bach Nguyen
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:4169-4172
مصطلحات موضوعية: Nonsteroidal, Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, General Medicine, Metabolic stability, Pharmacology, Ligands, Biochemistry, chemistry.chemical_compound, Receptors, Glucocorticoid, Glucocorticoid receptor, Drug Discovery, medicine, Humans, Molecular Medicine, Molecular Biology, Glucocorticoid, Protein Binding, medicine.drug
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4
المصدر: Tetrahedron Letters. 38:2031-2034
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Base (chemistry), Organic Chemistry, Drug Discovery, Polymer chemistry, Condensation, Chromophore, Biochemistry, Porphyrin, Pyrrole, Catalysis
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5
المؤلفون: Di Zhang, Sridhar Peddi, Marc J. C. Scanio, Prisca Honore, Betty B. Yao, Carol S. Surowy, Jyoti R. Patel, David A. DeGoey, Zhi Wang, Murali Gopalakrishnan, Xu-Feng Zhang, Rama Thimmapaya, Arturo Perez-Medrano, John L. Baranowski, David J. Anderson
المصدر: Journal of neuroscience methods. 200(1)
مصطلحات موضوعية: Membrane potential, KCNQ Potassium Channels, Chemistry, General Neuroscience, Retigabine, HEK 293 cells, Channel modulator, Molecular Pharmacology, Pharmacology, Phenylenediamines, Potassium channel, KCNQ3 Potassium Channel, chemistry.chemical_compound, HEK293 Cells, Mutation, Biophysics, Homomeric, Humans, KCNQ2 Potassium Channel, Carbamates, Thallium, Selectivity, Ion Channel Gating
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6
المصدر: ChemInform. 28
مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Condensation, Polymer chemistry, Organic chemistry, General Medicine, Chromophore, Porphyrin, Catalysis, Pyrrole
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7
المؤلفون: David W A Beno, Wenying Qin, J.T. Link, Jiahong Wang, Liping Pan, M. Winn, Peer B. Jacobson, Francis A. J. Kerdesky, Seble Wagaw, Michael E. Brune, Hing L. Sham, Jyoti R. Patel, Russell A. Judge, DeAnne Stolarik, Linda E. Chovan, Jürgen Dinges, Steven Fung, Hovis M. Imade, Qi Shuai, Kenton L. Longenecker, Kenneth M. Engstrom, Katina Monzon, Marina A. Pliushchev, William J. Chiou
المصدر: Bioorganicmedicinal chemistry letters. 17(3)
مصطلحات موضوعية: Models, Molecular, endocrine system, animal structures, Hydrogenase, Alkylation, Stereochemistry, Adamantane, Clinical Biochemistry, Pharmaceutical Science, Ether, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mice, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Animals, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Mice, Knockout, biology, Dose-Response Relationship, Drug, Organic Chemistry, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Microsomes, Liver, Molecular Medicine, Indicators and Reagents, Selectivity, Ex vivo, Ethers, Half-Life
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8
المؤلفون: Peer B. Jacobson, David Madar, Vince S.C. Yeh, Jiahong Wang, Steven Fung, Katina Monzon, Jyoti R. Patel, J.T. Link, Ravi Kurukulasuriya, Hing L. Sham, William Chiou
المصدر: Bioorganicmedicinal chemistry letters. 16(20)
مصطلحات موضوعية: Stereochemistry, Adamantane, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Stereoisomerism, In Vitro Techniques, Biochemistry, Chemical synthesis, 11β hsd1 inhibitors, Cell Line, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 11-beta-Hydroxysteroid Dehydrogenase Type 2, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Bicyclic molecule, biology, Organic Chemistry, Enzyme Activation, chemistry, Enzyme inhibitor, biology.protein, Microsomes, Liver, Molecular Medicine, Selectivity
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9
المؤلفون: Bryan K. Sorensen, James T. Link, Maurice Emery, Jyoti R. Patel, Annika Goos-Nilsson, Marlena Grynfarb
المصدر: ChemInform. 35
مصطلحات موضوعية: inorganic chemicals, Tertiary amine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Receptors, Glucocorticoid, Glucocorticoid receptor, Pharmacokinetics, In vivo, Benzyl Compounds, Drug Discovery, polycyclic compounds, Animals, Humans, heterocyclic compounds, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Nonsteroidal, organic chemicals, Organic Chemistry, General Medicine, Combinatorial chemistry, In vitro, Rats, Sulfonamide, chemistry, Molecular Medicine
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10
المؤلفون: Irini Akritopoulou-Zanze, Kresna Hartandi, Thomas W. von Geldern, Annika Goos-Nisson, Philip R. Kym, Martin Winn, Jyoti R. Patel, John K. Pratt, Jehrod Burnett Brenneman, Marlene Grynfarb
المصدر: ChemInform. 35
مصطلحات موضوعية: Nonsteroidal, medicine.medical_treatment, General Medicine, Glucocorticoid Receptor Antagonists, Steroid, Receptor selectivity, chemistry.chemical_compound, Glucocorticoid receptor, Biochemistry, chemistry, medicine, Potency, Receptor, Biological evaluation