المؤلفون: David W. Piotrowski, Jason S. Chen, Peng-Xiang Shen, yu j, Liu T, Paul G. Richardson, Zhao S, Qian Shao, Flanagan Me, Cui Z, Zhuang Z, Ratnayake As, Kölmel Dk, Zhoulong Fan

مصطلحات موضوعية: Text mining, Dna encoding, business.industry, Chemical diversity, Computational biology, Biology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::06625d6774159cdd6436fbeb21e89a10
https://doi.org/10.26434/chemrxiv.11514774.v1

المؤلفون: Ratnayake AS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: anokha.ratnayake@pfizer.com., Flanagan ME; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: mark.e.flanagan@pfizer.com., Foley TL; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Timothy.Foley@pfizer.com., Hultgren SL; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Scott.Hultgren@pfizer.com., Bellenger J; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Justin.Bellenger@pfizer.com., Montgomery JI; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Justin.Montgomery@pfizer.com., Lall MS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Manjinder.Lall@pfizer.com., Liu B; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Bo.Liu2@pfizer.com., Ryder T; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: tim.ryder@pfizer.com., Kölmel DK; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Dominik.Koelmel@pfizer.com., Shavnya A; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: andre.shavnya@pfizer.com., Feng X; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Xidong.Feng@pfizer.com., Lefker B; Lefker Biopharma Consulting LLC, Arlington, MA 02474 United States. Electronic address: bruce@lefkerbiopharmaconsulting.com., Byrnes LJ; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Laura.Byrnes@pfizer.com., Sahasrabudhe PV; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: Parag.Sahasrabudhe@Pfizer.com., Farley KA; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, United States. Electronic address: kathleen.a.farley@pfizer.com., Chen S; HitGen Inc., Shuangliu District, Chengdu, China. Electronic address: shi.chen@hitgen.com., Wan J; HitGen Inc., Shuangliu District, Chengdu, China. Electronic address: jq.wan@hitgen.com.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Jul 01; Vol. 41, pp. 116205. Date of Electronic Publication: 2021 May 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery* , Gene Library*, DNA/*chemistry , Mass Spectrometry/*methods, Combinatorial Chemistry Techniques ; Ligands ; Molecular Structure ; Small Molecule Libraries/chemistry

المؤلفون: Kölmel DK; Worldwide Research and Development, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States., Zhu H; Worldwide Research and Development, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States., Flanagan ME; Worldwide Research and Development, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States., Sakata SK; Worldwide Research and Development, Pfizer Inc, 10770 Science Center Drive, San Diego, CA 92121, United States., Harris AR; Worldwide Research and Development, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States., Wan J; HitGen Inc Building 6, No. 8, Huigu first East Road, Tianfu International, Bio-Town, Shuangliu District, Chengdu City, Sichuan Province, P. R. China., Morgan BA; HitGen Inc Building 6, No. 8, Huigu first East Road, Tianfu International, Bio-Town, Shuangliu District, Chengdu City, Sichuan Province, P. R. China.; HitGen Pharmaceuticals Inc, PO Box 88240, Houston, TX 77288, United States.

المصدر: Chemical record (New York, N.Y.) [Chem Rec] 2021 Apr; Vol. 21 (4), pp. 616-630. Date of Electronic Publication: 2021 Feb 11.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101085550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0691 (Electronic) Linking ISSN: 15280691 NLM ISO Abbreviation: Chem Rec Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design* , Gene Library*, DNA/*chemistry , Small Molecule Libraries/*chemical synthesis, Catalysis ; Combinatorial Chemistry Techniques ; Photochemical Processes ; Small Molecule Libraries/chemistry

المؤلفون: Kölmel DK; Pfizer Worldwide Research and Development, Groton, CT, 06340, United States. Electronic address: dominik.koelmel@pfizer.com., Ratnayake AS; Pfizer Worldwide Research and Development, Groton, CT, 06340, United States., Flanagan ME; Pfizer Worldwide Research and Development, Groton, CT, 06340, United States. Electronic address: mark.e.flanagan@pfizer.com.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 03; Vol. 533 (2), pp. 201-208. Date of Electronic Publication: 2020 May 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Alkanes/*chemistry , Bromides/*chemistry , DNA/*chemistry , Hydrocarbons, Aromatic/*chemistry , Iodides/*chemistry, Alkanes/chemical synthesis ; Alkylation ; Bromides/chemical synthesis ; Catalysis ; Combinatorial Chemistry Techniques ; DNA/chemical synthesis ; Hydrocarbons, Aromatic/chemical synthesis ; Iodides/chemical synthesis ; Ligands ; Nickel/chemistry ; Oxidation-Reduction ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry

المؤلفون: Fan Z; Department of Chemistry, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla CA 92037 USA yu200@scripps.edu., Zhao S; Department of Chemistry, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla CA 92037 USA yu200@scripps.edu., Liu T; Department of Chemistry, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla CA 92037 USA yu200@scripps.edu., Shen PX; Department of Chemistry, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla CA 92037 USA yu200@scripps.edu., Cui ZN; Department of Chemistry, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla CA 92037 USA yu200@scripps.edu., Zhuang Z; Department of Chemistry, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla CA 92037 USA yu200@scripps.edu., Shao Q; Department of Chemistry, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla CA 92037 USA yu200@scripps.edu., Chen JS; Automated Synthesis Facility, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla CA 92037 USA., Ratnayake AS; Pfizer Medicinal Chemistry Eastern Point Road, Groton Connecticut 06340 USA., Flanagan ME; Pfizer Medicinal Chemistry Eastern Point Road, Groton Connecticut 06340 USA., Kölmel DK; Pfizer Medicinal Chemistry Eastern Point Road, Groton Connecticut 06340 USA., Piotrowski DW; Pfizer Medicinal Chemistry Eastern Point Road, Groton Connecticut 06340 USA., Richardson P; Pfizer Medicinal Chemistry, 10578 Science Center Drive San Diego CA 09121 USA., Yu JQ; Department of Chemistry, The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla CA 92037 USA yu200@scripps.edu.

المصدر: Chemical science [Chem Sci] 2020 Sep 07; Vol. 11 (45), pp. 12282-12288. Date of Electronic Publication: 2020 Sep 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: Electronic Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

المؤلفون: Flood DT; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA., Zhang X; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Fu X; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Zhao Z; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA., Asai S; Department of Chemistry and Biological Sciences, Faculty of and Engineering, Iwate University, 4-3-5 Ueda, Morioka, 020-8551, Japan., Sanchez BB; Automated Synthesis Facility, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA., Sturgell EJ; Automated Synthesis Facility, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA., Vantourout JC; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA., Richardson P; Pfizer Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA, 92121, USA., Flanagan ME; Pfizer Medicinal Chemistry, Eastern Point Road, Groton, CT, 06340, USA., Piotrowski DW; Pfizer Medicinal Chemistry, Eastern Point Road, Groton, CT, 06340, USA., Kölmel DK; Pfizer Medicinal Chemistry, Eastern Point Road, Groton, CT, 06340, USA., Wan J; HitGen Inc., Building 6, No. 8 Huigu 1st East Road Tianfu International Bio-Town, Shuangliu District, Chengdu, 610200, Sichuan, China., Tsai MH; HitGen Inc., Building 6, No. 8 Huigu 1st East Road Tianfu International Bio-Town, Shuangliu District, Chengdu, 610200, Sichuan, China., Chen JS; Automated Synthesis Facility, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA., Baran PS; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA., Dawson PE; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 May 04; Vol. 59 (19), pp. 7377-7383. Date of Electronic Publication: 2020 Mar 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: DNA/*chemical synthesis, Adsorption ; Chemistry Techniques, Synthetic ; Combinatorial Chemistry Techniques ; Drug Discovery ; Indicators and Reagents ; Small Molecule Libraries ; Solubility ; Sulfones/chemistry ; Sulfoxides/chemistry

المؤلفون: Kölmel DK; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Ratnayake AS; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Flanagan ME; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Tsai MH; HitGen Inc, Building 6, No. 8, Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu City, Sichuan Province P. R. China., Duan C; HitGen Inc, Building 6, No. 8, Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu City, Sichuan Province P. R. China., Song C; HitGen Inc, Building 6, No. 8, Huigu first East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu City, Sichuan Province P. R. China.

المصدر: Organic letters [Org Lett] 2020 Apr 17; Vol. 22 (8), pp. 2908-2913. Date of Electronic Publication: 2020 Apr 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

مواضيع طبية MeSH: Cyclobutanes/*chemistry , DNA/*chemical synthesis, Catalysis ; Cycloaddition Reaction ; DNA/chemistry ; Molecular Structure ; Photochemical Processes

المؤلفون: Kölmel DK; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States., Meng J; HitGen Inc , Building 6, No. 8, Huigu first East Road , Tianfu International Bio-Town, Shuangliu District, Chengdu City , Sichuan Province , P. R. China., Tsai MH; HitGen Inc , Building 6, No. 8, Huigu first East Road , Tianfu International Bio-Town, Shuangliu District, Chengdu City , Sichuan Province , P. R. China., Que J; HitGen Inc , Building 6, No. 8, Huigu first East Road , Tianfu International Bio-Town, Shuangliu District, Chengdu City , Sichuan Province , P. R. China., Loach RP; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States., Knauber T; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States., Wan J; HitGen Inc , Building 6, No. 8, Huigu first East Road , Tianfu International Bio-Town, Shuangliu District, Chengdu City , Sichuan Province , P. R. China., Flanagan ME; Pfizer Worldwide Research and Development , Groton , Connecticut 06340 , United States.

المصدر: ACS combinatorial science [ACS Comb Sci] 2019 Aug 12; Vol. 21 (8), pp. 588-597. Date of Electronic Publication: 2019 Jul 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101540531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2156-8944 (Electronic) Linking ISSN: 21568944 NLM ISO Abbreviation: ACS Comb Sci Subsets: MEDLINE

مواضيع طبية MeSH: DNA/*chemistry , Nickel/*chemistry , Water/*chemistry, Catalysis ; Combinatorial Chemistry Techniques ; Decarboxylation ; Ligands ; Molecular Structure ; Oxidation-Reduction ; Photochemical Processes ; Solutions

المؤلفون: Braun AB; Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany., Wehl I; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany., Kölmel DK; Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany., Schepers U; Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany., Bräse S; Institute of Organic Chemistry, Karlsruhe Institute of Technology, Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany.; Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.

المصدر: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2019 Jun 18; Vol. 25 (34), pp. 7998-8002. Date of Electronic Publication: 2019 May 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry

مواضيع طبية MeSH: Carbocyanines/*chemistry , Fluorescent Dyes/*chemistry , Hydrocarbons, Fluorinated/*chemistry , Microscopy, Fluorescence/*methods , Mitochondria/*ultrastructure , Optical Imaging/*methods, A549 Cells ; Carbocyanines/chemical synthesis ; Cell Line ; Fluorescent Dyes/chemical synthesis ; Halogenation ; HeLa Cells ; Hep G2 Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydrocarbons, Fluorinated/chemical synthesis ; Infrared Rays ; Microscopy, Confocal/methods

المؤلفون: Kölmel DK; Pfizer Worldwide Research and Development, Groton, CT, 06340, USA., Loach RP; Pfizer Worldwide Research and Development, Groton, CT, 06340, USA., Knauber T; Pfizer Worldwide Research and Development, Groton, CT, 06340, USA., Flanagan ME; Pfizer Worldwide Research and Development, Groton, CT, 06340, USA.

المصدر: ChemMedChem [ChemMedChem] 2018 Oct 22; Vol. 13 (20), pp. 2159-2165. Date of Electronic Publication: 2018 Aug 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

مواضيع طبية MeSH: Amino Acids/*chemistry , DNA/*chemistry, Acrylamides/chemistry ; Alkylation ; Amines/chemical synthesis ; Amino Acids/radiation effects ; Catalysis ; Coordination Complexes/chemistry ; Coordination Complexes/radiation effects ; Decarboxylation ; Free Radicals/chemistry ; Iridium/chemistry ; Light ; Oxidation-Reduction ; Proof of Concept Study