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المؤلفون: Martha Nance, Izelle Labuschagne, Karen Marder, C. Herd, Mays A. El-Dairi, Scott R. Evans, A. Daley, Henry Moore, Phyllis Chua, Jody Corey-Bloom, S. Targum, Patrick Mitchell, Jody Goldstein, David Ames, Rajeev Ananda Kumar, H. Mack, Eric Molho, S. Wray, Susan R. Criswell, Carlos Singer, Ronda Clouse, Anita M.Y. Goh, Karen Anderson, Andrew Feigin, David Oakes, Jane Griffith, Peter K. Panegyres, Carr J. Vaughan, Alessandro Iannaccone, Andrew Churchyard, Leah Levi, Craig W. Ritchie, Russell L. Margolis, D. L. Lim, Nadine Yoritomo, Barbara J. Jennings, Cameron Stone, Vicki Sergo, Constance Orme, Sarah Janicki, D. Angus, K. Helles, H. D. Rosas, Ralf Reilmann, Carolyn M. Drazinic, Arthur Watts, B. Hennig, Shea Gluhm, Sharon Fekrat, Sandra K. Kostyk, Earl Ray Dorsey, M. Moscovitch-Lopatin, Mark S. LeDoux, S. Gao, R. Ranzi, N. Padron, Elise Kayson, Shannon Guyot, K. Baker, Pinky Agarwal, Clement T. Loy, Marguerite Wieler, Steven M. Hersch, Cindy Casaceli, M. Murathodizic, Julie C. Stout, Blair R. Leavitt, D. Germaine
المصدر: The Lancet. Neurology. 14(1)
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Population, Trail Making Test, Placebo-controlled study, Placebo, Placebos, Huntington's disease, Double-Blind Method, Internal medicine, medicine, Humans, education, Adverse effect, education.field_of_study, business.industry, Montreal Cognitive Assessment, Clioquinol, Middle Aged, medicine.disease, Huntington Disease, Treatment Outcome, Tolerability, Female, Neurology (clinical), business, Cognition Disorders, Biomarkers
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2دورية أكاديمية
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3دورية أكاديمية
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4دورية أكاديمية
المؤلفون: Beal MF; Department of Neurology, Weill Cornell Medical College, New York Hospital, New York., Oakes D; Department of Biostatistics, University of Rochester Medical Center, Rochester, New York., Shoulson I; Department of Neurology, Georgetown University, Washington, DC., Henchcliffe C; Department of Neurology, Weill Cornell Medical College, New York Hospital, New York., Galpern WR; National Institutes of Health, Bethesda, Maryland., Haas R; Department of Neurosciences, University of California, San Diego, La Jolla., Juncos JL; Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia., Nutt JG; Department of Neurology, Oregon Health and Science University, Portland., Voss TS; Merck, New Jersey., Ravina B; Biogen Idec, Cambridge, Massachusetts., Shults CM; Department of Neurosciences, University of California, San Diego, La Jolla10VA Medical Center, San Diego, California., Helles K; Department of Biostatistics, University of Rochester Medical Center, Rochester, New York., Snively V; Department of Biostatistics, University of Rochester Medical Center, Rochester, New York., Lew MF; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles., Griebner B; Department of Biostatistics, University of Rochester Medical Center, Rochester, New York., Watts A; Department of Biostatistics, University of Rochester Medical Center, Rochester, New York12Department of Neurology, University of Rochester, Rochester, New York., Gao S; Department of Biostatistics, University of Rochester Medical Center, Rochester, New York., Pourcher E; Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada., Bond L; Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte-Anne, Québec, Canada., Kompoliti K; Rush University Medical Center, Chicago, Illinois., Agarwal P; Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington., Sia C; Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington., Jog M; London Health Sciences Centre, London, Ontario, Canada., Cole L; London Health Sciences Centre, London, Ontario, Canada., Sultana M; London Health Sciences Centre, London, Ontario, Canada., Kurlan R; Overlook Medical Center, Atlantic Neuroscience Institute, Summit, New Jersey., Richard I; Department of Neurology, University of Rochester, Rochester, New York., Deeley C; Department of Neurology, University of Rochester, Rochester, New York., Waters CH; Columbia University Medical Center, Neurological Institute, New York, New York., Figueroa A; Columbia University Medical Center, Neurological Institute, New York, New York., Arkun A; Department of Neurology, Weill Cornell Medical College, New York Hospital, New York., Brodsky M; Department of Neurology, Oregon Health and Science University, Portland., Ondo WG; Department of Neurology, University of Texas Health Science Center at Houston., Hunter CB; Department of Neurology, Baylor College of Medicine, Houston, Texas., Jimenez-Shahed J; Department of Neurology, Baylor College of Medicine, Houston, Texas., Palao A; Department of Neurology, Baylor College of Medicine, Houston, Texas., Miyasaki JM; Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada., So J; Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada., Tetrud J; The Parkinson's Institute and Clinical Center, Sunnyvale, California., Reys L; The Parkinson's Institute and Clinical Center, Sunnyvale, California., Smith K; The Parkinson's Institute and Clinical Center, Sunnyvale, California., Singer C; Department of Neurology, University of Miami School of Medicine, Miami, Florida., Blenke A; Department of Neurology, University of Miami School of Medicine, Miami, Florida., Russell DS; Institute for Neurodegenerative Disorders, New Haven, Connecticut., Cotto C; Institute for Neurodegenerative Disorders, New Haven, Connecticut., Friedman JH; Department of Neurology, Butler Hospital, Providence, Rhode Island26Alpert Medical School, Brown University, Providence, Rhode Island., Lannon M; Department of Neurology, Butler Hospital, Providence, Rhode Island27Port City Neurology, Inc, Scarborough, Maine., Zhang L; Department of Neurology, University of California, Davis, School of Medicine and Sacramento VA Medical Center, Sacramento., Drasby E; Port City Neurology, Inc, Scarborough, Maine., Kumar R; Colorado Neurological Institute, Englewood., Subramanian T; Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey., Ford DS; Milton S. Hershey Medical Center, Department of Neurology, Pennsylvania State Hershey College of Medicine, Hershey., Grimes DA; Ottawa Hospital Civic Site, Ottawa, Ontario, Canada., Cote D; Ottawa Hospital Civic Site, Ottawa, Ontario, Canada., Conway J; Ottawa Hospital Civic Site, Ottawa, Ontario, Canada., Siderowf AD; Avid Radiopharmaceuticals, Philadelphia, Pennsylvania., Evatt ML; Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia33Atlanta VA Medical Center, Atlanta, Georgia., Sommerfeld B; Department of Neurology, Emory University School of Medicine, Wesley Woods Center, Atlanta, Georgia., Lieberman AN; Muhammad Ali Parkinson Center, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, Phoenix, Arizona., Okun MS; Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville., Rodriguez RL; Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville., Merritt S; Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville., Swartz CL; Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville., Martin WR; Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada., King P; Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada., Stover N; Department of Neurology, University of Alabama at Birmingham., Guthrie S; Department of Neurology, University of Alabama at Birmingham., Watts RL; Department of Neurology, University of Alabama at Birmingham., Ahmed A; Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio., Fernandez HH; Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio., Winters A; Center for Neurological Restoration, Department of Neurology, Cleveland Clinic, Cleveland, Ohio., Mari Z; Department of Neurology, Johns Hopkins University, Baltimore, Maryland., Dawson TM; Department of Neurology, Johns Hopkins University, Baltimore, Maryland., Dunlop B; Department of Neurology, Johns Hopkins University, Baltimore, Maryland., Feigin AS; Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York., Shannon B; Feinstein Institute for Medical Research, Center for Neurosciences, Manhasset, New York., Nirenberg MJ; Department of Neurology, New York University Langone Medical Center, New York., Ogg M; Department of Neurology, Weill Cornell Medical College, New York Hospital, New York., Ellias SA; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts., Thomas CA; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts., Frei K; The Parkinson's and Movement Disorder Institute, Fountain Valley, California., Bodis-Wollner I; State University of New York, Downstate Medical Center, Brooklyn, New York., Glazman S; State University of New York, Downstate Medical Center, Brooklyn, New York., Mayer T; State University of New York, Downstate Medical Center, Brooklyn, New York., Hauser RA; Department of Neurology, University of South Florida, Tampa., Pahwa R; Department of Neurology, University of Kansas Medical Center, Kansas City., Langhammer A; Department of Neurology, University of Kansas Medical Center, Kansas City., Ranawaya R; Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada., Derwent L; Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada., Sethi KD; Department of Neurology, Georgia Health Science University, Augusta., Farrow B; Department of Neurology, Georgia Health Science University, Augusta., Prakash R; Department of Neurology, Georgia Health Science University, Augusta., Litvan I; Department of Neurosciences, University of California, San Diego, La Jolla., Robinson A; Department of Neurology, University of Louisville, Kentucky., Sahay A; University of Cincinnati College of Medicine, Cincinnati, Ohio., Gartner M; University of Cincinnati College of Medicine, Cincinnati, Ohio., Hinson VK; Department of Neurology, Medical University of South Carolina, Charleston., Markind S; Associated Neurologists, PC, Danbury, Connecticut., Pelikan M; Associated Neurologists, PC, Danbury, Connecticut., Perlmutter JS; Department of Neurology, Washington University in St Louis, Missouri., Hartlein J; Department of Neurology, Washington University in St Louis, Missouri., Molho E; Movement Disorders Center, Albany Medical Center, Albany, New York., Evans S; Movement Disorders Center, Albany Medical Center, Albany, New York., Adler CH; Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona., Duffy A; Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona., Lind M; Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic, Scottsdale, Arizona., Elmer L; Center for Neurological Health, University of Toledo, Toledo, Ohio., Davis K; Department of Neurology, Medical University of Ohio at Toledo., Spears J; Department of Neurology, Medical University of Ohio at Toledo., Wilson S; Department of Neurology, Medical University of Ohio at Toledo., Leehey MA; Department of Neurology, University of Colorado Health Science Center, Denver., Hermanowicz N; Department of Neurology, University of California, Irvine Medical Center, Irvine., Niswonger S; Department of Neurology, University of California, Irvine Medical Center, Irvine., Shill HA; Banner Sun Health Research Institute, Sun City, Arizona., Obradov S; Banner Sun Health Research Institute, Sun City, Arizona., Rajput A; Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada., Cowper M; Department of Neurology, University of Saskatchewan, Royal University Hospital, Saskatchewan, Canada., Lessig S; Department of Neurology, University of California, San Diego, La Jolla., Song D; Department of Neurology, University of California, San Diego, La Jolla., Fontaine D; Department of Neurology, University of California, San Diego, La Jolla., Zadikoff C; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Williams K; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Blindauer KA; Department of Neurology, Medical College of Wisconsin, Milwaukee., Bergholte J; Department of Neurology, Medical College of Wisconsin, Milwaukee., Propsom CS; Department of Neurology, Medical College of Wisconsin, Milwaukee., Stacy MA; Department of Neurology, Duke University, Durham, North Carolina., Field J; Department of Neurology, Duke University, Durham, North Carolina., Mihaila D; State University of New York Upstate Medical Center and Syracuse VA Medical Center, Syracuse., Chilton M; State University of New York Upstate Medical Center and Syracuse VA Medical Center, Syracuse., Uc EY; Department of Neurology, University of Iowa, Iowa City., Sieren J; Department of Neurology, University of Iowa, Iowa City., Simon DK; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts., Kraics L; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts., Silver A; Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts., Boyd JT; Department of Neurology, University of Vermont College of Medicine, Burlington., Hamill RW; Department of Neurology, University of Vermont College of Medicine, Burlington., Ingvoldstad C; Department of Neurology, University of Vermont College of Medicine, Burlington., Young J; Department of Neurology, University of Vermont College of Medicine, Burlington., Thomas K; Department of Neurology, Ohio State University, Columbus., Kostyk SK; Department of Neurology, Ohio State University, Columbus., Wojcieszek J; Department of Neurology, Indiana University School of Medicine, Indianapolis., Pfeiffer RF; Department of Neurology, University of Tennessee Health Science Center, Memphis., Panisset M; Department of Neurology, CHUM-Hôpital Notre-Dame, Montréal, Québec, Canada., Beland M; Department of Neurology, CHUM-Hôpital Notre-Dame, Montréal, Québec, Canada., Reich SG; Department of Neurology, University of Maryland School of Science, Baltimore., Cines M; Department of Neurology, University of Maryland School of Science, Baltimore., Zappala N; Department of Neurology, University of Maryland School of Science, Baltimore., Rivest J; Department of Neurology, University of Sherbrooke, Québec, Canada., Zweig R; Department of Neurology, Louisiana State University Health Science Center, Shreveport., Lumina LP; Department of Neurology, Louisiana State University Health Science Center, Shreveport., Hilliard CL; Lewis Hall Singletary Oncology Center, Thomasville, Georgia., Grill S; Department of Neurology, Johns Hopkins University, Baltimore, Maryland., Kellermann M; Parkinson and Movement Disorders Center of Maryland, Elkridge., Tuite P; Department of Neurology, University of Minnesota, Minneapolis., Rolandelli S; Department of Neurology, University of Minnesota, Minneapolis., Kang UJ; Department of Neurology, University of Chicago, Chicago, Illinois., Young J; Department of Neurology, University of Chicago, Chicago, Illinois., Rao J; Department of Neurology, Ochsner Clinic Foundation, New Orleans, Louisiana., Cook MM; Department of Neurology, Ochsner Clinic Foundation, New Orleans, Louisiana., Severt L; Department of Neurology, Beth Israel Medical Center, New York, New York., Boyar K; Department of Neurology, Beth Israel Medical Center, New York, New York.
مؤلفون مشاركون: Parkinson Study Group QE3 Investigators
المصدر: JAMA neurology [JAMA Neurol] 2014 May; Vol. 71 (5), pp. 543-52.
نوع المنشور: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
مواضيع طبية MeSH: Antioxidants/*administration & dosage , Parkinson Disease/*diagnosis , Parkinson Disease/*drug therapy , Ubiquinone/*analogs & derivatives, Aged ; Antioxidants/metabolism ; Dose-Response Relationship, Drug ; Double-Blind Method ; Early Diagnosis ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/enzymology ; Prospective Studies ; Treatment Outcome ; Ubiquinone/administration & dosage ; Ubiquinone/blood