المؤلفون: K. Pospisilova, Pavlína Řezáčová, Jan Nekvinda, Zdeňka Růžičková, Bohumír Grüner, Suzan El Anwar, Jiří Brynda, Josef Holub, M. Kugler

المصدر: Chemistry – A European Journal. 26:16541-16553

مصطلحات موضوعية: Carbonic Anhydrase I, Stereochemistry, Crystal structure, 010402 general chemistry, Inhibitory postsynaptic potential, 01 natural sciences, Isozyme, Catalysis, Structure-Activity Relationship, Antigens, Neoplasm, Neoplasms, Carbonic anhydrase, Humans, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, chemistry.chemical_classification, biology, 010405 organic chemistry, Organic Chemistry, General Chemistry, In vitro, 0104 chemical sciences, Sulfonamide, Isoenzymes, Enzyme, chemistry, biology.protein, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908302526305d1f537475e2775022970
https://doi.org/10.1002/chem.202002809

المؤلفون: Soňa Gurská, Bohumír Grüner, Jana Štěpánková, Marian Hajduch, K. Pospisilova, Alice Nova, Pavlína Řezáčová, Václav Šícha, Milan Fábry, Vlastimil Mašek, Petr Džubák, Stanislava Matějková, Jan Nekvinda, Petr Pachl, Josef Holub, Viswanath Das, Jiří Brynda, Barbora Lišková, Martina Medvedíková, Vlastimil Král, M. Kugler

المصدر: Journal of Medicinal Chemistry. 62:9560-9575

مصطلحات موضوعية: Models, Molecular, Gene isoform, Mice, Catalytic Domain, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Doxorubicin, Boranes, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, chemistry.chemical_classification, biology, Chemistry, Active site, Biological Transport, Drug Synergism, Amides, Xenograft Model Antitumor Assays, Transmembrane protein, Cytosol, Enzyme, Cell culture, Drug Design, biology.protein, Cancer research, Molecular Medicine, Syngenic, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ed48e61de08139656b184ea62fe554
https://doi.org/10.1021/acs.jmedchem.9b00945

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المؤلفون: Marian Hajduch, Bohumír Grüner, Jan Nekvinda, K. Pospisilova, Pavlína Řezáčová, Václav Šícha, Milan Fábry, Josef Holub, Viswanath Das, Jiří Brynda, Vlastimil Král, M. Kugler, Suzan El Anwar, Václav Kašička

المصدر: Chembiochem : a European journal of chemical biology. 22(18)

مصطلحات موضوعية: Boron Compounds, Combination therapy, chemistry.chemical_element, Molecular Dynamics Simulation, 010402 general chemistry, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Carbonic anhydrase, Neoplasms, Organometallic Compounds, Humans, Boron, Structural motif, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Binding Sites, biology, 010405 organic chemistry, Organic Chemistry, Active site, Combinatorial chemistry, 0104 chemical sciences, Enzyme, chemistry, Drug development, biology.protein, Molecular Medicine, Carborane

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f775f6a731302a55ab224f3696706f
https://pubmed.ncbi.nlm.nih.gov/33939874

المؤلفون: Jiří Brynda, Pavlína Řezáčová, Suzan El Anwar, K. Pospisilova, Josef Holub, Milan Fábry, Dmytro Bavol, Miroslav Havránek, Vlastimil Král, M. Kugler, Bohumír Grüner

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1800-1810 (2020)

مصطلحات موضوعية: Boron Compounds, Carbonic anhydrase IX, enzyme inhibitors, Antineoplastic Agents, RM1-950, Crystallography, X-Ray, 01 natural sciences, carborane, Antigens, Neoplasm, Catalytic Domain, Drug Discovery, medicine, Structure–activity relationship, Humans, Amino Acid Sequence, Carbonic Anhydrase Inhibitors, Pharmacology, Solid tumour, Sulfonamides, 010405 organic chemistry, Chemistry, structure-activity relationship, Cancer, A protein, General Medicine, Carbonic Anhydrase IX, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Biochemistry, Carborane, Therapeutics. Pharmacology, Drug Screening Assays, Antitumor, Selectivity, Hydrophobic and Hydrophilic Interactions, Protein Binding, Research Article, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449c33e7427effc015e0730de6c6a47c
https://pubmed.ncbi.nlm.nih.gov/32962427

المؤلفون: Suzan El Anwar, K. Pospisilova, Josef Holub, Pavlína Řezáčová, Dmytro Bavol, Milan Fábry, Zdeňka Růžičková, Vlastimil Král, M. Kugler, Jiří Brynda, Bohumír Grüner, Jan Nekvinda

المصدر: ChemPlusChem. 86(3)

مصطلحات موضوعية: Sulfonamides, Binding Sites, 010405 organic chemistry, Stereochemistry, Tumor specific, Molecular Conformation, chemistry.chemical_element, General Chemistry, Cobalt, Carbonic Anhydrase IX, 010402 general chemistry, Highly selective, Crystallography, X-Ray, 01 natural sciences, 0104 chemical sciences, Molecular Docking Simulation, chemistry, Coordination Complexes, Catalytic Domain, Neoplasms, Humans, Carbonic Anhydrase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02faad6894441ed42b69b4d6b6e044e5
https://pubmed.ncbi.nlm.nih.gov/32955786

المؤلفون: Viswanath Das, Jan Nekvinda, Jiří Brynda, K. Pospisilova, Marian Hajduch, Stanislava Matějková, Jana Dvořanová, Martina Medvedíková, Josef Holub, Soňa Gurská, Bohumír Grüner, Miroslav Havránek, Vlastimil Král, M. Kugler, Barbora Liskova, Pavlína Řezáčová, Suzan El Anwar, Václav Šícha, Milan Fábry, Petr Džubák

المصدر: European journal of medicinal chemistry. 200

مصطلحات موضوعية: Cell, Antineoplastic Agents, Breast Neoplasms, Mice, SCID, 01 natural sciences, 03 medical and health sciences, Mice, Structure-Activity Relationship, Dogs, Antigens, Neoplasm, Drug Discovery, medicine, Animals, Humans, Doxorubicin, Cytotoxicity, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, Cells, Cultured, 030304 developmental biology, ADME, Cell Proliferation, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Mice, Inbred BALB C, Sulfonamides, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Active site, General Medicine, Neoplasms, Experimental, Recombinant Proteins, 0104 chemical sciences, Enzyme, medicine.anatomical_structure, chemistry, Biochemistry, Cell culture, biology.protein, Carborane, Drug Screening Assays, Antitumor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bb479421d4d79625909803ff9b18a6
https://pubmed.ncbi.nlm.nih.gov/32505851

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المؤلفون: Vlastimil Král, M. Kugler, Suzan El Anwar, Pavlína Řezáčová, Jiří Brynda, Milan Fábry, Zdeňka Růžičková, Josef Holub, Bohumír Grüner, Dmytro Bavol, Jan Nekvinda, K. Pospisilova

المصدر: ChemPlusChem. 86:347-347

مصطلحات موضوعية: Front cover, chemistry, Tumor specific, chemistry.chemical_element, General Chemistry, Carbonic Anhydrase IX, Highly selective, Cobalt, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8bcdcea03a8e558107afd7a0b9330651
https://doi.org/10.1002/cplu.202000723

المؤلفون: Young, E. Noerenberg, D. Mansouri, L. Ljungström, V. Frick, M. Sutton, L.-A. Blakemore, S.J. Galan-Sousa, J. Plevova, K. Baliakas, P. Rossi, D. Clifford, R. Roos-Weil, D. Navrkalova, V. Dörken, B. Schmitt, C.A. Smedby, K.E. Juliusson, G. Giacopelli, B. Blachly, J.S. Belessi, C. Panagiotidis, P. Chiorazzi, N. Davi, F. Langerak, A.W. Oscier, D. Schuh, A. Gaidano, G. Ghia, P. Xu, W. Fan, L. Bernard, O.A. Nguyen-Khac, F. Rassenti, L. Li, J. Kipps, T.J. Stamatopoulos, K. Pospisilova, S. Zenz, T. Oakes, C.C. Strefford, J.C. Rosenquist, R. Damm, F.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2127::8a1f09dcc6f090a2d6237af030848cb8
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3085766