المؤلفون: Habibi A; Department of Basic Sciences, Faculty of Sciences, Imam Hossein University, Tehran, Iran. Alirh110@gmail.com., Davari A; Department of Molecular-Cell Biology, Faculty of Sciences, Lahijan Branch, Islamic Azad University, Lahijan, Iran., Isazadeh K; Department of Microbiology, Faculty of Basic Sciences, Lahijan Branch, Islamic Azad University, Lahijan, Iran. issa_kaam@yahoo.com.

المصدر: Scientific reports [Sci Rep] 2024 Sep 27; Vol. 14 (1), pp. 22245. Date of Electronic Publication: 2024 Sep 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation*/drug effects , Antimicrobial Cationic Peptides*/pharmacology , Antimicrobial Cationic Peptides*/chemistry , Cathelicidins* , Apoptosis*/drug effects, Humans ; K562 Cells ; Tumor Suppressor Protein p53/metabolism ; Tumor Suppressor Protein p53/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Magnetite Nanoparticles/chemistry ; Magnetic Iron Oxide Nanoparticles/chemistry ; bcl-2-Associated X Protein/metabolism ; bcl-2-Associated X Protein/genetics ; Cell Survival/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry

المؤلفون: Beraldo-Neto E; Biochemistry Laboratory, Butantan Institute, São Paulo 05503-900, Brazil.; Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo, São Paulo 04023-062, Brazil., Amador FC; Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo, São Paulo 04023-062, Brazil., Fernandes KR; Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo, São Paulo 04023-062, Brazil., Justo GZ; Department of Biochemistry, Paulista School of Medicine, Federal University of São Paulo, São Paulo 04023-062, Brazil., Lacerda JT; Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo, São Paulo 04023-062, Brazil., Juliano MA; Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo, São Paulo 04023-062, Brazil.

المصدر: Cells [Cells] 2024 Aug 26; Vol. 13 (17). Date of Electronic Publication: 2024 Aug 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: Proteomics*/methods , Drug Resistance, Multiple*/drug effects , Drug Resistance, Neoplasm*/drug effects, Humans ; K562 Cells ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily B/genetics ; Tubulin/metabolism ; Cell Line, Tumor

المؤلفون: Lu Y; College of Life Science and Bioengineering, Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing, 100124, China.; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Ma WB; Institute of Health Service and Transfusion Medicine, Beijing, 100850, China., Ren GM; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Li YT; College of Life Science and Bioengineering, Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing, 100124, China.; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Wang T; College of Life Science and Bioengineering, Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing, 100124, China.; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Zhan YQ; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Xiang SS; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Chen H; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Gao HY; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Zhao K; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Yu M; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Li CY; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China., Yang XM; College of Life Science and Bioengineering, Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing, 100124, China. xiaomingyang@sina.com.; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China. xiaomingyang@sina.com., Yin RH; State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine, Beijing, 100850, China. yrh1980110@126.com.

المصدر: International journal of hematology [Int J Hematol] 2024 Aug; Vol. 120 (2), pp. 157-166. Date of Electronic Publication: 2024 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Japan Country of Publication: Japan NLM ID: 9111627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-3774 (Electronic) Linking ISSN: 09255710 NLM ISO Abbreviation: Int J Hematol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation* , Erythropoiesis*/genetics , Hemin*/pharmacology , Leukemia, Erythroblastic, Acute*/pathology , Leukemia, Erythroblastic, Acute*/metabolism , Leukemia, Erythroblastic, Acute*/genetics , Nuclear Receptor Co-Repressor 1*/metabolism , Nuclear Receptor Co-Repressor 1*/genetics, Humans ; 5-Aminolevulinate Synthetase/genetics ; 5-Aminolevulinate Synthetase/metabolism ; Erythroid Cells/metabolism ; Erythroid Cells/cytology ; Gene Knockdown Techniques ; Hemoglobins/metabolism ; Intracellular Signaling Peptides and Proteins ; K562 Cells

المؤلفون: Bisogni AJ; Department of Biomedical Sciences, Cornell University, Ithaca, NY 14850, USA; Inso Biosciences, 237 Tower Road, Ithaca, NY 14850, USA., Armstead BL; Department of Biomedical Sciences, Cornell University, Ithaca, NY 14850, USA., Lin DM; Department of Biomedical Sciences, Cornell University, Ithaca, NY 14850, USA. Electronic address: dml45@cornell.edu.

المصدر: STAR protocols [STAR Protoc] 2024 Sep 20; Vol. 5 (3), pp. 103192. Date of Electronic Publication: 2024 Jul 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE

مواضيع طبية MeSH: Cell Adhesion*/physiology, Humans ; K562 Cells ; Cell Adhesion Molecules/metabolism ; Electroporation/methods ; Flow Cytometry/methods

المؤلفون: Chardon FM; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., McDiarmid TA; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Page NF; Department of Psychiatry and Behavioral Sciences, Kavli Institute for Fundamental Neuroscience, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Daza RM; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Martin BK; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Domcke S; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Regalado SG; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Lalanne JB; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Calderon D; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Li X; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Starita LM; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Sanders SJ; Department of Psychiatry and Behavioral Sciences, Kavli Institute for Fundamental Neuroscience, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Institute of Developmental and Regenerative Medicine, Department of Paediatrics, University of Oxford, Oxford, OX3 7TY, UK., Ahituv N; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA. Nadav.Ahituv@ucsf.edu.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. Nadav.Ahituv@ucsf.edu., Shendure J; Department of Genome Sciences, University of Washington, Seattle, WA, USA. shendure@uw.edu.; Seattle Hub for Synthetic Biology, Seattle, WA, USA. shendure@uw.edu.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA. shendure@uw.edu.; Howard Hughes Medical Institute, Seattle, WA, USA. shendure@uw.edu.; Allen Discovery Center for Cell Lineage Tracing, Seattle, WA, USA. shendure@uw.edu.

المصدر: Nature communications [Nat Commun] 2024 Sep 18; Vol. 15 (1), pp. 8209. Date of Electronic Publication: 2024 Sep 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Single-Cell Analysis*/methods , CRISPR-Cas Systems* , Enhancer Elements, Genetic*/genetics, Humans ; K562 Cells ; Promoter Regions, Genetic/genetics ; RNA, Guide, CRISPR-Cas Systems/genetics ; Autism Spectrum Disorder/genetics ; Neurons/metabolism ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/cytology ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics

المؤلفون: Liu C; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306,China; National Demonstration Center for Experimental Fisheries Science Education,Shanghai Ocean University, Shanghai, 201306,China. Electronic address: lcfzby@163.com., Wang Y; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306,China; National Demonstration Center for Experimental Fisheries Science Education,Shanghai Ocean University, Shanghai, 201306,China. Electronic address: wanyuch123@163.com., Shi M; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306,China; National Demonstration Center for Experimental Fisheries Science Education,Shanghai Ocean University, Shanghai, 201306,China. Electronic address: mjshi2021@163.com., Tao X; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306,China; National Demonstration Center for Experimental Fisheries Science Education,Shanghai Ocean University, Shanghai, 201306,China. Electronic address: xiaoxiaotao6222@163.com., Man D; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306,China; National Demonstration Center for Experimental Fisheries Science Education,Shanghai Ocean University, Shanghai, 201306,China. Electronic address: daman0421@163.com., Zhang J; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306,China; National Demonstration Center for Experimental Fisheries Science Education,Shanghai Ocean University, Shanghai, 201306,China; Marine Biomedical Science and Technology Innovation Platform of Lin-gang Special Area, Shanghai, 201306, China. Electronic address: jfzhang@shou.edu.cn., Han B; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306,China; National Demonstration Center for Experimental Fisheries Science Education,Shanghai Ocean University, Shanghai, 201306,China; Marine Biomedical Science and Technology Innovation Platform of Lin-gang Special Area, Shanghai, 201306, China. Electronic address: bs-han@shou.edu.cn.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Sep 10; Vol. 724, pp. 150221. Date of Electronic Publication: 2024 Jun 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation* , Leukemia*/genetics , Leukemia*/metabolism , Leukemia*/pathology , Proto-Oncogene Proteins c-myb*/metabolism , Proto-Oncogene Proteins c-myb*/genetics , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism, Humans ; Cell Line, Tumor ; Cell Movement/genetics ; Enhancer Elements, Genetic ; Gene Expression Regulation, Leukemic ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; K562 Cells ; Protein Binding

المؤلفون: Moritsuka N; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan., Kiya N; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan., Moriyama T; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan., Koshino H; RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan., Yoritate M; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan., Matoba H; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan., Hirai G; Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

المصدر: The Journal of organic chemistry [J Org Chem] 2024 Sep 06; Vol. 89 (17), pp. 11909-11920. Date of Electronic Publication: 2024 Aug 09.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cell Proliferation*/drug effects, Humans ; K562 Cells ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Glucosamine/chemistry ; Disaccharides/chemistry ; Disaccharides/chemical synthesis ; Disaccharides/pharmacology ; Stereoisomerism ; Molecular Structure ; Galactose/chemistry ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship

المؤلفون: Baidya SK; Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Natural Science Laboratory, Jadavpur University, Kolkata, India.; School of Pharmacy, Sister Nivedita University, Kolkata, India., Patel T; Department of Pharmacy, Epigenetic Research Laboratory, Birla Institute of Technology and Science-Pilani, Hyderabad, India., Himaja A; Department of Pharmacy, Epigenetic Research Laboratory, Birla Institute of Technology and Science-Pilani, Hyderabad, India., Banerjee S; Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Natural Science Laboratory, Jadavpur University, Kolkata, India., Das S; Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Natural Science Laboratory, Jadavpur University, Kolkata, India.; School of Pharmacy, Sister Nivedita University, Kolkata, India., Ghosh B; Department of Pharmacy, Epigenetic Research Laboratory, Birla Institute of Technology and Science-Pilani, Hyderabad, India., Jha T; Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Natural Science Laboratory, Jadavpur University, Kolkata, India., Adhikari N; Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Natural Science Laboratory, Jadavpur University, Kolkata, India.

المصدر: Drug development research [Drug Dev Res] 2024 Sep; Vol. 85 (6), pp. e22255.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Docking Simulation* , Sulfonamides*/pharmacology , Sulfonamides*/chemistry , Sulfonamides*/chemical synthesis , Matrix Metalloproteinase 2*/metabolism , Matrix Metalloproteinase Inhibitors*/pharmacology , Matrix Metalloproteinase Inhibitors*/chemistry , Matrix Metalloproteinase Inhibitors*/chemical synthesis , Molecular Dynamics Simulation* , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis, Humans ; K562 Cells ; Biphenyl Compounds/chemistry ; Biphenyl Compounds/pharmacology ; Apoptosis/drug effects ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Cell Proliferation/drug effects ; Structure-Activity Relationship

المؤلفون: Abou-Elnour FS; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt., El-Habashy SE; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. Electronic address: salma.elhaleem@alexu.edu.eg., Essawy MM; Department of Oral Pathology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt; Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine, Alexandria University, Alexandria, Egypt., Abdallah OY; Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

المصدر: Biomaterials advances [Biomater Adv] 2024 Sep; Vol. 162, pp. 213924. Date of Electronic Publication: 2024 Jun 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE

مواضيع طبية MeSH: Drug Carriers*/chemistry , Lactoferrin*/chemistry , Lactoferrin*/pharmacology , Lactoferrin*/administration & dosage , Alendronate*/chemistry , Alendronate*/pharmacology , Alendronate*/administration & dosage , Ivermectin*/chemistry , Ivermectin*/analogs & derivatives , Ivermectin*/pharmacology , Ivermectin*/administration & dosage , Ivermectin*/pharmacokinetics, Humans ; Animals ; K562 Cells ; Nanoparticles/chemistry ; Mice ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/administration & dosage ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Lipids/chemistry ; Apoptosis/drug effects

المؤلفون: Che H; Department of Hematology, Affiliated to Qingdao University Yuhuangding Hospital of Yantai, Shandong, China., Ding H; Department of Hematology, Affiliated to Qingdao University Yuhuangding Hospital of Yantai, Shandong, China., Jia X; Department of Operation Room, Affiliated to Qingdao University Yuhuangding Hospital of Yantai, Shandong, China.

المصدر: Cancer biotherapy & radiopharmaceuticals [Cancer Biother Radiopharm] 2024 Sep; Vol. 39 (7), pp. 478-491. Date of Electronic Publication: 2020 Jun 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 9605408 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8852 (Electronic) Linking ISSN: 10849785 NLM ISO Abbreviation: Cancer Biother Radiopharm Subsets: MEDLINE

مواضيع طبية MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy , Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics , Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/pathology , Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/metabolism , Imatinib Mesylate*/pharmacology , Imatinib Mesylate*/therapeutic use , Drug Resistance, Neoplasm*/genetics , RNA, Circular*/genetics , RNA, Circular*/metabolism, Humans ; Mice ; Animals ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Male ; Female ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Xenograft Model Antitumor Assays ; Mice, Nude ; K562 Cells ; Cell Line, Tumor