نتائج البحث - "KD, Knockdown"

1

Sestrin Proteins Protect Against Lipotoxicity-Induced Oxidative Stress in the Liver via Suppression of C-Jun N-Terminal KinasesSummary

المؤلفون: Menghao Huang, Kushan Chowdhury, Zhigang Fang, X. Charlie Dong, Ming O. Li, Suthat Liangpunsakul, Hyeong-Geug Kim

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 921-942 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Sestrins, MPO, myeloperoxidase, Mitogen-Activated Protein Kinase Kinase 7, RC799-869, DMSO, dimethyl sulfoxide, FoxO, forkhead box O, Sesn1/2/3, sestrin1/2/3, medicine.disease_cause, TKO, triple knockout, Mice, PCR, polymerase chain reaction, 0302 clinical medicine, GSH, glutathione, Phosphorylation, NF-κB, nuclear factor kappa B, Original Research, Cat, catalase, Mice, Knockout, Sestrin, Gpx3, glutathione peroxidase 3, Il6, interleukin 6, WD, Western diet, biology, Chemistry, Kinase, Fatty liver, Tgfbr1, transforming growth factor beta receptor 1, Gastroenterology, Col1a1, collagen type 1 alpha 1, Nox1, NADPH oxidase 1, Diseases of the digestive system. Gastroenterology, Dgat2, diacylglycerol O-acyltransferase 2, Cell biology, Keap1, Kelch-like ECH-associated protein 1, C-Jun N-Terminal Kinase, Liver, Lipotoxicity, c-Jun N-terminal kinases, JNK, c-Jun N-terminal kinase, 030211 gastroenterology & hepatology, Disease Susceptibility, Signal transduction, NASH, nonalcoholic steatohepatitis, Gss, glutathione synthetase, Pdgfrb, platelet-derived growth factor receptor beta, Timp1, tissue inhibitor of metalloproteinase 1, Fasn, fatty acid synthase, Fatty Liver Disease, Sod, superoxide dismutase, Acta2, smooth muscle actin alpha 2, ER, endoplasmic reticulum, PA, palmitic acid, 03 medical and health sciences, 4-HNE, 4-hydroxynonenal, MKK, mitogen-activated protein kinase kinase, medicine, Animals, Humans, Srebp, sterol regulatory element-binding protein, Protein kinase A, KD, knockdown, MDA, malondialdehyde, Inflammation, KO, knockout, Hepatology, NRF2, nuclear factor erythroid 2-related like 2, JNK Mitogen-Activated Protein Kinases, Lipid Metabolism, medicine.disease, Tgfb1, transforming growth factor beta 1, WT, wild-type, mTORC, mechanistic target of rapamycin complex, Fatty Liver, AMPK, AMP-activated protein kinase, Disease Models, Animal, Oxidative Stress, Scd1, stearoyl-CoA desaturase 1, 030104 developmental biology, Gene Expression Regulation, Cytoprotection, Hepatocytes, biology.protein, BSA, bovine serum albumin, SD, standard deviation, DHE, dihydroethidium, PERK, protein kinase R-like endoplasmic reticulum kinase, Tnf, tumor necrosis factor, Biomarkers, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1574bc0f082fa7f7fd23bf88f6f9c6fc
http://www.sciencedirect.com/science/article/pii/S2352345X21000862

2

DAB2IP modulates primary cilia formation associated with renal tumorigenesis

المؤلفون: Chun-Jung Lin, Jer Tsong Hsieh, Andrew Dang, Elizabeth Hernandez

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 169-180 (2021)
Neoplasia (New York, N.Y.)

مصطلحات موضوعية: 0301 basic medicine, WT, wild type, Cancer Research, Kinesins, Con, vector control, medicine.disease_cause, Mice, 0302 clinical medicine, Primary cilia, DAB2IP, DAB2 Interacting Protein, C2, protein kinase C conserved region 2 domain, PH, Pleckstrin homology domain, DAPI, 4’, 6-diamidino-2-phenylindole, Tumor suppressor gene, ac-tubulin, acetylated tubulin, STR, short tandem repeat, Kidney, qRT-PCR, Quantitative real-time PCR, Cilium, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Kidney Neoplasms, Renal cell carcinoma, Cell biology, medicine.anatomical_structure, Cell Transformation, Neoplastic, UTSW, University of Texas Southwestern Medical Center, ras GTPase-Activating Proteins, 030220 oncology & carcinogenesis, Kinesin, RCC, renal cell carcinoma, Disease Susceptibility, Protein Binding, Original article, AIG, anchorage independent growth assay, Biology, lcsh:RC254-282, DAB2IP, Cell Line, 03 medical and health sciences, FBS, fetal bovine serum, Microtubule, Ciliogenesis, medicine, Animals, Humans, KIF3A, Cilia, KD, knockdown, KO, knockout, ATCC, American Type Culture Collection, VHL, von Hippel-Lindau, 030104 developmental biology, TCGA, The Cancer Genome Atlas, HIF, hypoxia-inducible factors, KIF3a, kinesin family member 3A, Carcinogenesis, KIF3a, IFT, intraflagellar transport, Protein Processing, Post-Translational, OE, overexpression

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361470a71f476fd73c328cb0a2367cb3
http://www.sciencedirect.com/science/article/pii/S1476558620301834

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3

Activation of AhR-NQO1 Signaling Pathway Protects Against Alcohol-Induced Liver Injury by Improving Redox BalanceSummary

المؤلفون: Liuyi Hao, Haibo Dong, Xinguo Sun, Zhanxiang Zhou, Ruichao Yue, Wei Guo, Wenliang Zhang, Wei Zhong

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 793-811 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, NADH, reduced nicotinamide adenine dinucleotide, Gene Expression, MPO, myeloperoxidase, Dehydrogenase, Apoptosis, AST, aspartate aminotransferase, RC799-869, Pharmacology, Nicotinamide adenine dinucleotide, AH, alcoholic hepatitis, PF, pair-fed, Liver disease, chemistry.chemical_compound, Mice, 0302 clinical medicine, PCR, polymerase chain reaction, Acetamides, Basic Helix-Loop-Helix Transcription Factors, NAD(P)H Dehydrogenase (Quinone), FFA, free fatty acids, ALD, alcohol-related liver disease, NRF2, nuclear factor erythroid 2–related factor 2, Cells, Cultured, Original Research, Liver injury, biology, Chemistry, ACD, acetaldehyde, Gastroenterology, TG, triglycerides, respiratory system, Diseases of the digestive system. Gastroenterology, Organ Specificity, Chemical and Drug Induced Liver Injury, Chronic, Gene Knockdown Techniques, AhR, aryl hydrocarbon receptor, NAD+-to-NADH Ratio, NQO1, 030211 gastroenterology & hepatology, I3C, indole-3-carbinol, Disease Susceptibility, Signal transduction, Chemical and Drug Induced Liver Injury, Oxidation-Reduction, IHC, immunohistochemistry, PBS, phosphate-buffered saline, NAD+, oxidized nicotinamide adenine dinucleotide, ADH, alcohol dehydrogenase, Immunophenotyping, 03 medical and health sciences, cDNA, complementary DNA, ROS, reactive oxygen species, 4-HNE, 4-hydroxynonenal, ALT, alanine aminotransferase, medicine, Animals, Humans, IF, immunofluorescence, AF, alcohol-fed, KD, knockdown, Hepatology, Ethanol, AhR, medicine.disease, Aryl hydrocarbon receptor, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, ALDH, aldehyde dehydrogenase, Receptors, Aryl Hydrocarbon, biology.protein, Hepatocytes, Alcohol-Related Liver Disease, NAD+ kinase, NQO1, NAD(P)H quinone dehydrogenase 1, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15d326a88be99d219c0ba4eb3ebc90e
http://www.sciencedirect.com/science/article/pii/S2352345X21001028

4

Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome ActivationSummary

المؤلفون: Naoki Minami, Hisanori Horiuchi, Kohei Wagatsuma, Daisuke Hirayama, Ryutaro Shirakawa, Tomoya Iida, Seiichi Hirota, Hiroki Ikeuchi, Minoru Matsuura, Hiroshi Nakase, Kentaro Kawakami, Masanori Nojima, Kanna Nagaishi

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 2, Pp 277-293 (2020)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Th, T-helper cell, STAT3, signal transducer and activator of transcription 3, Inflammasomes, medicine.medical_treatment, medicine.disease_cause, chemistry.chemical_compound, 0302 clinical medicine, AOM, azoxymethane, GTPase, guanosine triphosphatase, TNF-α, tumor necrosis factor α, WT-T, tumors of wild-type mice, Original Research, IBD, inflammatory bowel disease, Dextran Sulfate, Gastroenterology, Colitis, mRNA, messenger RNA, SM, submucosal, MMP, matrix metalloproteinase, Real-time polymerase chain reaction, WB, Western blot, qPCR, quantitative polymerase chain reaction, RalGAP, Ral guanosine triphosphatase–activating protein, 030211 gastroenterology & hepatology, ASC, apoptosis associated speck-like protein containing a CARD, animal structures, WT-N, normal colon tissues of wild-type mice, CAC, colitis-associated cancer, Intraperitoneal injection, Guanosine, NF-κB, nuclear factor-κB, Down-Regulation, 03 medical and health sciences, Downregulation and upregulation, DSS, dextran sulfate sodium, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Humans, lcsh:RC799-869, KD, knockdown, KO-N, normal colon tissues of RalGAPα2 knockout mice, KO, knockout, Hepatology, Azoxymethane, KO-T, tumors of RalGAPα2 knockout mice, Molecular biology, WT, wild-type, IL, interleukin, Ral, 030104 developmental biology, chemistry, Apoptosis, siRNA, small interfering RNA, Colitis-Associated Cancer, Triphosphatase, lcsh:Diseases of the digestive system. Gastroenterology, NLRP3 Inflammasome, Carcinogenesis, Ral-GTPase Activating Protein (RalGAP)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d16d8f812582cc3f7b9947159562783
http://www.sciencedirect.com/science/article/pii/S2352345X19301390

5

Long interspersed element-1 ribonucleoprotein particles protect telomeric ends in alternative lengthening of telomeres dependent cells

المؤلفون: Marek Ehrlich, Viktoria Laszlo, Olivia Aschacher, Sabine Spiegl-Kreinecker, Günther Laufer, Florian K. Enzmann, Michael Bergmann, Serge Weis, Barbara Messner, Adrian Türkcan, Thomas Aschacher, Klaus Holzmann, Brigitte Wolf

المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 61-75 (2020)

مصطلحات موضوعية: Cancer Research, Telomerase, Original article, TopoIIIα, Topoisomerase III-alpha, Telomeric repeat-containing RNAs, GBM, Glioblastoma, RNP, ribonucleoprotein, DNA damage response, lcsh:RC254-282, DDR, DNA damage response, hTERT, human telomerase reverse transcriptase, TBP, telomere binding proteins, LINE-1, ORF, open reading frame, LINE-1/L1, long interspersed nuclear element-1, TSCE, telomeric sister chromatid exchange, Alternative lengthening of telomeres, Cell Line, Tumor, Humans, Ribonucleoprotein, KD, knockdown, Gene knockdown, Cell growth, Chemistry, Telomere Homeostasis, TERRA, Glioma, Telomere, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Shelterin, TL, telomere length, TA, telomerase activity, Cell biology, Long interspersed nuclear element, DNA-Binding Proteins, ALT, alternative telomere lengthening, Long Interspersed Nucleotide Elements, DNA Topoisomerases, Type I, Ribonucleoproteins, Poly(A), poly-adenylation, TERRA, telomeric repeat containing RNA, ABP, ALT-associated PML bodies, DNA Damage, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17811524cf8890da0946f2a0da5a152
http://europepmc.org/articles/PMC6920197

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6

Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling

المؤلفون: Catarina Perdigão, Tatiana Burrinha, Mariana A. Barata, Claudia G. Almeida

المساهمون: iNOVA4Health - pólo NMS, Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

المصدر: The Journal of Biological Chemistry
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: Small interfering RNA, Bin1, SNX4, sorting nexin-4, LOAD, late-onset Alzheimer's disease, Endocytic recycling, medicine.disease_cause, BAR, BIN1/amphiphysin/RVS167 domain, GWAS, genome-wide association studies, Biochemistry, Mice, 0302 clinical medicine, neurodegenerative disease, BIN1, bridging integrator 1/MYC box-dependent-interacting protein 1, cell biology, Amyloid precursor protein, Aspartic Acid Endopeptidases, genetic polymorphism, pAb, polyclonal antibody, SDS-PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis, GFP, green fluorescent protein, 0303 health sciences, Mutation, Gene knockdown, Mice, Inbred BALB C, biology, EGTA, ethylene glycol tetraacetic acid, SH3, src homology 3 domain, amyloid-beta (Aβ), Nuclear Proteins, HRP, horseradish peroxidase, BACE1, IP, immunoprecipitation, Alzheimer's disease, CLAP, clathrin and AP2-binding domain, BACE1, β-site APP-cleaving enzyme 1 or β-secretase 1, 3. Good health, Cell biology, RVS167, reduced viability upon starvation protein 167, Aβ, amyloid-beta, Protein Transport, AD, Alzheimer's disease, Research Article, PIC, protease inhibitor cocktail, Amyloid beta, Endosome, IgG, immunoglobulin G, PBS, phosphate-buffered saline, AP-2, adaptor protein complex 2, CTF, carboxyl-terminal fragment, Endosomes, RIPA, radio-immunoprecipitation assay, Polymorphism, Single Nucleotide, endocytic recycling, EEA1, 03 medical and health sciences, cDNA, complementary DNA, FBS, fetal bovine serum, Alzheimer Disease, genetic disease, trafficking, APP, amyloid precursor protein, medicine, Animals, Humans, APOE4, apolipoprotein E ε4, mAb, monoclonal antibody, Molecular Biology, 030304 developmental biology, Adaptor Proteins, Signal Transducing, FAD, familial Alzheimer's disease, KD, knockdown, Amyloid beta-Peptides, N2a, Neuro2a, Tumor Suppressor Proteins, Cell Biology, DMEM, Dulbecco's modified eagle medium, siRNA, small interfering RNA, biology.protein, ARF6, ADP-ribosylation factor 6, BSA, bovine serum albumin, EEA1, early endosome antigen 1, Amyloid Precursor Protein Secretases, 030217 neurology & neurosurgery, OE, overexpression