المؤلفون: Lucía Prieto Santamaría, Alejandro Rodríguez-González, Marina Díaz Uzquiano, Esther Ugarte Carro, Yuliana Pérez Gallardo, Ernestina Menasalvas Ruiz

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4559-4573 (2021)

مصطلحات موضوعية: Computer science, Drug repurposing, ND, New Disease, SRD5A1, Steroid 5 Alpha-Reductase 1, DR, Drug Repurposing or Drug Repositioning, computer.software_genre, Biochemistry, AHR, Aryl Hydrocarbon Receptor, FCGR3B, Fc Fragment Of IgG Receptor IIIb, Structural Biology, DISNET knowledge base, PTGS2, Prostaglandin-endoperoxidase synthase 2, Disease understanding, UMLS, Unified Medical Language System, Repurposing, ESR2, Estrogen Receptor 2, GDA, Gene Disease Association, OD, Original Disease, FCGR3A, Fc Fragment Of IgG Receptor IIIa, TNFα, Tumour Necrosis Factor alpha, Computer Science Applications, Drug-disease validation, Drug repositioning, Drug development, Data integration, SM, Supplementary Material, Research Article, SRD5A2, Steroid 5 Alpha-Reductase 2, Biotechnology, CUI, Concept Unique Identifier, Process (engineering), DRD3, Dopamine Receptor D3, Biophysics, Data-driven, KDR, Kinase insert Domain Receptor, NLM, National Library of Medicine, Biomedical data, ComputerApplications_MISCELLANEOUS, Genetics, ALK, Anaplastic Lymphoma Kinase, ESR1, Estrogen Receptor 1, ComputingMethodologies_COMPUTERGRAPHICS, LTα, Lymphotoxin alpha, COX-2, Cyclooxygenase 2, MeSH-PA, Medical Subject Headings – Pharmacological Action, Significant difference, Data science, ICD-10-CM, International Classification of Diseases, 10th revision, Clinical Modification, ComputingMethodologies_PATTERNRECOGNITION, API, Application Programming Interface, ID, Identifier, ACE, Angiotensin I Converting Enzyme, CMap, Connectivity Map, FCGR2A, Fc Fragment Of IgG Receptor IIa, computer, TP248.13-248.65

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0161caf3f0dc9bcf4a7eacdbdeed248
https://doi.org/10.1016/j.csbj.2021.08.003

المؤلفون: McGaughey, Georgia B., Culberson, J. Chris, Feuston, Bradley P., Kreatsoulas, Constantine, Maiorov, Vladimir, Shpungin, Joseph

المصدر: Molecular Diversity. August 2006 10(3):341-347

المؤلفون: Francesca Simorini, Lisa Dalla Via, Stefano Tomassi, Giorgio Amendola, Sabrina Taliani, Concettina La Motta, Anna Maria Marini, Elisabetta Barresi, Federico Da Settimo, Silvia Salerno, Ettore Novellino, Sandro Cosconati, Aída Nelly García-Argáez

المساهمون: Salerno, Silvia, García-Argáez, Aída Nelly, Barresi, Elisabetta, Taliani, Sabrina, Simorini, Francesca, La Motta, Concettina, Amendola, Giorgio, Tomassi, Stefano, Cosconati, Sandro, Novellino, Ettore, Da Settimo, Federico, Marini, Anna Maria, Via, Lisa Dalla, Salerno, S, García-Argáez, An, Barresi, E, Taliani, S, Simorini, F, La Motta, C, Amendola, G, Tomassi, S, Cosconati, S, Novellino, E, Da Settimo, F, Marini, Am, Via, Ld.

المصدر: European Journal of Medicinal Chemistry. 150:446-456

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Pyrimidine, medicine.drug_class, Angiogenesis, Antineoplastic Agents, Antiproliferative activity, Monoclonal antibody, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, Human Umbilical Vein Endothelial Cells, medicine, Humans, Protein Kinase Inhibitors, Cell Proliferation, Pyrans, Pharmacology, Kinase inhibitor, Aniline Compounds, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Kinase insert domain receptor, General Medicine, Vascular Endothelial Growth Factor Receptor-2, Small molecule, Benzothiopyranopyrimidine, Pyrimidines, 030104 developmental biology, chemistry, Biochemistry, Kinase inhibitors, Cell culture, KDR kinase, 030220 oncology & carcinogenesis, Drug Screening Assays, Antitumor, Benzothiopyranopyrimidines, Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd5debc73b013120b1d974e0de4849e
https://doi.org/10.1016/j.ejmech.2018.03.013

المؤلفون: Harada, Y., Ogata, Y., Shirouzu, K.

المصدر: International Journal of Clinical Oncology. October 2001 6(5):221-228

المؤلفون: Giorgio Amendola, Sabrina Taliani, Sandro Cosconati, Ettore Novellino, Aída Nelly García-Argáez, Elisabetta Barresi, Federico Da Settimo, Stefano Tomassi, Francesca Simorini, Silvia Salerno, Anna Maria Marini, Lisa Dalla Via

المساهمون: Silviasalerno, Elisabettabarresi, AídaNellyGarcía-Argaéz, Sabrinataliani, Francescasimorini, Giorgio, Amendola, Tomassi, S, Sandro, Cosconati, Novellino, Ettore, Federico Da Settimo, Anna Maria Marini, Lisa Dalla Via, Salerno, S., Barresi, E., Garcia-Argaez, A. N., Taliani, S., Simorini, F., Amendola, G., Tomassi, S., Cosconati, S., Novellino, E., Da Settimo, F., Marini, A. M., Dalla Via, L.

مصطلحات موضوعية: antiproliferative activity, Pyridothiopyranopyrimidines, Pyrimidine, Angiogenesis, Kinase, Organic Chemistry, Pyridothiopyranopyrimidine, Biochemistry, Multikinase inhibitor, Human tumor, chemistry.chemical_compound, chemistry, Cell culture, KDR kinase, Drug Discovery, Cancer cell, multitargeted kinase inhibitors, Cancer research, Tumor growth, multitargeted kinase inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bed2ff2bb9b372659ee05a9ca9d38ea
https://europepmc.org/articles/PMC6466516/

المؤلفون: Zhanggui Wang, Xinbing Sui, Liangkun You, Jiansheng Xie, Zhao Jing, Hongsen Li, Jiawei Shou, Hongming Pan, Weidong Han

المصدر: Autophagy

مصطلحات موضوعية: ATF4, activating transcription factor 4, NES, nuclear export signal, ConA, concanavalin A, Cellular homeostasis, Review, Stat3 Signaling Pathway, STAT3, BNIP3, BCL2/adenovirus E1B 19kDa interacting protein 3, EIF2A, eukaryotic initiation factor 2A, 65kDa, Neoplasms, ALK, anaplastic lymphoma receptor tyrosine kinase, miRNA, microRNA, Mitophagy, FOXO1/3, forkhead box O1/3, RTK, receptor tyrosine kinases, receptor tyrosine kinases, PTPN6, protein tyrosine phosphatase, non-receptor type 6, BECN1, targeted therapy, CuB, cucurbitacin B, Mitochondria, Cell biology, STAT3, signal transducer and activator of transcription 3 (acute-phase response factor), COX8, cytochrome c oxidase subunit VIII, PDGFRB, platelet-derived growth factor receptor, β polypeptide, IMM, inner mitochondrial membrane, Subcellular Fractions, CNTF, ciliary neurotrophic factor, STAT3 Transcription Factor, KDR, kinase insert domain receptor, autophagy, MMP14, matrix metallopeptidase 14 (membrane-inserted), Programmed cell death, Cell signaling, MLS, mitochondrial localization sequence, PTPN2, protein tyrosine phosphatase, non-receptor type 2, IL6, interleukin 6, ETC, electron transport chain, HIF1A, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor), VHL, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase, CTSB, cathepsin B, NFKB1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Biology, BAG3, Models, Biological, ER, endoplasmic reticulum, XPO1, exportin 1, ROS, reactive oxygen species, MAPK1, mitogen-activated protein kinase 1, SH2, src homology 2, Animals, Humans, cancer, PRKAA2, protein kinase, AMP-activated, α 2 catalytic subunit, Molecular Biology, EIF2AK2, eukaryotic translation initiation factor 2-α kinase 2, EGF, epidermal growth factor, PTPN11, protein tyrosine phosphatase, non-receptor type 11, Autophagy, HDAC3, histone deacetylase 3, NDUFA13, NADH dehydrogenase (ubiquinone) 1 α subcomplex, 13, Cell Biology, LMP, lysosomal membrane permeabilization, CTSL, cathepsin L, mitophagy, NLS, nuclear localization signal, mitoSTAT3, mitochondrial STAT3, Cancer research, CYCS, cytochrome c, somatic, MAP1LC3A, microtubule-associated protein 1 light chain 3 α

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7370b1766f56b7801df377b10de63140
https://doi.org/10.1080/15548627.2015.1017192

المؤلفون: Rui Cheng, Siribhinya Benyajati, Jian Xing Ma, Xuemin He

المصدر: Clinical Science (London, England : 1979)

مصطلحات موضوعية: IGF, insulin-like growth factor, Angiogenesis, tissue distribution, ATRA, all-trans retinoic acid, RCL, reactive centre loop, Angiogenesis Inhibitors, Review Article, LR, laminin receptor, PDGF, platelet-derived growth factor, Neovascularization, Diabetes mellitus genetics, angiogenesis, bFGF, basic fibroblast growth factor, HUVEC, human umbilical vein endothelial cell, Hypoxia, diabetes, PEDF, pigment epithelium-derived factor, Neovascularization, Pathologic, serpin, serine proteinase inhibitor, serpin, JNK, c-Jun N-terminal kinases, General Medicine, PAI-1, plaminogen activator inhibitor-1, PEDF-R, PEDF receptor, c-FLIP, cellular FLICE-like inhibitory protein, VEGF, vascular endothelial growth factor, Cell biology, PEDF-tg, transgenic overexpression of PEDF, MMP, matrix metalloproteinase, OIR, oxygen-induced retinopathy, DR, diabetic retinopathy, E, embryonic day, RARE, retinoic acid-response element, medicine.symptom, Signal transduction, NF-κB, nuclear factor κB, Signal Transduction, KDR, kinase insert domain receptor, Adult, ER, oestrogen receptor, RXR, retinoid X receptor, IκB, inhibitor of κB kinase, Neovascularization, Physiologic, Inflammation, S9, Serpin, Biology, ERK, extracellular-signal-regulated kinase, Neuroprotection, PEDF, NFATc2, nuclear factor of activated T-cells cytoplasmic 2, medicine, Diabetes Mellitus, Humans, Nerve Growth Factors, Eye Proteins, PPAR-γ, peroxisome proliferator-activated receptor γ, Serpins, PEDF receptor, ATGL, adipose triglyceride lipase, pigment epithelium-derived factor (PEDF), Flt-1, FMS-like tyrosine kinase 1, Gene Expression Profiling, HIF-1, hypoxia-inducible factor 1, RPE, retinal pigment epithelial, CK2, casein kinase 2, FasL, Fas ligand, NFAT, nuclear factor of activated T-cells, AGE, advanced glycation end-product, MEK5, MAPK/ERK kinase 5, RAR, retinoic acid receptor, Immunology, LRP, low-density lipoprotein receptor-related protein, PKA, protein kinase A, MAPK, mitogen-activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f0eb505cdd8e879711ecfdef97aa4c
http://europepmc.org/articles/PMC4557399

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المؤلفون: Hideto Yonekura, Naoki Tsuruoka, Yoshino Yoshitake, Yasuo Yoshitomi, Takayuki Ikeda, Li Li Sun, Yasuhito Ishigaki

المصدر: Biochemical Journal

مصطلحات موضوعية: Angiogenesis, vascular endothelial growth factor (VEGF), Biochemistry, MVEC, microvascular EC, angiogenesis, chemistry.chemical_compound, bFGF, basic fibroblast growth factor, KDR, kinase insert domain-containing receptor, Cells, Cultured, mRNA 3′-end processing, HEK-293TN cell, HEK (human embryonic kidney)-293 cell expressing the large T-antigen of SV40 (simian virus 40) and the neomycin-resistance gene, soluble Flt-1, RT, reverse transcription, VEGF, vascular endothelial growth factor, Cell Hypoxia, HIF, hypoxia-inducible factor, Vascular endothelial growth factor, vascular endothelial cell, embryonic structures, hnRNP, heterogeneous nuclear ribonucleoprotein, ARE, A+U-rich element, RNA 3' End Processing, medicine.symptom, Research Article, CFIM25, 25-kDa subunit of the cleavage factor Im, Molecular Sequence Data, Down-Regulation, CstF, cleavage stimulation factor, Biology, PHD, prolyl hydroxylase, FBS, fetal bovine serum, Downregulation and upregulation, medicine, Humans, RNA, Messenger, mFlt-1, membrane-bound Flt-1, Molecular Biology, HUVEC, human umbilical vein EC, sFlt-1, soluble Flt-1, Messenger RNA, Vascular Endothelial Growth Factor Receptor-1, Base Sequence, VEGFR, VEGF receptor, hypoxia, EC, endothelial cell, Microcirculation, HMVEC, human MVEC, Alternative splicing, Endothelial Cells, sVEGFR, soluble VEGFR, RNA, Cell Biology, Hypoxia (medical), Molecular biology, Alternative Splicing, chemistry, Cst F64, 64-kDa subunit of CstF, DMOG, dimethyloxaloylglycine, Minigene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec7044d06178ad1c8045ef47d4879ba
https://doi.org/10.1042/bj20101490