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المؤلفون: Tony S. Eteläinen, Tommi P. Kilpeläinen, Adele Ignatius, Samuli Auno, Francesca De Lorenzo, Johanna K. Uhari-Väänänen, Ulrika H. Julku, Timo T. Myöhänen

المساهمون: Divisions of Faculty of Pharmacy, PREP in neurodegenerative disorders, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Research Services, Regenerative Neuroscience

المصدر: Neuropharmacology. 218

مصطلحات موضوعية: Parkinson?s disease, Cell Survival, DOPAMINE TRANSPORTER, Cellular and Molecular Neuroscience, Mice, PROLYL OLIGOPEPTIDASE INHIBITOR, TYROSINE-HYDROXYLASE, Animals, MOTOR BEHAVIOR, SYNUCLEIN, Neurodegeneration, OXIDATIVE STRESS, BRAIN, KYP-2047, Pharmacology, Parkinson Disease, AGGREGATION, Disease Models, Animal, Prolyl oligopeptidase, 317 Pharmacy, Oligomers, alpha-Synuclein, AUTOPHAGY, Endopeptidase K, A53T-?-synuclein, Prolyl Oligopeptidases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37fd177c4900db144ba2b10c11f9c49
https://pubmed.ncbi.nlm.nih.gov/35964686

المؤلفون: Samuli Auno, Sampo Kurvonen, Poul Henning Jensen, Tommi Kilpeläinen, Lydia Zouzoula, Susanna Norrbacka, Hengjing Cui, Iiris Hovatta, Kalevi Trontti, Timo T. Myöhänen

المساهمون: Division of Pharmacology and Pharmacotherapy, PREP in neurodegenerative disorders, SLEEPWELL Research Program, Department of Psychology and Logopedics, Neuroscience Center, Mind and Matter, Iiris Hovatta / Principal Investigator, Genetics, Faculty of Pharmacy, Regenerative pharmacology group, Drug Research Program, Divisions of Faculty of Pharmacy

المصدر: Journal of Cellular and Molecular Medicine
Cui, H, Kilpeläinen, T, Zouzoula, L, Auno, S, Trontti, K, Kurvonen, S, Norrbacka, S, Hovatta, I, Jensen, P H & Myöhänen, T T 2021, ' Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy ', Journal of Cellular and Molecular Medicine, vol. 25, no. 20, pp. 9634-9646 . https://doi.org/10.1111/jcmm.16910

مصطلحات موضوعية: alpha-synuclein, multiple system atrophy, TOXICITY, DISEASE, chemistry.chemical_compound, 0302 clinical medicine, KYP‐2047, Phosphorylation, PHOSPHORYLATION, KYP-2047, 0303 health sciences, Neurodegeneration, neurodegeneration, PROTEIN PHOSPHATASE 2A, MOUSE MODEL, Transfection, Cell biology, Oligodendroglia, medicine.anatomical_structure, alpha‐synuclein, 317 Pharmacy, PROLINE, alpha-Synuclein, Molecular Medicine, AUTOPHAGY, Original Article, Cellular model, Prolyl Oligopeptidases, Cell Survival, Nerve Tissue Proteins, Protein Aggregation, Pathological, Cell Line, 03 medical and health sciences, Protein Aggregates, SDG 3 - Good Health and Well-being, medicine, Humans, Viability assay, PARKINSONS, 030304 developmental biology, Alpha-synuclein, Synucleinopathies, Autophagy, synucleinopathies, Cell Biology, Original Articles, DEGRADATION, medicine.disease, Oligodendrocyte, chemistry, prolyl oligopeptidase, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126329cf3d916b265e7db63e93e55f8c
https://pubmed.ncbi.nlm.nih.gov/34486218

المؤلفون: Laura Hellinen, Ali Koskela, Elina Vattulainen, Mikko Liukkonen, Christine Wegler, Andrea Treyer, Niklas Handin, Richard Svensson, Timo Myöhänen, Antti Poso, Kai Kaarniranta, Per Artursson, Arto Urtti

المساهمون: Faculty of Pharmacy, Regenerative pharmacology group, Drug Research Program, Divisions of Faculty of Pharmacy, PREP in neurodegenerative disorders, Division of Pharmacology and Pharmacotherapy, Division of Pharmaceutical Biosciences, Drug Delivery Unit, Drug Delivery

المصدر: Biomedicine & Pharmacotherapy, Vol 146, Iss, Pp 112501-(2022)

مصطلحات موضوعية: Proteomics, Target engagement, RM1-950, Cell Line, Inhibitory Concentration 50, Macular Degeneration, 03 medical and health sciences, 0302 clinical medicine, DIGESTION, Autophagy, Humans, ASSAYS, KYP-2047, Retinal pigment epithelium, 030304 developmental biology, Pharmacology, 0303 health sciences, Prolyl oligopeptidase inhibitor, Dose-Response Relationship, Drug, Age-related macular degeneration, Biochemistry and Molecular Biology, TOTAL PROTEIN, General Medicine, RETINAL-PIGMENT EPITHELIUM, eye diseases, 3. Good health, Phenotype, 317 Pharmacy, CELLS, sense organs, Therapeutics. Pharmacology, Prolyl Oligopeptidases, Microtubule-Associated Proteins, 030217 neurology & neurosurgery, Biokemi och molekylärbiologi

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e0b00551b7d329646b39f3762187c0
http://www.sciencedirect.com/science/article/pii/S0753332221012877

المؤلفون: Susanna Norrbacka, Dan Lindholm, Timo T. Myöhänen

المساهمون: Division of Pharmacology and Pharmacotherapy, PREP in neurodegenerative disorders, Department of Biochemistry and Developmental Biology, Medicum, Faculty of Pharmacy, Drug Research Program, Regenerative pharmacology group

المصدر: Journal of Cellular and Molecular Medicine
Norrbacka, S, Lindholm, D & Myöhänen, T T 2019, ' Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington’s disease ', Journal of Cellular and Molecular Medicine, vol. 23, no. 12, pp. 8511-8515 . https://doi.org/10.1111/jcmm.14675

مصطلحات موضوعية: INVOLVEMENT, 0301 basic medicine, Huntingtin, ALPHA-SYNUCLEIN, PROTEIN, Protein aggregation, chemistry.chemical_compound, 0302 clinical medicine, Trinucleotide Repeats, DRUG, PROTEASOME, KYP-2047, Huntingtin Protein, Serine Endopeptidases, Neurodegeneration, neurodegeneration, protein processing, Cell biology, Huntington Disease, 030220 oncology & carcinogenesis, Molecular Medicine, Prolyl Oligopeptidases, Intracellular, Proteasome Endopeptidase Complex, autophagy, Proline, Cell Survival, huntingtin, Short Communication, education, Short Communications, Cysteine Proteinase Inhibitors, Biology, Protein Aggregation, Pathological, protein aggregation, Protein Aggregates, 03 medical and health sciences, Huntington's disease, medicine, Humans, PARKINSONS, Alpha-synuclein, Autophagy, Cell Biology, medicine.disease, Acetylcysteine, 030104 developmental biology, chemistry, Proteasome, Biocatalysis, 1182 Biochemistry, cell and molecular biology, 3111 Biomedicine, Peptides, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036071831b3dbd9768026c7a737c3a88
https://doi.org/10.1111/jcmm.14675

المؤلفون: Pyry M. J. Dillemuth, Timo T. Myöhänen, Maija Lahtela-Kakkonen, Henri T. Pätsi, Samuli Auno, Erik A.A. Wallén, Khaled Arja, Tommi Kilpeläinen

المساهمون: Division of Pharmaceutical Chemistry and Technology, PREP in neurodegenerative disorders, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Regenerative pharmacology group, Pharmaceutical Design and Discovery group, Erik Wallen / Principal Investigator

المصدر: ACS Medicinal Chemistry Letters

مصطلحات موضوعية: autophagy, Letter, Stereochemistry, alpha-synuclein, 116 Chemical sciences, Triazole, Oligopeptidase, Pyrazole, 010402 general chemistry, 01 natural sciences, Biochemistry, imidazole, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Imidazole, Tetrazole, KYP-2047, 030304 developmental biology, 0303 health sciences, Organic Chemistry, Endopeptidase, 3. Good health, 0104 chemical sciences, pyrazole, triazole, chemistry, Prolyl oligopeptidase, 317 Pharmacy, Electrophile, ENDOPEPTIDASE, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2b18fee964d75dc4dbbf9ec8da5bbf
http://hdl.handle.net/10138/336056

المؤلفون: Kati-Sisko Vellonen, Laura Hellinen, Johannes Vrijdag, Henri J. Huttunen, Arto Urtti, Xu Yan, Tommi Kilpeläinen, Reinis Svarcbahs, Timo T. Myöhänen, Anne-Marie Lambeir, Erik A.A. Wallén

المساهمون: PREP in neurodegenerative disorders, Division of Pharmacology and Pharmacotherapy, Drug Research Program, Neuroscience Center, Regenerative pharmacology group, Henri Juhani Huttunen / Principal Investigator, Drug Delivery Unit, Division of Pharmaceutical Biosciences, Division of Pharmaceutical Chemistry and Technology, Pharmaceutical Design and Discovery group, Erik Wallen / Principal Investigator, Faculty of Pharmacy, Divisions of Faculty of Pharmacy

المصدر: Biomedicine and pharmacotherapy
Biomedicine & Pharmacotherapy, Vol 128, Iss, Pp 110253-(2020)

مصطلحات موضوعية: 0301 basic medicine, Parkinson's disease, PROTEIN, Oligopeptidase, Antiparkinson Agents, chemistry.chemical_compound, 0302 clinical medicine, Protein-fragment complementation assay, BRAIN, KYP-2047, chemistry.chemical_classification, biology, medicine.diagnostic_test, ACTIVE-SITE, Pharmacology. Therapy, General Medicine, Endopeptidase, 3. Good health, Cell biology, Serine protease, Protein conformation, 317 Pharmacy, 030220 oncology & carcinogenesis, alpha-Synuclein, ENDOPEPTIDASE, Prolyl Oligopeptidases, Microtubule-Associated Proteins, Serine Proteinase Inhibitors, Proline, RM1-950, 03 medical and health sciences, Protein Aggregates, Western blot, medicine, Autophagy, Humans, CELL, Pharmacology, Alpha-synuclein, Dose-Response Relationship, Drug, 030104 developmental biology, Enzyme, HEK293 Cells, chemistry, biology.protein, Parkinson’s disease, Therapeutics. Pharmacology, Human medicine, Protein Multimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8181c8c2661c4f09336610da8742f81f
https://repository.uantwerpen.be/docstore/d:irua:3139

المؤلفون: Jonna Tyni, Maija Lahtela-Kakkonen, Timo T. Myöhänen, Erik A.A. Wallén, Tommi Kilpeläinen, Tony Eteläinen

المساهمون: PREP in neurodegenerative disorders, Division of Pharmacology and Pharmacotherapy, Drug Research Program, Regenerative pharmacology group, Division of Pharmaceutical Chemistry and Technology, Pharmaceutical Design and Discovery group, Erik Wallen / Principal Investigator, University Management

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: synthesis, Stereochemistry, PROLINE ENDOPEPTIDASE, Carboxylic acid, alpha-synuclein aggregation, 116 Chemical sciences, Oligopeptidase, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Drug Discovery, Ic50 values, HUMAN PERIPHERAL-TISSUES, Tetrazole, KYP-2047, IC50, KINETICS, chemistry.chemical_classification, tetrazole, 010405 organic chemistry, Chemistry, Organic Chemistry, molecular docking, 3. Good health, 0104 chemical sciences, inhibitor, 010404 medicinal & biomolecular chemistry, Enzyme, Prolyl oligopeptidase, 317 Pharmacy, Electrophile, Bioisostere

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73545c046ba9a0c2e7d7a0042e7946f3
http://hdl.handle.net/10138/325038