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3مورد إلكتروني
المؤلفون: Uhlich, N, Natalello, A, Kadam, R, Doglia, S, Reymond, J, Darbre, T, Uhlich, NA, NATALELLO, ANTONINO, Kadam, RU, DOGLIA, SILVIA MARIA, Reymond, JL, Darbre, T.
مصطلحات الفهرس: Dendrimer, Kinetic, Protein model, Thiol ligand, Vitamin B, 12, FIS/01 - FISICA SPERIMENTALE, BIO/10 - BIOCHIMICA, info:eu-repo/semantics/article
URL:
http://hdl.handle.net/10281/9265
info:eu-repo/semantics/altIdentifier/pmid/20014271
info:eu-repo/semantics/altIdentifier/wos/WOS:000275039500012
volume:11
issue:3
firstpage:358
lastpage:365
numberofpages:8
journal:CHEMBIOCHEM -
4دورية أكاديمية
المؤلفون: Kitamura S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Lin TH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Lee CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Takamura A; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037., Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Zhang D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Dada L; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Nagai E; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Yao Y; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037., Sharpless KB; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037., Wolan DW; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 28; Vol. 121 (22), pp. e2310677121. Date of Electronic Publication: 2024 May 16.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
مواضيع طبية MeSH: Hemagglutinin Glycoproteins, Influenza Virus*/metabolism , Hemagglutinin Glycoproteins, Influenza Virus*/chemistry , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry, Humans ; Chemistry, Pharmaceutical/methods ; High-Throughput Screening Assays/methods ; Influenza, Human/drug therapy ; Influenza, Human/virology ; Crystallography, X-Ray/methods ; Click Chemistry/methods ; Animals ; Influenza A virus/drug effects ; Madin Darby Canine Kidney Cells ; Viral Fusion Protein Inhibitors/pharmacology ; Viral Fusion Protein Inhibitors/chemistry ; Dogs
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5دورية أكاديمية
المؤلفون: Cao L; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Coventry B; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Molecular Engineering Graduate Program, University of Washington, Seattle, WA, USA., Goreshnik I; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Huang B; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., Sheffler W; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Park JS; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA., Jude KM; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Marković I; VIB-UGent Center for Inflammation Research, Ghent, Belgium.; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Verschueren KHG; VIB-UGent Center for Inflammation Research, Ghent, Belgium.; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Verstraete K; VIB-UGent Center for Inflammation Research, Ghent, Belgium.; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Walsh STR; Chemical Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.; J.A.M.E.S. Farm, Clarksville, MD, USA., Bennett N; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Molecular Engineering Graduate Program, University of Washington, Seattle, WA, USA., Phal A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Yang A; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Kozodoy L; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., DeWitt M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Picton L; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Miller L; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Strauch EM; Deptartment of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA., DeBouver ND; UCB Pharma, Bainbridge Island, WA, USA.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, USA., Pires A; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, USA.; Seattle Children's Center for Global Infectious Disease Research, Seattle, WA, USA., Bera AK; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Halabiya S; Department of Electrical and Computer Engineering, University of Washington, Seattle, WA, USA., Hammerson B; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, USA., Yang W; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Bernard S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Stewart L; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Ruohola-Baker H; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA., Lee S; Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA., Savvides SN; VIB-UGent Center for Inflammation Research, Ghent, Belgium.; Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Garcia KC; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
المصدر: Nature [Nature] 2022 May; Vol. 605 (7910), pp. 551-560. Date of Electronic Publication: 2022 Mar 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Intramural
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
مواضيع طبية MeSH: Carrier Proteins*/metabolism , Proteins*/chemistry, Amino Acids/metabolism ; Binding Sites ; Protein Binding
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6دورية أكاديمية
المؤلفون: Yao Y; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037., Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Lee CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Woehl JL; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037., Wu NC; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Kitamura S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037; wilson@scripps.edu wolan@scripps.edu.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037., Wolan DW; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037; wilson@scripps.edu wolan@scripps.edu.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18431-18438. Date of Electronic Publication: 2020 Jul 20.
نوع المنشور: Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
مواضيع طبية MeSH: Antiviral Agents/*pharmacology , Drug Evaluation, Preclinical/*methods , Fluorescence Polarization/*methods , Influenza A Virus, H1N1 Subtype/*drug effects , Influenza A Virus, H5N1 Subtype/*drug effects , Influenza, Human/*virology , Small Molecule Libraries/*pharmacology, Antiviral Agents/chemistry ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Hemagglutinin Glycoproteins, Influenza Virus/metabolism ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/metabolism ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza A Virus, H5N1 Subtype/metabolism ; Small Molecule Libraries/chemistry
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7دورية أكاديمية
المؤلفون: Tzarum N; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Giang E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Chen F; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Nagy K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Augestad EH; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Velázquez-Moctezuma R; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Keck ZY; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Hua Y; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Stanfield RL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Dreux M; CIRI, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, F-69007, Lyon, France., Prentoe J; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Foung SKH; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA., Bukh J; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre Hospital, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Law M; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
المصدر: Science advances [Sci Adv] 2020 Jul 24; Vol. 6 (30), pp. eabb5642. Date of Electronic Publication: 2020 Jul 24 (Print Publication: 2020).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: eCollection Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
مواضيع طبية MeSH: Hepatitis C* , Viral Hepatitis Vaccines*, Antibodies, Neutralizing ; Epitopes ; Hepacivirus ; Hepatitis C Antibodies ; Humans
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8دورية أكاديمية
المؤلفون: Wu NC; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Lv H; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China., Thompson AJ; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Wu DC; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Ng WWS; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China., Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Lin CW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., Nycholat CM; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., McBride R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Liang W; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China., Paulson JC; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Mok CKP; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China. Electronic address: ch02mkp@hku.hk., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: wilson@scripps.edu.
المصدر: Cell host & microbe [Cell Host Microbe] 2019 Jun 12; Vol. 25 (6), pp. 836-844.e5. Date of Electronic Publication: 2019 May 28.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
مواضيع طبية MeSH: Mutation, Missense*, Hemagglutinin Glycoproteins, Influenza Virus/*genetics , Hemagglutinin Glycoproteins, Influenza Virus/*immunology , Influenza A Virus, H3N2 Subtype/*growth & development , Influenza A Virus, H3N2 Subtype/*immunology , Influenza Vaccines/*genetics , Influenza Vaccines/*immunology, Adaptation, Biological ; Animals ; Antigens, Viral/chemistry ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Binding Sites ; Chick Embryo ; Crystallography, X-Ray ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry ; Influenza A Virus, H3N2 Subtype/genetics ; Protein Conformation ; Technology, Pharmaceutical/methods ; Virus Cultivation/methods
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9دورية أكاديمية
المؤلفون: van Dongen MJP; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands. mvandon@its.jnj.com wilson@scripps.edu.; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Juraszek J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Lawson E; Discovery Sciences, Janssen Research & Development, 1400 McKean Rd., Spring House, PA, USA., Brandenburg B; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Schmitz F; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Schepens WBG; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Stoops B; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., van Diepen HA; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Jongeneelen M; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Tang C; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Vermond J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., van Eijgen-Obregoso Real A; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Blokland S; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Garg D; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA., Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Goutier W; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Lanckacker E; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Klap JM; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Peeters DCG; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Wu J; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Buyck C; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Jonckers THM; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Roymans D; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Roevens P; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Vogels R; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Koudstaal W; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Friesen RHE; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Raboisson P; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Dhanak D; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.; Discovery Sciences, Janssen Research & Development, 1400 McKean Rd., Spring House, PA, USA., Goudsmit J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. mvandon@its.jnj.com wilson@scripps.edu.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.
المصدر: Science (New York, N.Y.) [Science] 2019 Mar 08; Vol. 363 (6431).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science
مواضيع طبية MeSH: Antibodies, Neutralizing/*chemistry , Biomimetic Materials/*pharmacology , Influenza A Virus, H1N1 Subtype/*drug effects , Influenza, Human/*prevention & control , Piperazines/*pharmacology , Pyridines/*pharmacology , Tetrazoles/*pharmacology , Viral Fusion Protein Inhibitors/*pharmacology , Virus Internalization/*drug effects, Administration, Oral ; Animals ; Biomimetic Materials/administration & dosage ; Biomimetic Materials/pharmacokinetics ; Bronchi/virology ; Cells, Cultured ; Dogs ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Hemagglutinin Glycoproteins, Influenza Virus/metabolism ; Humans ; Madin Darby Canine Kidney Cells ; Mice ; Piperazines/administration & dosage ; Piperazines/pharmacokinetics ; Pyridines/administration & dosage ; Pyridines/pharmacokinetics ; Respiratory Mucosa/virology ; Tetrazoles/administration & dosage ; Tetrazoles/pharmacokinetics ; Viral Fusion Protein Inhibitors/administration & dosage ; Viral Fusion Protein Inhibitors/pharmacokinetics
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10دورية أكاديمية
المؤلفون: Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037; wilson@scripps.edu.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Apr 17; Vol. 115 (16), pp. 4240-4245. Date of Electronic Publication: 2018 Apr 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
مواضيع طبية MeSH: Antibodies, Neutralizing/*metabolism , Antigen-Antibody Reactions/*drug effects , Antigens, Viral/*metabolism , Hemagglutinin Glycoproteins, Influenza Virus/*metabolism , Taurine/*analogs & derivatives, Binding Sites/drug effects ; Crystallization ; Crystallography, X-Ray ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Influenza A virus/immunology ; Influenza, Human/immunology ; Models, Molecular ; Molecular Mimicry ; Molecular Structure ; N-Acetylneuraminic Acid/chemistry ; Protein Binding/drug effects ; Protein Conformation ; Receptors, Virus/chemistry ; Taurine/pharmacology
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