المؤلفون: Carrillo AK; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Kadayat TM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509, United States., Hwang JY; Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon, KR 34114, United States., Chen Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509, United States., Zhu F; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Holbrook G; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Gillingwater K; Department of Medical Parasitology & Infection Biology, Swiss Tropical and Public Health Institute, Kreuzstrasse 2, Allschwil 4123, Switzerland., Connelly MC; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Yang L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Kaiser M; Department of Medical Parasitology & Infection Biology, Swiss Tropical and Public Health Institute, Kreuzstrasse 2, Allschwil 4123, Switzerland.; Faculty of Science, University of Basel, Petersplatz 1, Basel 4003, Switzerland., Guy RK; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3437-3447. Date of Electronic Publication: 2024 Feb 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosomiasis, African*/drug therapy , Trypanosoma brucei brucei* , Trypanocidal Agents*/toxicity , Trypanocidal Agents*/therapeutic use, Humans ; Animals ; Mice ; Trypanosoma brucei rhodesiense ; Trypanosoma brucei gambiense

المؤلفون: Kim HS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Ortiz D; Department of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States., Kadayat TM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Fargo CM; Department of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States.; Department of Chemical Physiology & Biochemistry, Oregon Health and Science University, Portland, Oregon 97239 United States., Hammill JT; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Chen Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Rice AL; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Begley KL; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Shoeran G; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Pistel W; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States., Yates PA; Department of Chemical Physiology & Biochemistry, Oregon Health and Science University, Portland, Oregon 97239 United States., Sanchez MA; Department of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States., Landfear SM; Department of Molecular Microbiology & Immunology, Oregon Health and Science University, Portland, Oregon 97239 United States.; Department of Chemical Physiology & Biochemistry, Oregon Health and Science University, Portland, Oregon 97239 United States., Guy RK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Jun 08; Vol. 66 (11), pp. 7374-7386. Date of Electronic Publication: 2023 May 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Leishmania* , Leishmaniasis*/drug therapy , Leishmaniasis*/chemically induced , Leishmaniasis*/parasitology , Antiprotozoal Agents*/chemistry, Humans ; Animals ; Mice ; Benzamides/pharmacology ; Benzamides/therapeutic use

المؤلفون: Hwang SY; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Shrestha A; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Park S; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Bist G; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Kunwar S; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Kadayat TM; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Jang H; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Seo M; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Sheen N; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Kim S; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Jeon KH; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea., Lee ES; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea. Electronic address: eslee@yu.ac.kr., Kwon Y; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea. Electronic address: ykwon@ewha.ac.kr.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Jan 05; Vol. 227, pp. 113916. Date of Electronic Publication: 2021 Oct 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , DNA Topoisomerases, Type I/*metabolism , DNA Topoisomerases, Type II/*metabolism , Halogens/*pharmacology , Indenes/*pharmacology , Poly-ADP-Ribose Binding Proteins/*metabolism , Pyridones/*pharmacology , Topoisomerase Inhibitors/*pharmacology, Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Halogens/chemistry ; Humans ; Indenes/chemical synthesis ; Indenes/chemistry ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Pyridones/chemical synthesis ; Pyridones/chemistry ; Structure-Activity Relationship ; Topoisomerase Inhibitors/chemical synthesis ; Topoisomerase Inhibitors/chemistry ; Tumor Cells, Cultured

المؤلفون: Kunwar S; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Hwang SY; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program, Ewha Womans University, Seoul, 120-750, Republic of Korea., Katila P; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Park S; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program, Ewha Womans University, Seoul, 120-750, Republic of Korea., Jeon KH; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program, Ewha Womans University, Seoul, 120-750, Republic of Korea., Kim D; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program, Ewha Womans University, Seoul, 120-750, Republic of Korea., Kadayat TM; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea., Kwon Y; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Global Top 5 Program, Ewha Womans University, Seoul, 120-750, Republic of Korea. Electronic address: ykwon@ewha.ac.kr., Lee ES; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Republic of Korea. Electronic address: eslee@yu.ac.kr.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 15; Vol. 226, pp. 113860. Date of Electronic Publication: 2021 Sep 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Amines/*pharmacology , Antineoplastic Agents/*pharmacology , DNA Topoisomerases, Type II/*metabolism , Topoisomerase II Inhibitors/*pharmacology, Amines/chemical synthesis ; Amines/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Topoisomerase II Inhibitors/chemical synthesis ; Topoisomerase II Inhibitors/chemistry ; Tumor Cells, Cultured

المؤلفون: Shrestha A; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea., Kim N; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea., Lee SJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea., Jeon YH; Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea., Song JJ; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea., An H; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea., Cho SJ; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea., Kadayat TM; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea., Chin J; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Oct 28; Vol. 64 (20), pp. 14913-14929. Date of Electronic Publication: 2021 Sep 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Enzyme Inhibitors/*pharmacology , Neoplasms/*drug therapy , Small Molecule Libraries/*pharmacology, Antineoplastic Agents/chemistry ; Enzyme Inhibitors/chemistry ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Molecular Structure ; Neoplasms/metabolism ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/metabolism ; Repressor Proteins/antagonists & inhibitors ; Repressor Proteins/metabolism ; Small Molecule Libraries/chemistry

المؤلفون: Kim J; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea; College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea., Hwang H; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Yoon H; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Lee JE; Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Pusan, South Korea., Oh JM; Department of Nuclear Medicine, School of Medicine, Kyungpook National University Hospital, Daegu, South Korea., An H; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Ji HD; Department of Nuclear Medicine, School of Medicine, Kyungpook National University Hospital, Daegu, South Korea., Lee S; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, 41404, South Korea., Cha E; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Ma MJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Kim DS; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Lee SJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Kadayat TM; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Song J; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea., Lee SW; Department of Nuclear Medicine, School of Medicine, Kyungpook National University Hospital, Daegu, South Korea., Jeon JH; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, 41404, South Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea., Park KG; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea., Lee IK; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, 41404, South Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea., Jeon YH; Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea. Electronic address: jeon9014@gmail.com., Chin J; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea. Electronic address: jwchin@dgmif.re.kr., Cho SJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061, South Korea; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, 41404, South Korea. Electronic address: sjcho@dgmif.re.kr.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2020 Nov 01; Vol. 205, pp. 112501. Date of Electronic Publication: 2020 Jul 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Inverse Agonism*, Antineoplastic Agents/*pharmacokinetics , Antineoplastic Agents/*pharmacology , Iodine Radioisotopes/*therapeutic use , Receptors, Estrogen/*antagonists & inhibitors , Thyroid Neoplasms/*drug therapy, Administration, Oral ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Biological Availability ; Cell Line, Tumor ; Humans ; Molecular Docking Simulation ; Protein Conformation ; Receptors, Estrogen/chemistry ; Receptors, Estrogen/metabolism ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/radiotherapy

المؤلفون: Kadayat TM; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea., Shrestha A; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea., Jeon YH; Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 41404, Republic of Korea., An H; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea., Kim J; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea., Cho SJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.; Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 41404, Republic of Korea., Chin J; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Sep 24; Vol. 63 (18), pp. 10109-10134. Date of Electronic Publication: 2020 Jul 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Organic Chemicals/*therapeutic use , PPAR delta/*agonists, Animals ; Chemistry, Pharmaceutical ; Humans ; Molecular Structure ; Organic Chemicals/chemistry ; Organic Chemicals/pharmacology ; PPAR delta/antagonists & inhibitors ; Structure-Activity Relationship

المؤلفون: Kadayat TM; College of Pharmacy , Yeungnam University , Gyeongsan 38541 , Republic of Korea.; New Drug Development Center , Daegu-Gyeongbuk Medical Innovation Foundation , Daegu 41061 , Republic of Korea., Park S; College of Pharmacy, Graduate School of Pharmaceutical Sciences , Ewha Womans University , Seoul 120-750 , Republic of Korea., Shrestha A; College of Pharmacy , Yeungnam University , Gyeongsan 38541 , Republic of Korea., Jo H; College of Pharmacy, Graduate School of Pharmaceutical Sciences , Ewha Womans University , Seoul 120-750 , Republic of Korea., Hwang SY; College of Pharmacy, Graduate School of Pharmaceutical Sciences , Ewha Womans University , Seoul 120-750 , Republic of Korea., Katila P; College of Pharmacy , Yeungnam University , Gyeongsan 38541 , Republic of Korea., Shrestha R; College of Pharmacy , Yeungnam University , Gyeongsan 38541 , Republic of Korea., Nepal MR; College of Pharmacy , Yeungnam University , Gyeongsan 38541 , Republic of Korea., Noh K; College of Pharmacy , Yeungnam University , Gyeongsan 38541 , Republic of Korea., Kim SK; Laboratory Animal Center , Daegu-Gyeongbuk Medical Innovation Foundation , Daegu 41061 , Republic of Korea., Koh WS; Laboratory Animal Center , Daegu-Gyeongbuk Medical Innovation Foundation , Daegu 41061 , Republic of Korea., Kim KS; Laboratory Animal Center , Daegu-Gyeongbuk Medical Innovation Foundation , Daegu 41061 , Republic of Korea.; College of Veterinary Medicine , Kyungpook National University , Daegu 41566 , Republic of Korea., Jeon YH; Laboratory Animal Center , Daegu-Gyeongbuk Medical Innovation Foundation , Daegu 41061 , Republic of Korea., Jeong TC; College of Pharmacy , Yeungnam University , Gyeongsan 38541 , Republic of Korea., Kwon Y; College of Pharmacy, Graduate School of Pharmaceutical Sciences , Ewha Womans University , Seoul 120-750 , Republic of Korea., Lee ES; College of Pharmacy , Yeungnam University , Gyeongsan 38541 , Republic of Korea.

المصدر: Journal of medicinal chemistry [J Med Chem] 2019 Sep 12; Vol. 62 (17), pp. 8194-8234. Date of Electronic Publication: 2019 Aug 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Antineoplastic Agents/*pharmacology , Biphenyl Compounds/*pharmacology , Breast Neoplasms/*drug therapy , DNA Topoisomerases, Type II/*metabolism , Pyridines/*pharmacology , Topoisomerase II Inhibitors/*pharmacology, Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Biphenyl Compounds/chemical synthesis ; Biphenyl Compounds/chemistry ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Male ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred ICR ; Microwaves ; Molecular Structure ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Topoisomerase II Inhibitors/chemical synthesis ; Topoisomerase II Inhibitors/chemistry ; Tumor Cells, Cultured

المؤلفون: Kim DS; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea., Lee J; The Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Republic of Korea., Londhe AM; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea., Kadayat TM; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea., Joo J; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea., Hwang H; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea., Kim KH; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea., Pae AN; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea., Chin J; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea. Electronic address: jwchin@dgmif.re.kr., Cho SJ; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea. Electronic address: sjcho@dgmif.re.kr., Kang H; The Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Republic of Korea; Research Institute of Oceanography, Seoul National University, NS-80, Seoul 151-747, Republic of Korea. Electronic address: hjkang@snu.ac.kr.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 Aug 15; Vol. 26 (15), pp. 4382-4389. Date of Electronic Publication: 2018 Jul 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Acetates/*chemistry , Biphenyl Compounds/*chemical synthesis , PPAR delta/*agonists, Acetates/chemical synthesis ; Acetates/pharmacokinetics ; Administration, Oral ; Animals ; Binding Sites ; Biphenyl Compounds/chemistry ; Biphenyl Compounds/pharmacology ; Crystallography, X-Ray ; Drug Design ; Half-Life ; Humans ; Inhibitory Concentration 50 ; Mice ; Microsomes/metabolism ; Molecular Docking Simulation ; PPAR delta/metabolism ; Protein Structure, Tertiary ; Rats ; Stereoisomerism ; Structure-Activity Relationship ; Thiazoles/chemistry ; Thiazoles/metabolism

المؤلفون: Kadayat TM; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea., Banskota S; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea., Bist G; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea., Gurung P; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea., Magar TBT; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea., Shrestha A; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea., Kim JA; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address: jakim@yu.ac.kr., Lee ES; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address: eslee@yu.ac.kr.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Aug 01; Vol. 28 (14), pp. 2436-2441. Date of Electronic Publication: 2018 Jun 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Inflammatory Agents, Non-Steroidal/*pharmacology , Indans/*pharmacology , Inflammatory Bowel Diseases/*drug therapy , Pyridines/*pharmacology, Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Cell Adhesion/drug effects ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/pathology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; HT29 Cells ; Humans ; Indans/administration & dosage ; Indans/chemical synthesis ; Inflammatory Bowel Diseases/pathology ; Molecular Structure ; Monocytes/drug effects ; Monocytes/metabolism ; Pyridines/administration & dosage ; Pyridines/chemistry ; Rats ; Structure-Activity Relationship ; Trinitrobenzenesulfonic Acid ; Tumor Necrosis Factor-alpha/metabolism