المؤلفون: Haupeltshofer S; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany. steffen.haupeltshofer@uk-essen.de., Mencl S; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany., Szepanowski RD; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany., Hansmann C; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany., Casas AI; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany.; Department of Pharmacology & Personalized Medicine, MeHNS, Faculty of Health, Medicine & Life Science, Maastricht University, Maastricht, The Netherlands., Abberger H; Institute of Medical Microbiology, University Hospital Essen, Virchowstr. 179, D-45147, Essen, Germany.; Division of Immunology, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Hansen W; Institute of Medical Microbiology, University Hospital Essen, Virchowstr. 179, D-45147, Essen, Germany., Blusch A; Department of Neurology, Center for Huntington's Disease NRW, St. Josef-Hospital, Ruhr-University Bochum, Gudrunstr. 56, D-44791, Bochum, Germany., Deuschl C; Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany., Forsting M; Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany., Hermann DM; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany.; Chair of Vascular Neurology, Dementia and Ageing, Department of Neurology, Medical Research Centre, University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany., Langhauser F; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany., Kleinschnitz C; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, Hufelandstr. 55, D-45147, Essen, Germany.

المصدر: Journal of neuroinflammation [J Neuroinflammation] 2024 Jun 13; Vol. 21 (1), pp. 155. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE

مواضيع طبية MeSH: Recovery of Function*/drug effects , Recovery of Function*/physiology , Plasma Kallikrein*/antagonists & inhibitors , Plasma Kallikrein*/metabolism, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Infarction, Middle Cerebral Artery ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Stroke/drug therapy ; Thrombosis ; Ischemic Stroke/drug therapy ; Inflammation

المؤلفون: Oduro-Kwateng E; Molecular Bio-Computation and Drug Design Research Group, School of Health Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4001, South Africa., Soliman MES; Molecular Bio-Computation and Drug Design Research Group, School of Health Sciences, University of KwaZulu Natal, Westville Campus, Durban, 4001, South Africa. soliman@ukzn.ac.za.

المصدر: Cell biochemistry and biophysics [Cell Biochem Biophys] 2024 Jun; Vol. 82 (2), pp. 1159-1177. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Dynamics Simulation* , Angioedemas, Hereditary*/drug therapy , Plasma Kallikrein*/antagonists & inhibitors , Plasma Kallikrein*/metabolism, Humans ; Hydrogen Bonding ; Neoplasms/drug therapy ; Prodrugs/chemistry ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; Molecular Docking Simulation

المؤلفون: Wisniewski P; Individualized Pharmacotherapy, Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, 48149, Münster, Germany., Gangnus T; Individualized Pharmacotherapy, Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, 48149, Münster, Germany., Burckhardt BB; Individualized Pharmacotherapy, Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, 48149, Münster, Germany. burckhardt@uni-muenster.de.

المصدر: Journal of translational medicine [J Transl Med] 2024 Apr 26; Vol. 22 (1), pp. 388. Date of Electronic Publication: 2024 Apr 26.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Kallikrein-Kinin System*/physiology , Drug Discovery*, Humans ; Drug Development ; Animals

المؤلفون: Mohammadi K; Shahid Chamran Heart Center, Isfahan University of Medical Sciences, Isfahan, Iran., Shafie D; Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran., Ghomashi N; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Abdolizadeh A; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Sadeghpour M; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. majidsadeghpour76@gmail.com.

المصدر: Heart failure reviews [Heart Fail Rev] 2024 May; Vol. 29 (3), pp. 729-737. Date of Electronic Publication: 2024 Feb 21.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Kluwer Academic Publishers Country of Publication: United States NLM ID: 9612481 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7322 (Electronic) Linking ISSN: 13824147 NLM ISO Abbreviation: Heart Fail Rev Subsets: MEDLINE

مواضيع طبية MeSH: Heart Failure*/physiopathology , Heart Failure*/drug therapy , Heart Failure*/metabolism , Kallikrein-Kinin System*/physiology , Kinins*/metabolism , Kallikreins*/metabolism , Renin-Angiotensin System*/physiology , Renin-Angiotensin System*/drug effects, Humans ; Signal Transduction ; Bradykinin/metabolism

المؤلفون: Zampieri FG; HCOR Research Institute, São Paulo, SP, Brazil; Department of Critical Care Medicine, University of Alberta, Edmonton, Canada. Electronic address: fzampier@ualberta.ca., Westphal GA; Centro Hospitalar Unimed, Joinville, SC., Santos MAD; Hospital Dona Helena, Joinville, SC, Brazil., Gomes SPC; HCOR Research Institute, São Paulo, SP, Brazil., Gomes JO; HCOR Research Institute, São Paulo, SP, Brazil., Negrelli KL; HCOR Research Institute, São Paulo, SP, Brazil., Santos RHN; HCOR Research Institute, São Paulo, SP, Brazil., Ishihara LM; HCOR Research Institute, São Paulo, SP, Brazil., Miranda TA; HCOR Research Institute, São Paulo, SP, Brazil., Laranjeira LN; HCOR Research Institute, São Paulo, SP, Brazil., Valeis N; HCOR Research Institute, São Paulo, SP, Brazil., Santucci EV; HCOR Research Institute, São Paulo, SP, Brazil., de Souza Dantas VC; Hospital Naval Marcílio Dias, Rio de Janeiro, RJ, Brazil., Gebara O; Hospital Santa Paula, São Paulo, SP, Brazil., Cohn DM; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Amsterdam, Netherlands., Buchele G; Ionis Pharmaceuticals, California, USA., Janiszewski M; Ionis Pharmaceuticals, California, USA., de Freitas FG; Hospital Sepaco, São Paulo, SP, Brazil., Dal-Pizzol F; Hospital São José, Criciúma, SC, Brazil., de Matos Soeiro A; Instituto do Coração do Hospital das Clínicas da FMUSP, São Paulo, SP, Brazil., Berti IR; Hospital Tacchini, Bento Gonçalves, RS, Brazil., Germano A; Hospital Universitário Regional de Maringá, PR, Brazil., Schettini DA; Hospital da Luz, São Paulo, SP, Brazil., Rosa RG; Internal Medicine Department, Hospital Moinhos de vento, Porto Alegre (RS), Brazil., Falavigna M; Internal Medicine Department, Hospital Moinhos de vento, Porto Alegre (RS), Brazil., Veiga VC; BP - A Beneficência Portuguesa de São Paulo, São Paulo, SP, Brazil., Azevedo LCP; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil; Universidade Federal de São Paulo, São Paulo, SP, Brazil., Damiani LP; HCOR Research Institute, São Paulo, SP, Brazil., Machado FR; Universidade Federal de São Paulo, São Paulo, SP, Brazil., Cavalcanti AB; HCOR Research Institute, São Paulo, SP, Brazil.

مؤلفون مشاركون: BRICNet

المصدر: Journal of critical care [J Crit Care] 2024 Dec; Vol. 84, pp. 154892. Date of Electronic Publication: 2024 Aug 03.

نوع المنشور: Journal Article; Randomized Controlled Trial; Multicenter Study

بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8610642 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8615 (Electronic) Linking ISSN: 08839441 NLM ISO Abbreviation: J Crit Care Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19*/therapy , COVID-19*/mortality , Kallikrein-Kinin System* , SARS-CoV-2*, Humans ; Male ; Female ; Middle Aged ; Double-Blind Method ; Aged ; Respiration, Artificial ; Brazil/epidemiology ; Oligonucleotides, Antisense/therapeutic use ; COVID-19 Drug Treatment ; Treatment Outcome

المؤلفون: Kearney KJ; Department of Discovery and Translational Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom., Spronk HMH; Laboratory for Clinical Thrombosis and Haemostasis, Departments of Biochemistry and Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands., Emsley J; Biodiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom., Key NS; Division of Hematology and UNC Blood Research Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina., Philippou H; Department of Discovery and Translational Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.

المصدر: Seminars in thrombosis and hemostasis [Semin Thromb Hemost] 2024 Oct; Vol. 50 (7), pp. 953-961. Date of Electronic Publication: 2023 Apr 18.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Thieme Country of Publication: United States NLM ID: 0431155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-9064 (Electronic) Linking ISSN: 00946176 NLM ISO Abbreviation: Semin Thromb Hemost Subsets: MEDLINE

مواضيع طبية MeSH: Plasma Kallikrein*/metabolism, Humans ; Animals ; Blood Coagulation/physiology ; Mice

المؤلفون: Wan J; UNC Blood Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, Soochow University, Suzhou, China., Dhrolia S; UNC Blood Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Kasthuri RR; UNC Blood Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Prokopenko Y; UNC Blood Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Ilich A; UNC Blood Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Saha P; School of Cardiovascular and Metabolic Medicine & Sciences, British Heart Foundation Centre of Research Excellence, King's College London, London, United Kingdom., Roest M; Synapse Research Institute, Maastricht, The Netherlands., Wolberg AS; UNC Blood Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Key NS; UNC Blood Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Pawlinski R; UNC Blood Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Bendapudi PK; Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA.; Division of Hematology and Blood Transfusion Service, Massachusetts General Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Mackman N; UNC Blood Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC., Grover SP; UNC Blood Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC.; Division of Hematology, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

المصدر: Blood advances [Blood Adv] 2024 Jun 25; Vol. 8 (12), pp. 3045-3057.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

مواضيع طبية MeSH: Thrombin*/metabolism , Plasma Kallikrein*/metabolism , Factor XII*/metabolism, Animals ; Mice ; Blood Coagulation ; Mice, Knockout

المؤلفون: Coelho SVA; Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil., Augusto FM; Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil., Arruda LB; Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.

المصدر: Viruses [Viruses] 2024 Feb 03; Vol. 16 (2). Date of Electronic Publication: 2024 Feb 03.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

مواضيع طبية MeSH: Kallikrein-Kinin System* , COVID-19*, Humans ; Endothelial Cells/metabolism ; Microcirculation ; Bradykinin

المؤلفون: Al-Adimi G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Bhakta V; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Eltringham-Smith LJ; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Shirobokov V; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Sheffield WP; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address: sheffiel@mcmaster.ca.

المصدر: Journal of biotechnology [J Biotechnol] 2024 Aug 10; Vol. 391, pp. 11-19. Date of Electronic Publication: 2024 Jun 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8411927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4863 (Electronic) Linking ISSN: 01681656 NLM ISO Abbreviation: J Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Recombinant Fusion Proteins*/pharmacokinetics , Recombinant Fusion Proteins*/genetics , Recombinant Fusion Proteins*/pharmacology , Recombinant Fusion Proteins*/chemistry, Animals ; Mice ; Humans ; Half-Life ; Plasma Kallikrein/metabolism ; Plasma Kallikrein/genetics ; Serum Albumin, Human/chemistry ; Serum Albumin, Human/genetics ; Serum Albumin, Human/metabolism ; Saccharomycetales/genetics ; Saccharomycetales/metabolism ; Receptors, Fc ; Histocompatibility Antigens Class I

SCR Organism: Komagataella pastoris

المؤلفون: Mendes EP; Department of Physiological Sciences, ICB, UFG, Goiania, GO, Brazil., Ianzer D; Department of Physiological Sciences, ICB, UFG, Goiania, GO, Brazil; National Institute of Science and Technology in Nanobiopharmaceutics, INCT-Nanobiofar, Belo Horizonte, MG, Brazil., Peruchetti DB; Department of Physiology and Biophysics, ICB, UFMG, Belo Horizonte, MG, Brazil; National Institute of Science and Technology in Nanobiopharmaceutics, INCT-Nanobiofar, Belo Horizonte, MG, Brazil., Santos RAS; Department of Physiology and Biophysics, ICB, UFMG, Belo Horizonte, MG, Brazil; National Institute of Science and Technology in Nanobiopharmaceutics, INCT-Nanobiofar, Belo Horizonte, MG, Brazil., Vieira MAR; Department of Physiology and Biophysics, ICB, UFMG, Belo Horizonte, MG, Brazil. Electronic address: marv@icb.ufmg.br.

المصدر: Peptides [Peptides] 2024 Sep; Vol. 179, pp. 171246. Date of Electronic Publication: 2024 May 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 8008690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5169 (Electronic) Linking ISSN: 01969781 NLM ISO Abbreviation: Peptides Subsets: MEDLINE

مواضيع طبية MeSH: Angiotensin I*/pharmacology , Angiotensin I*/metabolism , Bradykinin*/pharmacology , Bradykinin*/analogs & derivatives , Peptide Fragments*/pharmacology , Receptor, Bradykinin B1*/metabolism , Vascular Resistance*/drug effects, Animals ; Cricetinae ; Male ; Rats ; Angiotensin II/analogs & derivatives ; CHO Cells ; Cricetulus ; Kallikrein-Kinin System/physiology ; Kallikrein-Kinin System/drug effects ; Kidney/metabolism ; Kidney/drug effects ; Kinins/metabolism ; Proto-Oncogene Mas ; Proto-Oncogene Proteins/metabolism ; Rats, Wistar ; Receptors, G-Protein-Coupled/metabolism ; Renal Circulation/drug effects ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology