المؤلفون: Matchett, KP, Wilson-Kanamori, JR, Portman, JR, Kapourani, CA, Fercoq, F, May, S, Zajdel, E, Beltran, M, Sutherland, EF, Mackey, JBG, Brice, M, Wilson, GC, Wallace, SJ, Kitto, L, Younger, NT, Dobie, R, Mole, DJ, Oniscu, GC, Wigmore, SJ, Ramachandran, P, Vallejos, CA, Carragher, NO, Saeidinejad, MM, Quaglia, A, Jalan, R, Simpson, KJ, Kendall, TJ, Rule, JA, Lee, WM, Hoare, M, Weston, CJ, Marioni, JC, Teichmann, SA, Bird, TG, Carlin, LM, Henderson, NC

المصدر: Nature. 629(630):158-165

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:158226172

المؤلفون: Gangoso E; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Southgate B; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Bradley L; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Rus S; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Galvez-Cancino F; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London WC1E 6BT, UK., McGivern N; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Güç E; Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh Little France Crescent, Edinburgh EH16 4TJ, UK., Kapourani CA; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Byron A; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Ferguson KM; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Alfazema N; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Morrison G; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Grant V; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Blin C; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Sou I; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Marques-Torrejon MA; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Conde L; Bill Lyons Informatics Centre, Department of Cancer Biology, University College London Cancer Institute, London WC1E 6BT., Parrinello S; Samantha Dickson Brain Cancer Unit, Department of Cancer Biology, University College London Cancer Institute, London WC1E 6BT, UK., Herrero J; Bill Lyons Informatics Centre, Department of Cancer Biology, University College London Cancer Institute, London WC1E 6BT., Beck S; Medical Genomics Research Group, Department of Cancer Biology, University College London Cancer Institute, London, WC1E 6BT., Brandner S; Division of Neuropathology and Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, UCL, London, UK., Brennan PM; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Bertone P; Department of Medicine, Alpert Medical School, Brown University, Providence, RI 02903, USA., Pollard JW; Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh Little France Crescent, Edinburgh EH16 4TJ, UK., Quezada SA; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London WC1E 6BT, UK., Sproul D; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Frame MC; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK., Serrels A; Centre for Inflammation Research, The University of Edinburgh, The Queen's Medical Research Institute, Edinburgh Little France Crescent, Edinburgh EH16 4TJ, UK., Pollard SM; Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK; CRUK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, University of Edinburgh, Edinburgh EH42XR, UK. Electronic address: steven.pollard@ed.ac.uk.

المصدر: Cell [Cell] 2021 Apr 29; Vol. 184 (9), pp. 2454-2470.e26. Date of Electronic Publication: 2021 Apr 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Epigenesis, Genetic*, Brain Neoplasms/*immunology , Glioblastoma/*immunology , Immune Evasion/*immunology , Myeloid Cells/*immunology , Neoplastic Stem Cells/*immunology , Tumor Microenvironment/*immunology, Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Proliferation ; DNA Methylation ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Myeloid Cells/metabolism ; Myeloid Cells/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Kapourani CA; MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; School of Informatics, University of Edinburgh, Edinburgh, UK., Argelaguet R; European Bioinformatics Institute (EMBL-EBI), Hinxton, UK., Sanguinetti G; School of Informatics, University of Edinburgh, Edinburgh, UK. gsanguin@sissa.it.; SISSA, International School of Advanced Studies, Trieste, Italy. gsanguin@sissa.it., Vallejos CA; MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. catalina.vallejos@igmm.ed.ac.uk.; The Alan Turing Institute, London, UK. catalina.vallejos@igmm.ed.ac.uk.

المصدر: Genome biology [Genome Biol] 2021 Apr 20; Vol. 22 (1), pp. 114. Date of Electronic Publication: 2021 Apr 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE

مواضيع طبية MeSH: Bayes Theorem* , DNA Methylation* , Epigenesis, Genetic* , Genetic Heterogeneity* , Software*, Epigenomics/*methods , Single-Cell Analysis/*methods, Algorithms ; Computational Biology/methods

المؤلفون: Argelaguet R; European Bioinformatics Institute (EMBL-EBI), Cambridge, UK., Clark SJ; Epigenetics Programme, Babraham Institute, Cambridge, UK. stephen.clark@babraham.ac.uk., Mohammed H; Epigenetics Programme, Babraham Institute, Cambridge, UK., Stapel LC; Epigenetics Programme, Babraham Institute, Cambridge, UK., Krueger C; Epigenetics Programme, Babraham Institute, Cambridge, UK., Kapourani CA; School of Informatics, University of Edinburgh, Edinburgh, UK.; MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Imaz-Rosshandler I; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Lohoff T; Epigenetics Programme, Babraham Institute, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Xiang Y; Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China.; THU-PKU Center for Life Sciences, Tsinghua University, Beijing, China., Hanna CW; Epigenetics Programme, Babraham Institute, Cambridge, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, UK., Smallwood S; Epigenetics Programme, Babraham Institute, Cambridge, UK., Ibarra-Soria X; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Buettner F; Helmholtz Zentrum München-German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany., Sanguinetti G; School of Informatics, University of Edinburgh, Edinburgh, UK., Xie W; Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China.; THU-PKU Center for Life Sciences, Tsinghua University, Beijing, China., Krueger F; Bioinformatics Group, Babraham Institute, Cambridge, UK., Göttgens B; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Rugg-Gunn PJ; Epigenetics Programme, Babraham Institute, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, UK., Kelsey G; Epigenetics Programme, Babraham Institute, Cambridge, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, UK., Dean W; Department of Biochemistry and Molecular Biology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada., Nichols J; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Stegle O; European Bioinformatics Institute (EMBL-EBI), Cambridge, UK. o.stegle@dkfz.de.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. o.stegle@dkfz.de.; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany. o.stegle@dkfz.de., Marioni JC; European Bioinformatics Institute (EMBL-EBI), Cambridge, UK. john.marioni@cruk.cam.ac.uk.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. john.marioni@cruk.cam.ac.uk.; Wellcome Sanger Institute, Cambridge, UK. john.marioni@cruk.cam.ac.uk., Reik W; Epigenetics Programme, Babraham Institute, Cambridge, UK. wolf.reik@babraham.ac.uk.; Centre for Trophoblast Research, University of Cambridge, Cambridge, UK. wolf.reik@babraham.ac.uk.; Wellcome Sanger Institute, Cambridge, UK. wolf.reik@babraham.ac.uk.

المصدر: Nature [Nature] 2019 Dec; Vol. 576 (7787), pp. 487-491. Date of Electronic Publication: 2019 Dec 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: DNA Methylation* , Epigenesis, Genetic* , Gene Expression Regulation, Developmental* , Single-Cell Analysis*, Gastrula/*cytology , Gastrula/*metabolism , Gastrulation/*genetics , RNA/*genetics, Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Chromatin/genetics ; Chromatin/metabolism ; Demethylation ; Embryoid Bodies/cytology ; Endoderm/cytology ; Endoderm/embryology ; Endoderm/metabolism ; Enhancer Elements, Genetic/genetics ; Epigenome/genetics ; Erythropoiesis ; Factor Analysis, Statistical ; Gastrula/embryology ; Gastrulation/physiology ; Mesoderm/cytology ; Mesoderm/embryology ; Mesoderm/metabolism ; Mice ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; RNA/analysis ; Time Factors ; Zinc Fingers

المؤلفون: Kapourani CA; School of Informatics, University of Edinburgh, Edinburgh, EH8 9AB, UK. C.A.Kapourani@ed.ac.uk.; MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK. C.A.Kapourani@ed.ac.uk., Sanguinetti G; School of Informatics, University of Edinburgh, Edinburgh, EH8 9AB, UK. G.Sanguinetti@ed.ac.uk.; Synthetic and Systems Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK. G.Sanguinetti@ed.ac.uk.

المصدر: Genome biology [Genome Biol] 2019 Mar 21; Vol. 20 (1), pp. 61. Date of Electronic Publication: 2019 Mar 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol

مواضيع طبية MeSH: Bayes Theorem* , DNA Methylation* , Models, Statistical*, Computational Biology/*methods , Embryonic Stem Cells/*metabolism , Single-Cell Analysis/*methods, Algorithms ; Computer Simulation ; CpG Islands ; Embryonic Stem Cells/cytology ; Humans ; Models, Genetic

المؤلفون: Kapourani CA; School of Informatics, University of Edinburgh, Edinburgh, UK., Sanguinetti G; School of Informatics, University of Edinburgh, Edinburgh, UK.; Synthetic and Systems Biology, University of Edinburgh, Edinburgh, UK.

المصدر: Bioinformatics (Oxford, England) [Bioinformatics] 2018 Jul 15; Vol. 34 (14), pp. 2485-2486.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9808944 Publication Model: Print Cited Medium: Internet ISSN: 1367-4811 (Electronic) Linking ISSN: 13674803 NLM ISO Abbreviation: Bioinformatics Subsets: MEDLINE

مواضيع طبية MeSH: DNA Methylation* , Software*, Epigenomics/*instrumentation, Linear Models

المؤلفون: Clark SJ; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK. stephen.clark@babraham.ac.uk., Argelaguet R; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, UK., Kapourani CA; School of Informatics, University of Edinburgh, Scotland, EH8 9AB, UK., Stubbs TM; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK., Lee HJ; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, 2308, Australia., Alda-Catalinas C; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK., Krueger F; Bioinformatics Group, Babraham Institute, Cambridge, CB22 3AT, UK., Sanguinetti G; School of Informatics, University of Edinburgh, Scotland, EH8 9AB, UK., Kelsey G; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK., Marioni JC; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK. marioni@ebi.ac.uk.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, UK. marioni@ebi.ac.uk.; Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. marioni@ebi.ac.uk., Stegle O; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK. oliver.stegle@ebi.ac.uk., Reik W; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK. wolf.reik@babraham.ac.uk.; Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK. wolf.reik@babraham.ac.uk.; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK. wolf.reik@babraham.ac.uk.

المصدر: Nature communications [Nat Commun] 2018 Feb 22; Vol. 9 (1), pp. 781. Date of Electronic Publication: 2018 Feb 22.

نوع المنشور: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Transcription, Genetic*, Chromatin/*metabolism , Embryonic Stem Cells/*metabolism , Nucleosomes/*metabolism , Sequence Analysis, DNA/*methods, Animals ; Cell Differentiation ; DNA Methylation ; Female ; Histones/metabolism ; Male ; Mice ; Nucleosomes/genetics ; Single-Cell Analysis

المؤلفون: Kapourani CA; IANC, School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK., Sanguinetti G; IANC, School of Informatics, University of Edinburgh, Edinburgh EH8 9AB, UK Synthetic and Systems Biology, University of Edinburgh, Edinburgh EH9 3JD, UK.

المصدر: Bioinformatics (Oxford, England) [Bioinformatics] 2016 Sep 01; Vol. 32 (17), pp. i405-i412.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9808944 Publication Model: Print Cited Medium: Internet ISSN: 1367-4811 (Electronic) Linking ISSN: 13674803 NLM ISO Abbreviation: Bioinformatics Subsets: MEDLINE

مواضيع طبية MeSH: DNA Methylation* , Epigenomics* , Gene Expression* , Machine Learning*, CpG Islands ; Forecasting ; Genome ; Promoter Regions, Genetic