المؤلفون: Ewout Landeloos, Tatjana Geukens, Joost Wauters, Geert Meyfroidt, Linden LVd, Iwein Gyselinck, Matthias M. Engelen, Rita Vos, Lana Langendries, Spriet I, Peter Verhamme, Laure-Anne Teuwen, Birgit Weynand, Kaptein Sjf, Laurens Liesenborghs, Leen Delang, Thomas Vanassche, Sofie Jacobs, Eric Van Wijngaerden, Johan Neyts, Wim Janssens, Horst St, Helga Ceunen, Dirk Jochmans, Pieter Vermeersch, Barbara Debaveye, Geert Verbeke, Erwin Dreesen, Ann Belmans, Joana Rocha-Pereira, Paul De Munter, Geldhof, Timothy Devos, Robbert Boudewijns, Bert Vandenberk

المصدر: SSRN Electronic Journal.

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Itraconazole, Antifungal drug, Interim analysis, Clinical trial, Internal medicine, Good clinical practice, medicine, Dosing, business, Viral load, Declaration of Helsinki, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e8a7f8ee4e036884f9dd1b7889ef40f9
https://doi.org/10.2139/ssrn.3731461

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المؤلفون: Kiemel D; Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg, Germany., Kroell AH; Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg, Germany., Denolly S; Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg, Germany., Haselmann U; Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg, Germany., Bonfanti JF; Janssen Infectious Diseases Discovery, Janssen-Cilag, Val de Reuil, France.; Evotec, Toulouse, France., Andres JI; Discovery Chemistry, Janssen R&D, a Johnson & Johnson company, Toledo, Spain., Ghosh B; Discovery Chemistry, Janssen R&D, a Johnson & Johnson company, Spring House, PA, USA., Geluykens P; Discovery, Charles River Beerse, Beerse, Belgium., Kaptein SJF; Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium., Wilken L; Leibniz Institute of Virology, Hamburg, Germany., Scaturro P; Leibniz Institute of Virology, Hamburg, Germany., Neyts J; Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium., Van Loock M; Janssen Global Public Health, Janssen Pharmaceutica NV, a Johnson & Johnson company, Beerse, Belgium., Goethals O; Janssen Global Public Health, Janssen Pharmaceutica NV, a Johnson & Johnson company, Beerse, Belgium., Bartenschlager R; Heidelberg University, Medical Faculty Heidelberg, Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research, Heidelberg, Germany. ralf.bartenschlager@med.uni-heidelberg.de.; German Centre for Infection Research, Heidelberg partner site, Heidelberg, Germany. ralf.bartenschlager@med.uni-heidelberg.de.

المصدر: Nature communications [Nat Commun] 2024 Jul 19; Vol. 15 (1), pp. 6080. Date of Electronic Publication: 2024 Jul 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Dengue Virus*/drug effects , Dengue Virus*/genetics , Dengue Virus*/physiology , Viral Nonstructural Proteins*/metabolism , Viral Nonstructural Proteins*/genetics , Viral Nonstructural Proteins*/antagonists & inhibitors , Virus Replication*/drug effects , Antiviral Agents*/pharmacology , Dengue*/virology , Dengue*/drug therapy, Humans ; Serogroup ; RNA Helicases/metabolism ; RNA Helicases/antagonists & inhibitors ; RNA Helicases/genetics ; Serine Endopeptidases/metabolism ; Serine Endopeptidases/genetics ; Protein Binding ; Animals ; Organelles/metabolism ; Organelles/drug effects ; Viral Proteases ; Aminophenols ; Membrane Proteins ; Indoles ; DEAD-box RNA Helicases ; Nucleoside-Triphosphatase ; Butyrates

المؤلفون: Kesteleyn B; Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium., Bonfanti JF; Janssen Infectious Diseases Discovery, Janssen-Cilag, Chaussée du Vexin, Val de Reuil 27106, France., Bardiot D; CISTIM Leuven vzw, Bioincubator 2, Gaston Geenslaan 2, Leuven 3001, Belgium., De Boeck B; Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium., Goethals O; Janssen Global Public Health R&D, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium., Kaptein SJF; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, Leuven 3000, Belgium., Stoops B; Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium., Coesemans E; Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium., Fortin J; Janssen Infectious Diseases Discovery, Janssen-Cilag, Chaussée du Vexin, Val de Reuil 27106, France., Muller P; Janssen Infectious Diseases Discovery, Janssen-Cilag, Chaussée du Vexin, Val de Reuil 27106, France., Doublet F; Janssen Infectious Diseases Discovery, Janssen-Cilag, Chaussée du Vexin, Val de Reuil 27106, France., Carlens G; CISTIM Leuven vzw, Bioincubator 2, Gaston Geenslaan 2, Leuven 3001, Belgium., Koukni M; CISTIM Leuven vzw, Bioincubator 2, Gaston Geenslaan 2, Leuven 3001, Belgium., Smets W; CISTIM Leuven vzw, Bioincubator 2, Gaston Geenslaan 2, Leuven 3001, Belgium., Raboisson P; Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium., Chaltin P; CISTIM Leuven vzw, Bioincubator 2, Gaston Geenslaan 2, Leuven 3001, Belgium.; Centre for Drug Design and Discovery (CD3), KU Leuven, Bioincubator 2, Gaston Geenslaan 2, Leuven 3000, Belgium., Simmen K; Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium., Loock MV; Janssen Global Public Health R&D, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium., Neyts J; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, Leuven 3000, Belgium.; Global Virus Network (GVN), Baltimore, Maryland 21201, United States., Marchand A; CISTIM Leuven vzw, Bioincubator 2, Gaston Geenslaan 2, Leuven 3001, Belgium., Jonckers THM; Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 4063-4082. Date of Electronic Publication: 2024 Feb 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Dengue Virus* , Dengue*/drug therapy , Hydrocarbons, Halogenated* , Indoles*, Mice ; Humans ; Animals ; Serogroup