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1دورية أكاديمية
المؤلفون: Rachel Kimble, Lucy Murray, Karen M. Keane, Karen Haggerty, Glyn Howatson, John K. Lodge
المصدر: Journal of Nutritional Science, Vol 10 (2021)
مصطلحات موضوعية: Anthocyanin, Arterial stiffness, Blood pressure, Cherry, Metabolomics, Nutrition. Foods and food supply, TX341-641, Medicine
وصف الملف: electronic resource
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المؤلفون: Benoit Carbain, Keisha Hearn, Ildiko Maria Buck, Burcu Anil, Sarah J. Cully, Gianni Chessari, Jane A. Endicott, John Lunec, Neil T. Thompson, Juan Castro, Roger J. Griffin, Rhian S. Holvey, Karen Haggerty, Charlotte H. Revill, Ruth H. Bawn, Stephen R. Wedge, Christiane Riedinger, Christopher N. Johnson, Bernard T. Golding, Lynsey Fazal, Ian R. Hardcastle, Mladen Vinkovic, Claire E. Jennings, Jong Sook Ahn, Bian Zhang, Pamela A. Williams, Celine Cano, Suzannah J. Harnor, Ben Cons, Stephen J. Hobson, E. Anscombe, Jeffrey D. St. Denis, Steven Howard, David R. Newell, Emiliano Tamanini, Nicola E. Wilsher, Miller Duncan Charles, Huw D. Thomas, Timothy J. Blackburn, Martin E.M. Noble, Judith Reeks, Yan Zhao, Luke Bevan
المصدر: Journal of Medicinal Chemistry. 64:4071-4088
مصطلحات موضوعية: Male, Metabolite, Mice, Nude, Antineoplastic Agents, Bone Neoplasms, Isoindoles, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Stability, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, neoplasms, Cell Proliferation, 030304 developmental biology, Mice, Inbred BALB C, Osteosarcoma, 0303 health sciences, Molecular Structure, biology, Chemistry, Proto-Oncogene Proteins c-mdm2, Ligand (biochemistry), Xenograft Model Antitumor Assays, Cytostasis, Small molecule, In vitro, 0104 chemical sciences, Macaca fascicularis, 010404 medicinal & biomolecular chemistry, Microsomes, Liver, biology.protein, Molecular Medicine, Mdm2, Female, Protein Multimerization, Tumor Suppressor Protein p53, Protein Binding
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المؤلفون: Glyn Howatson, Karen Haggerty, Karen M. Keane, John K Lodge, Lucy Murray, Rachel Kimble
المصدر: Journal of Nutritional Science
مصطلحات موضوعية: Anthocyanin, Male, Endocrinology, Diabetes and Metabolism, Urinary system, Physiology, Blood Pressure, Pilot Projects, Prunus avium, Urine, B400, Placebo, Cardiovascular System, Metabolomics, Vascular Stiffness, medicine, Metabolome, Cherry, Humans, Nutrition and Dietetics, biology, business.industry, Brief Report, Metabolism and Metabolic Studies, medicine.disease, biology.organism_classification, C700, Arterial stiffness, Prunus cerasus, Blood pressure, Fruit, Dietary Supplements, Female, Vascular function, business, Food Science
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9094df48b9b785c2b5b207e8305d16
https://nrl.northumbria.ac.uk/id/eprint/46995/1/the-influence-of-tart-cherries-prunus-cerasus-on-vascular-function-and-the-urinary-metabolome-a-randomised-placebo-controlled-pilot-study.pdf -
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المؤلفون: Lucy Murray, Glyn Howatson, Karen Haggerty, Rachel Kimble, Karen M. Keane, John K Lodge
المصدر: Medicine & Science in Sports & Exercise. 52:1073-1073
مصطلحات موضوعية: business.industry, Urinary system, Healthy individuals, Metabolome, Physiology, Medicine, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, Vascular function, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ebce581497cb2b183a2c06b467443b0d
https://doi.org/10.1249/01.mss.0000687308.34690.30 -
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المؤلفون: Shafiq U. Ahmed, James M. McDonnell, Junfeng Liu, Timothy J. Blackburn, Catherine J. Drummond, Bernard T. Golding, Karen Haggerty, David R. Newell, Martin E.M. Noble, Claire Hutton, Xiaohong Lu, Anna Watson, Jane A. Endicott, John Lunec, Jan Gruber, Charlotte H. Revill, Qing Xu, Stuart J. Kemp, William Clegg, Sara L. Payne, Ross W. Harrington, Karim Bennaceur, Roger J. Griffin, Christiane Riedinger, Eric Valeur, Ian R. Hardcastle
المصدر: Journal of Medicinal Chemistry. 54:1233-1243
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Stereochemistry, Antineoplastic Agents, Stereoisomerism, Plasma protein binding, Isoindoles, Crystallography, X-Ray, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Potency, Structure–activity relationship, Hydroxymethyl, neoplasms, Cell Proliferation, Molecular Structure, Proto-Oncogene Proteins c-mdm2, Nuclear magnetic resonance spectroscopy, chemistry, Cell culture, Molecular Medicine, Drug Screening Assays, Antitumor, Tumor Suppressor Protein p53, Growth inhibition, Protein Binding
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المؤلفون: S Wedge, Roger J. Griffin, Maria Ahn, Karen Haggerty, Juan Castro, Ian R. Hardcastle, Celine Cano, Christopher N. Johnson, Bernard T. Golding, Herbie Newell, Steven Howard, Luke Bevan, Timothy J. Blackburn, Pamela A. Williams, Martin E.M. Noble, Yan Zhao, Judith Reeks, Ruth H. Bawn, Neil Thompson, Emiliano Tamanini, Ben Cons, Huw Thomas, Lynsey Fazal, Hugh Walton, Elaine Willmore, Sarah J. Cully, Gianni Chessari, Keisha Hearn, Ildiko Maria Buck
المصدر: Cancer Research. 78:1652-1652
مصطلحات موضوعية: Cancer Research, biology, Philosophy, Cell cycle progression, Cancer therapy, P53 Tumor Suppressor, Small molecule, Ubiquitin ligase, Protein–protein interaction, Oncology, biology.protein, Cancer research, Mdm2, Mdm2 p53
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8f11828bba8837e5bc77a00d94f5218f
https://doi.org/10.1158/1538-7445.am2018-1652 -
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المؤلفون: Karen Haggerty, Reinner I. Lerrick, Andrew C. Benniston, Thomas P. L. Winstanley, Ross W. Harrington, Wouter A. Herrebout, Michael J. Hall, Patrick Bultinck, William Clegg, Corinne Wills
المصدر: ChemComm
مصطلحات موضوعية: Boron Compounds, Stereochemistry, Chemistry, Resolution (electron density), Metals and Alloys, Late stage, Stereoisomerism, General Chemistry, Fluorescence, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Organic molecules, Chiral column chromatography, chemistry.chemical_compound, Computational chemistry, Materials Chemistry, Ceramics and Composites, BODIPY, Axial symmetry, Crystallization, Fluorescent Dyes
وصف الملف: pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3977c7cf9f7e84961d378aadce3b30e2
https://pubmed.ncbi.nlm.nih.gov/24676233 -
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المؤلفون: E. Anscombe, Bernard T. Golding, David J. Paterson, David R. Newell, Benoit Carbain, Lan Z. Wang, Celine Roche, Celine Cano, Allyson J. Campbell, Aude Echalier, Philip J. Jewsbury, Ian R. Hardcastle, Roger J. Griffin, Jane A. Endicott, Karen Haggerty, Martin E.M. Noble
المصدر: Journal of medicinal chemistry. 57(1)
مصطلحات موضوعية: Purine, Steric effects, chemistry.chemical_classification, Models, Molecular, Binding Sites, biology, Stereochemistry, Cyclin-dependent kinase 2, Cyclin-Dependent Kinase 2, Substituent, Crystallography, X-Ray, chemistry.chemical_compound, Structure-Activity Relationship, chemistry, Drug Design, Drug Discovery, biology.protein, Molecular Medicine, Structure based, Potency, Transferase, Protein Kinase Inhibitors, Alkyl
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المؤلفون: David R. Newell, Ian R. Hardcastle, Bernard T. Golding, Xiaohong Lu, Roger J. Griffin, Christiane Riedinger, Karim Bennaceur, Charlotte H. Revill, Yan Zhao, Jane A. Endicott, John Lunec, Catherine J. Drummond, Anna Watson, Junfeng Liu, James M. McDonnell, Karen Haggerty, Martin E.M. Noble, Qing Xu
المصدر: Bioorganic & Medicinal Chemistry Letters.
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Stereoisomerism, Isoindoles, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Potency, Structure–activity relationship, Hydroxymethyl, Molecular Biology, Dose-Response Relationship, Drug, Organic Chemistry, Wild type, Proto-Oncogene Proteins c-mdm2, HCT116 Cells, chemistry, Drug Design, Molecular Medicine, Drug Screening Assays, Antitumor, Tumor Suppressor Protein p53, Growth inhibition, Enantiomer, Selectivity
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المؤلفون: Faye Craven, Julia Bardos, Bernard T. Golding, Gavin Jones, Ian R. Hardcastle, Karen Haggerty, Celine Cano, Attilla Ting, Roger J. Griffin, Pia Thommes, Kate M. Clapham, Tommy Rennison
المصدر: Organic & Biomolecular Chemistry. 10:6747
مصطلحات موضوعية: Models, Molecular, Atropisomer, Binding Sites, Swine, Stereochemistry, Chemistry, Morpholines, Organic Chemistry, Stereoisomerism, Biological activity, DNA-Activated Protein Kinase, Biochemistry, Chiral column chromatography, Structure-Activity Relationship, Chromones, Animals, Humans, Structure–activity relationship, Physical and Theoretical Chemistry, Enantiomer, Pharmacophore, Protein kinase A, Protein Kinase Inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b2d6f5c46d63b3169c87e4923677fa
https://doi.org/10.1039/c2ob26035b