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المؤلفون: Robert I. Haddad, Kevin Harrington, Makoto Tahara, Robert L. Ferris, Maura Gillison, Jerome Fayette, Amaury Daste, Piotr Koralewski, Bogdan Zurawski, Miren Taberna, Nabil F. Saba, Milena Mak, Andrzej Kawecki, Gustavo Girotto, Miguel Angel Alvarez Avitia, Caroline Even, Joaquin Gabriel Reinoso Toledo, Alexander Guminski, Urs Müller-Richter, Naomi Kiyota, Mustimbo Roberts, Tariq Aziz Khan, Karen Miller-Moslin, Li Wei, Athanassios Argiris
المصدر: Journal of Clinical Oncology. 41:2166-2180
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea41d080266110a8825a284e080af38
https://doi.org/10.1200/jco.22.00332 -
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المؤلفون: Sonia Dolfi, Tracy Tang, Georgina Long AO, Paolo Ascierto, F Stephen Hodi, Evan Lipson, Dirk Schadendorf, John Wojcik, Jennifer Postelnek, Yu Wang, Anne Marie Sobiesk, Kaushal Mishra, Sarah Keidel, Karen Miller-Moslin, Hussein Tawbi, Charlie Garnett-Benson
المصدر: Regular and Young Investigator Award Abstracts.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e071b53d84af30fd8a79d3dca441b00b
https://doi.org/10.1136/jitc-2022-sitc2022.0606 -
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المؤلفون: Karen Miller-Moslin, Jillian Brechbiel, Alex A. Adjei
المصدر: Cancer Treatment Reviews. 40:750-759
مصطلحات موضوعية: MAPK/ERK pathway, MAP Kinase Signaling System, Fusion Proteins, bcr-abl, Vismodegib, Pharmacology, Sonidegib, Proto-Oncogene Proteins p21(ras), Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, Neoplasms, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, Hedgehog Proteins, Radiology, Nuclear Medicine and imaging, Molecular Targeted Therapy, Protein kinase B, PI3K/AKT/mTOR pathway, Receptors, Notch, business.industry, TOR Serine-Threonine Kinases, Combination chemotherapy, Receptor Cross-Talk, General Medicine, Janus Kinase 2, ErbB Receptors, Crosstalk (biology), Oncology, chemistry, Cancer research, raf Kinases, Smoothened, business, Proto-Oncogene Proteins c-akt, Signal Transduction, medicine.drug
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المؤلفون: Miao Dai, Feng He, Michael A Mcewan, Karen Miller-Moslin, Stefan Peukert, Adam Amaral, Rajesh Karki, Rui Zhang, Lei Huangshu, Rishi K. Jain, Luis Llamas, Tao Sheng, Yanhong Li, Jing Yuan, Melissa Matsumoto, Aaron Bourret, Joseph Kelleher, Walter Michael, Arun Ramamurthy, Marion Dorsch, Ribo Guo, Juliet Williams, Anthony Vattay, Yingchuan Sun, Lawrence Blas Perez, Wieslawa Maniara, Naeem Yusuff
المصدر: Journal of Medicinal Chemistry. 52:3954-3968
مصطلحات موضوعية: Cell, Administration, Oral, Antineoplastic Agents, Pharmacology, Receptors, G-Protein-Coupled, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Hedgehog Proteins, Hedgehog, G protein-coupled receptor, Chemistry, Neoplasms, Experimental, Smoothened Receptor, Hedgehog signaling pathway, medicine.anatomical_structure, Phthalazines, Molecular Medicine, Signal transduction, Smoothened, Medulloblastoma, Signal Transduction
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المؤلفون: Karen Miller-Moslin, Bharat Lagu, John Green, Miao Dai, Michael A Mcewan, Wieslawa Maniara, Juliet Williams, Aaron Bourret, Arun Ramamurthy, Rui Zhang, Silvia Buonamici, Jing Yuan, Kate Wang, Yingchuan Sun, Marion Dorsch, Anlai Wang, Adam Amaral, Feng He, Naeem Yusuff, Anthony Vattay, Joseph Kelleher, Ribo Guo, Stefan Peukert
المصدر: ChemMedChem. 8(8)
مصطلحات موضوعية: ERG1 Potassium Channel, Mutant, Drug Evaluation, Preclinical, Pharmacology, Biology, Biochemistry, Cell Line, Receptors, G-Protein-Coupled, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, medicine, Potency, Animals, Humans, General Pharmacology, Toxicology and Pharmaceutics, NVP-LEQ506, Hedgehog, Medulloblastoma, Organic Chemistry, medicine.disease, Smoothened Receptor, Hedgehog signaling pathway, Ether-A-Go-Go Potassium Channels, Rats, Pyridazines, Disease Models, Animal, Solubility, Pyrazines, Molecular Medicine, Smoothened, Half-Life
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المؤلفون: Dale Porter, Lawrence Blas Perez, Kymberly Levine, Walter Michael, Catherine Fiorilla, Michael Dore, Raviraj Kulathila, Kara Herlihy, Michael Scott Visser, Simon van der Plas, Dipietro Lucian, Michael A Mcewan, Clayton Springer, Xiaoling Xie, Francois Lenoir, Karen Miller-Moslin, Madelene Y. Hoe, B. Barry Touré, Naeem Yusuff, Rajesh Karki, John Sullivan, Carol Joud
مصطلحات موضوعية: Programmed cell death, Apoptosis Inhibitor, business.industry, Organic Chemistry, Sulfonamide (medicine), Bcl-2 family, Pharmacology, Biochemistry, Protein–protein interaction, Apoptosis, Drug Discovery, Cancer cell, medicine, Moiety, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175a4571a176ef8fb09f300f0c02b1fa
https://europepmc.org/articles/PMC4027142/ -
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المؤلفون: Stefan Peukert, Karen Miller-Moslin
المصدر: ChemInform. 41
مصطلحات موضوعية: biology, Drug discovery, Chemistry, Cancer, General Medicine, medicine.disease, Small molecule, Hedgehog signaling pathway, GLI1, biology.protein, medicine, Sonic Hedgehog Protein, Cancer research, Smoothened, Hedgehog
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المؤلفون: Joseph Kelleher, Yan Wang, AnneMarie Culazzo Pferdekamper, Jun Liu, Fangxian Sun, Stephanie Kay Dodd, Melissa Matsumoto, Nathan P. Englund, Xu Wu, Jeffrey Tsao, Juliet Williams, Jing Yuan, Dai Cheng, Yun Jiang, Jiqing Jiang, Anthony Vattay, Wenqi Gao, Tove Tuntland, Markus Warmuth, Yung-mae Yao, Stefan Peukert, Ribo Guo, Yongqin Wan, Wieslawa Maniara, Karen Miller-Moslin, Dong Han, Shifeng Pan, Marion Dorsch
مصطلحات موضوعية: Organic Chemistry, Antagonist, Pharmacology, Biochemistry, Sonidegib, Hedgehog signaling pathway, Blockade, chemistry.chemical_compound, Smoothened Receptor, chemistry, Drug Discovery, Smoothened, Antagonism, Hedgehog
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2ce5eef6382294d82ddf4576370849
https://europepmc.org/articles/PMC4007689/ -
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المؤلفون: Karen Miller-Moslin, Stefan Peukert
المصدر: ChemMedChem. 5(4)
مصطلحات موضوعية: Drug Industry, Antineoplastic Agents, Pharmacology, Biochemistry, Cell Line, Receptors, G-Protein-Coupled, Small Molecule Libraries, GLI1, Neoplasms, Drug Discovery, Sonic Hedgehog Protein, Animals, Humans, Hedgehog Proteins, General Pharmacology, Toxicology and Pharmaceutics, Hedgehog, biology, Drug discovery, Organic Chemistry, Small molecule, Smoothened Receptor, Hedgehog signaling pathway, Disease Models, Animal, Cancer research, biology.protein, Molecular Medicine, Smoothened, Signal Transduction
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المؤلفون: Stefan Peukert, Karen Miller-Moslin
مصطلحات موضوعية: Patched, Tumor microenvironment, medicine.medical_specialty, Cancer, Biology, medicine.disease, medicine.disease_cause, Hedgehog signaling pathway, Endocrinology, PTCH1, Internal medicine, medicine, Cancer research, Carcinogenesis, Hedgehog, Tissue homeostasis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e0103d7cde360feab9d77ed8dbd0488c
https://doi.org/10.1016/s0065-7743(09)04416-9