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المؤلفون: Karen Owens
المصدر: Journal of Invitational Theory and Practice. 4
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::563b21d3aa95915973f5b50b5efac51c
https://doi.org/10.26522/jitp.v4i2.3888 -
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المؤلفون: Haifeng Tang, Zack Zhiqiang Guo, Lee-Yuh Pai, Adam B. Weinglass, Xin Gu, Shuzhi Dong, Alexander Pasternak, Yang Yu, Kathleen A. Sullivan, Mengwei Hu, Kelsey VanGelder, Gloria J. Zingaro, Sophie Roy, Jessica Liu, Qinghong Fu, Birgit T. Priest, Michael Margulis, Brande Thomas-Fowlkes, Pierre Morissette, Robin E. Haimbach, Zhicai Wu, Juliann Ehrhart, Karen Owens, Caryn Hampton, Zhi-Cai Shi, Jessica Frie, Ron Ferguson, Shiyao Xu, Vincent Tong
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2559-2566
مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, Scaffold, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Dogs, 0302 clinical medicine, Thiadiazoles, In vivo, Rats, Inbred SHR, Drug Discovery, Potassium Channel Blockers, medicine, Animals, Structure–activity relationship, Spiro Compounds, Potassium Channels, Inwardly Rectifying, Molecular Biology, biology, Chemistry, Organic Chemistry, Potassium channel blocker, Rats, Disease Models, Animal, Pyrimidines, 030104 developmental biology, 030220 oncology & carcinogenesis, Hypertension, ROMK, biology.protein, Molecular Medicine, Pharmacophore, Half-Life, medicine.drug
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المؤلفون: Lee-Yuh Pai, Aaron Corona, Harry R. Chobanian, John P. Felix, Matthew J. Clements, Karen Owens, Haifeng Tang, Brande Thomas-Fowlkes, Kathleen A. Sullivan, Alexander Pasternak, Caryn Hampton, Jessica Frie, Vincent Tong, Ron Ferguson, Jessica Liu, Birgit T. Priest, Barbara Pio, Yan Guo, Elizabeth Joshi, Nardos Teumelsan, Ling Xu, Martin Köhler, Joseph M. Metzger, Zach Guo, Kevin M. Maloney
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1109-1114
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, hERG, Pharmaceutical Science, Diuresis, Biochemistry, Natriuresis, Sulfone, 03 medical and health sciences, chemistry.chemical_compound, Heterocyclic Compounds, Rats, Inbred SHR, Drug Discovery, medicine, Animals, Moiety, Organic chemistry, Sulfones, Enzyme Inhibitors, Potassium Channels, Inwardly Rectifying, Diuretics, Molecular Biology, biology, Chemistry, Organic Chemistry, Rats, 030104 developmental biology, Drug Design, ROMK, biology.protein, Molecular Medicine, Diuretic, Selectivity
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المؤلفون: Shawn P. Walsh, Lee-Yuh Pai, Yuping Zhu, John P. Felix, Caryn Hampton, Xiaoyan Zhou, Melba Hernandez, Brande Thomas-Fowlkes, Richard M. Brochu, Nardos Teumelsan, Gregory J. Kaczorowski, Emma R. Parmee, Maria L. Garcia, Alexander Pasternak, Jinlong Jiang, Sookhee Ha, Sophie Roy, Kathleen A. Sullivan, Haifeng Tang, Lihu Yang, Karen Owens, Reynalda K. de Jesus, Xin Gu, Birgit T. Priest, Barbara Pio, Fa-Xiang Ding, Andrew M. Swensen, Magdalena Alonso-Galicia, Aurash Shahripour, Juliann Ehrhart, Timothy Bailey
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:5695-5702
مصطلحات موضوعية: 0301 basic medicine, QTC PROLONGATION, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Dog model, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Transcriptional Regulator ERG, Pharmacokinetics, In vivo, Oxazines, Drug Discovery, Animals, Humans, Potassium Channels, Inwardly Rectifying, Molecular Biology, Heart Failure, biology, Chemistry, Organic Chemistry, Macaca mulatta, Small molecule, Diuresis, Piperazine, 030104 developmental biology, 030220 oncology & carcinogenesis, Hypertension, ROMK, biology.protein, Molecular Medicine
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المؤلفون: Steven Fried, L. Alexandra Wickham, Andrea D. Basso, Xinkang Wang, Lin Chu, Gary R. Sitko, Jason E. Imbriglio, Joseph M. Metzger, Karen Owens, Maria Maderia, Gino Castriota, Tian-Quan Cai, Maria Stranieri-Michener, Zhu Chen, Larry Handt
المصدر: Thrombosis Research. 145:133-139
مصطلحات موضوعية: 0301 basic medicine, Antagonist, Hemorrhage, Thrombosis, Hematology, 030204 cardiovascular system & hematology, Pharmacology, Biology, Platelet Activation, Macaca fascicularis, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Thrombin, In vivo, Hemostasis, cardiovascular system, medicine, Animals, Receptors, Thrombin, Platelet, Platelet activation, Receptor, Ex vivo, medicine.drug
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المؤلفون: Michael J. Forrest, John P. Felix, Lee-Yuh Pai, Melba Hernandez, Yuping Zhu, Aaron Corona, Joseph M. Metzger, Gregory J. Kaczorowski, Nardos Teumelsan, Lihu Yang, Karen Owens, Timothy Bailey, Caryn Hampton, Vincent Tong, Alexander Pasternak, Brande Thomas-Fowlkes, Shawn P. Walsh, Emma R. Parmee, Haifeng Tang, Richard M. Brochu, Maria L. Garcia, Xiaoyan Zhou, Magdalena Alonso-Galicia, Sophie Roy, Birgit T. Priest, Andrew M. Swensen, Aurash Shahripour
المصدر: ACS Medicinal Chemistry Letters. 7:697-701
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Kidney, biology, Chemistry, Organic Chemistry, hERG, Diuresis, Nephron, Pharmacology, Biochemistry, Natriuresis, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Internal medicine, Drug Discovery, medicine, biology.protein, Loop of Henle, ROMK, Thiazide, medicine.drug
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المؤلفون: Lee-Yuh Pai, Yuping Zhu, Richard Visconti, Xiaoyan Zhou, John P. Felix, Melba Hernandez, Jing Chen, Michael Margulis, Nardos Teumelsan, Sophie Roy, Kathleen A. Sullivan, Jessica Liu, Joseph M. Metzger, Aaron Corona, Gregory J. Kaczorowski, Maria L. Garcia, Lihu Yang, Shawn P. Walsh, Birgit T. Priest, Alexander Pasternak, Caryn Hampton, Emma R. Parmee, Vincent Tong, Brande Thomas-Fowlkes, Haifeng Tang, Magdalena Alonso-Galicia, Kashmira Shah, Michael J. Forrest, Richard M. Brochu, Ross Bentley, Sookhee Ha, Karen Owens, Aurash Shahripour, Andrew M. Swensen, Jessica Frie, Adam B. Weinglass, Timothy Bailey
المصدر: ACS Medicinal Chemistry Letters. 6:747-752
مصطلحات موضوعية: Pharmacokinetics, Chemistry, Pharmacodynamics, Organic Chemistry, Drug Discovery, ROMK, Pharmacology, Biochemistry
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المؤلفون: Yan Yan, Richard M. Brochu, Maria L. Garcia, Lihu Yang, Sophie Roy, Gregory J. Kaczorowski, Reynald K. de Jesus, Birgit T. Priest, Xiaoyan Zhou, Lee-Yuh Pai, Shawn P. Walsh, Yuping Zhu, Karen Owens, Caryn Hampton, Timothy Bailey, Andrew M. Swensen, Brande Thomas-Fowlkes, Magdalena Alonso-Galicia, John P. Felix, Melba Hernandez, Alexander Pasternak, Haifeng Tang
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:5829-5832
مصطلحات موضوعية: Natriuretic Agents, Isobenzofuran, Stereochemistry, Clinical Biochemistry, hERG, Tetrazoles, Pharmaceutical Science, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Potassium Channels, Inwardly Rectifying, Molecular Biology, Benzofurans, biology, Chemistry, Organic Chemistry, Small molecule, Ether-A-Go-Go Potassium Channels, Diuresis, Rats, ROMK, biology.protein, Molecular Medicine
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المؤلفون: Haifeng Tang, Kashmira Shah, Maria L. Garcia, Alexander Pasternak, Magdalena Alonso-Galicia, Brande Thomas-Fowlkes, Cordelia Rasa, Joseph M. Metzger, Sophie Roy, Lee-Yuh Pai, Jessica Liu, Olga Price, Vince Tong, Birgit T. Priest, Gregory J. Kaczorowski, James D. Ormes, Charles Gill, Aaron Corona, John P. Felix, Jianying Xiao, Kathleen A. Sullivan, Karen Owens, Caryn Hampton, Xiaoyan Zhou, Martin Köhler
المصدر: The Journal of pharmacology and experimental therapeutics. 359(1)
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Diuresis, Tetrazoles, Blood Pressure, Pharmacology, Bartter syndrome, Piperazines, Natriuresis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Internal medicine, medicine, Potassium Channel Blockers, Animals, Humans, Potassium Channels, Inwardly Rectifying, Benzofurans, Aldosterone, Dose-Response Relationship, Drug, Chemistry, Biphenyl Compounds, Bartter Syndrome, Potassium channel blocker, Drug Synergism, medicine.disease, Rats, Bartter's syndrome, 030104 developmental biology, Endocrinology, HEK293 Cells, Hydrochlorothiazide, Phenotype, 030220 oncology & carcinogenesis, Kaliuresis, ROMK, Molecular Medicine, Benzimidazoles, Female, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a55d5d0f3672edd7db9d025d76d0fd
https://pubmed.ncbi.nlm.nih.gov/27432892 -
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المؤلفون: Shawn P. Walsh, Jessica Frie, Nardos Teumelsan, Maria L. Garcia, Karen Owens, Sophie Roy, Caryn Hampton, Reynalda K. de Jesus, Birgit T. Priest, Magdalena Alonso-Galicia, Aurash Shahripour, Richard M. Brochu, Juliann Ehrhart, Andrew M. Swensen, Haifeng Tang, Timothy Bailey, Alexander Pasternak, Lee-Yuh Pai, Yuping Zhu, Lihu Yang, Gregory J. Kaczorowski, John P. Felix, Melba Hernandez, Brande Thomas-Fowlkes, Xiaoyan Zhou
المصدر: Bioorganicmedicinal chemistry letters. 26(9)
مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, medicine.medical_treatment, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, Biochemistry, Piperazines, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, In vivo, Heterocyclic Compounds, Drug Discovery, medicine, Potency, Structure–activity relationship, Molecular Biology, biology, Chemistry, Organic Chemistry, Small molecule, Piperazine, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, ROMK, Molecular Medicine, Diuretic
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