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1
المؤلفون: Karin Kaspersson, Ian Gurrell, Elisabeth Bäck, Samantha Budd Haeberlein, Karin Kolmodin, Roland Bürli, Michael J. McKenzie, Susanna Eketjäll, Philip Thorne, Patrik Johansson, Jörg Holenz, Gvido Cebers, Clay W Scott, Mark E. Duggan, Paul R. J. Davey, Haydn Beaton
المصدر: Journal of medicinal chemistry. 61(8)
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Male, Proteolysis, Melanocyte, Cocrystal, Madin Darby Canine Kidney Cells, Pathogenesis, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Catalytic Domain, mental disorders, Drug Discovery, medicine, Structure–activity relationship, Animals, Aspartic Acid Endopeptidases, Humans, Protein Isoforms, Protease Inhibitors, Spiro Compounds, Oxazoles, Amyloid beta-Peptides, medicine.diagnostic_test, Molecular Structure, Chemistry, Brain, Peptide Fragments, PMEL, Rats, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Biochemistry, Molecular Medicine, Female, Amyloid Precursor Protein Secretases, Selectivity, 030217 neurology & neurosurgery, gp100 Melanoma Antigen
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2
المؤلفون: Britt-Marie Swahn, Ylva Gravenfors, Gunnar Nordvall, Jenny Viklund, Fredrik Rahm, Karin Kolmodin, Mats Svensson
المصدر: ACS Medicinal Chemistry Letters. 5:440-445
مصطلحات موضوعية: biology, Chemistry, In silico, Organic Chemistry, hERG, Computational biology, computer.software_genre, Scaffold hopping, Biochemistry, Prediction methods, Drug Discovery, β secretase, biology.protein, Data mining, computer
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3
المؤلفون: Karin Kolmodin, Juliette Janson, Britt-Marie Swahn, Stefan von Berg, Tjerk Bueters, Gvido Cebers, Ann-Cathrine Radesäter, Johanna Fälting, Fredrik Jeppsson, Susanne Gustavsson, Bart Ploeger, Sofia Karlström, Susanna Eketjäll, Lise-Lotte Olsson
المصدر: Journal of Biological Chemistry. 287:41245-41257
مصطلحات موضوعية: Male, Indoles, Amyloid, Guinea Pigs, Drug Evaluation, Preclinical, Cathepsin D, Biology, Pharmacology, Biochemistry, Cell Line, Guinea pig, Mice, Neurobiology, Alzheimer Disease, In vivo, mental disorders, Fluorescence Resonance Energy Transfer, Amyloid precursor protein, medicine, Animals, Aspartic Acid Endopeptidases, Humans, Molecular Biology, Amyloid beta-Peptides, Dose-Response Relationship, Drug, Drug discovery, P3 peptide, Brain, Cell Biology, medicine.disease, Mice, Inbred C57BL, Pyrimidines, Treatment Outcome, Drug Design, Disease Progression, biology.protein, Female, Amyloid Precursor Protein Secretases, Alzheimer's disease, Biomarkers
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be78180b718cc33322fedb5df5eba93
https://doi.org/10.1074/jbc.m112.409110 -
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المؤلفون: Mickaël Maudet, Jennifer M. A. Laird, Ronald Zemribo, Paul Jones, Michael Dabrowski, Andis Slaitas, Yevgeni Besidski, Gitte Terp, Karin Kolmodin, Andrea Penwell, Andrew Griffin, Didier Rotticci, Anna K. Sundgren-Andersson, Christopher Walpole, Dean Johnson, Alexander Munro, Yin Hu, Therese Lundström, Maryse Labarre, Inger Kers, Huascar Villanueva, Johan Bylund, Martin Nylöf, Mats Svensson, Denis Labrecque, Magali Harter, Sandrine Leclerc, William Brown, Sophie Dautrey, Shawn Johnstone, John Martino, Lucy Horoszok
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:6205-6211
مصطلحات موضوعية: Drug, media_common.quotation_subject, High-throughput screening, Clinical Biochemistry, TRPV1, Pain, TRPV Cation Channels, Pharmaceutical Science, Pharmacology, Biochemistry, law.invention, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, law, Drug Discovery, Animals, Humans, Structure–activity relationship, Benzothiazoles, Molecular Biology, media_common, Inflammation, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Amides, Recombinant Proteins, Rats, Disease Models, Animal, Solubility, Benzothiazole, chemistry, Recombinant DNA, Molecular Medicine, Pharmacophore
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5
المؤلفون: Karin Kolmodin, David A. Cosgrove, Peter W. Kenny, Niklas Blomberg
المصدر: Journal of Computer-Aided Molecular Design. 23:513-525
مصطلحات موضوعية: Library design, Magnetic Resonance Spectroscopy, Protein Conformation, Computer science, Fragment-based lead discovery, Crystallography, X-Ray, Ligands, Small Molecule Libraries, Structure-Activity Relationship, Fragment (logic), Drug Discovery, Combinatorial Chemistry Techniques, Humans, Molecular Targeted Therapy, Physical and Theoretical Chemistry, Layer (object-oriented design), Binding Sites, Information retrieval, Drug discovery, Fingerprint (computing), Combinatorial chemistry, Computer Science Applications, Computer-Aided Design, Software, Protein Binding
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المؤلفون: Pär Nordlund, Karin Kolmodin, Johan Åqvist
المصدر: Proteins: Structure, Function, and Genetics. 36:370-379
مصطلحات موضوعية: Reaction mechanism, Chemistry, Stereochemistry, Phosphatase, Inorganic chemistry, Substrate (chemistry), Protonation, Protein tyrosine phosphatase, Biochemistry, Free energy perturbation, Dephosphorylation, Structural Biology, Nucleophilic substitution, Molecular Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bbae6a350f3885c913ff42709d403fa9
https://doi.org/10.1002/(sici)1097-0134(19990815)36:3<370::aid-prot11>3.0.co;2-9 -
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المؤلفون: Karin Kolmodin, Jan Florián, Johan Åqvist, Arieh Warshel
المصدر: Chemistry & Biology. 6:R71-R80
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Hydrolysis, Clinical Biochemistry, Experimental data, Esters, General Medicine, Phosphate, Biochemistry, Organophosphates, Phosphoric Monoester Hydrolases, Kinetics, chemistry.chemical_compound, Enzyme, chemistry, Drug Discovery, Animals, Humans, Molecular Medicine, Organic chemistry, Molecular Biology
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8Computational modeling of catalysis and binding in low-molecular-weight protein tyrosine phosphatase
المؤلفون: Johan Åqvist, Karin Kolmodin
المصدر: International Journal of Quantum Chemistry. 73:147-159
مصطلحات موضوعية: Free energy perturbation, Molecular dynamics, Biochemistry, Chemistry, Low molecular weight protein, Protein tyrosine phosphatase, Physical and Theoretical Chemistry, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Enzyme catalysis, Catalysis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cef1b3d99ecc07b7a7bb3aba80936315
https://doi.org/10.1002/(sici)1097-461x(1999)73:2<147::aid-qua9>3.0.co;2-m -
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المؤلفون: Karin Kolmodin, Isabella Feierberg, Johan Åqvist, John Marelius
المصدر: Journal of Molecular Graphics and Modelling. 16:213-225
مصطلحات موضوعية: Models, Molecular, Macromolecular Substances, Static Electricity, Ligands, Quantitative Biology::Subcellular Processes, Free energy perturbation, Molecular dynamics, Nucleophile, Computational chemistry, Static electricity, Materials Chemistry, Computer Simulation, Physical and Theoretical Chemistry, Binding site, Spectroscopy, Quantitative Biology::Biomolecules, Binding Sites, Chemistry, Quantitative Biology::Molecular Networks, Water, Interaction energy, Computer Graphics and Computer-Aided Design, Chemical physics, Mutation, Thermodynamics, Valence bond theory, Protein Tyrosine Phosphatases, Algorithms, Software, Energy (signal processing), Protein Binding
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المؤلفون: Britt-Marie Swahn, Sveinn Briem, Susanna Eketjäll, Fredrik Jeppsson, Kristina Eliason, Juliette Janson, Alexander Svanhagen, Camilla Niva, Anna-Lena Berg, Sofia Karlström, Karin Kolmodin, Susanne Gustavsson, Johanna Fälting, Ann-Cathrin Radesäter, Paulina Appelkvist
المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(24)
مصطلحات موضوعية: Genetically modified mouse, Male, Amyloid, Time Factors, Pyridones, Transgene, Guinea Pigs, Mice, Transgenic, Pharmacology, Isoindoles, Amyloid beta-Protein Precursor, Mice, In vivo, Alzheimer Disease, mental disorders, Amyloid precursor protein, medicine, Potency, Animals, Aspartic Acid Endopeptidases, Humans, Enzyme Inhibitors, IC50, Cells, Cultured, Cerebral Cortex, Neurons, Amyloid beta-Peptides, biology, Dose-Response Relationship, Drug, Chemistry, General Neuroscience, Amyloidosis, P3 peptide, Articles, medicine.disease, Embryo, Mammalian, Peptide Fragments, Mice, Inbred C57BL, Disease Models, Animal, Mutation, biology.protein, Female, Amyloid Precursor Protein Secretases
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c92f198c1a255d3d4f750e538efd83e
https://pubmed.ncbi.nlm.nih.gov/23761903