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1
المؤلفون: Xiaotian Zhu, Dong Zou, Chester A. Metcalf, Raji Sundaramoorthi, Frank Wang, Feng Li, Jan Romero, John Iuliucci, Lois Commodore, Shuangying Liu, Wei-Sheng Huang, Lisi Cai, Qihong Xu, Jeff Keats, Tim Clackson, David C. Dalgarno, Joseph Snodgrass, Jiwei Qi, Yihan Wang, Victor M. Rivera, Mathew Thomas, Ingrid Chen, Tianjun Zhou, Yaoyu Ning, David Wen, Tomi K. Sawyer, Karin Russian, William C. Shakespeare, Marc I Broudy, Scott Wardwell
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3743-3748
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Pharmaceutical Science, Carboxamide, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Molecular Biology, Aniline Compounds, Molecular Structure, biology, Chemistry, Organic Chemistry, Ponatinib, Biological activity, medicine.disease, In vitro, Rats, Disease Models, Animal, Cyclization, Enzyme inhibitor, Alkynes, Mutation, biology.protein, Molecular Medicine, Linker, Toluene, Chronic myelogenous leukemia
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2
المؤلفون: Yaoyu Ning, Chester A. Metcalf, Lois Commodore, Jan Romero, Scott Wardwell, Tomi K. Sawyer, Yihan Wang, Qurish K. Mohemmad, Scott Paul Lentini, Ingrid Chen, Victor M. Rivera, Karin Russian, Geetha Banda, Sasmita Das, Narayana I. Narasimhan, Xiaotian Zhu, Raji Sundaramoorthi, Lisi Cai, Tianjun Zhou, Jeff Keats, Frank Wang, Tim Clackson, Qihong Xu, Jiwei Qi, David Wen, Joseph Snodgrass, Shuangying Liu, William C. Shakespeare, R. Mathew Thomas, Marc I Broudy, John Iuliucci, Wei-Sheng Huang, David C. Dalgarno, Dong Zou
المصدر: Journal of Medicinal Chemistry. 53:4701-4719
مصطلحات موضوعية: Models, Molecular, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Antineoplastic Agents, Mice, SCID, Pharmacology, Crystallography, X-Ray, Mice, chemistry.chemical_compound, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Kinase activity, Benzamide, Protein Kinase Inhibitors, ADME, Kinase, Chemistry, Imidazoles, breakpoint cluster region, Myeloid leukemia, medicine.disease, Rats, Pyridazines, Leukemia, Blood-Brain Barrier, Mutation, Molecular Medicine, Drug Screening Assays, Antitumor
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3
المؤلفون: Jeff Keats, Marc I Broudy, John Iuliucci, Scott Wardwell, Karin Russian, Sasmita Das, Yaoyu Ning, Scott Paul Lentini, Yihan Wang, David Wen, William C. Shakespeare, Joseph Snodgrass, Tomi K. Sawyer, David C. Dalgarno, R. Mathew Thomas, Xiaotian Zhu, Mohammad Azam, Shuangying Liu, George Q. Daley, Wei-Sheng Huang, Raji Sundaramoorthi, Tim Clackson, Geetha Banda, Qihong Xu, Frank Wang
المصدر: Journal of Medicinal Chemistry. 52:4743-4756
مصطلحات موضوعية: Protein Conformation, Pharmacology, Mice, Structure-Activity Relationship, In vivo, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Proto-Oncogene Proteins c-abl, Protein Kinase Inhibitors, ABL, biology, Kinase, Chemistry, Wild type, Myeloid leukemia, Rats, src-Family Kinases, Purines, Enzyme inhibitor, Drug Design, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, K562 Cells, Proto-oncogene tyrosine-protein kinase Src, K562 cells
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4
المؤلفون: Scott Wardwell, Tomi K. Sawyer, Mark I. Broudy, David C. Dalgarno, Jeffrey A. Keats, Qihong Xu, Yihan Wang, William C. Shakespeare, Geeta Banda, Yaoyu Ning, Tim Clackson, Shuangying Liu, Scott Paul Lentini, Joseph Snodgrass, David Wen, Karin Russian, Sasmita Das, Wei-Sheng Huang, Frank Wang, Xiaotian Zhu, Raji Sundaramoorthi
المصدر: Bioorganicmedicinal chemistry letters. 18(17)
مصطلحات موضوعية: Purine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Purine metabolism, Proto-Oncogene Proteins c-abl, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, ABL, Chemistry, Kinase, Organic Chemistry, Growth Inhibitors, Rats, src-Family Kinases, Purines, Molecular Medicine, K562 Cells, Proto-oncogene tyrosine-protein kinase Src, K562 cells
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المؤلفون: Scott Wardwell, Thomas O'Hare, Tim Clackson, Brian J. Druker, Jeffrey Keats, Qihong Xu, Karin Russian, Victor M. Rivera, John D. Iuliucci, Joseph Snodgrass, Yaoyu Ning, William C. Shakespeare, Amie S. Corbin, Sarah Lamore, Marc Broudy, Frank Wang
المصدر: Blood. 110:1032-1032
مصطلحات موضوعية: ABL, Cell growth, Kinase, Immunology, Imatinib, Cell Biology, Hematology, Pharmacology, Biology, Biochemistry, Dasatinib, Cell killing, In vivo, hemic and lymphatic diseases, medicine, Kinase activity, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::31c95b19df84b8f1952d2e35a94e93bc
https://doi.org/10.1182/blood.v110.11.1032.1032 -
6دورية أكاديمية
المؤلفون: Wei-Sheng Huang, Xiaotian Zhu, Yihan Wang, Mohammad Azam, David Wen, Raji Sundaramoorthi, R. Mathew Thomas, Shuangying Liu, Geetha Banda, Scott P. Lentini, Sasmita Das, Qihong Xu, Jeff Keats, Frank Wang, Scott Wardwell, Yaoyu Ning, Joseph T. Snodgrass, Marc I. Broudy, Karin Russian, George Q. Daley
المصدر: Journal of Medicinal Chemistry; Aug2009, Vol. 52 Issue 15, p4743-4756, 14p