المؤلفون: Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiao-Lan Shen, Tian-Quan Cai, Kashmira Shah, Ester Carballo-Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li-Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea M. Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian K. Jensen, Shirly Pinto

المصدر: Cell Reports Medicine, Vol 1, Iss 4, Pp 100056- (2020)

مصطلحات موضوعية: fibrosis, metabolism, fatty acid oxidation, TGF-β, PGC1α, MK-8722, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379120300720; https://doaj.org/toc/2666-3791

URL الوصول: https://doaj.org/article/063a70c64d8f4793abcfad76e4a93d9a

المؤلفون: David G. McLaren, Lan Yi, Shirly Pinto, Ye Tian, Kristian K. Jensen, Kristine Devito, Elizabeth Smith, Philippe Costet, Iyassu K. Sebhat, Stephen F. Previs, Emanuel Zycband, James Conway, Eric S. Muise, Seongah Han, Yongcheng Huang, Kashmira Shah, Ying Chen, Jason E. Imbriglio, Ji Zhang, Vinit Shah, Peter S. Kutchukian, Haihong Zhou, Tian-Quan Cai, Li-Jun Ma, Yonghua Zhu, Yanqing Kan, Taro E. Akiyama, Ester Carballo-Jane, Maarten Hoek, Xiaolan Shen, Saswata Talukdar, Andrea M. Peier, Ashmita Saigal

المصدر: Cell Reports Medicine
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056-(2020)

مصطلحات موضوعية: TGF-β, AMPK, Male, MK-8722, Pyridines, Phenotypic screening, Peroxisome proliferator-activated receptor, Gene Expression, Biology, Kidney, PPAR, General Biochemistry, Genetics and Molecular Biology, Article, Extracellular matrix, Transcriptome, Rats, Sprague-Dawley, Mice, Downregulation and upregulation, Fibrosis, Transforming Growth Factor beta, PGC1α, medicine, Animals, Humans, Beta oxidation, fatty acid oxidation, Cells, Cultured, chemistry.chemical_classification, MK-4074, lcsh:R5-920, Gene Expression Profiling, fibrosis, Adenylate Kinase, medicine.disease, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Extracellular Matrix, Rats, Mice, Inbred C57BL, chemistry, Organ Specificity, Cancer research, Benzimidazoles, lcsh:Medicine (General), metabolism, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdffc0cd9c8343fd1d503ee93abf772
http://europepmc.org/articles/PMC7659620

المؤلفون: O. Reardon, Christopher Sampson, John A. Schneider, Brendan Mulhern, R. Addo, Bert Janssen, Michael Herdman, Kashmira Shah, Kevin R. Page, M. Rodes Sanchez, P. Haywood, C. Thetford

المصدر: Value in Health. 22:S733

مصطلحات موضوعية: EQ-5D, Health Policy, Public Health, Environmental and Occupational Health, Cognition, Psychology, Cognitive psychology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f05fe3fa1e94093b25c99c3ec66b53a3
https://doi.org/10.1016/j.jval.2019.09.1759

المؤلفون: Eric S. Muise, Yanqing Kan, Stephen F. Previs, Li-Jun Ma, James Conway, Haihong Zhou, Vinit Shah, Yonghua Zhu, Peter S. Kutchukian, Yongcheng Huang, David G. McLaren, Ji Zhang, Shirly Pinto, Emanuel Zycband, Kristine Devito, Ying Chen, Jason E. Imbriglio, Maarten Hoek, Philippe Costet, Taro E. Akiyama, Elizabeth Smith, Tian-Quan Cai, Lan Yi, Ye Tian, Andrea M. Peier, Xiaolan Shen, Kashmira Shah

المصدر: SSRN Electronic Journal.

مصطلحات موضوعية: chemistry.chemical_classification, Angiotensin receptor, Fatty acid metabolism, business.industry, AMPK, Peroxisome proliferator-activated receptor, medicine.disease, Extracellular matrix, Transcriptome, chemistry.chemical_compound, chemistry, Fibrosis, Renal fibrosis, Cancer research, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a862d77b124f269e5f18774971616ae
https://doi.org/10.2139/ssrn.3209457

المؤلفون: Lee-Yuh Pai, Yuping Zhu, Richard Visconti, Xiaoyan Zhou, John P. Felix, Melba Hernandez, Jing Chen, Michael Margulis, Nardos Teumelsan, Sophie Roy, Kathleen A. Sullivan, Jessica Liu, Joseph M. Metzger, Aaron Corona, Gregory J. Kaczorowski, Maria L. Garcia, Lihu Yang, Shawn P. Walsh, Birgit T. Priest, Alexander Pasternak, Caryn Hampton, Emma R. Parmee, Vincent Tong, Brande Thomas-Fowlkes, Haifeng Tang, Magdalena Alonso-Galicia, Kashmira Shah, Michael J. Forrest, Richard M. Brochu, Ross Bentley, Sookhee Ha, Karen Owens, Aurash Shahripour, Andrew M. Swensen, Jessica Frie, Adam B. Weinglass, Timothy Bailey

المصدر: ACS Medicinal Chemistry Letters. 6:747-752

مصطلحات موضوعية: Pharmacokinetics, Chemistry, Pharmacodynamics, Organic Chemistry, Drug Discovery, ROMK, Pharmacology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c1f32ec6c3f7a915fe446fd2867a1
https://doi.org/10.1021/ml500440u

المؤلفون: Gloria C. Koo, Martin S. Springer, Lorraine Malkowitz, Douglas W. Kawka, Kang Cheng, Qi Luo, Serguei Stepaniants, Kenneth K. Wu, Irwin I. Singer, Jeffrey Yuan, Andrew S. Plump, Cheryl B. Le Grand, Jun Zhu, Milana Maletic, Samuel D. Wright, James M. Balkovec, Gloria J.-F. Ding, Sherman T. Waddell, Xia Yang, Rolf Thieringer, Kashmira Shah, Pek Yee Lum, Mingjuan Jane Luo, I-Ming Wang, Anne Hermanowski-Vosatka

المصدر: Physiological Genomics. 45:47-57

مصطلحات موضوعية: Vasculitis, Physiology, Genes, MHC Class II, 11β hsd1, Dehydrogenase, Laser Capture Microdissection, Biology, Proinflammatory cytokine, Mice, Apolipoproteins E, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Gene expression, Genetics, medicine, Animals, Enzyme Inhibitors, Glucocorticoids, Mice, Knockout, Gene Expression Profiling, Atherosclerosis, Microarray Analysis, medicine.disease, Lipids, Gene expression profiling, Cholesterol, Gene Expression Regulation, Immunology, Etiology, Metabolic syndrome, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62219a7783ded2299858a49a0cadc560
https://doi.org/10.1152/physiolgenomics.00109.2012

المؤلفون: Haifeng Tang, Kashmira Shah, Maria L. Garcia, Alexander Pasternak, Magdalena Alonso-Galicia, Brande Thomas-Fowlkes, Cordelia Rasa, Joseph M. Metzger, Sophie Roy, Lee-Yuh Pai, Jessica Liu, Olga Price, Vince Tong, Birgit T. Priest, Gregory J. Kaczorowski, James D. Ormes, Charles Gill, Aaron Corona, John P. Felix, Jianying Xiao, Kathleen A. Sullivan, Karen Owens, Caryn Hampton, Xiaoyan Zhou, Martin Köhler

المصدر: The Journal of pharmacology and experimental therapeutics. 359(1)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Diuresis, Tetrazoles, Blood Pressure, Pharmacology, Bartter syndrome, Piperazines, Natriuresis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Internal medicine, medicine, Potassium Channel Blockers, Animals, Humans, Potassium Channels, Inwardly Rectifying, Benzofurans, Aldosterone, Dose-Response Relationship, Drug, Chemistry, Biphenyl Compounds, Bartter Syndrome, Potassium channel blocker, Drug Synergism, medicine.disease, Rats, Bartter's syndrome, 030104 developmental biology, Endocrinology, HEK293 Cells, Hydrochlorothiazide, Phenotype, 030220 oncology & carcinogenesis, Kaliuresis, ROMK, Molecular Medicine, Benzimidazoles, Female, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a55d5d0f3672edd7db9d025d76d0fd
https://pubmed.ncbi.nlm.nih.gov/27432892

المؤلفون: Divya Kharbanda, Gina M. Santorelli, Jianying Xiao, Hratch J. Zokian, Mitree M. Ponpipom, Steven S. Mundt, Anne Hermanowski-Vosatka, Susan D. Aster, Donald W. Graham, Samuel D. Wright, James M. Balkovec, Gool F. Patel, Kashmira Shah, Rolf Thieringer, Marty S. Springer, Michael J. Szymonifka

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:2799-2804

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Nitro compound, Pharmaceutical Science, Dehydrogenase, Hydrocarbons, Aromatic, Biochemistry, Chemical synthesis, Sulfone, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, 11β-hydroxysteroid dehydrogenase type 1, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, Animals, Hypoglycemic Agents, Enzyme Inhibitors, Molecular Biology, Metabolic Syndrome, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, Triazoles, Disease Models, Animal, Enzyme, Models, Chemical, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40c1a0b59a6be6d9abd5ff2d5f9ef6b
https://doi.org/10.1016/j.bmcl.2008.04.010

المؤلفون: Kang Cheng, Matthias Strowski, Jianying Xiao, Tsuei-Ju Wu, Ning Ren, Nancy Robertson, Martin S. Springer, Kenneth K. Wu, Zhihua Li, James M. Balkovec, Melba Hernandez, Howard Y. Chen, Cheryl B. Le Grand, Bill Pikounis, Anne Hermanowski-Vosatka, Joseph M. Metzger, Samuel D. Wright, Steven H. Olson, Alison M. Strack, Gloria C. Koo, Steven S. Mundt, Rolf Thieringer, Heather Noonan, Kashmira Shah, James M. Schaeffer, Christian N. Nunes, Bei B. Zhang

المصدر: The Journal of Experimental Medicine

مصطلحات موضوعية: Apolipoprotein E, Blood Glucose, Male, medicine.medical_specialty, Hydrocortisone, Arteriosclerosis, medicine.medical_treatment, Immunology, Adamantane, Type 2 diabetes, Glucagon, Article, chemistry.chemical_compound, Mice, Insulin resistance, 11β-hydroxysteroid dehydrogenase type 1, Internal medicine, 11-beta-Hydroxysteroid Dehydrogenase Type 1, medicine, Immunology and Allergy, Animals, Insulin, Enzyme Inhibitors, Aorta, Triglycerides, Mice, Knockout, Mice, Inbred ICR, biology, Cholesterol, Fatty Acids, Azepines, Syndrome, Triazoles, medicine.disease, Cortisone, Enzyme Activation, Disease Models, Animal, Endocrinology, chemistry, biology.protein, Diet, Atherogenic, Metabolic syndrome, Insulin Resistance, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2100c617c4f08e8bc6b622a8ee436ebe
http://europepmc.org/articles/PMC2212859

المؤلفون: Gloria C. Koo, Laurie A. Castonguay, Mary Jo Staruch, Randal M. Bugianesi, John P. Felix, George A. Doss, Robert S. Slaughter, Marty S. Springer, Andrew Kotliar, Sookhee Ha, Kathleen M. Rupprecht, William H. Parsons, Gregory J. Kaczorowski, Kashmira Shah, Shouwu Miao, Jianming Bao, Maria L. Garcia, Frank Kayser, Robert K. Baker

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:447-451

مصطلحات موضوعية: Models, Molecular, Stereochemistry, T-Lymphocytes, T cell, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Potassium Channel Blockers, medicine, Humans, Channel blocker, Molecular Biology, Cell Proliferation, Kv1.3 Potassium Channel, Natural product, Cell growth, Organic Chemistry, Triterpenes, Potassium channel, In vitro, medicine.anatomical_structure, chemistry, Potassium Channels, Voltage-Gated, Molecular Medicine, Biological Assay, Ion Channel Gating, Enone, Immunosuppressive Agents, Ion channel blocker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b217212f1114b7e5c9d40397d6232c7
https://doi.org/10.1016/j.bmcl.2004.10.058