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المؤلفون: Katharina Brotzmann, Sylvia E. Escher, Paul Walker, Thomas Braunbeck
المصدر: Archives of Toxicology. 96:3033-3051
مصطلحات موضوعية: Mammals, Embryo, Nonmammalian, Molecular Structure, Valproic Acid, Health, Toxicology and Mutagenesis, Reproducibility of Results, General Medicine, Toxicology, Rats, Mice, Pharmaceutical Preparations, Toxicity Tests, Acute, Animals, Humans, Anticonvulsants, Child, Water Pollutants, Chemical, Zebrafish
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المؤلفون: Frédéric Y. Bois, Ciarán Fisher, Ségolène Siméon, Iain Gardner, Katharina Brotzmann, Thomas Braunbeck, Steve Silvester, Richard Maclennan, Paul Walker
المصدر: Reproductive Toxicology. 98:300-303
مصطلحات موضوعية: Valproic Acid, Physiologically based pharmacokinetic modelling, medicine, Developmental toxicity, Zebrafish embryo, Pharmacology, Biology, Toxicology, medicine.drug
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المؤلفون: Alejandro Aguayo-Orozco, Liliana Capinha, Nazanin Golbamaki, Enrico Mombelli, Matthias Wehr, Bart van der Burg, Daria Goldmann, Nanette G Vrijenhoek, Thomas Exner, Richard Maclennan, Katharina Brotzmann, Ulf Norinder, Oliver Hatley, Alice Limonciel, Thomas Braunbeck, Sylvia Escher, Barbara Zdrazil, Frédéric Y. Bois, Paul Jennings, Emilio Benfenati, Domenico Gadaleta, Jose Castel, Ciarán Fisher, Sankalp Jain, Anthony Long, Rabea Graepel, Laia Tolosa, Andrew White, Bob van de Water, Barbara M.A. van Vugt-Lussenburg, Paul Walker, Annette Bitsch, Olivier Taboureau, Iain Gardner
المساهمون: AIMMS, Molecular and Computational Toxicology, Publica
المصدر: Toxicology in Vitro, 79:105269, 1-16. Elsevier Limited
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269, pp. 1-16 . https://doi.org/10.1016/j.tiv.2021.105269
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269 . https://doi.org/10.1016/j.tiv.2021.105269
Toxicology in Vitro
Toxicology In Vitro, 79مصطلحات موضوعية: Test strategy, Mechanistic hazard assessment, Adverse Outcome Pathways, Computer science, In silico, Gene Expression Profiling, Liver steatosis, Carboxylic Acids, General Medicine, Computational biology, Toxicology, AOP-network, Fatty Liver, Differentially expressed genes, Workflow, Action (philosophy), NAM, Read-across, Adverse Outcome Pathway, Animals, Humans, Computer Simulation, Zebrafish
وصف الملف: application/pdf
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المساهمون: Institut National de l'Environnement Industriel et des Risques (INERIS), Stress Environnementaux et BIOsurveillance des milieux aquatiques (SEBIO), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Reims Champagne-Ardenne (URCA)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Institut National de l'Environnement Industriel et des Risques (INERIS), Centre for Organismal Studies [Heidelberg] (COS), Heidelberg University, Certara UK Limited
المصدر: Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2021, 414, pp.115424
HALمصطلحات موضوعية: 0301 basic medicine, Embryo, Nonmammalian, animal structures, Multistate model, Developmental toxicity, Toxicology, Models, Biological, Andrology, 03 medical and health sciences, 0302 clinical medicine, Toxicity Tests, Acute, Animals, Computer Simulation, Zebrafish, Survival analysis, Pharmacology, [STAT.AP]Statistics [stat]/Applications [stat.AP], biology, Dose-Response Relationship, Drug, Hatching, Valproic Acid, Abnormalities, Drug-Induced, Embryo, Bayes Theorem, Numerical Analysis, Computer-Assisted, biology.organism_classification, Acute toxicity, Toxicokinetics, 030104 developmental biology, Teratogens, 030220 oncology & carcinogenesis, Dose-response analysis, Toxicity, embryonic structures, Piecewise, Malformations, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, Zebrafish embryo
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المؤلفون: Dinant Kroese, Andre Wolterbeek, Katharina Brotzmann, Thomas Braunbeck
المصدر: Archives of Toxicology
مصطلحات موضوعية: 0301 basic medicine, Embryo, Nonmammalian, animal structures, Analogues, Health, Toxicology and Mutagenesis, Neurotoxins, Danio, Context (language use), Ecotoxicology, Toxicology, Models, Biological, Organ Toxicity and Mechanisms, Lethal Dose 50, Andrology, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Correlation fish/mouse, Morphogenesis, Toxicity Tests, Acute, Neurotoxicity, medicine, Animals, Zebrafish, Neural tube defects, Valproic Acid, biology, Neural tube, Embryo, General Medicine, biology.organism_classification, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Neurodevelopmental Disorders, embryonic structures, Toxicity, 030217 neurology & neurosurgery, medicine.drug
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المصدر: Environmental Sciences Europe
مصطلحات موضوعية: 0303 health sciences, biology, Developmental toxicity, Danio, Embryo, 010501 environmental sciences, biology.organism_classification, Bioinformatics, 01 natural sciences, Pollution, Fish embryo, Acute toxicity, 03 medical and health sciences, Toxicity, Adverse effect, Zebrafish, 030304 developmental biology, 0105 earth and related environmental sciences
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المؤلفون: Thomas Braunbeck, Katharina Brotzmann, Rebecca von Hellfeld
المصدر: Reproductive Toxicology. 88:22
مصطلحات موضوعية: biology, Danio, Mammal, Embryo, Toxicology, biology.organism_classification, Zebrafish, Cell biology
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المؤلفون: Thomas Braunbeck, Ségolène Siméon, Paul Walker, Iain Gardner, Katharina Brotzmann, Steve Silvester, Richard Maclennan, Frédéric Y. Bois, Ciarán Fisher
المساهمون: Institut National de l'Environnement Industriel et des Risques (INERIS), Heidelberg University, Simcyp Division [UK], Certara UK Limited, Cyprotex PLC
المصدر: Reproductive Toxicology
Reproductive Toxicology, Elsevier, 2020, 93, pp.219-229. ⟨10.1016/j.reprotox.2020.02.010⟩مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, Embryo, Nonmammalian, DANIO RERIO, Bayesian inference, Developmental toxicity, Danio, 010501 environmental sciences, Pharmacology, Toxicology, 01 natural sciences, Models, Biological, TOXICITY, 03 medical and health sciences, BAYESIAN, DEVELOPMENT, Pharmacokinetics, VALPROIC ACID, Animals, Dosing, ZEBRAFISH EMBRYO, Zebrafish, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, biology, Chemistry, Embryo, biology.organism_classification, EFFECT CONCENTRATION, INTERNAL CONCENTRATION, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Toxicity, Anticonvulsants, PBPK MODEL
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa25d38cbc767a01c5f184b3c407a2f
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