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المؤلفون: Sam T. Chao, Yufen Zhao, Katherine A. Rouleau, Zheng Yang, Henry H. Gu, Catherine A. Fleener, Zhongqi Shen, Jeffrey A. Robl, Kim W. McIntyre, Edwin J. Iwanowicz, Mark R. Witmer, Scott H. Watterson, Arvind Mathur, Bang-Chi Chen, Mary T. Obermeier, and Robert Townsend, Donna M. Dambach, T. G. Murali Dhar, Zili Xiao, Joel C. Barrish, Shelley K. Ballentine, David J. Shuster, Ping Chen
المصدر: Journal of Medicinal Chemistry. 50:3730-3742
مصطلحات موضوعية: Male, Administration, Oral, Biological Availability, Guanosine, Pharmacology, Mycophenolate, Piperazines, Mycophenolic acid, Cell Line, Arthritis, Rheumatoid, Structure-Activity Relationship, chemistry.chemical_compound, IMP Dehydrogenase, IMP dehydrogenase, Drug Discovery, medicine, Animals, Humans, Inosine-5′-monophosphate dehydrogenase, Cell Proliferation, biology, Stereoisomerism, Prodrug, Arthritis, Experimental, Rats, Gastrointestinal Tract, Acridone, Macaca fascicularis, chemistry, Biochemistry, Rats, Inbred Lew, Enzyme inhibitor, Leukocytes, Mononuclear, biology.protein, Acridines, Molecular Medicine, Half-Life, medicine.drug
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2
المؤلفون: Robert M. Townsend, Zhongqi Shen, Catherine A. Fleener, Derek J. Norris, Scott H. Watterson, Henry H. Gu, Ping Chen, Diane Hollenbaugh, T. G. Murali Dhar, Joel C. Barrish, Shelley K. Ballentine, Edwin J. Iwanowicz, Katherine A. Rouleau
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:3557-3560
مصطلحات موضوعية: Indoles, Guanine, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Catalysis, Structure-Activity Relationship, chemistry.chemical_compound, IMP Dehydrogenase, IMP dehydrogenase, Drug Discovery, medicine, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Small molecule, Kinetics, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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3
المؤلفون: Catherine A. Fleener, Henry H. Gu, Daniel L. Cheney, Edwin J. Iwanowicz, Robert M. Townsend, Ping Chen, Katherine A. Rouleau, Junqing Guo, T. G. Murali Dhar, William J. Pitts, Diane Hollenbaugh, Scott H. Watterson, Zhongqi Shen
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:2059-2063
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, T-Lymphocytes, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Lymphocyte Activation, Biochemistry, Chemical synthesis, Cell Line, Inhibitory Concentration 50, Structure-Activity Relationship, Cricetulus, IMP Dehydrogenase, IMP dehydrogenase, Cricetinae, Drug Discovery, medicine, Animals, Structure–activity relationship, Moiety, Enzyme Inhibitors, Oxazoles, Molecular Biology, chemistry.chemical_classification, biology, Bicyclic molecule, Chemistry, Phenylurea Compounds, Organic Chemistry, Mycophenolic Acid, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Carbamates
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المؤلفون: Edwin J. Iwanowicz, Kristin D. Haslow, Donna A. Bassolino, Derek J. Norris, Robert M. Townsend, Daniel L. Cheney, Joel C. Barrish, William J. Pitts, Scott H. Watterson, Katherine A. Rouleau, Catherine A. Fleener, T. G. Murali Dhar, Diane Hollenbaugh, Ping Chen
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:1345-1348
مصطلحات موضوعية: Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Chemical synthesis, IMPDH Inhibitors, Structure-Activity Relationship, chemistry.chemical_compound, IMP Dehydrogenase, IMP dehydrogenase, Drug Discovery, Escherichia coli, Humans, Potency, Enzyme Inhibitors, Isoquinoline, Oxazoles, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Isoquinolines, NAD, In vitro, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine
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5
المؤلفون: Marianne Carlsen, Daniel L. Cheney, Junqing Guo, John S. Chorba, Robert M. Townsend, Edwin J. Iwanowicz, Henry H. Gu, Mark R. Witmer, Derek J. Norris, Katherine A. Rouleau, Zhongqi Shen, William J. Pitts, Diane Hollenbaugh, Scott H. Watterson, T. G. Murali Dhar, Catherine A. Fleener, Ping Chen
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:543-546
مصطلحات موضوعية: chemistry.chemical_classification, biology, Bicyclic molecule, medicine.drug_class, Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Quinolone, Biochemistry, Small molecule, Chemical synthesis, In vitro, Enzyme, Enzyme inhibitor, IMP dehydrogenase, Drug Discovery, medicine, biology.protein, Molecular Medicine, Molecular Biology
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6
المؤلفون: Edwin J. Iwanowicz, Henry Gu, N.Z. Sherbina, Joel C. Barrish, T. G. Murali Dhar, Catherine A. Fleener, Katherine A. Rouleau, Chunjian Liu, Junquing Guo, William J. Pitts, Scott H. Watterson, Diane Hollenbaugh
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:3125-3128
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, In Vitro Techniques, Ligands, Biochemistry, Chemical synthesis, Structure-Activity Relationship, IMP Dehydrogenase, Heterocyclic Compounds, IMP dehydrogenase, Drug Discovery, Humans, Moiety, Lymphocytes, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Stereoisomerism, Small molecule, In vitro, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Indicators and Reagents
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7
المؤلفون: N.Z. Sherbina, Chunjian Liu, Diane Hollenbaugh, Katherine A. Rouleau, Toomas Mitt, Scott H. Watterson, Joel C. Barrish, Katerina Leftheris, Henry H. Gu, Catherine A. Fleener, Edwin J. Iwanowicz
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:2931-2934
مصطلحات موضوعية: Guanine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, IMP Dehydrogenase, IMP dehydrogenase, Drug Discovery, Humans, Enzyme Inhibitors, Guanidine, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, biology, Organic Chemistry, Small molecule, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Indicators and Reagents
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8
المؤلفون: T G Murali, Dhar, Zhongqi, Shen, Junqing, Guo, Chunjian, Liu, Scott H, Watterson, Henry H, Gu, William J, Pitts, Catherine A, Fleener, Katherine A, Rouleau, N Z, Sherbina, Kim W, McIntyre, David J, Shuster, Mark R, Witmer, Jeffrey A, Tredup, Bang-Chi, Chen, Rulin, Zhao, Mark S, Bednarz, Daniel L, Cheney, John F, MacMaster, Laura M, Miller, Karen K, Berry, Timothy W, Harper, Joel C, Barrish, Diane L, Hollenbaugh, Edwin J, Iwanowicz
المصدر: Journal of Medicinal Chemistry. 45:2127-2130
مصطلحات موضوعية: Male, Purine, Stereochemistry, Morpholines, Enzyme-Linked Immunosorbent Assay, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, IMP Dehydrogenase, In vivo, IMP dehydrogenase, Drug Discovery, Animals, Structure–activity relationship, Nucleotide, Enzyme Inhibitors, Oxazoles, chemistry.chemical_classification, Mice, Inbred BALB C, biology, Mycophenolic Acid, Arthritis, Experimental, Rats, De novo synthesis, Biochemistry, chemistry, Rats, Inbred Lew, Enzyme inhibitor, Antibody Formation, biology.protein, Molecular Medicine
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المؤلفون: Philip M. Wallace, John F. MacMaster, Katherine A. Rouleau, T. Joseph Brown, James K. Loy, Karen L. Donaldson, Alan F. Wahl
المصدر: The Journal of Immunology. 162:5547-5555
مصطلحات موضوعية: Immunology, Immunology and Allergy
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::73dcb1d36adf8f331b20e5ab7a9fa889
https://doi.org/10.4049/jimmunol.162.9.5547 -
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المؤلفون: Daniel L. Cheney, Diane Hollenbaugh, Robert M. Townsend, Scott H. Watterson, Shelley K. Ballentine, Joel C. Barrish, Katherine A. Rouleau, Edwin J. Iwanowicz, Zhongqi Shen, Catherine A. Fleener, T. G. Murali Dhar
المصدر: Bioorganicmedicinal chemistry letters. 13(7)
مصطلحات موضوعية: Indoles, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Quinolones, Biochemistry, Aldehyde, Chemical synthesis, Structure-Activity Relationship, Glucuronides, IMP Dehydrogenase, IMP dehydrogenase, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Indole test, biology, Bicyclic molecule, Hydrogen bond, Organic Chemistry, Hydrogen Bonding, Stereoisomerism, Isoenzymes, Enzyme, chemistry, Enzyme inhibitor, Immune System, biology.protein, Molecular Medicine, Mitogens, Cell Division
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