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1
المؤلفون: E. Michael August, Lana Louise Smith Keenan, Jun Li, S. Mariana Margarit, Alexander Heim-Riether, Hans-Dieter Junker, Kathleen Haverty, Neil A. Farrow, Brandon Collins, Bennett T. Farmer, Thomas Neumann, Shuang Liang, John R. Proudfoot, Renate Sekul, Qiang Zhang, Donghong Amy Gao, Steven John Taylor, Zhaoming Xiong, Neil Moss, Melissa Hill-Drzewi
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:5321-5324
مصطلحات موضوعية: Models, Molecular, Matrix metalloproteinase inhibitor, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Matrix Metalloproteinase Inhibitors, Biochemistry, Structure-Activity Relationship, Catalytic Domain, Matrix Metalloproteinase 13, Drug Discovery, medicine, Potency, Structure–activity relationship, Protease Inhibitors, Molecular Biology, Chelating Agents, chemistry.chemical_classification, biology, Organic Chemistry, Active site, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Selectivity, Protein Binding
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2
المؤلفون: Neil Moss, Racheline Schwartz, Erick R. R. Young, Michael J. Burke, Eugene R. Hickey, Matthew R. Netherton, Raj Nagaraja, Yancey David Ward, Alexander Heim-Riether, Kathleen Haverty, Derek Cogan, Daw-Tsun Shih, Philip D. Ramsden, Qing Zhang, Gao Donghong A, Zhaoming Xiong, Kathy O’Shea
المصدر: Bioorganicmedicinal chemistry letters. 22(23)
مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Triazole, Pharmaceutical Science, Thiophenes, Metabolic stability, Triazoles, Biochemistry, Amides, Cathepsins, chemistry.chemical_compound, Structure-Activity Relationship, Amide, Drug Discovery, Microsomes, Liver, Molecular Medicine, Humans, Protease Inhibitors, Molecular Biology, Cathepsin S, Half-Life, Protein Binding
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3
المؤلفون: Shuang Liang, Kathleen Haverty, Donghong Amy Gao, Jun Li, Xiang Li, Sabine Schlyer, Alexander Heim-Riether, Melissa Hill-Drzewi, Steven John Taylor, Steluta Mariana Margarit, Lana Louise Smith Keenan, Neil Moss, Nelamangala V. Nagaraja, Xianhua Cao, Dieter Wiedenmayer, Neil A. Farrow, Kyle E. Harrington, Brandon Collins, E. Michael August, Leonard Ciccarelli, Rene Roman, Bernd Wellenzohn, Zhaoming Xiong, Laura Amodeo, John R. Proudfoot
المصدر: Bioorganicmedicinal chemistry letters. 20(17)
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Matrix Metalloproteinase Inhibitors, Biochemistry, Chemical synthesis, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Chelation, Protease Inhibitors, Molecular Biology, Chelating Agents, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Zinc, Enzyme, Enzyme inhibitor, Lipophilicity, biology.protein, Molecular Medicine, Selectivity