المؤلفون: Kathleen Keatley, Samuel Stromei-Cleroux, Tammy Wiltshire, Nina Rajala, Gary Burton, William V. Holt, D. Timothy J. Littlewood, Andrew G. Briscoe, Josephine Jung, Keyoumars Ashkan, Simon J. Heales, Geoffrey J. Pilkington, Brigitte Meunier, John E. McGeehan, Iain P. Hargreaves, Rhiannon E. McGeehan

المصدر: International Journal of Molecular Sciences, Vol 20, Iss 13, p 3364 (2019)

مصطلحات موضوعية: glioblastoma, mtDNA, mutation, mitochondria, OXPHOS, ROS, CoQ10, prognosis, clomipramine, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1422-0067/20/13/3364; https://doaj.org/toc/1422-0067

URL الوصول: https://doaj.org/article/0099cc077a444987ab0fa88885d12c8e

المؤلفون: Tammy Wiltshire, Gary Burton, D. Timothy J. Littlewood, Simon Heales, Josephine Jung, Keyoumars Ashkan, John McGeehan, Nina Rajala, Geoffrey J. Pilkington, Kathleen Keatley, William V. Holt, Samuel Stromei-Cleroux, Brigitte Meunier, Andrew G. Briscoe, Rhiannon E. McGeehan, Iain P. Hargreaves

المساهمون: Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Biogenèse et fonctionnement des complexes OXPHOS mitochondriaux (BIOMIT), Département Biologie Cellulaire (BioCell), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

المصدر: Keatley, K, Stromei-Cleroux, S, Wiltshire, T, Rajala, N K M, Burton, G D, Holt, W V, Littlewood, D T J, Briscoe, A G, Jung, J, Ashkan, K, Heales, S J, Pilkington, G, Meunier, B, McGeehan, J, Hargreaves, I & Lloyd, R 2019, ' Integrated approach reveals role of mitochondrial germ-line mutation F18L in respiratory chain, oxidative alterations, drug sensitivity, and patient prognosis in glioblastoma ', International Journal of Molecular Sciences, vol. 20, no. 13, 3364 . https://doi.org/10.3390/ijms20133364
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2019, 20 (13), ⟨10.3390/ijms20133364⟩
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3364 (2019)
Volume 20
Issue 13
International Journal of Molecular Sciences, 2019, 20 (13), ⟨10.3390/ijms20133364⟩

مصطلحات موضوعية: Male, Ubiquinone, [SDV]Life Sciences [q-bio], Respiratory chain, Kaplan-Meier Estimate, Mitochondrion, medicine.disease_cause, lcsh:Chemistry, 0302 clinical medicine, Medicine, lcsh:QH301-705.5, clomipramine, Spectroscopy, 0303 health sciences, Mutation, mtDNA, ROS, General Medicine, OXPHOS, 3. Good health, Computer Science Applications, mitochondria, Mitochondrial respiratory chain, 030220 oncology & carcinogenesis, Biomarker (medicine), Oxidation-Reduction, Mitochondrial DNA, RM, DNA, Mitochondrial, Catalysis, Article, Inorganic Chemistry, RC0254, 03 medical and health sciences, Germline mutation, Humans, Physical and Theoretical Chemistry, Molecular Biology, neoplasms, Germ-Line Mutation, 030304 developmental biology, business.industry, Organic Chemistry, glioblastoma, CoQ10, lcsh:Biology (General), lcsh:QD1-999, Coenzyme Q – cytochrome c reductase, Cancer research, prognosis, mutation, business, Reactive Oxygen Species, Glioblastoma

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df3023dbe4ac9f53e0ac4db645bc3b0
https://researchportal.port.ac.uk/portal/en/publications/integrated-approach-reveals-role-of-mitochondrial-germline-mutation-f18l-in-respiratory-chain-oxidative-alterations-drug-sensitivity-and-patient-prognosis-in-glioblastoma(03b1669a-dc97-4eb5-9449-1d94bf97b60c).html

المؤلفون: Diana Eccles, Kathleen Keatley, Qian An, Rhiannon E. McGeehan, Lewis A. Cockram, D. Timothy J. Littlewood

المصدر: Lloyd, R, Cockram, L A, Littlewood, T J, Keatley, K, Eccles, D M & An, Q 2018, ' Deep sequencing reveals the mitochondrial DNA variation landscapes of breast-to-brain metastasis blood samples ', Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis, vol. 29, no. 5, pp. 703-713 . https://doi.org/10.1080/24701394.2017.1350950

مصطلحات موضوعية: Adult, 0301 basic medicine, Mitochondrial DNA, 3D protein structural mapping and analysis, Breast Neoplasms, Biology, DNA, Mitochondrial, Oxidative Phosphorylation, Deep sequencing, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, breast cancer, Genetics, medicine, Humans, Neoplasm Invasiveness, Amino Acid Sequence, Neoplasm Metastasis, breast-to-brain metastasis, Molecular Biology, OXPHOS and long PCR, mtDNA, Brain, Genetic Variation, High-Throughput Nucleotide Sequencing, medicine.disease, Mitochondria, 030104 developmental biology, 030220 oncology & carcinogenesis, Genome, Mitochondrial, Mutation, Immunology, Cancer research, Female, Sanctuary site, Brain metastasis

وصف الملف: application/pdf; text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2adf85e2a8ca4f3092a426147c4d30a0

المؤلفون: Stavros Polyzoidis, Helen L. Fillmore, Qian An, John McGeehan, Keyoumars Ashkan, Katie F. Stephenson, Geoffrey J. Pilkington, Samantha C. Higgins, D. Timothy J. Littlewood, Kathleen Keatley, Rhiannon E. Lloyd, William V. Holt, Brigitte Meunier

المساهمون: Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Biogenèse et fonctionnement des complexes OXPHOS mitochondriaux (BIOMIT), Département Biologie Cellulaire (BioCell), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

المصدر: Neuro-Oncology
Neuro-Oncology, 2015, 17 (7), pp.942--952. ⟨10.1093/neuonc/nov020⟩
Lloyd, R, Keatley, K, Littlewood, D T J, Meunier, B, Holt, W V, An, Q, Higgins, S C, Polyzoidis, S, Stephenson, K F, Ashkan, K, Fillmore, H L, Pilkington, G J & Mcgeehan, J E 2015, ' Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma ', Neuro-Oncology, vol. 17, no. 7, pp. 942-952 . https://doi.org/10.1093/neuonc/nov020

مصطلحات موضوعية: Nonsynonymous substitution, Male, Cancer Research, [SDV]Life Sciences [q-bio], APC-PAID, Pharmacy, Mitochondrion, medicine.disease_cause, Genome, mitochondrial DNA (mtDNA) mutation, Electron Transport Complex III, 0302 clinical medicine, EPRC, Genetics, 0303 health sciences, education.field_of_study, Mutation, Brain Neoplasms, Middle Aged, Heteroplasmy, 3. Good health, Mitochondrial, Molecular Docking Simulation, Mitochondrial respiratory chain, Oncology, functional prediction, 030220 oncology & carcinogenesis, Basic and Translational Investigations, Female, subgrouping, Adult, Mitochondrial DNA, Adolescent, Population, Biology, DNA, Mitochondrial, Electron Transport Complex IV, 03 medical and health sciences, medicine, Humans, EP/E500595/1, structural analysis, education, 030304 developmental biology, Aged, glioblastoma, RCUK, DNA, Neurology (clinical)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3450abff905154ff416e4391c1877e40
https://hal.science/hal-02397513

المؤلفون: Stavros Polyzoidis, Rhiannon E. Lloyd, Kathleen Keatley, Keyoumars Ashkan, Geoffrey J. Pilkington, Iain P. Hargreaves, John McGeehan, Helen L. Fillmore, Stephanie Lurshay, Brigitte Meunier

المصدر: Neuro-Oncology. 18:vi82-vi82

مصطلحات موضوعية: Drug, Cancer Research, Mitochondrial DNA, media_common.quotation_subject, Biology, medicine.disease, Molecular biology, In vitro, Oncology, medicine, Neurology (clinical), Sensitivity (control systems), media_common, Glioblastoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::57b188eeedd82d0847f53ce06e1fec7a
https://doi.org/10.1093/neuonc/now212.344

المؤلفون: Kathleen Keatley, Iain P. Hargreaves, Geoffrey J. Pilkington, Rhiannon E. Lloyd, Keyoumars Ashkan, Helen L. Fillmore, Simon Heales, Stavros Polyzoidis, John McGeehan

المصدر: Neuro-Oncology. 17:viii10.5-viii11

مصطلحات موضوعية: Genetics, chemistry.chemical_classification, Cancer Research, Mutation, Mitochondrial DNA, Protein subunit, Biology, medicine.disease_cause, Molecular biology, Abstracts, Enzyme, Mitochondrial respiratory chain, Oncology, chemistry, Cell culture, Coenzyme Q – cytochrome c reductase, medicine, Neurology (clinical), Inner mitochondrial membrane

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600317ae19ac9a8cd3dd42380ebdbaf0
https://doi.org/10.1093/neuonc/nov284.51

المؤلفون: Keyoumars Ashkan, Anaïs Laleve, John McGeehan, Stavros Polyzoidis, Simon Heales, Geoffrey J. Pilkington, Brigitte Meunier, Iain P. Hargreaves, Helen L. Fillmore, Samantha C. Higgins, Rhiannon E. Lloyd, Kathleen Keatley

المصدر: Cancer Research. 75:3042-3042

مصطلحات موضوعية: Genetics, Cancer Research, Oncology, medicine, Integrated approach, Biology, medicine.disease, Mitochondrial mutation, Glioblastoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a02f8cb1fcc8822326b40838819ab6c7
https://doi.org/10.1158/1538-7445.am2015-3042

المؤلفون: Rhiannon E. Lloyd, Geoff Pilkington, D.J. Littlewood, Helen L. Fillmore, Qian An, William V. Holt, John McGeehan, Kathleen Keatley, Samantha C. Higgins

المصدر: Neuro-Oncology. 16:ii99-ii99

مصطلحات موضوعية: Genetics, Cancer Research, Mitochondrial DNA, Temozolomide, Cost effectiveness, Respiratory chain, Cancer, Biology, medicine.disease, Heteroplasmy, DNA sequencing, law.invention, Poster Presentations, Oncology, law, medicine, Neurology (clinical), Polymerase chain reaction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e17c73623ce1c8bff2a36886d75ac22
https://doi.org/10.1093/neuonc/nou174.380