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1
المؤلفون: Kathleen W. Mosure, Michele Matchett, Ronald J. Knox, Richard E. Olson, Joanne J. Bronson, Nicholas A. Meanwell, Matthew G. Soars, Linda J. Bristow, Ramkumar Rajamani, James Herrington, Amy Easton, Digavalli V. Sivarao, Dawn D. Parker, Rick L. Pieschl, Ping Chen, Guanglin Luo, Omar S. Barnaby, Lorin A. Thompson, Yong-Jin Wu, Andrea McClure, Jason M. Guernon, Amy Newton, Alicia Ng, Clotilde Bourin, Carolyn Diane Dzierba
المصدر: Bioorganic & Medicinal Chemistry. 25:5490-5505
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Membrane permeability, Bicyclic molecule, Aryl, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Sulfonamide, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, medicine.anatomical_structure, Nociception, chemistry, Drug Discovery, NAV1, medicine, Molecular Medicine, Moiety, Neuron, Molecular Biology
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المؤلفون: Debra J. Post-Munson, Amy Easton, Carolyn Diane Dzierba, Amy Newton, Yong-Jin Wu, Ronald J. Knox, Kevin J. Robbins, Jason M. Guernon, Clotilde Bourin, Ramkumar Rajamani, Richard E. Olson, James Herrington, Michele Matchett, Kimberly Newberry, John D. Graef, Jianliang Shi, Lorin A. Thompson, Shuya Wang, Jonathan L. Ditta, Nicholas A. Meanwell, Rick L. Pieschl, Matthew G. Soars, Linda J. Bristow, Kathleen W. Mosure
المصدر: Journal of Medicinal Chemistry. 60:2513-2525
مصطلحات موضوعية: 0301 basic medicine, Formalin Test, Membrane permeability, 010405 organic chemistry, Drug discovery, Stereochemistry, Cyclohexylamine, Pharmacology, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, medicine.anatomical_structure, chemistry, Dorsal root ganglion, Drug Discovery, NAV1, medicine, Molecular Medicine, Piperidine
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3
المؤلفون: Xiaohua Stella Huang, Dieter M. Drexler, Xiaoliang Zhuo, John E. Leet, Benjamin M. Johnson, Kyle Parcella, Joseph L. Cantone, Matthew G. Soars, Kathleen W. Mosure, Kap-Sun Yeung, Kyle J. Eastman, Yingzi Wang, John F. Kadow
المصدر: Drug Metabolism and Disposition. 44:1332-1340
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, chemistry.chemical_classification, Bicyclic molecule, Stereochemistry, Metabolite, Pharmaceutical Science, 030226 pharmacology & pharmacy, Hydroxylation, 03 medical and health sciences, chemistry.chemical_compound, Metabolic pathway, 030104 developmental biology, 0302 clinical medicine, Enzyme, chemistry, Biochemistry, Moiety, POPC, Phosphocholine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b7011e0ca07188f4028e1a99e2be88
https://doi.org/10.1124/dmd.115.069062 -
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المؤلفون: Karen Rigat, Voss Stacey A, Min Gao, Min Ding, Bender John A, Robert G. Gentles, Lenore A. Pelosi, John F. Kadow, Mengping Liu, Jay O. Knipe, Susan B. Roberts, Ying-Kai Wang, Julie A. Lemm, Kenneth S. Santone, Nicholas A. Meanwell, Kathleen W. Mosure, Richard J. Colonno
المصدر: Antimicrobial Agents and Chemotherapy
مصطلحات موضوعية: Male, Indoles, Genotype, Cell Survival, viruses, Hepatitis C virus, medicine.medical_treatment, Hepacivirus, Viral Nonstructural Proteins, Biology, medicine.disease_cause, Antiviral Agents, Rats, Sprague-Dawley, chemistry.chemical_compound, Dogs, Allosteric Regulation, Interferon, Cell Line, Tumor, Chlorocebus aethiops, Drug Resistance, Viral, Ribavirin, medicine, Animals, Humans, Pharmacology (medical), NS5A, Vero Cells, NS5B, Pharmacology, NS3, Protease, Nucleoside analogue, virus diseases, Interferon-alpha, Benzazepines, RNA-Dependent RNA Polymerase, Virology, digestive system diseases, Rats, Infectious Diseases, Liver, chemistry, Drug Therapy, Combination, Replicon, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7508943f17da9aa6954c0351821157b9
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المؤلفون: T. Thanga Mariappan, Sagnik Chatterjee, Ravindranath Reddy Gilibili, Kathleen W. Mosure, Pravin Bagul, Yurong Lai, Bokka Venkata Murali, Sandhya Mandlekar
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 45(6)
مصطلحات موضوعية: 0301 basic medicine, Coproporphyrins, Kinetics, Pharmaceutical Science, Endogeny, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, In vivo, Humans, Binding site, Fluorescent Dyes, Pharmacology, Binding Sites, Estradiol, Chemistry, Multidrug resistance-associated protein 2, Vesicle, Substrate (chemistry), Membrane Transport Proteins, Biological Transport, In vitro, Multidrug Resistance-Associated Protein 2, 030104 developmental biology, Biochemistry, Multidrug Resistance-Associated Proteins
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd4c21db6b8173831939091b48a6bdc
https://pubmed.ncbi.nlm.nih.gov/28325716 -
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المؤلفون: Jay O. Knipe, Kathleen W. Mosure
المصدر: Biopharmaceutics & Drug Disposition. 29:270-279
مصطلحات موضوعية: Male, Antifungal, Antifungal Agents, medicine.drug_class, education, Pharmaceutical Science, In Vitro Techniques, Pharmacology, Ravuconazole, Beagle, Rats, Sprague-Dawley, chemistry.chemical_compound, Dogs, Species Specificity, Pharmacokinetics, medicine, Animals, Humans, Prodrugs, Pharmacology (medical), Incubation, Hydrolysis, digestive, oral, and skin physiology, Blood Proteins, General Medicine, Triazoles, Prodrug, Phosphate, In vitro, Rats, Macaca fascicularis, Thiazoles, stomatognathic diseases, chemistry, Protein Binding
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7
المؤلفون: Fiona McPhee, Marc Browning, Yue-Zhong Shu, Matthew G. Soars, Kathleen W. Mosure, Vinod Arora, Thomas Phillip, Michael Sinz, Jay O. Knipe, Anand Balakrishnan, Kenneth S. Santone, Paul Michael Scola
المصدر: Journal of pharmaceutical sciences. 104(9)
مصطلحات موضوعية: Male, animal structures, Hepatitis C virus, Pharmaceutical Science, Biological Availability, Hepacivirus, Biology, Pharmacology, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Dogs, Pharmacokinetics, medicine, Animals, Bile, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Humans, Protease inhibitor (pharmacology), Protease Inhibitors, ATP Binding Cassette Transporter, Subfamily B, Member 1, ADME, NS3, Sulfonamides, CYP3A4, Isoquinolines, Virology, Rats, Macaca fascicularis, chemistry, Liver, embryonic structures, Hepatocytes, Microsomes, Liver, Asunaprevir, Viral load, Oxidation-Reduction
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المؤلفون: Marco Dodier, Rebecca L. Drain, Alain Martel, Joanne J. Bronson, Kathleen W. Mosure, Patrice Gill, Stephan Roy, Terry M. Stickle, John W. Russell, Danielle Beaulieu, Cheryl Ferraro, Lawrence B. Snyder, Hyekyung Yang, Susan Chaniewski, Junius Clarke, Ken Denbleyker, Kenneth S. Santone, Stanley D'andrea, MaryBeth Frosco, Anne Marinier, Claude A. Quesnelle, Glen A. Warr, John F. Barrett, Jay O. Knipe, Dennis Taylor
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:2728-2733
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Gram-positive bacteria, Clinical Biochemistry, Antibiotics, Biphenyl derivatives, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Molecular Biology, Antibacterial agent, biology, Chemistry, Organic Chemistry, Isoxazoles, biology.organism_classification, Haemophilus influenzae, Anti-Bacterial Agents, Rats, Molecular Medicine, Antibacterial activity, Bacteria
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المؤلفون: Joanne L. Sproston, Robert J. Riley, Lisa Elkin, Patrick Barton, Kathleen W. Mosure, Matthew G. Soars
المصدر: Xenobiotica; the fate of foreign compounds in biological systems. 44(7)
مصطلحات موضوعية: Drug, Male, Quantitative structure–activity relationship, Organic anion transporter 1, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Drug Evaluation, Preclinical, Quantitative Structure-Activity Relationship, Pharmacology, Organic Anion Transporters, Sodium-Independent, Toxicology, Kidney, Biochemistry, Inhibitory Concentration 50, Organic Anion Transport Protein 1, Pharmacokinetics, In vivo, Animals, Humans, media_common, biology, Transporter, General Medicine, In vitro, Rats, Renal Elimination, HEK293 Cells, Drug Design, biology.protein, Clearance
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المؤلفون: Junius Clarke, Susan Chaniewski, Alain Martel, Joanne J. Bronson, MaryBeth Frosco, Glen A. Warr, Kathleen W. Mosure, Lawrence B. Snyder, Cheryl Ferraro, Stanley D'andrea, Ken Denbleyker, Patrice Gill, Stephan Roy, Claude A. Quesnelle, Terry M. Stickle, Rebecca L. Drain, Marco Dodier, John F. Barrett, Jay O. Knipe, John W. Russell, Danielle Beaulieu, Anne Marinier, Hyekyung Yang, Kenneth S. Santone, Dennis Taylor
المصدر: 19th International Congress on Heterocyclic Chemistry
مصطلحات موضوعية: chemistry.chemical_classification, Alicyclic compound, chemistry, Organic chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::473bc30d6f1159c1508b3c67afbede04
https://doi.org/10.1016/b978-0-08-044304-1.50285-9