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المؤلفون: Marie L. Woolley, Lee A. Dawson, Elisa Ballini, Kerry A. Waters, Mark H Harries, Laura Aldegheri, Simon E. Ward, Joanne Pardoe, Laurent Lacroix, John R. Atack, Kathryn R. Starr, Annette Weil, Andrea M. Bradford
المصدر: J Psychopharmacol
مصطلحات موضوعية: Pyrrolidines, Allosteric modulator, Allosteric regulation, AMPA receptor, Synaptic Transmission, Article, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Seizures, medicine, Animals, Humans, Pharmacology (medical), Receptors, AMPA, Patch clamp, Nootropic Agents, 030304 developmental biology, Pharmacology, Electroshock, 0303 health sciences, Dose-Response Relationship, Drug, Chemistry, musculoskeletal, neural, and ocular physiology, Glutamate receptor, medicine.disease, Rats, Psychiatry and Mental health, nervous system, Mood disorders, Convulsant, Neuroscience, 030217 neurology & neurosurgery, Ionotropic effect
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc536032e13d6250b637c40721273ae8
https://doi.org/10.1177/0269881119872198 -
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المؤلفون: Novella Calcinaghi, Declan N.C. Jones, Laurent Lacroix, Lee A. Dawson, M. H. Selina Mok, Kathryn R. Starr, Jane Gartlon, Joanne Pardoe, Francesca Graziani, Mark H Harries, Simon E. Ward, Marie L. Woolley, Paul John Beswick, Beatrice Oliosi
المصدر: British Journal of Pharmacology. 174:370-385
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Allosteric modulator, Chemistry, Allosteric regulation, Water maze, AMPA receptor, Neurotransmission, In vitro, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, In vivo, Receptor, 030217 neurology & neurosurgery
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المؤلفون: Jim J. Hagan, Claire M. Scott, Jeannette M. Watson, Kathryn R. Starr, Zoe A. Hughes, Trevor Sharp, Michael J. Newson, Lee A. Dawson
مصطلحات موضوعية: Male, medicine.medical_specialty, Serotonin, medicine.drug_class, Microdialysis, Guinea Pigs, Prefrontal Cortex, Pharmacology, Biology, Serotonin 5-HT1 Receptor Antagonists, Rats, Sprague-Dawley, Radioligand Assay, Dorsal raphe nucleus, Piperidines, Species Specificity, Seizures, Internal medicine, medicine, Animals, Receptor, 5-HT receptor, Neurons, Serotonin Plasma Membrane Transport Proteins, Electroshock, Dose-Response Relationship, Drug, Mood Disorders, Transport inhibitor, Receptor antagonist, Benzoxazines, Rats, Electrophysiology, Endocrinology, Dentate Gyrus, Autoreceptor, Quinolines, Raphe Nuclei, Ex vivo, Locomotion, Selective Serotonin Reuptake Inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6725de5da20a0659e2eba1f53cdc2273
https://doi.org/10.1007/s00213-006-0691-x -
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المؤلفون: Halina T Serafinowska, Claire M. Scott, Jeannette M. Watson, Kathryn R. Starr, Peter J. Lovell, Giancarlo Merlo, Frank E. Blaney, Paul W. Smith
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:5581-5585
مصطلحات موضوعية: Male, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Molecular Conformation, Administration, Oral, Pharmaceutical Science, Serotonin 5-HT1 Receptor Antagonists, Biochemistry, Reuptake, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Receptor, Neurotransmitter, Molecular Biology, 5-HT receptor, Serotonin transporter, Chromatography, biology, Chemistry, Organic Chemistry, Rats, Kinetics, Models, Chemical, Docking (molecular), Drug Design, biology.protein, Molecular Medicine, Serotonin, Reuptake inhibitor, Selective Serotonin Reuptake Inhibitors
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المؤلفون: Ceri H. Davies, Adrianna Teriakidis, Anita K. Roopun, James N.C. Kew, Andrew D. Randall, Zining Wu, Hugh J. Herdon, Jon T. Brown, Ross Jeggo, Nisha Patel, Ian Thomson Forbes, Clive Leslie Branch, Gareth A. Jones, Miles A. Whittington, Victoria Anne Honey Fry, Nigel E. Austin, Martyn D. Wood, Rosemary A. Melarange, Katherine A. Buchanan, Joanne Pardoe, Christopher J. Langmead, Claire Roberts, Kathryn R. Starr, Angelica Mazzali, Jeannette M. Watson, Jim J. Hagan
المصدر: British Journal of Pharmacology. 154:1104-1115
مصطلحات موضوعية: Pharmacology, Agonist, chemistry.chemical_classification, medicine.drug_class, Allosteric regulation, 77-LH-28-1, Muscarinic acetylcholine receptor M1, Biology, chemistry.chemical_compound, chemistry, In vivo, Muscarinic acetylcholine receptor, medicine, Inositol phosphate, Acetylcholine receptor
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المؤلفون: James N.C. Kew, Peter R. Maycox, Ellen M. Soffin, Rosemary A. Melarange, Andrew Jonathan Harris, Melanie J. Robbins, Claire Rourke, Jay Strum, Fiona M. Kelly, Magalie Rocheville, Gareth A. Jones, Declan N.C. Jones, Paul R. Murdock, Tom Rupniak, Andy Honey, Kathryn R. Starr
المصدر: Brain Research. 1152:215-227
مصطلحات موضوعية: Male, Agonist, Psychosis, medicine.drug_class, Glycine, Phencyclidine, Anxiety, Motor Activity, Neurotransmission, Pharmacology, Receptors, Metabotropic Glutamate, Benzoates, Synaptic Transmission, Rats, Sprague-Dawley, Mice, Seizures, medicine, Animals, Humans, Amphetamine, Molecular Biology, Autoreceptors, Mice, Knockout, Electroshock, Seizure threshold, General Neuroscience, Brain, medicine.disease, Rats, Disease Models, Animal, Metabotropic glutamate receptor, Dentate Gyrus, Synapses, Schizophrenia, Autoreceptor, Anticonvulsants, Central Nervous System Stimulants, Neurology (clinical), Psychology, Neuroscience, Developmental Biology, medicine.drug
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المؤلفون: Paul W. Smith, Christopher J. Langmead, Gary W. Price, James J. Hagan, Jeannette M. Watson, Wyman Paul Adrian, Kirsten L. Clarke, Kathryn R. Starr, Claire M. Scott, Lee A. Dawson
المصدر: Neuropharmacology. 50:984-990
مصطلحات موضوعية: Agonist, Serotonin, Indoles, Patch-Clamp Techniques, medicine.drug_class, Stereochemistry, Guinea Pigs, CHO Cells, In Vitro Techniques, Serotonin 5-HT1 Receptor Antagonists, Biology, Tritium, Binding, Competitive, Piperazines, Membrane Potentials, Cellular and Molecular Neuroscience, In vivo, Cricetinae, Sulfur Isotopes, medicine, Animals, Humans, Drug Interactions, Receptor, 5-HT receptor, Cerebral Cortex, Neurons, Pharmacology, Analysis of Variance, Oxadiazoles, Dose-Response Relationship, Drug, Chinese hamster ovary cell, Antagonist, Receptor antagonist, Electric Stimulation, Rats, Guanosine 5'-O-(3-Thiotriphosphate), Autoreceptor, Serotonin Antagonists, Protein Binding
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المؤلفون: Lee A. Dawson, Alessandro Poffe, Roberto Arban, Fabrizio Bacchi, James J. Hagan, Sergio Melotto, Zoe A. Hughes, James Storey, Gary W. Price, Letizia Bettelini, Kathryn R. Starr
المصدر: Neuropharmacology. 50:975-983
مصطلحات موضوعية: Male, Agonist, Serotonin, Indoles, Time Factors, medicine.drug_class, Guinea Pigs, Hypothermia, Motor Activity, Pharmacology, Anxiolytic, Piperazines, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, Neurochemical, In vivo, medicine, Animals, Drug Interactions, Receptor, Swimming, 5-HT receptor, Brain Chemistry, Analysis of Variance, Behavior, Animal, Dose-Response Relationship, Drug, Chemistry, Callithrix, Immobility Response, Tonic, Receptor antagonist, Antidepressive Agents, Rats, Anti-Anxiety Agents, Serotonin Antagonists, Vocalization, Animal, Behavioural despair test
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المؤلفون: Christopher J. Langmead, Lee A. Dawson, Derek N. Middlemiss, James J. Hagan, Matthew Hill, Gerd D. Bartoszyk, Zoe A. Hughes, Kathryn R. Starr
المصدر: European Journal of Pharmacology. 510:49-57
مصطلحات موضوعية: Male, Agonist, Benzylamines, Serotonin, Indoles, Time Factors, Pyridines, medicine.drug_class, Dopamine, Microdialysis, Serotonin reuptake inhibitor, Vilazodone Hydrochloride, Pharmacology, Sulfur Radioisotopes, Tritium, Binding, Competitive, Hippocampus, Partial agonist, Piperazines, Reuptake, Rats, Sprague-Dawley, Norepinephrine, chemistry.chemical_compound, Vilazodone, medicine, Animals, Spiro Compounds, Piperidones, Benzofurans, 8-Hydroxy-2-(di-n-propylamino)tetralin, Dose-Response Relationship, Drug, Chemistry, Cell Membrane, Serotonin 5-HT1 Receptor Agonists, Receptor antagonist, Frontal Lobe, Rats, Serotonin Receptor Agonists, Paroxetine, Guanosine 5'-O-(3-Thiotriphosphate), 5-HT1A receptor, Serotonin Antagonists, Extracellular Space, Selective Serotonin Reuptake Inhibitors
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المؤلفون: Mark S. Duxon, Peter J. Atkinson, Tracey E. Shaw, David R. Thomas, Kevin M. Thewlis, Michael S. Hadley, Beverley Hammond, Geoffrey Stemp, Gary W. Price, Claire M. Scott, Vong Antonio Kuok Keong, Jeannette M. Watson, Steven Mark Bromidge, Christopher N. Johnson, Graham J. Riley, Derek N. Middlemiss, Harshad Kantilal Rami, Stephanie E. North, Laramie Mary Gaster, Kathryn R. Starr, Mervyn Thompson
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:737-741
مصطلحات موضوعية: Intrinsic activity, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Serotonin 5-HT1 Receptor Antagonists, Pharmacology, Biochemistry, Cell Line, Reuptake, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Drug Stability, Drug Discovery, Animals, Humans, Structure–activity relationship, Receptor, Neurotransmitter, Molecular Biology, Benzoxazinones, Organic Chemistry, Brain, Benzoxazines, Rats, chemistry, Molecular Medicine, 5-HT1A receptor, Reuptake inhibitor, Selective Serotonin Reuptake Inhibitors, Synaptosomes