نتائج البحث - "Keap1, Kelch-like ECH-associated protein 1"

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 921-942 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Sestrins, MPO, myeloperoxidase, Mitogen-Activated Protein Kinase Kinase 7, RC799-869, DMSO, dimethyl sulfoxide, FoxO, forkhead box O, Sesn1/2/3, sestrin1/2/3, medicine.disease_cause, TKO, triple knockout, Mice, PCR, polymerase chain reaction, 0302 clinical medicine, GSH, glutathione, Phosphorylation, NF-κB, nuclear factor kappa B, Original Research, Cat, catalase, Mice, Knockout, Sestrin, Gpx3, glutathione peroxidase 3, Il6, interleukin 6, WD, Western diet, biology, Chemistry, Kinase, Fatty liver, Tgfbr1, transforming growth factor beta receptor 1, Gastroenterology, Col1a1, collagen type 1 alpha 1, Nox1, NADPH oxidase 1, Diseases of the digestive system. Gastroenterology, Dgat2, diacylglycerol O-acyltransferase 2, Cell biology, Keap1, Kelch-like ECH-associated protein 1, C-Jun N-Terminal Kinase, Liver, Lipotoxicity, c-Jun N-terminal kinases, JNK, c-Jun N-terminal kinase, 030211 gastroenterology & hepatology, Disease Susceptibility, Signal transduction, NASH, nonalcoholic steatohepatitis, Gss, glutathione synthetase, Pdgfrb, platelet-derived growth factor receptor beta, Timp1, tissue inhibitor of metalloproteinase 1, Fasn, fatty acid synthase, Fatty Liver Disease, Sod, superoxide dismutase, Acta2, smooth muscle actin alpha 2, ER, endoplasmic reticulum, PA, palmitic acid, 03 medical and health sciences, 4-HNE, 4-hydroxynonenal, MKK, mitogen-activated protein kinase kinase, medicine, Animals, Humans, Srebp, sterol regulatory element-binding protein, Protein kinase A, KD, knockdown, MDA, malondialdehyde, Inflammation, KO, knockout, Hepatology, NRF2, nuclear factor erythroid 2-related like 2, JNK Mitogen-Activated Protein Kinases, Lipid Metabolism, medicine.disease, Tgfb1, transforming growth factor beta 1, WT, wild-type, mTORC, mechanistic target of rapamycin complex, Fatty Liver, AMPK, AMP-activated protein kinase, Disease Models, Animal, Oxidative Stress, Scd1, stearoyl-CoA desaturase 1, 030104 developmental biology, Gene Expression Regulation, Cytoprotection, Hepatocytes, biology.protein, BSA, bovine serum albumin, SD, standard deviation, DHE, dihydroethidium, PERK, protein kinase R-like endoplasmic reticulum kinase, Tnf, tumor necrosis factor, Biomarkers, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1574bc0f082fa7f7fd23bf88f6f9c6fc
http://www.sciencedirect.com/science/article/pii/S2352345X21000862

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The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway

المؤلفون: Hui Liu, Sara Maimouni, Sara Coppola, Ye Zhang, Jianliang Shen, Yijun Wang, Shenglan Gao, Ying-Tang Gao, Fengmei Wang, Heineken Queen Daguplo, Wei-Xing Zong, Junrong Yan, Zhi Du, Fang Wang, Yongbo Wang, Peng Wang, Bin Yang, Qin Zhang, Grace L. Guo, Kesong Peng, Wen-Xing Ding, Weiwei Dai, Fei Tang

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1369-1385 (2021)

مصطلحات موضوعية: Male, 0301 basic medicine, PCNA, proliferation cell nuclear antigen, Carcinogenesis, Apoptosis, RC799-869, DMEM, Dulbecco’s modified Eagle’s medium, TRIM21, tripartite motif-containing protein 21, Mice, PCR, polymerase chain reaction, 0302 clinical medicine, Ubiquitin, Tumor Cells, Cultured, Diethylnitrosamine, 8-oxo-dG, 8-oxo-2-deoxyguanosine, Original Research, Mice, Knockout, Kelch-Like ECH-Associated Protein 1, AFP, α-fetoprotein, biology, p62, Liver Neoplasms, Gastroenterology, RNA-Binding Proteins, Diseases of the digestive system. Gastroenterology, PBST, phosphate-buffered saline with 0.02% Tween 20, Prognosis, mRNA, messenger RNA, Ubiquitin ligase, Keap1, Kelch-like ECH-associated protein 1, Gene Expression Regulation, Neoplastic, Survival Rate, Ribonucleoproteins, Knockout mouse, 030211 gastroenterology & hepatology, IHC, immunohistochemistry, Programmed cell death, LD, ligase dead, SDS, sodium dodecyl sulfate, Carcinoma, Hepatocellular, NF-E2-Related Factor 2, PBS, phosphate-buffered saline, Oxidative phosphorylation, Nrf2, α-SMA, α-smooth muscle actin, PI, propidium iodide, cDNA, complementary DNA, 03 medical and health sciences, ROS, reactive oxygen species, Immune system, FBS, fetal bovine serum, Biomarkers, Tumor, Animals, Humans, Carcinogen, Cell Proliferation, KO, knockout, Hepatology, Nrf2, nuclear factor E2-related factor 2, RNA-seq, RNA sequencing, Hepatocellular Carcinoma, WB, western blotting, MEF, mouse embryonic fibroblast, WT, wild-type, KEAP1, Mice, Inbred C57BL, 030104 developmental biology, PB, phenobarbital, biology.protein, Cancer research, TCGA, The Cancer Genome Atlas, HCC, hepatocellular carcinoma, TRIM21, DEN, diethylnitrosamine