-
1
المؤلفون: Hiroyoshi Yamada, Yoshiaki Shimada, Keitaro Kadono, Susumu Yamaki, Akira Nagashima, Mitsuhiro Kondo, Kosei Yoshihara
المصدر: Bioorganic & Medicinal Chemistry. 25:6024-6038
مصطلحات موضوعية: Male, 0301 basic medicine, Pyrimidine, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, 030209 endocrinology & metabolism, Inhibitory postsynaptic potential, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Pharmacokinetics, Oral administration, Drug Discovery, Animals, Enzyme Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Chemical modification, Adhesion, Rats, Bioavailability, Macaca fascicularis, 030104 developmental biology, Injections, Intravenous, Molecular Medicine, Amine Oxidase (Copper-Containing), Carbamates, Cell Adhesion Molecules, Ex vivo
-
2
المؤلفون: Ayako Moritomo, Kosei Yoshihara, Susumu Yamaki, Mitsuhiro Kondo, Yuji Koga, Yoshiaki Shimada, Keitaro Kadono, Akira Nagashima
المصدر: Bioorganic & Medicinal Chemistry. 25:4110-4122
مصطلحات موضوعية: 0301 basic medicine, Spectrometry, Mass, Electrospray Ionization, Proton Magnetic Resonance Spectroscopy, Clinical Biochemistry, Glycine, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Diabetic nephropathy, 03 medical and health sciences, chemistry.chemical_compound, Oral administration, Drug Discovery, medicine, Animals, Humans, Diabetic Nephropathies, Molecular Biology, Benzoic acid, Proteinuria, CYP3A4, 010405 organic chemistry, Organic Chemistry, Adhesion, bacterial infections and mycoses, Streptozotocin, medicine.disease, Rats, respiratory tract diseases, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, chemistry, Cytochrome P-450 CYP2C19 Inhibitors, Cytochrome P-450 CYP3A Inhibitors, Molecular Medicine, Amine Oxidase (Copper-Containing), medicine.symptom, Cell Adhesion Molecules, Lead compound, medicine.drug
-
3
المؤلفون: Kenji Tabata, Shigeyuki Terashita, Toshio Teramura, Yoichi Naritomi, Akiko Koakutsu, Keitaro Kadono
المصدر: Xenobiotica. 44:511-521
مصطلحات موضوعية: Male, Time Factors, CYP3A, Health, Toxicology and Mutagenesis, Portal vein, Serum albumin, Pharmacology, Toxicology, Biochemistry, Substrate Specificity, Xenobiotics, Rats, Sprague-Dawley, Pharmacokinetics, Microsomes, Animals, Cytochrome P-450 CYP3A, Humans, Intestinal Metabolism, Intestinal Mucosa, biology, Portal Vein, Serum Albumin, Bovine, General Medicine, In vitro, Sprague dawley, Portal System, biology.protein, Microsome, Cattle
-
4
المؤلفون: Takafumi Akabane, Akira Nagashima, Ayako Moritomo, Jiro Fujiyasu, Susumu Yamaki, Kosei Yoshihara, Keitaro Kadono, Masahiro Neya, Suzuki Daisuke, Mitsuhiro Kondo
المصدر: Bioorganicmedicinal chemistry. 25(1)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Glycine, Pharmaceutical Science, CHO Cells, Inhibitory postsynaptic potential, 01 natural sciences, Biochemistry, 03 medical and health sciences, Glycine amide, chemistry.chemical_compound, Structure-Activity Relationship, Cricetulus, Drug Stability, Oral administration, Amide, Drug Discovery, Acetamides, Moiety, Animals, Humans, Molecular Biology, Enzyme Assays, Chemistry, Organic Chemistry, Adhesion, bacterial infections and mycoses, respiratory tract diseases, 0104 chemical sciences, Rats, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular Medicine, Amine Oxidase (Copper-Containing), Cell Adhesion Molecules, Ex vivo, VASCULAR ADHESION PROTEIN 1
-
5
المؤلفون: Katsuhiro Yamano, Keitaro Kadono, Hiroyuki Moriguchi, Fumihiro Nakamori, Shigeyuki Terashita, Yoichi Naritomi, Toshio Teramura, Kazuhiro Tetsuka, Ken Ichi Hosoya, Takako Furukawa
المصدر: Drug Metabolism and Disposition. 40:1771-1777
مصطلحات موضوعية: Cell Membrane Permeability, Metabolic Clearance Rate, Glucuronidation, Administration, Oral, Pharmaceutical Science, Models, Biological, digestive system, Isozyme, Intestinal absorption, Substrate Specificity, Glucuronides, Cytochrome P-450 Enzyme System, In vivo, Microsomes, Humans, Glucuronosyltransferase, Biotransformation, Pharmacology, biology, Cytochrome P450, Recombinant Proteins, In vitro, Intestines, Isoenzymes, Kinetics, Intestinal Absorption, Pharmaceutical Preparations, Biochemistry, Free fraction, biology.protein, Microsome
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b695ba66971d2a4ca20d2cb3e7fff315
https://doi.org/10.1124/dmd.112.045476 -
6
المؤلفون: Katsuhiko Gato, Keitaro Kadono, Shigeyuki Terashita, Toshio Teramura, Takafumi Akabane, Kenji Tabata
المصدر: Drug Metabolism and Disposition. 38:1230-1237
مصطلحات موضوعية: Quinidine, Stereochemistry, Drug Evaluation, Preclinical, Biological Availability, Pharmaceutical Science, In Vitro Techniques, Permeability, Intestinal mucosa, Pharmacokinetics, In vivo, Microsomes, medicine, Cytochrome P-450 CYP3A, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Intestinal Mucosa, Pharmacology, CYP3A4, Chemistry, INT, Models, Theoretical, In vitro, Microsome, Forecasting, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3a464d34f84fd2be44f4ed71124669
https://doi.org/10.1124/dmd.109.029322 -
7
المؤلفون: Shigeyuki Terashita, Kenji Tabata, Toshio Teramura, Keitaro Kadono, Shuichi Sakuda, Takafumi Akabane
المصدر: Drug Metabolism and Disposition. 38:308-316
مصطلحات موضوعية: Male, Drug, Time Factors, Membrane permeability, media_common.quotation_subject, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmaceutical Science, Pharmacology, Models, Biological, Permeability, Species Specificity, Pharmacokinetics, Oral administration, Microsomes, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Intestinal Mucosa, P-glycoprotein, media_common, biology, Membranes, Artificial, Metabolism, In vitro, Bioavailability, Macaca fascicularis, Liver, Pharmaceutical Preparations, Injections, Intravenous, biology.protein, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acee6bc0f7d578d7c602ef46fe95ab7
https://doi.org/10.1124/dmd.109.028829 -
8
المؤلفون: Norio Iwasaki, Keitaro Kadono, Jun ichi Yokoe, Ken Ichi Ogawara, Shunji Haruta, Toshikiro Kimura, Kazutaka Higaki
المصدر: Journal of Controlled Release. 86:305-313
مصطلحات موضوعية: Male, Colon, Pharmaceutical Science, Absorption (skin), Models, Biological, Cecum, Pharmacokinetics, Oral administration, Sasa, Blood plasma, medicine, Animals, Humans, Prodrugs, Rats, Wistar, Gastrointestinal Transit, Chromatography, biology, Chemistry, Prodrug, biology.organism_classification, Rats, Bioavailability, medicine.anatomical_structure, Intestinal Absorption, Biochemistry, Forecasting
-
9
المصدر: Drug metabolism and pharmacokinetics. 17(4)
مصطلحات موضوعية: Pharmacology, Absorption (pharmacology), Chromatography, Gastric emptying, Chemistry, digestive, oral, and skin physiology, Pharmaceutical Science, Biopharmaceutics Classification System, Small intestine, Jejunum, medicine.anatomical_structure, Oral administration, medicine, Pharmacology (medical), Dissolution testing, Theophylline, medicine.drug