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1
المؤلفون: Frédéric St-Jean, Scott Savage, Keith Lee Spencer, Alan Deese, Brian Wong, Lane Jonathan W, David Askin, Herbert Yajima, Travis Remarchuk, Srinivasan Babu, Michael W. Dong, Jeffrey Stults, Diane E. Carrera
المصدر: Organic Process Research & Development. 18:1652-1666
مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Total synthesis, Physical and Theoretical Chemistry, Akt inhibitor, Ipatasertib
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2
المؤلفون: Travis Remarchuk, Peter J. Stengel, Keith Lee Spencer, Nicholas C. Kallan, Shakya Sagar, Lane Jonathan W
المصدر: Organic Process Research & Development. 18:1641-1651
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Ketone, Natural product, chemistry, Process development, Process chemistry, Organic Chemistry, Organic chemistry, Physical and Theoretical Chemistry, Akt inhibitor, Ring (chemistry), Ipatasertib
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3
المؤلفون: Josef R. Bencsik, Barbara J. Brandhuber, Banka Anna L, Guy Vigers, Nicholas J. Skelton, Stefan D. Gross, Wen-I Wu, Matthew Martinson, Ian S. Mitchell, Susan L. Gloor, Rui Xu, Keith Lee Spencer, Tyler Risom, James F. Blake, Nicholas C. Kallan, Eli M. Wallace, Tony Morales
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2335-2340
مصطلحات موضوعية: Molecular model, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, medicine, Computer Simulation, Spiro Compounds, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, Sulfonamides, Binding Sites, Bicyclic molecule, biology, Chemistry, Organic Chemistry, Sulfonamide (medicine), Rational design, Cyclic AMP-Dependent Protein Kinases, Enzyme inhibitor, biology.protein, Molecular Medicine, Selectivity, Proto-Oncogene Proteins c-akt, medicine.drug
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4
المؤلفون: Nicholas J. Skelton, Matthew Martinson, Ian S. Mitchell, Josef R. Bencsik, Susan L. Gloor, Tony Morales, Rui Xu, Keith Lee Spencer, Tyler Risom, Barbara J. Brandhuber, Guy Vigers, Nicholas C. Kallan, Justin W. Heizer, James F. Blake, Wen-I Wu, Stefan D. Gross
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2410-2414
مصطلحات موضوعية: education, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Binding site, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, chemistry.chemical_classification, Binding Sites, biology, Chemistry, Organic Chemistry, humanities, body regions, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction, Selectivity, Proto-Oncogene Proteins c-akt
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5
المؤلفون: Keith Lee Spencer, Tyler Risom, Guy Vigers, Nicholas J. Skelton, Stefan D. Gross, Nicholas C. Kallan, Josef R. Bencsik, James F. Blake, Matthew Martinson, Ian S. Mitchell, Rui Xu, Richard Woessner, Tony Morales, Susan L. Gloor, Dengming Xiao, Barbara J. Brandhuber
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5607-5612
مصطلحات موضوعية: Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Cell Line, Mice, Structure-Activity Relationship, Drug Discovery, LNCaP, Animals, Humans, Protein Isoforms, Pyrroles, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, Adaptor Proteins, Signal Transducing, chemistry.chemical_classification, Gene knockdown, Binding Sites, biology, Chemistry, Organic Chemistry, Phosphoproteins, Xenograft Model Antitumor Assays, In vitro, High-Throughput Screening Assays, Protein Structure, Tertiary, Pyrimidines, Enzyme, Cell culture, Enzyme inhibitor, Drug Design, Cancer research, biology.protein, Molecular Medicine, Signal transduction, Proto-Oncogene Proteins c-akt
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6
المؤلفون: Keith Lee Spencer, Barbara Hanney, Eileen S. Walsh, George D. Hartman, Stephen C. Beck, Carolyn A. Buser, Weikang Tao, Robert B. Lobell, Youwei Yan, Lawrence C. Kuo, Kenneth L. Arrington, Edward J. Brnardic, Mari Ikuta, Sanjeev Munshi, Mark E. Fraley, Constantine Kreatsoulas, Justin T. Steen, Bob Drakas, Laura Sepp-Lorenzino, Kelly Hamilton, Yuntae Kim, Xianzhi Mao, James Hardwick, Steven M. Stirdivant, Keith W. Rickert
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:6049-6053
مصطلحات موضوعية: Models, Molecular, Indazoles, Stereochemistry, Clinical Biochemistry, Triazole, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Structure–activity relationship, Moiety, Potency, Hydroxymethyl, Protein Kinase Inhibitors, Molecular Biology, Indazole, Molecular Structure, biology, Cell Cycle, Organic Chemistry, chemistry, Enzyme inhibitor, Checkpoint Kinase 1, biology.protein, Molecular Medicine, Selectivity, Protein Kinases
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7
المؤلفون: Jun Li, Dengming Xiao, Eli M. Wallace, Brian Safina, Deepak Sampath, Christine Chabot, Matthew Martinson, Ian S. Mitchell, Barbara J. Brandhuber, Jason Oeh, Rui Xu, Steven Do, Leslie Lee, Jun Liang, Susan L. Gloor, Birong Zhang, Kui Lin, Stephen T. Schlachter, Nicholas J. Skelton, Brian Lee, Bianca M. Liederer, Richard Woessner, Guy Vigers, James F. Blake, Josef R. Bencsik, Banka Anna L, Nicholas C. Kallan, Keith Lee Spencer
المصدر: Journal of medicinal chemistry. 55(18)
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Antineoplastic Agents, Pharmacology, Binding, Competitive, Piperazines, MAP2K7, Substrate Specificity, Inhibitory Concentration 50, Adenosine Triphosphate, Drug Discovery, Humans, Protein kinase A, Protein kinase B, Protein Kinase Inhibitors, PHLPP, biology, Cyclin-dependent kinase 4, Chemistry, Akt/PKB signaling pathway, Cyclin-dependent kinase 2, Protein kinase R, Pyrimidines, biology.protein, Molecular Medicine, Proto-Oncogene Proteins c-akt
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8
المؤلفون: Dengming Xiao, Matthew Martinson, Ian S. Mitchell, Keith Lee Spencer, Tyler Risom, Guy Vigers, James F. Blake, Lesley J. Murray, Susan L. Gloor, Nicholas J. Skelton, Rui Xu, Nicholas C. Kallan, Barbara J. Brandhuber, Wen-I Wu, Wei Wei Prior, Josef R. Bencsik, Richard Woessner, Faith P. Dizon
المصدر: Bioorganicmedicinal chemistry letters. 20(23)
مصطلحات موضوعية: Male, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Binding site, Molecular Biology, Protein kinase B, Protein Kinase Inhibitors, chemistry.chemical_classification, Binding Sites, biology, Dose-Response Relationship, Drug, Chemistry, Kinase, Organic Chemistry, Prostatic Neoplasms, Amino acid, Tumor Burden, Disease Models, Animal, Enzyme, Pyrimidines, Enzyme inhibitor, biology.protein, Molecular Medicine, Proto-Oncogene Proteins c-akt