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1
المؤلفون: Xin Chen, Poli Gregory B, Joseph T. Tsay, Jiesheng Kang, Ying Zhang, Anne Minnich, Keith Sides, Qingping Wang, Yong Mi Choi-Sledeski, Patrick Wai-Kwok Shum, Guyan Liang, Vasant Kumar
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1606-1610
مصطلحات موضوعية: Models, Molecular, Benzylamines, ERG1 Potassium Channel, Scaffold, Molecular model, Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Thiophenes, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Benzylamine, Drug Stability, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, Serine protease, biology, Chemistry, Organic Chemistry, Cytochrome P450, Ether-A-Go-Go Potassium Channels, In vitro, Potassium channel, biology.protein, Molecular Medicine, Tryptases, Protein Binding
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2
المؤلفون: Keith Sides, James Pribish, Magali Mathieu, Sam Rebello, Gregory H. Merriman, Henry W. Pauls, Guyan Liang, Xin Chen, Julian Levell, Jennifer Cairns, Isabelle Morize, Brian Whitely, Joseph T. Tsay, Aldous Suzanne C, Sébastien Maignan
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1049-1054
مصطلحات موضوعية: Models, Molecular, Library design, Proteases, Molecular model, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Tryptase, Pharmacology, Crystallography, X-Ray, Biochemistry, Small Molecule Libraries, Serine, Structure-Activity Relationship, Drug Discovery, Hydrolase, medicine, Animals, Combinatorial Chemistry Techniques, Humans, Mast Cells, Enzyme Inhibitors, Molecular Biology, Serine protease, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Mast cell, Recombinant Proteins, Rats, medicine.anatomical_structure, biology.protein, Molecular Medicine, Tryptases
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3
المؤلفون: Michael Gardyan, Mathew Rose M, Jane Davidson, Joseph Romano, Alain Dupuy, Aldous Suzanne C, Jennifer Kwong, Sam S. Rebello, Jennifer Cairns, Odessa Giardino, Yongyi Luo, Sébastien Maignan, Andrew David Morley, Clive Mccarthy, Joseph T. Tsay, Darren Engers, Guyan Liang, Houille Olivier, Julian Levell, Pribish James R, Jean-Pierre Guilloteau, Garry Fenton, Simon Watson, Trevor K.P. Harrison, Peter C. Astles, Liduo Shen, Mark Czekaj, Gregory H. Merriman, Keith Sides, Pauls Henry W, Keith Smith, Jie Wang, Heng-Keang Lim, Paul R. Eastwood, Brian Whiteley
المصدر: Bioorganic & Medicinal Chemistry. 13:2859-2872
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, Arginine, Protein Conformation, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Tryptase, Crystallography, X-Ray, Biochemistry, Benzamidine, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Drug Discovery, medicine, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Serine protease, Molecular Structure, biology, Chemistry, Serine Endopeptidases, Organic Chemistry, Mast cell, Amides, Benzamidines, Recombinant Proteins, Rats, Enzyme, medicine.anatomical_structure, Liver, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Tryptases, Caco-2 Cells, Factor Xa Inhibitors
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4
المؤلفون: Magali Mathieu, Jackson Sharon, Guyan Liang, Henry Pauls, Sebastien Maignan, Nieduzak Thaddeus R, Kent W. Neuenschwander, Anthony C. Scotese, Corey R. Hopkins, Dona Cramer, Keith Sides, Jennifer Cairns
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:4819-4823
مصطلحات موضوعية: chemistry.chemical_classification, Serine Proteinase Inhibitors, biology, Serine Endopeptidases, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biological activity, Tryptase, Biochemistry, Chemical synthesis, Mast cell tryptase, Structure-Activity Relationship, Enzyme, chemistry, Enzyme inhibitor, Pyrazines, Drug Discovery, biology.protein, Molecular Medicine, Tryptases, Molecular Biology
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5
المؤلفون: Keith Sides, Rosalyn D. Blumenthal, Robert M. Sharkey, Rina Kashi, David M. Goldenberg, Rhona Stein
المصدر: Tumor Biology. 18:367-377
مصطلحات موضوعية: Cytotoxicity, Immunologic, Antimetabolites, Antineoplastic, Pathology, medicine.medical_specialty, medicine.medical_treatment, Antidotes, Transplantation, Heterologous, Leucovorin, Mice, Nude, Vascular permeability, Capillary Permeability, Mice, Nude mouse, Antigen, Antibodies, Bispecific, Tumor Cells, Cultured, Animals, Humans, Medicine, Chemotherapy, Neovascularization, Pathologic, biology, business.industry, Neoplasms, Experimental, General Medicine, Radioimmunotherapy, biology.organism_classification, Transplantation, Radiation therapy, Fluorouracil, Colonic Neoplasms, Cancer research, Female, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7d7afe016024fdcd3d176e6c385297
https://doi.org/10.1159/000218051 -
6
المؤلفون: Rina Kashi, Xavier Filella, Yu-Hsueh Wang, Marianne Grob, Pablo Carretero, Yoshikazu Hayatsu, Yoshihisa Fujikura, Rafael Molina, Keith Sides, Paul M. Sondel, Rosalyn D. Blumenthal, David M. Goldenberg, Sallie S. Boggs, Fumihiko Shinozaki, M. Deutsch, Rhona Stein, Xinwei Li, Tetsuo Fukumoto, Rehana Sultana Lovely, Nobuko Tokuda, Dawn H. Siegel, Patrizia Lorenzoni, E.S. Redgate, Antonio M. Ballesta, Max M. Burger, C.M. Nicolet, Dorit Goren, Alfredo Rodríguez, Tomoo Sawada, J.E. Surfus, Juan Alcover, A. Gabryel-Grudziak, Robert M. Sharkey
المصدر: Tumor Biology. 18:I-IV
مصطلحات موضوعية: General Medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5c5edc1caf00d9f247675696864cfd5a
https://doi.org/10.1159/000218045 -
7
المؤلفون: Xin Chen, Eric W. MacMillan, Guyan Liang, Isabelle Morize, Yong Gong, Yong Mi Choi-Sledeski, Joseph T. Tsay, David J. Aldous, Berndt Kulitzscher, Jennifer Cairns, Keith Sides, Pauls Henry W
المصدر: Bioorganicmedicinal chemistry letters. 22(9)
مصطلحات موضوعية: Serine protease, Binding Sites, Serine Proteinase Inhibitors, Molecular model, biology, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Tryptase, Biochemistry, Protein multimerization, Folding (chemistry), Drug Discovery, biology.protein, Molecular Medicine, Tryptases, Binding site, Protein Multimerization, Molecular Biology
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8
المؤلفون: Jie Wang, Qingping Wang, Roy J. Vaz, Guyan Liang, Jennifer Cairns, Keith Sides, Joseph T. Tsay, Zhicheng Zhao, Gregory T Stoklosa, Yong Mi Choi-Sledeski, Patrick Wai-Kwok Shum, Xin Chen, Anne Minnich, Gregory B. Poli, Thaddeus R. Nieduzak
المصدر: Bioorganicmedicinal chemistry letters. 20(22)
مصطلحات موضوعية: Molecular model, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Tryptase, Molecular Dynamics Simulation, Biochemistry, chemistry.chemical_compound, Molecular dynamics, Benzylamine, X-Ray Diffraction, Drug Discovery, Molecule, Potency, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Indole test, biology, Organic Chemistry, chemistry, biology.protein, Molecular Medicine, Tryptases, Amine Oxidase (Copper-Containing), Linker
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9
المؤلفون: Julian Levell, Yi Li, Larry Davis, Sam S. Rebello, Michael Elliot, Dona M. Cramer, Maurice Brollo, Pribish James R, Eva Albert, Vinolia Chellaraj, Jennifer Cairns, Keith Sides, Xin Chen, Robert W. Singleton, Jennifer Kwong, Antonio Ugolini, Jiesheng Kang, Feng Liu, Roy J. Vaz, Heng-Keang Lim, Zhongli Gao
المصدر: Bioorganicmedicinal chemistry letters. 14(24)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Tryptase, Ligands, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Molecule, Humans, Binding site, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Molecular Structure, Hydrogen bond, Organic Chemistry, Serine Endopeptidases, Hydrogen Bonding, Molecular Weight, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Tryptases
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10
المؤلفون: Guyan Liang, Xin Chen, Gregory B. Poli, Qingping Wang, Yong Mi Choi-Sledeski, Roy J. Vaz, Joseph T. Tsay, Anne Minnich, Keith Sides
المصدر: MedChemComm. 2:794
مصطلحات موضوعية: Pharmacology, Indole test, Amine oxidase, Scaffold, biology, Chemistry, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Tryptase, Biochemistry, chemistry.chemical_compound, Benzylamine, Drug Discovery, biology.protein, Microsome, Molecular Medicine, Potency, Linker
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a756fce5d94f38069ed857e17eefa56c
https://doi.org/10.1039/c1md00104c
