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المؤلفون: England E; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Rees DG; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Scott IC; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Carmen S; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Chan DTY; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Chaillan Huntington CE; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Houslay KF; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Erngren T; Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Penney M; Early Oncology DMPK, Oncology R&D, AstraZeneca, Cambridge, UK., Majithiya JB; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Rapley L; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Sims DA; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Hollins C; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Hinchy EC; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Strain MD; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Kemp BP; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Corkill DJ; Bioscience In Vivo, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., May RD; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Vousden KA; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Butler RJ; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Mustelin T; Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA., Vaughan TJ; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Lowe DC; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Colley C; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Cohen ES; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. suzanne.cohen@astrazeneca.com.

المصدر: Scientific reports [Sci Rep] 2023 Jun 17; Vol. 13 (1), pp. 9825. Date of Electronic Publication: 2023 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-1 Receptor-Like 1 Protein*/metabolism , Inflammation*/metabolism, Mice ; Humans ; Animals ; Interleukin-33/metabolism ; Cytokines/metabolism ; ErbB Receptors/metabolism ; Signal Transduction

المؤلفون: Chen B; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA Chenb@medimmune.com SimsG@MedImmune.com., Vousden KA; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, UK., Naiman B; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA., Turman S; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA., Sun H; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA., Wang S; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA.; Viela Bio, Gaithersburg, Maryland, USA., Vinall LMK; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, UK., Kemp BP; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, UK., Kasturiangan S; Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, USA., Rees DG; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, UK., Grant E; Department of Translational Medicine, MedImmune LLC, Gaithersburg, Maryland, USA., Hinrichs MJ; Department of Translational Medicine, MedImmune LLC, Gaithersburg, Maryland, USA., Eck S; Department of Translational Medicine, MedImmune LLC, Gaithersburg, Maryland, USA., DiGiandomenico A; Microbial Sciences, MedImmune, LLC, Gaithersburg, Maryland, USA., Jack Borrok M; Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland, USA., Ly N; Department of Translational Medicine, MedImmune LLC, Gaithersburg, Maryland, USA., Xiong X; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA., Gonzalez C; Department of Translational Medicine, MedImmune LLC, Gaithersburg, Maryland, USA., Morehouse C; Department of Translational Medicine, MedImmune LLC, Gaithersburg, Maryland, USA., Wang Y; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA., Zhou Y; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA., Cann J; Department of Translational Medicine, MedImmune LLC, Gaithersburg, Maryland, USA., Zhao W; Department of Translational Medicine, MedImmune LLC, Gaithersburg, Maryland, USA., Koelkebeck H; Department of Translational Medicine, MedImmune LLC, Gaithersburg, Maryland, USA., Okubo K; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Mayadas TN; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Howe D; Department of Clinical Development, MedImmune Ltd, Granta Park, Great Abington, UK., Griffiths J; Department of Translational Medicine, MedImmune LLC, Gaithersburg, Maryland, USA., Kolbeck R; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA., Herbst R; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA., Sims GP; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA Chenb@medimmune.com SimsG@MedImmune.com.

المصدر: Annals of the rheumatic diseases [Ann Rheum Dis] 2019 Feb; Vol. 78 (2), pp. 228-237. Date of Electronic Publication: 2018 Nov 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BMJ Country of Publication: England NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Anti-Idiotypic/*pharmacology , Antigen-Antibody Complex/*drug effects , Autoimmune Diseases/*drug therapy , Immunologic Factors/*pharmacology , Receptors, IgG/*immunology, Animals ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Antigen-Antibody Complex/immunology ; Autoimmune Diseases/immunology ; Dendritic Cells/immunology ; Humans ; Immunoglobulin G/immunology ; Interleukin-6/immunology ; Macaca fascicularis ; Mice ; Mice, Transgenic ; Neutrophils/immunology ; Reactive Oxygen Species/immunology ; Tumor Necrosis Factor-alpha/immunology

المؤلفون: Cohen ES; Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Scott IC; Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Majithiya JB; Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Rapley L; Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Kemp BP; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., England E; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Rees DG; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Overed-Sayer CL; Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Woods J; Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Bond NJ; Department of Biopharmaceutical Development, Analytical Biotechnology, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Veyssier CS; Department of Biopharmaceutical Development, Analytical Biotechnology, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Embrey KJ; Department of Discovery Sciences, Innovative Medicines, AstraZeneca, Mereside, Alderley Park, SK10 4TG, UK., Sims DA; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland 20878, USA., Snaith MR; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Vousden KA; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Strain MD; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Chan DT; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Carmen S; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Huntington CE; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Flavell L; Department of Discovery Sciences, Innovative Medicines, AstraZeneca, Mereside, Alderley Park, SK10 4TG, UK., Xu J; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Popovic B; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Brightling CE; Department of Infection, Immunity and Inflammation, Institute for Lung Health, Leicester LE3 9QP, UK; NIHR Respiratory Biomedical Research Unit, University Hospitals of Leicester, Leicester LE3 9QP, UK., Vaughan TJ; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Butler R; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Lowe DC; Department of Antibody Discovery and Protein Engineering, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Higazi DR; Department of Biopharmaceutical Development, Analytical Biotechnology, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Corkill DJ; Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., May RD; Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Sleeman MA; Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK., Mustelin T; Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland 20878, USA.

المصدر: Nature communications [Nat Commun] 2015 Sep 14; Vol. 6, pp. 8327. Date of Electronic Publication: 2015 Sep 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Asthma/*immunology , Interleukin-33/*metabolism , Receptors, Cell Surface/*immunology , Receptors, Interleukin/*immunology, Animals ; Asthma/genetics ; Asthma/metabolism ; Humans ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33/genetics ; Interleukin-33/immunology ; Male ; Mice ; Mice, Inbred BALB C ; Oxidation-Reduction ; Receptors, Cell Surface/genetics ; Receptors, Interleukin/genetics

المؤلفون: Kemp BP; Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK., Doughty J; Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.

المصدر: The New phytologist [New Phytol] 2007; Vol. 175 (4), pp. 619-629.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley on behalf of New Phytologist Trust Country of Publication: England NLM ID: 9882884 Publication Model: Print Cited Medium: Print ISSN: 0028-646X (Print) Linking ISSN: 0028646X NLM ISO Abbreviation: New Phytol Subsets: MEDLINE

مواضيع طبية MeSH: Brassica/*enzymology , Brassica/*metabolism , Plant Proteins/*chemistry , Plant Proteins/*metabolism, Amino Acid Sequence ; Brassica/genetics ; Flowers/cytology ; Flowers/metabolism ; Haplotypes ; Molecular Sequence Data ; Peptide Mapping ; Plant Proteins/genetics ; Plants, Genetically Modified ; Pollen ; Protein Binding ; Protein Structure, Tertiary ; Recombinant Proteins ; Nicotiana/genetics ; Nicotiana/metabolism