المؤلفون: Hegade VS; NIHR Newcastle Biomedical Research Centre and Institute of Cellular Medicine, Framlington Place, Newcastle University, Newcastle upon Tyne, UK. Electronic address: Vinod.hegade@ncl.ac.uk., Kendrick SF; GlaxoSmithKline, Stevenage, UK., Dobbins RL; GlaxoSmithKline, Research Triangle Park, NC, USA., Miller SR; GlaxoSmithKline, Stevenage, UK., Thompson D; GlaxoSmithKline, Stevenage, UK., Richards D; GlaxoSmithKline, Stevenage, UK., Storey J; GlaxoSmithKline, Stevenage, UK., Dukes GE; GlaxoSmithKline, Research Triangle Park, NC, USA., Corrigan M; University of Birmingham and NIHR Birmingham Liver Biomedical Research Unit, Birmingham, UK., Oude Elferink RP; Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Beuers U; Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Hirschfield GM; University of Birmingham and NIHR Birmingham Liver Biomedical Research Unit, Birmingham, UK., Jones DE; NIHR Newcastle Biomedical Research Centre and Institute of Cellular Medicine, Framlington Place, Newcastle University, Newcastle upon Tyne, UK.

المصدر: Lancet (London, England) [Lancet] 2017 Mar 18; Vol. 389 (10074), pp. 1114-1123. Date of Electronic Publication: 2017 Feb 08.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE

مواضيع طبية MeSH: Cholangitis/*complications , Liver Cirrhosis, Biliary/*complications , Methylamines/*therapeutic use , Pruritus/*drug therapy , Thiazepines/*therapeutic use, Adult ; Carrier Proteins/antagonists & inhibitors ; Cross-Over Studies ; Double-Blind Method ; Female ; Humans ; Ileum ; Male ; Membrane Glycoproteins/antagonists & inhibitors ; Middle Aged ; Pruritus/etiology ; Treatment Outcome

المؤلفون: Hegade VS; NIHR Newcastle Biomedical Research Centre and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. Vinod.Hegade@ncl.ac.uk.; Institute of Cellular Medicine, William Leech Building, Framlington Place, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. Vinod.Hegade@ncl.ac.uk., Kendrick SF; NIHR Newcastle Biomedical Research Centre and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.; GlaxoSmithKline Research and Development, Medicines Research Centre, Stevenage, UK., Dobbins RL; GlaxoSmithKline, Research Triangle Park, NC, USA., Miller SR; GlaxoSmithKline Research and Development, Medicines Research Centre, Stevenage, UK., Richards D; GlaxoSmithKline Research and Development, Medicines Research Centre, Stevenage, UK., Storey J; GlaxoSmithKline Research and Development, Medicines Research Centre, Stevenage, UK., Dukes G; GlaxoSmithKline, Research Triangle Park, NC, USA., Gilchrist K; GlaxoSmithKline, Collegeville, PA, USA., Vallow S; GlaxoSmithKline, Collegeville, PA, USA., Alexander GJ; Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust Cambridge, Cambridge, UK., Corrigan M; Centre for Liver Research, University of Birmingham and NIHR Birmingham Liver Biomedical Research Unit, Birmingham, UK., Hirschfield GM; Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust Cambridge, Cambridge, UK., Jones DE; NIHR Newcastle Biomedical Research Centre and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

المصدر: BMC gastroenterology [BMC Gastroenterol] 2016 Jul 19; Vol. 16 (1), pp. 71. Date of Electronic Publication: 2016 Jul 19.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE

مواضيع طبية MeSH: Liver Cirrhosis, Biliary/*complications , Methylamines/*therapeutic use , Organic Anion Transporters, Sodium-Dependent/*antagonists & inhibitors , Pruritus/*drug therapy , Symporters/*antagonists & inhibitors , Thiazepines/*therapeutic use, Adolescent ; Adult ; Aged ; Bile Acids and Salts/blood ; Biomarkers/blood ; Cholagogues and Choleretics/pharmacokinetics ; Cholagogues and Choleretics/therapeutic use ; Cross-Over Studies ; Drug Therapy, Combination ; Female ; Humans ; Male ; Methylamines/administration & dosage ; Methylamines/adverse effects ; Methylamines/pharmacokinetics ; Middle Aged ; Organic Anion Transporters, Sodium-Dependent/therapeutic use ; Pruritus/etiology ; Symporters/therapeutic use ; Thiazepines/administration & dosage ; Thiazepines/adverse effects ; Thiazepines/pharmacokinetics ; Ursodeoxycholic Acid/pharmacokinetics ; Ursodeoxycholic Acid/therapeutic use ; Young Adult

المؤلفون: Hegade VS; Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK, and Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK vinod.hegade@ncl.ac.uk., Kendrick SF; Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK, and Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Jones DE; Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK, and Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

المصدر: Clinical medicine (London, England) [Clin Med (Lond)] 2015 Aug; Vol. 15 (4), pp. 351-7.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: The College Country of Publication: England NLM ID: 101092853 Publication Model: Print Cited Medium: Print ISSN: 1470-2118 (Print) Linking ISSN: 14702118 NLM ISO Abbreviation: Clin Med (Lond) Subsets: MEDLINE

مواضيع طبية MeSH: Anticholesteremic Agents/*therapeutic use , Cytochrome P-450 CYP2B6 Inducers/*therapeutic use , Liver Diseases/*complications , Selective Serotonin Reuptake Inhibitors/*therapeutic use, Humans ; Pruritus/drug therapy ; Pruritus/etiology ; Pruritus/psychology ; Quality of Life

المؤلفون: Hegade VS; Institute of Cellular Medicine, Newcastle University and Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne., Kendrick SF; GlaxoSmithKline Research and Development, Stevenage and Cambridge University Hospitals NHS Foundation Trust, Cambridge., Rehman J; Westcliffe Medical Practice, Bradford., Jones DE; Institute of Cellular Medicine, Newcastle University and Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne.

المصدر: The British journal of general practice : the journal of the Royal College of General Practitioners [Br J Gen Pract] 2015 Jun; Vol. 65 (635), pp. e418-20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Royal College of General Practitioners Country of Publication: England NLM ID: 9005323 Publication Model: Print Cited Medium: Internet ISSN: 1478-5242 (Electronic) Linking ISSN: 09601643 NLM ISO Abbreviation: Br J Gen Pract Subsets: MEDLINE

مواضيع طبية MeSH: Primary Health Care*, Alkaline Phosphatase/*blood , Cholestasis/*complications , Liver/*physiopathology , Liver Diseases/*complications , Liver Function Tests/*methods , Pruritus/*etiology, Anticholesteremic Agents/therapeutic use ; Cholestasis/blood ; Cholestasis/drug therapy ; Cholestyramine Resin/therapeutic use ; Female ; Humans ; Liver/metabolism ; Liver Diseases/drug therapy ; Liver Diseases/physiopathology ; Male ; Practice Guidelines as Topic ; Pruritus/blood ; Pruritus/drug therapy ; Rifampin/therapeutic use

المؤلفون: Kendrick SF; Institute of Cellular Medicine, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Day CP

المصدر: Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2010 Nov; Vol. 7 (11), pp. 593-4.

نوع المنشور: News

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500079 Publication Model: Print Cited Medium: Internet ISSN: 1759-5053 (Electronic) Linking ISSN: 17595045 NLM ISO Abbreviation: Nat Rev Gastroenterol Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: Liver Cirrhosis/*drug therapy , Palliative Care/*methods , Pentoxifylline/*therapeutic use , Vasodilator Agents/*therapeutic use, Humans

المؤلفون: Kendrick SF; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. stuart.kendrick@ncl.ac.uk, Henderson E, Palmer J, Jones DE, Day CP

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2010 Jul; Vol. 52 (1), pp. 126-31.

نوع المنشور: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Adrenal Cortex Hormones/*therapeutic use , Dexamethasone/*therapeutic use , Hepatitis, Alcoholic/*drug therapy , Theophylline/*therapeutic use, Acute Disease ; Adult ; Drug Resistance/drug effects ; Drug Therapy, Combination ; Female ; Humans ; Lymphocytes/drug effects ; Male ; Middle Aged ; Spain ; Treatment Outcome

المؤلفون: Kendrick SF; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. stuart.kendrick@ncl.ac.uk, O'Boyle G, Mann J, Zeybel M, Palmer J, Jones DE, Day CP

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2010 Jun; Vol. 51 (6), pp. 1988-97.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation*, Acetates/*metabolism , Cytokines/*metabolism , Ethanol/*metabolism , Hepatitis, Alcoholic/*metabolism , Macrophages/*metabolism, Acetate-CoA Ligase/metabolism ; Acetyl Coenzyme A/metabolism ; Acetylation ; Cell Line ; Ethanol/adverse effects ; Gene Knockdown Techniques ; Hepatitis, Alcoholic/etiology ; Histone Acetyltransferases/metabolism ; Histone Deacetylases/metabolism ; Histones/metabolism ; Humans ; Promoter Regions, Genetic

المؤلفون: Kendrick SF; Institute of Cellular Medicine, Newcastle University., Stewart SF

المصدر: Clinical medicine (London, England) [Clin Med (Lond)] 2008 Oct; Vol. 8 (5), pp. 522-4.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: The College Country of Publication: England NLM ID: 101092853 Publication Model: Print Cited Medium: Print ISSN: 1470-2118 (Print) Linking ISSN: 14702118 NLM ISO Abbreviation: Clin Med (Lond) Subsets: MEDLINE

مواضيع طبية MeSH: Social Marketing*, Alcohol Drinking/*adverse effects , Alcoholism/*complications , Health Promotion/*economics, Alcohol Drinking/economics ; Alcoholism/economics ; Europe ; Humans ; Risk Reduction Behavior

المؤلفون: Kendrick SF; Liver Research Group, Institute of Cellular Medicine, Newcastle University, UK., Day CP

المصدر: Journal of hepatology [J Hepatol] 2007 May; Vol. 46 (5), pp. 980-2. Date of Electronic Publication: 2007 Mar 02.

نوع المنشور: Comment; Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0168-8278 (Print) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: PubMed not MEDLINE

المؤلفون: Cunnington AJ; Department of Paediatrics, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom. acunning@doctors.org.uk, Kendrick SF, Wamola B, Lowe B, Newton CR

المصدر: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2004 Jul; Vol. 71 (1), pp. 43-7.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Print Cited Medium: Print ISSN: 0002-9637 (Print) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE

مواضيع طبية MeSH: Carboxyhemoglobin/*analysis , Malaria, Falciparum/*metabolism, Anemia/epidemiology ; Anemia/etiology ; Anemia/pathology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Kenya/epidemiology ; Malaria, Falciparum/complications ; Malaria, Falciparum/epidemiology ; Malaria, Falciparum/pathology ; Male ; Prospective Studies