المؤلفون: Douglas G. Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Elisabetta Bianchi, Danila Branca, Paul G. Bulger, Inne Crevecoeur, Fa-Xiang Ding, Robert M. Garbaccio, Erik D. Guetschow, Yan Guo, Sookhee N. Ha, Jennifer M. Johnston, Hubert Josien, Eunkyung A. Kauh, Kenneth A. Koeplinger, Jeffrey T. Kuethe, Eseng Lai, Christine L. Lanning, Anita Y.H. Lee, Li Li, Anilkumar G. Nair, Edward A. O’Neill, S. Aubrey Stoch, David A. Thaisrivongs, Thomas J. Tucker, Petr Vachal, Kristien van Dyck, Frederic P. Vanhoutte, Bram Volckaert, Dennis G. Wolford, Andy Xu, Tian Zhao, Dan Zhou, Susan Zhou, Xiaohong Zhu, Hratch J. Zokian, Abbas Walji, Harold B. Wood

المصدر: Circulation.

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6f19bd0c61c330917293f0ae4cf3d908
https://doi.org/10.1161/circulationaha.122.063372

المؤلفون: Thomas J. Tucker, Nianyu Li, Scott P. Salowe, Harold B. Wood, Danila Branca, Alan S. Bass, Rupesh P. Amin, BethAnn Murphy, Aurash Shahripour, Angela Kerekes, Abbas Walji, Nicole Buist, Jeffrey T. Kuethe, Huaibing He, Rodger Tracy, Kenneth A. Koeplinger, Weixun Wang, Bhavana Bhatt, Candice Alleyne, Sookhee Ha, Douglas G. Johns, Elisabetta Bianchi, Chengwei Wu, Peter Orth, Tjerk Bueters, Yusheng Xiong, Hratch J. Zokian, Michael J. Hafey, Mark W. Embrey, John Higgins

المصدر: Journal of Medicinal Chemistry. 64:16770-16800

مصطلحات موضوعية: chemistry.chemical_classification, Molecular Structure, biology, PCSK9, PCSK9 Inhibitors, Administration, Oral, Biological Availability, Peptide, Pharmacology, Crystallography, X-Ray, Proprotein convertase, Peptides, Cyclic, Rats, Bioavailability, Macaca fascicularis, Structure-Activity Relationship, chemistry, Drug Discovery, biology.protein, Animals, Molecular Medicine, Kexin, Dosing, Antibody, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01cd83054fdae5294b50a6dbca9f594
https://doi.org/10.1021/acs.jmedchem.1c01599

المؤلفون: Bhavana Bhatt, Frank D. Sistare, Kiran Palyada, Feifei Chen, Isabelle Bourgeois, Christopher Brynczka, Rupesh P. Amin, Katerina Vlasakova, José A. Lebrón, Roger Smith, Kenneth A. Koeplinger, Kenneth D Anderson, Kathleen Cox, Robert Houle, Warren E. Glaab, Yi-Zhong Gu, Xiaoyan Chu

المصدر: Toxicological Sciences. 172:155-166

مصطلحات موضوعية: PEG 400, Kidney, Organic cation transport proteins, biology, Organic anion transporter 1, 02 engineering and technology, Polyethylene glycol, Prodrug, Pharmacology, 021001 nanoscience & nanotechnology, Toxicology, 030226 pharmacology & pharmacy, Nephrotoxicity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine.anatomical_structure, chemistry, PEG ratio, biology.protein, medicine, 0210 nano-technology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7c8a93f2d09b4d982560ba5c94462b
https://doi.org/10.1093/toxsci/kfz186

المؤلفون: Shih Lin Goh, Min Xu, Arthur Fridman, Jiajie Wei, Dai Wang, Steve S. Carroll, Xi He, Shuo Quan, Amy S. Espeseth, Daria J. Hazuda, Jay A. Grobler, Silveria Rodriguez, David B. Olsen, Kenneth A. Koeplinger

المصدر: Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: 0301 basic medicine, viruses, Biology, Virus Replication, Antiviral Agents, Microbiology, Genome, 03 medical and health sciences, antivirals, 0302 clinical medicine, high-throughput antiviral screening, In vivo, Biosafety level, Chlorocebus aethiops, Animals, Humans, 030212 general & internal medicine, Replicon, skin and connective tissue diseases, Vero Cells, Coronavirus RNA-Dependent RNA Polymerase, Multidisciplinary, SARS-CoV-2, fungi, HEK 293 cells, COVID-19, Biological Sciences, biochemical phenomena, metabolism, and nutrition, Virology, High-Throughput Screening Assays, HEK293 Cells, 030104 developmental biology, Viral replication, A549 Cells, Cell culture, Vero cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affed28558dbadd92df206cde2b2cb62
https://doi.org/10.1073/pnas.2025866118

المؤلفون: Xi He, Arthur Fridman, Jiajie Wei, Jay A. Grobler, Daria J. Hazuda, Shih Lin Goh, Steve S. Carroll, Min Xu, Kenneth A. Koeplinger, Dai Wang, Shuo Quan, Silveria Rodriguez, Amy S. Espeseth, David B. Olsen

مصطلحات موضوعية: viruses, fungi, Cell, biochemical phenomena, metabolism, and nutrition, Biology, Genome, Virology, Replication (computing), medicine.anatomical_structure, Viral replication, In vivo, Cell culture, Biosafety level, medicine, Replicon

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7cd732eb52a5d2143ba02c98824cd13a
https://doi.org/10.1101/2020.12.12.422532

المؤلفون: William J. Ray, Mark T. Bilodeau, Matthew A. Seager, Marion Wittmann, Thomas J. Greshock, Scott D. Kuduk, Joy Fuerst, Lei Ma, Douglas C. Beshore, Kenneth A. Koeplinger, Christina N. Di Marco, Charles D. Thompson, George D. Hartman, Ronald K. Chang

المصدر: ACS Medicinal Chemistry Letters. 9:652-656

مصطلحات موضوعية: 0301 basic medicine, Allosteric modulator, business.industry, Organic Chemistry, M1 muscarinic receptor, Highly selective, Biochemistry, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug Discovery, Muscarinic acetylcholine receptor, Medicine, In patient, Signal transduction, business, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0625a7772073f6756845a2f53172c029
https://doi.org/10.1021/acsmedchemlett.8b00095

المؤلفون: Linda A. Lieberman, Nicholas Murgolo, Alex G. Therien, Gokul Swaminathan, Philip M. McKenna, Daniel J. Klein, Daria J. Hazuda, Bonnie J. Howell, David B. Olsen, Kenneth A. Koeplinger, Gregory C. Adam, Jessica A. Flynn

المصدر: PLoS Pathogens, Vol 17, Iss 2, p e1009225 (2021)
PLoS Pathogens

مصطلحات موضوعية: RNA viruses, Viral Diseases, Lung Development, Pulmonology, Coronaviruses, Organogenesis, Review, Disease, Virus Replication, Bioinformatics, Biochemistry, Medical Conditions, 0302 clinical medicine, Drug Discovery, Medicine, Biology (General), Pathology and laboratory medicine, Furin, 0303 health sciences, Respiratory distress, Drug discovery, Serine Endopeptidases, Proteases, Medical microbiology, Endocytosis, Enzymes, Drug repositioning, Infectious Diseases, Drug development, Viruses, SARS CoV 2, Pathogens, Viral Entry, SARS coronavirus, QH301-705.5, Immunology, Microbiology, Cell Line, Respiratory Disorders, 03 medical and health sciences, Drug Development, Viral entry, Virology, Genetics, Humans, Molecular Biology, Tropism, 030304 developmental biology, Medicine and health sciences, Biology and life sciences, SARS-CoV-2, business.industry, Organisms, Viral pathogens, Proteins, COVID-19, Covid 19, Virus Internalization, RC581-607, Cathepsins, Microbial pathogens, COVID-19 Drug Treatment, Viral Tropism, Respiratory Infections, Enzymology, Tissue tropism, Parasitology, Immunologic diseases. Allergy, business, Organism Development, Viral Transmission and Infection, 030217 neurology & neurosurgery, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe9afa61e647c5d21342ce0e67973a4
https://doi.org/10.1371/journal.ppat.1009225

المؤلفون: Douglas C, Beshore, Christina, N Di Marco, Ronald K, Chang, Thomas J, Greshock, Lei, Ma, Marion, Wittmann, Matthew A, Seager, Kenneth A, Koeplinger, Charles D, Thompson, Joy, Fuerst, George D, Hartman, Mark T, Bilodeau, William J, Ray, Scott D, Kuduk

المصدر: ACS medicinal chemistry letters. 9(7)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::35f6ffa9fea65e0bca0cc8c24e1fc5cc
https://pubmed.ncbi.nlm.nih.gov/30034595

المؤلفون: Armando Lagrutta, Joseph J. DeGeorge, José A. Lebrón, Frederick Sannajust, Kenneth A. Koeplinger, Pierre Morissette, Liping Liu, Christopher P. Regan, Haoyu Zeng, Christopher Brynczka, Gordon K. Wollenberg, John P. Imredy

المصدر: Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Bradycardia, Calcium Channels, L-Type, Metabolite, Guinea Pigs, Induced Pluripotent Stem Cells, Amiodarone, Viral Nonstructural Proteins, Pharmacology, Antiviral Agents, Cathepsin A, Article, Cell Line, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Animals, Humans, Medicine, Drug Interactions, Myocytes, Cardiac, Prodrugs, Calcium Signaling, Multidisciplinary, Dose-Response Relationship, Drug, Molecular Structure, business.industry, Phosphoramidate, Prodrug, In vitro, 030104 developmental biology, chemistry, medicine.symptom, business, Anti-Arrhythmia Agents, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532de2ab44a0a669c6cf0bdd9fcf01b8

المؤلفون: Brian A. Carr, Inthirai Somasuntharam, Traci Q. Lifsted, Martha A. DiPietro, Christopher R. Gibson, Nicole T. Pudvah, Jerome Hochman, Scott Fauty, Marian E. Gindy, Sujal V. Deshmukh, Jillian DiMuzio, Thomayant Prueksaritanont, Hae Won Kwon, Ian Knemeyer, Paul Rearden, Deanne Jackson Rudd, Walter Strapps, Kelly Hamilton, Mihir Patel, Charles D. Thompson, Karsten Menzel, Roy Eisenhandler, Kenneth A. Koeplinger, Rob S. Burke, Duncan Brown, Jessica Seitzer

المصدر: Pharmaceutical Research. 31:3445-3460

مصطلحات موضوعية: Male, Diclofenac, Chemistry, Pharmaceutical, Midazolam, Pharmacology toxicology, Pharmaceutical Science, In Vitro Techniques, Biology, Pharmacology, Cytochrome P-450 Enzyme System, In vivo, Microsomes, Animals, Pharmacology (medical), RNA, Small Interfering, Gene knockdown, Organic Chemistry, Metabolism, Small molecule, Rats, P450 oxidoreductase, Biochemistry, Plasma exposure, Gene Knockdown Techniques, Microsomes, Liver, Nanoparticles, Molecular Medicine, Protein Binding, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb2347584ce9657204a33b8feae3136
https://doi.org/10.1007/s11095-014-1433-0