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المؤلفون: Velilla JA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Volpe MR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Kenney GE; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Walsh RM Jr; Harvard Cryo-EM Center for Structural Biology, Harvard Medical School, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Gaudet R; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. gaudet@mcb.harvard.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2023 Feb; Vol. 19 (2), pp. 151-158. Date of Electronic Publication: 2022 Oct 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Prodrugs* , Escherichia coli Proteins*/metabolism, Peptide Hydrolases/chemistry ; Escherichia coli/metabolism ; Peptides/chemistry

المؤلفون: Velilla JA; Department of Molecular and Cellular Biology, Harvard University, 52 Oxford St, Cambridge, MA, 02138, USA., Kenney GE; Department of Chemistry and Chemical Biology, Harvard University, 38 Oxford St, Cambridge, MA, USA., Gaudet R; Department of Molecular and Cellular Biology, Harvard University, 52 Oxford St, Cambridge, MA, 02138, USA. Electronic address: gaudet@mcb.harvard.edu.

المصدر: Biochimie [Biochimie] 2023 Feb; Vol. 205, pp. 124-135. Date of Electronic Publication: 2022 Nov 08.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE

مواضيع طبية MeSH: Prodrugs*/pharmacology , Prodrugs*/metabolism , Escherichia coli Proteins*/metabolism, Peptide Hydrolases/chemistry ; Escherichia coli/genetics

المؤلفون: Schachner LF; Department of Chemistry, the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States., Soye BD; Department of Chemistry, the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States.; Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States., Ro S; Department Molecular and Biological Sciences, Northwestern University, Evanston, Illinois 60208, United States., Kenney GE; Department Molecular and Biological Sciences, Northwestern University, Evanston, Illinois 60208, United States.; Department of Chemistry, Harvard University, Cambridge, Massachusetts 02140, United States., Ives AN; Department of Chemistry, the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States., Su T; Department of Chemistry, the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States., Goo YA; Department of Chemistry, the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States., Jewett MC; Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States., Rosenzweig AC; Department Molecular and Biological Sciences, Northwestern University, Evanston, Illinois 60208, United States., Kelleher NL; Department of Chemistry, the Proteomics Center of Excellence, Northwestern University, Evanston, Illinois 60208, United States.; Department Molecular and Biological Sciences, Northwestern University, Evanston, Illinois 60208, United States.

المصدر: ACS chemical biology [ACS Chem Biol] 2022 Oct 21; Vol. 17 (10), pp. 2769-2780. Date of Electronic Publication: 2022 Aug 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Triose-Phosphate Isomerase*/chemistry , Triose-Phosphate Isomerase*/metabolism , Molecular Dynamics Simulation*, Humans ; Phosphorylation ; Catalytic Domain ; Kinetics

المؤلفون: Park YJ; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Roberts GM; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Montaser R; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Kenney GE; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Thomas PM; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Kelleher NL; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States., Rosenzweig AC; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208, United States.

المصدر: Biochemistry [Biochemistry] 2021 Sep 28; Vol. 60 (38), pp. 2845-2850. Date of Electronic Publication: 2021 Sep 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Copper/*metabolism , Methylosinus/*enzymology , Methylosinus/*metabolism, Amino Acid Sequence/genetics ; Bacterial Proteins/metabolism ; Biological Products/metabolism ; Chelating Agents/chemistry ; Copper/chemistry ; Gene Expression/genetics ; Gene Expression Regulation, Bacterial/genetics ; Genome, Bacterial/genetics ; Imidazoles/metabolism ; Methane/metabolism ; Methylosinus/genetics ; Methylosinus trichosporium/enzymology ; Methylosinus trichosporium/genetics ; Methylosinus trichosporium/metabolism ; Oligopeptides/metabolism ; Operon/genetics ; Oxidation-Reduction ; Peptides/metabolism

المؤلفون: Chou JC; Department of Chemistry, Stanford University, Stanford, CA, United States., Stafford VE; Department of Chemistry, Stanford University, Stanford, CA, United States., Kenney GE; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, United States. Electronic address: gkenney@fas.harvard.edu., Dassama LMK; Department of Chemistry, Stanford University, Stanford, CA, United States; ChEM-H Institute, Stanford University, Stanford, CA, United States. Electronic address: dassama@stanford.edu.

المصدر: Methods in enzymology [Methods Enzymol] 2021; Vol. 656, pp. 341-373. Date of Electronic Publication: 2021 May 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE

مواضيع طبية MeSH: Oxazolone* , Thioamides*, Imidazoles ; Oligopeptides ; Protein Processing, Post-Translational

المؤلفون: McBride MJ, Sil D, Ng TL; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States., Crooke AM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States., Kenney GE; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States., Tysoe CR, Zhang B, Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States., Boal AK, Krebs C, Bollinger JM Jr

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2020 Jul 08; Vol. 142 (27), pp. 11818-11828. Date of Electronic Publication: 2020 Jun 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins/*metabolism , Ferric Compounds/*metabolism , Metalloproteins/*metabolism , Nitrosourea Compounds/*metabolism , Streptozocin/*biosynthesis, Bacterial Proteins/chemistry ; Bacterial Proteins/isolation & purification ; Ferric Compounds/chemistry ; Hydroxylation ; Metalloproteins/chemistry ; Metalloproteins/isolation & purification ; Models, Molecular ; Molecular Structure ; Nitrosourea Compounds/chemistry ; Streptomyces/enzymology ; Streptozocin/chemistry

SCR Organism: Streptomyces achromogenes

المؤلفون: Bisanz JE; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Soto-Perez P; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Noecker C; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Aksenov AA; Collaborative Mass Spectrometry Innovation Center, Department of Pediatrics, Center for Microbiome Innovation, Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA 92093, USA., Lam KN; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Kenney GE; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Bess EN; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Haiser HJ; Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA., Kyaw TS; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Yu FB; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Rekdal VM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Ha CWY; Department of Medicine, Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Devkota S; Department of Medicine, Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Dorrestein PC; Collaborative Mass Spectrometry Innovation Center, Department of Pediatrics, Center for Microbiome Innovation, Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA 92093, USA., Allen-Vercoe E; Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada., Turnbaugh PJ; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address: peter.turnbaugh@ucsf.edu.

المصدر: Cell host & microbe [Cell Host Microbe] 2020 Jun 10; Vol. 27 (6), pp. 1001-1013.e9. Date of Electronic Publication: 2020 Apr 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE

مواضيع طبية MeSH: Genomics*, Bacteria/*genetics , Bacteria/*isolation & purification , Dissection/*methods , Gastrointestinal Microbiome/*genetics, Actinobacteria/classification ; Actinobacteria/drug effects ; Actinobacteria/genetics ; Actinobacteria/isolation & purification ; Animals ; Anti-Bacterial Agents/pharmacology ; Bacteria/classification ; Bacteria/drug effects ; Gastrointestinal Microbiome/physiology ; Gastrointestinal Tract/microbiology ; Genes, Bacterial/genetics ; Germ-Free Life ; Humans ; Metagenome ; Metagenomics ; Mice ; Microbial Sensitivity Tests ; Multigene Family ; Phenotype ; Polymorphism, Genetic

SCR Organism: Eggerthella lenta

المؤلفون: Kenney GE; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208., Dassama LMK; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208., Manesis AC; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208., Ross MO; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208., Chen S; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208., Hoffman BM; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208., Rosenzweig AC; Departments of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois 60208 amyr@northwestern.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2019 Nov 01; Vol. 294 (44), pp. 16141-16151. Date of Electronic Publication: 2019 Sep 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Copper/*metabolism , Imidazoles/*metabolism , Methylosinus trichosporium/*metabolism , Oligopeptides/*genetics , Oligopeptides/*metabolism, Amino Acid Sequence/genetics ; Bacteria/metabolism ; Bacterial Proteins/metabolism ; Computational Biology/methods ; Homeostasis ; Oligopeptides/biosynthesis ; Operon/genetics ; Protein Processing, Post-Translational

المؤلفون: Ro SY; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA., Schachner LF; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA., Koo CW; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA., Purohit R; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA., Remis JP; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA., Kenney GE; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA., Liauw BW; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA., Thomas PM; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA., Patrie SM; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA., Kelleher NL; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA. n-kelleher@northwestern.edu., Rosenzweig AC; Departments of Molecular Biosciences and of Chemistry, Northwestern University, 2205 Tech Drive, Evanston, IL, 60208, USA. amyr@northwestern.edu.

المصدر: Nature communications [Nat Commun] 2019 Jun 17; Vol. 10 (1), pp. 2675. Date of Electronic Publication: 2019 Jun 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Models, Molecular*, Bacterial Proteins/*metabolism , Mass Spectrometry/*methods , Methylococcaceae/*metabolism , Oxygenases/*metabolism, Bacterial Proteins/chemistry ; Bacterial Proteins/ultrastructure ; Binding Sites ; Biocatalysis ; Catalytic Domain ; Copper/chemistry ; Copper/metabolism ; Cryoelectron Microscopy ; Methane/metabolism ; Methanol/metabolism ; Methylococcaceae/chemistry ; Methylococcaceae/ultrastructure ; Oxidation-Reduction ; Oxygenases/chemistry ; Oxygenases/ultrastructure ; Protein Processing, Post-Translational