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1
المؤلفون: Mark S. Tichenor, John J. M. Wiener, Navin L. Rao, Genesis M. Bacani, Jianmei Wei, Charlotte Pooley Deckhut, J. Kent Barbay, Kevin D. Kreutter, Leon Chang, Kathleen W. Clancy, Heather E. Murrey, Weixue Wang, Kay Ahn, Michael Huber, Elizabeth Rex, Kevin J. Coe, Jiejun Wu, Haopeng Rui, Kia Sepassi, Marcello Gaudiano, Mariette Bekkers, Ivo Cornelissen, Kathryn Packman, Mark Seierstad, Christos Xiouras, Scott D. Bembenek, Richard Alexander, Cynthia Milligan, Sriram Balasubramanian, Alec D. Lebsack, Jennifer D. Venable, Ulrike Philippar, James P. Edwards, Gavin Hirst
المصدر: Journal of Medicinal Chemistry. 65:14326-14336
مصطلحات موضوعية: Arthritis, Rheumatoid, Drug Discovery, Agammaglobulinaemia Tyrosine Kinase, Humans, Lupus Erythematosus, Systemic, Molecular Medicine, Protein Kinase Inhibitors, Autoimmune Diseases
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2
المؤلفون: Jennifer D. Venable, Weixue Wang, Jianmei Wei, Heather E. Murrey, Mark S. Tichenor, Kristi A. Leonard, Michael Huber, Alec D. Lebsack, Genesis M. Bacani, Scott D. Bembenek, Kay Ahn, J. Kent Barbay, Leon Chang, Kevin D. Kreutter, Navin Rao, Charlotte Pooley Deckhut, Jiejun Wu, Kevin J. Coe, Elizabeth B. Rex, John J. M. Wiener, James P. Edwards, Mark Seierstad
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Cell type, biology, 010405 organic chemistry, Chemistry, medicine.drug_class, Organic Chemistry, Arthritis, Inflammation, medicine.disease, 01 natural sciences, Biochemistry, Anti-inflammatory, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, immune system diseases, In vivo, hemic and lymphatic diseases, Drug Discovery, Cancer research, medicine, biology.protein, Bruton's tyrosine kinase, medicine.symptom, Tyrosine kinase, Cysteine
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3
المؤلفون: Anne M. Fourie, Glenda Castro, John Spurlino, Rachel Nishimura, Xiaohua Xue, Maxwell D. Cummings, Maud Urbanski, Kevin D. Kreutter, Umar Maharoof, Aihua Wang, David A. Kummer, J. Kent Barbay, James P. Edwards, Kristi A. Leonard, Ronald L. Wolin, Hariharan Venkatesan, Marta Cristina Abad, Celine Schalk-Hihi, Craig R. Woods, Cynthia M. Milligan, Joan Pierce, Virginia M. Tanis
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:5277-5283
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Substituent, Retinoic acid, Pharmaceutical Science, Crystallography, X-Ray, Ligands, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, RAR-related orphan receptor gamma, Drug Discovery, Humans, Inverse agonist, Receptor, Molecular Biology, Orphan receptor, Reporter gene, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Quinoline, Nuclear Receptor Subfamily 1, Group F, Member 3, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Quinolines, Molecular Medicine
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4دورية أكاديمية
المؤلفون: Tanis, Virginia M., Venkatesan, Hariharan, Cummings, Maxwell D., Albers, Michael, Kent Barbay, J., Herman, Krystal, Kummer, David A., Milligan, Cynthia, Nelen, Marina I., Nishimura, Rachel, Schlueter, Thomas, Scott, Brian, Spurlino, John, Wolin, Ronald, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi
المصدر: In Bioorganic & Medicinal Chemistry Letters 15 June 2019 29(12):1463-1470
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5
المؤلفون: Weimei Sun, James P. Edwards, Ricardo Attar, Tianbao Lu, Nigel Austin, Lieven Meerpoel, Ann Cai, Luc Gys, Ulrike Philippar, Maxwell D. Cummings, Kent Barbay, Peter J. Connolly, Luc Van Nuffel, Mariette Bekkers, Shen Fang
المصدر: Bioorganicmedicinal chemistry letters. 29(23)
مصطلحات موضوعية: chemistry.chemical_classification, Protease, medicine.medical_treatment, RELB, Organic Chemistry, Clinical Biochemistry, Allosteric regulation, Assay, Pharmaceutical Science, Biochemistry, Small molecule, Jurkat cells, Enzyme, chemistry, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein, Cell Line, Tumor, Drug Discovery, medicine, Molecular Medicine, Humans, Molecular Biology, IC50
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6
المؤلفون: Maxwell D. Cummings, Thomas Schlueter, David A. Kummer, J. Kent Barbay, Krystal Herman, Craig R. Woods, John Spurlino, Kristi A. Leonard, Cynthia M. Milligan, Hariharan Venkatesan, Rachel Nishimura, Michael Albers, Ronald L. Wolin, James P. Edwards, Marina I. Nelen, Xiaohua Xue, Anne M. Fourie, Virginia M. Tanis, Brian Scott
المصدر: Bioorganicmedicinal chemistry letters. 29(12)
مصطلحات موضوعية: Drug Inverse Agonism, Clinical Biochemistry, Heteroatom, Retinoic acid, Pharmaceutical Science, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, RAR-related orphan receptor gamma, Drug Discovery, Inverse agonist, Molecule, Animals, Humans, Solubility, Molecular Biology, Orphan receptor, Improved solubility, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Quinolines, Molecular Medicine
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7
المؤلفون: Joseph Kent Barbay, Marta Cristina Abad, Ronald L. Wolin, Craig R. Woods, Cynthia M. Milligan, Kristi A. Leonard, Glenda Castro, John Spurlino, Celine Schalk-Hihi, Aihua Wang, Anne M. Fourie, Maxwell D. Cummings, Maud Urbanski, James P. Edwards, Kevin D. Kreutter, Umar Maharoof, Hariharan Venkatesan, David A. Kummer, Xiaohua Xue, Rachel Nishimura, Joan Pierce
المصدر: Bioorganicmedicinal chemistry letters. 27(9)
مصطلحات موضوعية: 0301 basic medicine, Agonist, Thermal shift assay, Drug Inverse Agonism, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, RAR-related orphan receptor gamma, Drug Discovery, medicine, Inverse agonist, Humans, Molecular Biology, Orphan receptor, 010405 organic chemistry, Chemistry, Organic Chemistry, Quinoline, Retinoic acid receptor gamma, Nuclear Receptor Subfamily 1, Group F, Member 3, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Nuclear receptor, Drug Design, Quinolines, Molecular Medicine, Th17 Cells
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8
المؤلفون: Lori Westover, Nathaniel H. Wallace, Paul F. Jackson, Brian C. Shook, Lisa Lampron, Devraj Chakravarty, J. Kent Barbay, Mark T. Powell, Aihua Wang, Robert H. Scannevin, Kenneth J. Rhodes, Mark Ault, Vernon C. Alford, Jeffrey Crooke, Kristi A. Leonard, Stefanie Rassnick, Karen Carroll
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:2688-2691
مصطلحات موضوعية: Receptor, Adenosine A2A, Stereochemistry, Adenosine A2A Receptor Antagonists, Clinical Biochemistry, Pharmaceutical Science, Plasma protein binding, Catalepsy, Pharmacology, Biochemistry, Mice, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Brain, medicine.disease, Adenosine, Adenosine A2 Receptor Antagonists, Rats, Kinetics, Pyrimidines, Molecular Medicine, Half-Life, Protein Binding, medicine.drug
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9
المؤلفون: Devraj Chakravarty, Sandra Damon, Kenneth J. Rhodes, Mark Ault, Robert H. Scannevin, Lori Westover, Xun Li, Vernon C. Alford, Aihua Wang, Heng-Keang Lim, Lisa Lampron, Jeffrey Crooke, Scott Youells, Paul F. Jackson, Ronald K. Russell, J. Kent Barbay, Mark T. Powell, Stefanie Rassnick, Derek A. Beauchamp, Shawn Branum, Kenneth M. Wells, Kristi A. Leonard, Nathaniel H. Wallace, Karen Carroll, Brian C. Shook
المصدر: Journal of Medicinal Chemistry. 55:1402-1417
مصطلحات موضوعية: Parkinson's disease, Chemistry, Catalepsy, Pharmacology, medicine.disease, Adenosine, Lesion, Adenosine A1 receptor, Oral administration, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, medicine.symptom, Receptor, medicine.drug
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10
المؤلفون: Scott Youells, Robert H. Scannevin, Mark T. Powell, Sandra Damon, Ronald K. Russell, Paul F. Jackson, Lori Westover, Lisa Lampron, Jeffrey Crooke, Karen Carroll, Kristen Hansen, Geoffrey R. Heintzelman, Kenneth M. Wells, Kenneth J. Rhodes, J. Kent Barbay, N. H. Wallace, Devraj Chakravarty, Stefanie Rassnick, Brian C. Shook, Aihua Wang, Hall Daniel A, Kenneth C. Rupert, Xun Li, Vernon C. Alford, Derek A. Beauchamp, Shawn Branum, Kristi A. Leonard, Mark Ault, James L. Bullington
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2868-2871
مصطلحات موضوعية: Receptor, Adenosine A2A, Clinical Biochemistry, Pharmaceutical Science, Ether, Adenosine A1 Receptor Antagonists, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine A1 receptor, In vivo, Dopamine, Amide, Drug Discovery, medicine, Animals, Molecular Biology, Catalepsy, Neurotransmitter Agents, Receptor, Adenosine A1, Organic Chemistry, Antagonist, In vitro, Adenosine A2 Receptor Antagonists, Disease Models, Animal, Pyrimidines, chemistry, Adenosine a, Molecular Medicine, medicine.drug